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Delta-theraphotoxin

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Inhibits voltage-gated sodium channels, preferentially subtype Nav1.5/SCN5A (in cardiac myocytes), but also Nav1.6/SCN8A and Nav1.7/SCN9A (TTX-sensitive Nav in rat DRG neurons) and invertebrate Nav (in insect neurons) as well as voltage-gated potassium channels of the subtype Kv2.1/KCNB1. Is suggested to bind to site 3 of the sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. On potassium channels, inhibits activation of channels with an IC(50) of 8.05 uM through a voltage sensor-trapping mechanism and is suggested to act both presynaptically and postsynaptically.

Below are the list of possible Delta-theraphotoxin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Delta-theraphotoxin-Cg1a 1

 Delta-theraphotoxin-Cg1a 1 ELISA Kit
 Delta-theraphotoxin-Cg1a 1 Recombinant
 Delta-theraphotoxin-Cg1a 1 Antibody
Also known as Delta-theraphotoxin-Cg1a 1 (Delta-TRTX-Cg1a) (Jingzhaotoxin-1) (Jingzhaotoxin-I) (JZTX-I) (Peptide F5-24.92).
Inhibits voltage-gated sodium channels, preferentially subtype Nav1.5/SCN
>>>
5A (in cardiac myocytes), but also Nav1.6/SCN8A and Nav1.7/SCN9A (TTX-sensitive Nav in rat DRG neurons) and invertebrate Nav (in insect neurons) as well as voltage-gated potassium channels of the subtype Kv2.1/KCNB1. Is suggested to bind to site 3 of the sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. On potassium channels, inhibits activation of channels with an IC50 of 8.05 ┬ÁM through a voltage sensor-trapping mechanism (PubMed:23246579). Increases muscle contraction in several assays (mouse phrenic nerve-diaphragm, toad heart, rat vas deferens) and is suggested to act both presynaptically and postsynaptically.
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Delta-theraphotoxin-Cg1a 2

 Delta-theraphotoxin-Cg1a 2 ELISA Kit
 Delta-theraphotoxin-Cg1a 2 Recombinant
 Delta-theraphotoxin-Cg1a 2 Antibody
Also known as Delta-theraphotoxin-Cg1a 2 (Delta-TRTX-Cg1a) (Jingzhaotoxin-1.2) (JZTX-1.2) (Jingzhaotoxin-I.2) (JZTX-I.2) (Peptide F5-24.92).
Inhibits voltage-gated sodium channels, preferentially s
>>>
ubtype Nav1.5/SCN5A (in cardiac myocytes), but also Nav1.6/SCN8A and Nav1.7/SCN9A (TTX-sensitive Nav in rat DRG neurons) and invertebrate Nav (in insect neurons) as well as voltage-gated potassium channels of the subtype Kv2.1/KCNB1. Is suggested to bind to site 3 of the channels and inhibiting the inactivation of the activated channels, thereby blocking neuronal transmission. Increases muscle contraction in several assays (mouse phrenic nerve-diaphragm, toad heart, rat vas deferens) and is suggested to act both presynaptically and postsynaptically.
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Delta-theraphotoxin-Cg1a 3

 Delta-theraphotoxin-Cg1a 3 ELISA Kit
 Delta-theraphotoxin-Cg1a 3 Recombinant
 Delta-theraphotoxin-Cg1a 3 Antibody
Also known as Delta-theraphotoxin-Cg1a 3 (Delta-TRTX-Cg1a) (Jingzhaotoxin-1.3) (JZTX-1.3) (Jingzhaotoxin-I.3) (JZTX-I.3) (Peptide F5-24.92).
Inhibits voltage-gated sodium channels, preferentially s
>>>
ubtype Nav1.5/SCN5A (in cardiac myocytes), but also Nav1.6/SCN8A and Nav1.7/SCN9A (TTX-sensitive Nav in rat DRG neurons) and invertebrate Nav (in insect neurons) as well as voltage-gated potassium channels of the subtype Kv2.1/KCNB1. Is suggested to bind to site 3 of the channels and inhibiting the inactivation of the activated channels, thereby blocking neuronal transmission. Increases muscle contraction in several assays (mouse phrenic nerve-diaphragm, toad heart, rat vas deferens) and is suggested to act both presynaptically and postsynaptically.
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