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Desmoplakin

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Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

Below are the list of possible Desmoplakin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Desmoplakin

 Desmoplakin ELISA Kit
 Desmoplakin Recombinant
 Desmoplakin Antibody
Also known as Desmoplakin (DP).
Desmoplakin: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod regio
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n), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. Belongs to the plakin or cytolinker family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: basolateral plasma membrane; cornified envelope; desmosome; extracellular matrix; fascia adherens; intercellular junction; intermediate filament; membrane; nucleus; plasma membrane

Molecular Function: protein binding; protein binding, bridging; protein kinase C binding; structural molecule activity

Biological Process: cell-cell adhesion; intermediate filament cytoskeleton organization and biogenesis; intermediate filament organization; keratinocyte differentiation; peptide cross-linking; skin development
 Dsp ELISA Kit
 Dsp Recombinant
 Dsp Antibody
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