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DeltaKappa-actitoxin

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Acts as a gating modifier on both Kv and Nav ion channels. Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) and slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A .

Below are the list of possible DeltaKappa-actitoxin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DeltaKappa-actitoxin-Avd4a

 DeltaKappa-actitoxin-Avd4a ELISA Kit
 DeltaKappa-actitoxin-Avd4a Recombinant
 DeltaKappa-actitoxin-Avd4a Antibody
Also known as DeltaKappa-actitoxin-Avd4a (DeltaKappa-AITX-Avd4a) (Antihypertensive protein BDS-1) (Blood depressing substance I) (BDS-I).
Acts as a gating modifier on both Kv and Nav ion channels.
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Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) and slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A (PubMed:16177043, PubMed:22442564, PubMed:9506974). Inhibits all Kv3.1, Kv3.2 and Kv3.4 by about 50% when tested at a voltage of +40 mV (45%, 48% and 56%, respectively). May act by binding residues in voltage-sensing domains S3b and S4 of Kv3 (PubMed:16177043). Tests have been done on human Nav1.7/SCN9A (expressed in HEK293 cells) (EC(50)=3 nM) and rat SCG neurons that mostly carry Nav1.7 channels (EC(50)=300 nM) (PubMed:22442564). This toxin also reduces blood pressure (Ref. 1).
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DeltaKappa-actitoxin-Avd4b

 DeltaKappa-actitoxin-Avd4b ELISA Kit
 DeltaKappa-actitoxin-Avd4b Recombinant
 DeltaKappa-actitoxin-Avd4b Antibody
Also known as DeltaKappa-actitoxin-Avd4b (DeltaKappa-AITX-Avd4b) (Antihypertensive protein BDS-2) (Blood depressing substance II) (BDS-II).
Acts as a gating modifier on both Kv and Nav ion channels
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. Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) (PubMed:9506974, PubMed:16177043). Slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A (). Inhibits all Kv3.1, Kv3.2 and Kv3.4 by about 50% when tested at a voltage of +40 mV (PubMed:16177043). May act by binding residues in voltage-sensing domains S3b and S4 of Kv3 (PubMed:16177043). Tests have been done on human Nav1.7/SCN9A and rat SCG neurons that mostly carry Nav1.7 channels (EC(50)=300 nM) (). This toxin also reduces blood pressure (Ref. 1).
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