| Desmocollin-3 ELISA Kit|
|DSC3: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Defects in DSC3 are the cause of hypotrichosis and recurrent skin vesicles (HRSV). A disorder |
characterized by hypotrichosis and the appearance of recurrent skin vesicle formation. Affected individuals show sparse and fragile hair on scalp, as well as absent eyebrows and eyelashes. Vesicles filled with thin, watery fluid are observed on the scalp and skin of most of the boby. Mucosal vesicles are absent. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral
Cellular Component: cytoplasm; desmosome; extracellular region; plasma membrane
Biological Process: in utero embryonic development
| Dsc3 ELISA Kit|