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Disintegrin

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Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin cell adhesion molecule 1 (MADCAM-1).

Below are the list of possible Disintegrin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Disintegrin

 Disintegrin ELISA Kit
 Disintegrin Recombinant
 Disintegrin Antibody
Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin ce
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ll adhesion molecule 1 (MADCAM-1).
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Disintegrin CC5

 Disintegrin CC5 ELISA Kit
 Disintegrin CC5 Recombinant
 Disintegrin CC5 Antibody
Binds and inhibits integrins alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3) and alpha-5/beta-1 (ITGA5/ITGB1).
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Disintegrin CC8A

 Disintegrin CC8A ELISA Kit
 Disintegrin CC8A Recombinant
 Disintegrin CC8A Antibody
Inhibits integrins alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), and alpha-5/beta-1 (ITGA5/ITGB1).
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Disintegrin CC8B

 Disintegrin CC8B ELISA Kit
 Disintegrin CC8B Recombinant
 Disintegrin CC8B Antibody
Inhibits integrins alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), and alpha-5/beta-1 (ITGA5/ITGB1).
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Disintegrin CTF-II

 Disintegrin CTF-II ELISA Kit
 Disintegrin CTF-II Recombinant
 Disintegrin CTF-II Antibody
Also known as Disintegrin CTF-II (Cytotoxic factor 2).
Inhibits fibrinogen interaction with platelet receptors, and inhibits aggregation induced by ADP, thrombin, collagen and platelet-activating f
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actor. Acts by binding to the alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface ().
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Disintegrin CV

 Disintegrin CV ELISA Kit
 Disintegrin CV Recombinant
 Disintegrin CV Antibody
Also known as Disintegrin CV (Disintegrin CV-short).
Specifically interacts with the alpha-1/beta-1 integrin (ITGA1/ITGB1). Exhibits highly inhibitory effects on cell adhesion and cell migration to
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collagens I and IV. Also shows in vivo anti-angiogenic activity ().
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Disintegrin CV-11-alpha

 Disintegrin CV-11-alpha ELISA Kit
 Disintegrin CV-11-alpha Recombinant
 Disintegrin CV-11-alpha Antibody
Also known as Disintegrin CV-11-alpha (CV11).
Inhibits ADP-induced human platelet aggregation. Antagonist of alpha-IIb/beta-3 (ITGA2B/ITGB3) ().
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Disintegrin CV-11-beta

 Disintegrin CV-11-beta ELISA Kit
 Disintegrin CV-11-beta Recombinant
 Disintegrin CV-11-beta Antibody
Also known as Disintegrin CV-11-beta (CV11-beta).
Inhibits ADP-induced human platelet aggregation. Antagonist of alpha-IIb/beta-3 (ITGA2B/ITGB3) ().
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Disintegrin DisBa-01

 Disintegrin DisBa-01 ELISA Kit
 Disintegrin DisBa-01 Recombinant
 Disintegrin DisBa-01 Antibody
This recombinant disintegrin antagonizes integrins alpha-IIb/beta-3 (ITGA2B/ITGB3) and alpha-V/beta-3 (ITGAV/ITGB3). On ITGA2B/ITGB3, it interferes with the outside/-in phosphorylation of the focal ad
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hesion kinase (PTK2 / FAK) downstream of the integrin. It strongly inhibits platelet aggregation induced by ADP, thrombin, and collagen, abolishes and reverses dynamic platelet recruitment to immobilized fibrinogen. In vivo, it induces a dramatic increase in the tail bleeding time, and has a strong antithrombotic activity (PubMed:18508682). On ITGAV/ITGB3, it inhibits the adhesion of ITGAV/ITGB3-expressing human microvascular endothelial cell line and murine melanoma cell line to vitronectin (IC50 = 555 nM and 225 nM, respectively), and transiently inhibits their proliferation without direct cell toxicity. In vivo, it potently inhibits angiogenesis and metastasis (PubMed:17952617), probably due to its capability to strongly inhibit the expression of VEGF and its receptors in endothelial cells (PubMed:22561350). It also inhibits tumor cell migration in vitro (PubMed:22069567).
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Disintegrin DS-AC

 Disintegrin DS-AC ELISA Kit
 Disintegrin DS-AC Recombinant
 Disintegrin DS-AC Antibody
Inhibits ADP-induced platelet aggregation in human platelet-rich plasma (IC50 is 6 µM).
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Disintegrin DS-AN

 Disintegrin DS-AN ELISA Kit
 Disintegrin DS-AN Recombinant
 Disintegrin DS-AN Antibody
Inhibits ADP-induced platelet aggregation in human platelet-rich plasma (IC50 is 8 µM).
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Disintegrin DS-AS

