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Dihydromonacolin L monooxygenase

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Catalizes the oxidation of the nonaketide dihydromonacolin L to monacolin J during lovastatin biosynthesis.

Below are the list of possible Dihydromonacolin L monooxygenase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Dihydromonacolin L monooxygenase LovA

 Dihydromonacolin L monooxygenase LovA ELISA Kit
 Dihydromonacolin L monooxygenase LovA Recombinant
 Dihydromonacolin L monooxygenase LovA Antibody
Also known as Dihydromonacolin L monooxygenase LovA (Dihydromonacolin L hydroxylase) (Monacolin L hydroxylase).
Catalizes the oxidation of the nonaketide dihydromonacolin L to monacolin J during lovastatin biosynthesis.
 lovA ELISA Kit
 lovA Recombinant
 lovA Antibody
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Dihydromonacolin L monooxygenase mokC

 Dihydromonacolin L monooxygenase mokC ELISA Kit
 Dihydromonacolin L monooxygenase mokC Recombinant
 Dihydromonacolin L monooxygenase mokC Antibody
Also known as Dihydromonacolin L monooxygenase mokC (Dihydromonacolin L hydroxylase) (Monacolin K biosynthesis protein C) (Monacolin L hydroxylase).
P450 monoogygenase; Diketide synthase; part of the gene cluster that mediates the biosynthesis of monakolin K, also known as lovastatin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:18578535). Monakolin K biosynthes
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is is performed in two stages (PubMed:19693441). The first stage is catalyzed by the nonaketide synthase mokA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:18578535, PubMed:19693441). This PKS stage is completed by the action of deshydrogenase mokE, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydromonacolin L (PubMed:19693441). Covalently bound dihydromonacolin L is released from mokA by the mokD esterase (). Conversion of dihydromonacolin L into monacolin L and then monacolin J is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mokC (PubMed:19693441). Finally, mokF performs the conversion of monacoline J to monacoline K through the addition of the side-chain diketide moiety (2R)-2-methylbutyric acid produced by the diketide synthase mokB (PubMed:19693441).
 mokC ELISA Kit
 mokC Recombinant
 mokC Antibody
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