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Discoidin domain-containing receptor

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Below are the list of possible Discoidin domain-containing receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Discoidin domain-containing receptor 2

 Discoidin domain-containing receptor 2 ELISA Kit
 Discoidin domain-containing receptor 2 Recombinant
 Discoidin domain-containing receptor 2 Antibody
Also known as Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine.
DDR2: This tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Protein type: DDR family; EC; Kinase, protein; Membrane protein, integral; Prot
ein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: focal adhesion; plasma membrane

Molecular Function: collagen binding; protein binding; transmembrane receptor protein tyrosine kinase activity

Biological Process: biomineral formation; cell adhesion; collagen fibril organization; extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; positive regulation of fibroblast proliferation; positive regulation of osteoblast differentiation; positive regulation of protein kinase activity; positive regulation of transcription factor activity; protein amino acid autophosphorylation; regulation of bone mineralization; signal transduction

Disease: Spondylometaepiphyseal Dysplasia, Short Limb-hand Type
 DDR2 Recombinant
 DDR2 Antibody
 NTRKR3 Recombinant
 NTRKR3 Antibody
 TKT Recombinant
 TKT Antibody
 TYRO10 Recombinant
 TYRO10 Antibody
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Discoidin domain-containing receptor A

 Discoidin domain-containing receptor A ELISA Kit
 Discoidin domain-containing receptor A Recombinant
 Discoidin domain-containing receptor A Antibody
Receptor which, together with ddr-2, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development.
 ddr-1 ELISA Kit
 ddr-1 Recombinant
 ddr-1 Antibody
 C25F6.4 ELISA Kit
 C25F6.4 Recombinant
 C25F6.4 Antibody
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