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Dematin

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Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.

Below are the list of possible Dematin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Dematin

 Dematin ELISA Kit
 Dematin Recombinant
 Dematin Antibody
Also known as Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9).
dematin: a probable DNA binding protein, with a Myb-like DNA-binding and ELM2 domain.

Protein type: Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor

Cellular Component: actin filament; cell projection membrane; cortical cytoskeleton; cytoplasmic vesicle; cytosol; membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density

Molecular Function: actin binding; protein self-association; receptor binding; spectrin binding

Biological Process:
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actin cytoskeleton organization and biogenesis; erythrocyte development; negative regulation of focal adhesion formation; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of blood coagulation; protein complex assembly; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of filopodium formation
 Dmtn ELISA Kit
 Dmtn Recombinant
 Dmtn Antibody
 Epb4.9 ELISA Kit
 Epb4.9 Recombinant
 Epb4.9 Antibody
 Epb49 ELISA Kit
 Epb49 Recombinant
 Epb49 Antibody
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