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DENN domain-containing protein

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Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes .

Below are the list of possible DENN domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DENN domain-containing protein 1A

 DENN domain-containing protein 1A ELISA Kit
 DENN domain-containing protein 1A Recombinant
 DENN domain-containing protein 1A Antibody
Also known as DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn).
DENND1A: a guanine nucleotide exchange factor (GEF) associated with clathrin-coated vesicle and presynaptic membranes. Regulates clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated en
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docytosis of synaptic vesicles. Interacts with ITSN1 AND SH3GL2. Interacts with RAB35. Interacts with clathrin and with the adapter protein complex 2, AP-2. Localizes to clathrin patches at the plasma membrane and activatesRab35 in an endocytic pathway trafficking Shiga toxin to the trans-Golgi network. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rab; Vesicle

Cellular Component: cell soma; clathrin coated vesicle membrane; clathrin-coated vesicle; dendrite; synapse

Molecular Function: phosphatidylinositol 3-phosphate binding; protein binding; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity; SH3 domain binding

Biological Process: endocytic recycling; endocytosis; positive regulation of GTPase activity; regulation of Rab protein signal transduction; synaptic vesicle endocytosis
 Dennd1a ELISA Kit
 Dennd1a Recombinant
 Dennd1a Antibody
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DENN domain-containing protein 1B

 DENN domain-containing protein 1B ELISA Kit
 DENN domain-containing protein 1B Recombinant
 DENN domain-containing protein 1B Antibody
Also known as DENN domain-containing protein 1B (Connecdenn 2).
DENND1B: a guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Interacts with RAB35. Interacts with clathrin heavy chain/CLTC and with AP2A2. Highly expressed in dendritic
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and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T-cells as compared with naive T-cells. Five isoforms of the human protein are produced by alternative splicing. Isoform 5 interacts with AP2B1.

Protein type: GEFs; GEFs, Rab

Molecular Function: Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity

Biological Process: endocytic recycling; positive regulation of GTPase activity; regulation of immune response; T cell receptor signaling pathway
 Dennd1b ELISA Kit
 Dennd1b Recombinant
 Dennd1b Antibody
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DENN domain-containing protein 1C

 DENN domain-containing protein 1C ELISA Kit
 DENN domain-containing protein 1C Recombinant
 DENN domain-containing protein 1C Antibody
Also known as DENN domain-containing protein 1C (Connecdenn 3).
DENND1C: a guanine nucleotide exchange factor (GEF) associated with clathrin-associated vesicles. Appears to activate RAB35, RAB8A, and RAB13. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Exhibits low nucleotide-independent RAB35-binding activity. Interacts with c
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lathrin heavy chain/CLTC and with AP2A2, but not with AP2B1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rab

Molecular Function: Rab guanyl-nucleotide exchange factor activity
 Dennd1c ELISA Kit
 Dennd1c Recombinant
 Dennd1c Antibody
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DENN domain-containing protein 2A

 DENN domain-containing protein 2A ELISA Kit
 DENN domain-containing protein 2A Recombinant
 DENN domain-containing protein 2A Antibody
DENND2A: a guanine nucleotide exchange factor (GEF) protein associated with actin filaments and that controls Rab9-dependent trafficking of mannose-6-phosphate receptor to lysosomes. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. Two isoforms of the human
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protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rab

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: actin cytoskeleton

Molecular Function: Rab guanyl-nucleotide exchange factor activity

Biological Process: retrograde transport, endosome to Golgi
 DENND2A ELISA Kit
 DENND2A Recombinant
 DENND2A Antibody
 KIAA1277 ELISA Kit
 KIAA1277 Recombinant
 KIAA1277 Antibody
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DENN domain-containing protein 2C

 DENN domain-containing protein 2C ELISA Kit
 DENN domain-containing protein 2C Recombinant
 DENN domain-containing protein 2C Antibody
DENND2C: a guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Three isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rab

Chromosomal Location of Human Ortholog: 1p13.2

Molecular Function: Rab gu
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anyl-nucleotide exchange factor activity
 DENND2C ELISA Kit
 DENND2C Recombinant
 DENND2C Antibody
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DENN domain-containing protein 2D

 DENN domain-containing protein 2D ELISA Kit
 DENN domain-containing protein 2D Recombinant
 DENN domain-containing protein 2D Antibody
DENND2D: a guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epith
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elial cell lines and precancerous lesions. Two isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rab

Chromosomal Location of Human Ortholog: 1p13.3

Molecular Function: protein binding; Rab guanyl-nucleotide exchange factor activity
 DENND2D ELISA Kit
 DENND2D Recombinant
 DENND2D Antibody
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DENN domain-containing protein 3

 DENN domain-containing protein 3 ELISA Kit
 DENN domain-containing protein 3 Recombinant
 DENN domain-containing protein 3 Antibody
DENND3: a guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Plays a role in protein transport from recycling endosomes to lysosomes regulating, for example, the degradation of the transferrin receptor. Four isoforms of the human protein are produced by alternative splicing.

