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DihydroML-236B monooxygenase

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DihydroML-236B monooxygenase; part of the gene cluster that mediates the biosynthesis of ML-236B, also known as compactin, and which acts as a potent competitive inhibitor of HMG-CoA reductase .

Below are the list of possible DihydroML-236B monooxygenase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DihydroML-236B monooxygenase mlcC

 DihydroML-236B monooxygenase mlcC ELISA Kit
 DihydroML-236B monooxygenase mlcC Recombinant
 DihydroML-236B monooxygenase mlcC Antibody
Also known as DihydroML-236B monooxygenase mlcC (Compactin biosynthesis protein C) (DihydroML-236B hydroxylase).
DihydroML-236B monooxygenase; part of the gene cluster that mediates the biosynthesis of ML-236B, also known as compactin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:12172803, PubMed:12242508). Compactin biosynthesis is performed in two stages (PubM
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ed:12172803). The first stage is catalyzed by the nonaketide synthase mlcA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:12172803). This PKS stage completed by the action of deshydrogenase mlcG, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydroML-236B (PubMed:12172803). Covalently bound dihydroML-236B is released from mlcA by the mlcF esterase (PubMed:12172803). Conversion of dihydroML-236B into ML-236C and then ML-236A is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mlcC (PubMed:12172803). Finally, mlcH performs the conversion of ML-236A to ML-236B/compactin through the addition of the side-chain diketide moiety produced by the diketide synthase mlcB (PubMed:12172803).
 mlcC ELISA Kit
 mlcC Recombinant
 mlcC Antibody
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