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Deshydrogenase

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Deshydrogenase; part of the gene cluster that mediates the biosynthesis of ML-236B, also known as compactin, and which acts as a potent competitive inhibitor of HMG-CoA reductase .

Below are the list of possible Deshydrogenase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Deshydrogenase mlcG

 Deshydrogenase mlcG ELISA Kit
 Deshydrogenase mlcG Recombinant
 Deshydrogenase mlcG Antibody
Also known as Deshydrogenase mlcG (Compactin biosynthesis protein G) (Enoyl reductase).
Deshydrogenase; part of the gene cluster that mediates the biosynthesis of ML-236B, also known as compactin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:12172803). Compactin biosynthesis is performed in two stages (PubMed:12172803). The first stage is catalyzed by the nonake
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tide synthase mlcA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:12172803). This PKS stage completed by the action of deshydrogenase mlcG, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydroML-236B (PubMed:12172803). Covalently bound dihydroML-236B is released from mlcA by the mlcF esterase (PubMed:12172803). Conversion of dihydroML-236B into ML-236C and then ML-236A is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mlcC (PubMed:12172803). Finally, mlcH performs the conversion of ML-236A to ML-236B/compactin through the addition of the side-chain diketide moiety produced by the diketide synthase mlcB (PubMed:12172803).
 mlcG ELISA Kit
 mlcG Recombinant
 mlcG Antibody
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Deshydrogenase mokE

 Deshydrogenase mokE ELISA Kit
 Deshydrogenase mokE Recombinant
 Deshydrogenase mokE Antibody
Also known as Deshydrogenase mokE (Enoyl reductase) (Monacolin K biosynthesis protein E).
Deshydrogenase; part of the gene cluster that mediates the biosynthesis of monakolin K, also known as lovastatin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:18578535). Monakolin K biosynthesis is performed in two stages (PubMed:19693441). The first stage is catalyzed by t
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he nonaketide synthase mokA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:18578535, PubMed:19693441). This PKS stage is completed by the action of deshydrogenase mokE, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydromonacolin L (PubMed:19693441). Covalently bound dihydromonacolin L is released from mokA by the mokD esterase (). Conversion of dihydromonacolin L into monacolin L and then monacolin J is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mokC (PubMed:19693441). Finally, mokF performs the conversion of monacoline J to monacoline K through the addition of the side-chain diketide moiety (2R)-2-methylbutyric acid produced by the diketide synthase mokB (PubMed:19693441).
 mokE ELISA Kit
 mokE Recombinant
 mokE Antibody
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