Prot
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ein type: GEFs; GEFs, Rab

Molecular Function: Rab guanyl-nucleotide exchange factor activity

Biological Process: cellular protein catabolic process; endosome to lysosome transport
 Dennd3 ELISA Kit
 Dennd3 Recombinant
 Dennd3 Antibody
 Kiaa0870 ELISA Kit
 Kiaa0870 Recombinant
 Kiaa0870 Antibody
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DENN domain-containing protein 4B

 DENN domain-containing protein 4B ELISA Kit
 DENN domain-containing protein 4B Recombinant
 DENN domain-containing protein 4B Antibody
DENND4B: a Golgi-associated guanine nucleotide exchange factor (GEF) that activates RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Protein type: GEFs; GEFs, Rab

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: Golgi apparatus; nucleus

Molecular Function: Rab guanyl-nucleotide excha
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nge factor activity

Biological Process: regulation of Rab protein signal transduction
 DENND4B ELISA Kit
 DENND4B Recombinant
 DENND4B Antibody
 KIAA0476 ELISA Kit
 KIAA0476 Recombinant
 KIAA0476 Antibody
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DENN domain-containing protein 4C

 DENN domain-containing protein 4C ELISA Kit
 DENN domain-containing protein 4C Recombinant
 DENN domain-containing protein 4C Antibody
DENND4C: a cytoplasmic vesicle membrane-associated guanine nucleotide exchange factor (GEF) that activates RAB10, thereby stimulating the delivery of GLUT4 glucose transporter-enriched vesicles to the plasma membrane in response to insulin. Six isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rab; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p22.1

Cellular Component: cytosol; plasma membrane

Molecular Function: Rab guanyl-nucleotide exchange factor activity

Biological Process: cellular respon
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se to insulin stimulus
 DENND4C ELISA Kit
 DENND4C Recombinant
 DENND4C Antibody
 C9orf55 ELISA Kit
 C9orf55 Recombinant
 C9orf55 Antibody
 C9orf55B ELISA Kit
 C9orf55B Recombinant
 C9orf55B Antibody
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DENN domain-containing protein 5A

 DENN domain-containing protein 5A ELISA Kit
 DENN domain-containing protein 5A Recombinant
 DENN domain-containing protein 5A Antibody
Also known as DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1).
RAB6IP1: a Golgi-associated guanine nucleotide exchange factor (GEF) that activates RAB6A and RAB39A/B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Interacts with RAB6A bound to GTP. Belongs to the RAB6IP1 family.

Protein type: GEFs; GEFs, Rab

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: retromer complex; trans-Golgi network

Molecular Function: calcium channel activity; Rab guanyl-nucl
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eotide exchange factor activity

Biological Process: detection of mechanical stimulus; retrograde transport, endosome to Golgi
 DENND5A ELISA Kit
 DENND5A Recombinant
 DENND5A Antibody
 KIAA1091 ELISA Kit
 KIAA1091 Recombinant
 KIAA1091 Antibody
 RAB6IP1 ELISA Kit
 RAB6IP1 Recombinant
 RAB6IP1 Antibody
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DENN domain-containing protein 5B

 DENN domain-containing protein 5B ELISA Kit
 DENN domain-containing protein 5B Recombinant
 DENN domain-containing protein 5B Antibody
Also known as DENN domain-containing protein 5B (Rab6IP1-like protein).
Guanine nucleotide exchange factor (GEF) which may activate the small GTPases Rab. May promote the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form ().
 dennd5b ELISA Kit
 dennd5b Recombinant
 dennd5b Antibody
 si:ch211-11c20.2 ELISA Kit
 si:ch211-11c20.2 Recombinant
 si:ch211-11c20.2 Antibody
 zgc:77218 ELISA Kit
 zgc:77218 Recombinant
 zgc:77218 Antibody
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DENN domain-containing protein C297.05

 DENN domain-containing protein C297.05 ELISA Kit
 DENN domain-containing protein C297.05 Recombinant
 DENN domain-containing protein C297.05 Antibody
 SPCC297.05 ELISA Kit
 SPCC297.05 Recombinant
 SPCC297.05 Antibody
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Proteins Root Name Listing
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