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Disabled

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Adapter molecule functioning in neural development. May regulate SIAH1 activity (By similarity).

Below are the list of possible Disabled products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Disabled homolog 1

 Disabled homolog 1 ELISA Kit
 Disabled homolog 1 Recombinant
 Disabled homolog 1 Antibody
Adapter molecule functioning in neural development. May regulate SIAH1 activity ().
 DAB1 ELISA Kit
 DAB1 Recombinant
 DAB1 Antibody
 QflA-11558 ELISA Kit
 QflA-11558 Recombinant
 QflA-11558 Antibody
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Disabled homolog 2

 Disabled homolog 2 ELISA Kit
 Disabled homolog 2 Recombinant
 Disabled homolog 2 Antibody
Also known as Disabled homolog 2 (Adaptor molecule disabled-2) (C9) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Mitogen-responsive phosphoprotein).
DAB2: an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component o
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f the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described.

Protein type: Adaptor/scaffold; Tumor suppressor

Cellular Component: apical plasma membrane; clathrin coat of coated pit; clathrin coated vesicle membrane; clathrin-coated vesicle; coated pit; cytoplasm; focal adhesion; intracellular membrane-bound organelle; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: clathrin binding; integrin binding; phosphatidylinositol-4,5-bisphosphate binding; phosphoinositide binding; protein binding; protein C-terminus binding; SMAD binding

Biological Process: activation of JNK activity; cellular morphogenesis during differentiation; clathrin cage assembly; endoderm development; excretion; in utero embryonic development; integrin-mediated signaling pathway; leading edge cell differentiation; myeloid cell differentiation; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; pinocytosis; positive regulation of aldosterone biosynthetic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of endocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; positive regulation of receptor internalization; positive regulation of receptor recycling; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; receptor-mediated endocytosis; response to steroid hormone stimulus
 Dab2 ELISA Kit
 Dab2 Recombinant
 Dab2 Antibody
 Doc2 ELISA Kit
 Doc2 Recombinant
 Doc2 Antibody
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