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Delta-like protein

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Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (By similarity). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) .

Below are the list of possible Delta-like protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Delta-like protein 1

 Delta-like protein 1 ELISA Kit
 Delta-like protein 1 Recombinant
 Delta-like protein 1 Antibody
Also known as Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1).
DLL1: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain a
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nd muscle and almost no expression in placenta, lung, liver and kidney.

Protein type: Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: adherens junction; apical plasma membrane; cytoplasmic vesicle; lipid raft; plasma membrane

Molecular Function: Notch binding; protein binding; Tat protein binding

Biological Process: astrocyte development; cell fate determination; cell-cell signaling; cerebellar molecular layer formation; cerebellar Purkinje cell layer structural organization; compartment specification; determination of left/right symmetry; heart looping; inner ear development; lateral inhibition; marginal zone B cell differentiation; negative regulation of auditory receptor cell differentiation; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of epidermal cell differentiation; negative regulation of epithelial cell differentiation; negative regulation of interleukin-10 production; negative regulation of myeloid cell differentiation; negative regulation of myoblast differentiation; negative regulation of neuron differentiation; neuron fate specification; Notch signaling pathway; organ growth; positive regulation of cell proliferation; positive regulation of endocytosis; positive regulation of Notch signaling pathway; positive regulation of skeletal muscle growth; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation; regulation of blood pressure; regulation of cell adhesion; regulation of cell division; regulation of growth; regulation of neurogenesis; regulation of skeletal muscle growth; regulation of somitogenesis; retina development in camera-type eye; retina morphogenesis in camera-type eye; skeletal muscle growth; somite specification; somitogenesis; spinal cord development
 Dll1 ELISA Kit
 Dll1 Recombinant
 Dll1 Antibody
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Delta-like protein 3

 Delta-like protein 3 ELISA Kit
 Delta-like protein 3 Recombinant
 Delta-like protein 3 Antibody
Also known as Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3).
DLL3: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor.

Protein type: Cell development/differentiation; M
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embrane protein, integral

Chromosomal Location of Human Ortholog: 19q13

Biological Process: skeletal development

Disease: Spondylocostal Dysostosis 1, Autosomal Recessive
 DLL3 ELISA Kit
 DLL3 Recombinant
 DLL3 Antibody
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Delta-like protein 4

 Delta-like protein 4 ELISA Kit
 Delta-like protein 4 Recombinant
 Delta-like protein 4 Antibody
Also known as Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4).
DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium.

Protein type: Cell development/differentiation; Membrane protein, integral

Cellular Component: integral to plasma membrane

Molecular Function: Notch bindin
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g; protein binding

Biological Process: angiogenesis; blood vessel remodeling; negative regulation of blood vessel endothelial cell migration; negative regulation of cell proliferation; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; patterning of blood vessels; positive regulation of Notch signaling pathway; regulation of neurogenesis; T cell differentiation
 Dll4 ELISA Kit
 Dll4 Recombinant
 Dll4 Antibody
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Delta-like protein A

 Delta-like protein A ELISA Kit
 Delta-like protein A Recombinant
 Delta-like protein A Antibody
Also known as Delta-like protein A (DeltaA).
Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hi
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ndbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell fate. Plays a role in angiogenesis.
 dla ELISA Kit
 dla Recombinant
 dla Antibody
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Delta-like protein B

 Delta-like protein B ELISA Kit
 Delta-like protein B Recombinant
 Delta-like protein B Antibody
Also known as Delta-like protein B (DeltaB).
Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation.
 dlb ELISA Kit
 dlb Recombinant
 dlb Antibody
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Delta-like protein C

 Delta-like protein C ELISA Kit
 Delta-like protein C Recombinant
 Delta-like protein C Antibody
Also known as Delta-like protein C (DeltaC) (delC).
Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.
 dlc ELISA Kit
 dlc Recombinant
 dlc Antibody
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Delta-like protein D

 Delta-like protein D ELISA Kit
 Delta-like protein D Recombinant
 Delta-like protein D Antibody
Also known as Delta-like protein D (DeltaD) (After eight protein).
Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite se
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gmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.
 dld ELISA Kit
 dld Recombinant
 dld Antibody
 aei ELISA Kit
 aei Recombinant
 aei Antibody
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Proteins Root Name Listing
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