 Disintegrin DS-AS ELISA Kit
 Disintegrin DS-AS Recombinant
 Disintegrin DS-AS Antibody
Inhibits ADP-induced platelet aggregation in human platelet-rich plasma (IC50 is 8 µM).
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Disintegrin EC3A

 Disintegrin EC3A ELISA Kit
 Disintegrin EC3A Recombinant
 Disintegrin EC3A Antibody
Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin ce
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ll adhesion molecule 1 (MADCAM-1). It is also a weaker inhibitor of alpha-5/beta-1 (ITGA5/ITGB1) and alpha-2b/beta-3 (ITGA2B/ITGB3) integrins. The inhibitory activity of EC3 towards alpha-4 integrins is associated with the MLD sequence of EC3B subunit. The ability of EC3 to inhibit ITGA5/ITGB1 resides in both subunits A and B.
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Disintegrin EC3B

 Disintegrin EC3B ELISA Kit
 Disintegrin EC3B Recombinant
 Disintegrin EC3B Antibody
Inhibits adhesion of cells expressing alpha-4/beta-1 (ITGA4/ITGB1) and alpha-4/beta-7 (ITGA4/ITGB7) integrins to the natural ligands vascular cell adhesion molecule 1 (VCAM-1) and mucosal addressin ce
>>>
ll adhesion molecule 1 (MADCAM-1). It is also a weaker inhibitor of alpha-5/beta-1 (ITGA5/ITGB1) and alpha-2b/beta-3 (ITGA2B/ITGB3) integrins. The inhibitory activity of EC3 towards alpha-4 integrins is associated with the MLD sequence of EC3B subunit. The ability of EC3 to inhibit ITGA5/ITGB1 resides in both subunits A and B.
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Disintegrin EC6 subunit alpha

 Disintegrin EC6 subunit alpha ELISA Kit
 Disintegrin EC6 subunit alpha Recombinant
 Disintegrin EC6 subunit alpha Antibody
Also known as Disintegrin EC6 subunit alpha (EC6A).
Potently inhibits adhesion of alpha-4/beta-1 (ITGA4/ITGB1) and alpha-9/beta-1 (ITGA9/ITGB1) integrins to VCAM1, and adhesion of alpha-5/beta-1 (I
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TGA5/ITGB1) integrin to fibronectin. Has a much less effect on alpha-IIb/beta-3 (ITGA2B/ITGB3) integrin. Also potently inhibits neutrophil migration across TNF-alpha-activated human umbilical endothelial cells.
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Disintegrin EC6 subunit beta

 Disintegrin EC6 subunit beta ELISA Kit
 Disintegrin EC6 subunit beta Recombinant
 Disintegrin EC6 subunit beta Antibody
Also known as Disintegrin EC6 subunit beta (EC6B).
Potently inhibits adhesion of alpha-4/beta-1 (ITGA4/ITGB1) and alpha-9/beta-1 (ITGA9/ITGB1) integrins to VCAM1, and adhesion of alpha-5/beta-1 (IT
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GA5/ITGB1) integrin to fibronectin. Has a much less effect on alpha-IIb/beta-3 (ITGA2B/ITGB3) integrin. Also potently inhibits neutrophil migration across TNF-alpha-activated human umbilical endothelial cells.
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Disintegrin EMF10A

 Disintegrin EMF10A ELISA Kit
 Disintegrin EMF10A Recombinant
 Disintegrin EMF10A Antibody
Also known as Disintegrin EMF10A (EMF-10A) (Eristocophin I) (Platelet aggregation activation inhibitor).
Extremely potent and selective inhibitor of integrin alpha-5/beta-1 (ITGA5/ITGB1). Partially
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inhibits adhesion of cells expressing alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), and alpha-4/beta-1 (ITGA4/ITGB1) to appropriate ligands only at concentration higher than 500 nM. Weakly inhibits ADP-induced platelet aggregation.
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Disintegrin EMF10B

 Disintegrin EMF10B ELISA Kit
 Disintegrin EMF10B Recombinant
 Disintegrin EMF10B Antibody
Also known as Disintegrin EMF10B (EMF-10B) (Eristocophin II) (Platelet aggregation activation inhibitor).
Extremely potent and selective inhibitor of integrin alpha-5/beta-1 (ITGA5/ITGB1). Partiall
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y inhibits adhesion of cells expressing alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), and alpha-4/beta-1 (ITGA4/ITGB1) to appropriate ligands only at concentration higher than 500 nM. Weakly inhibits ADP-induced platelet aggregation.
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Disintegrin EMS11A

 Disintegrin EMS11A ELISA Kit
 Disintegrin EMS11A Recombinant
 Disintegrin EMS11A Antibody
Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of both the alpha-4/beta-1 (ITGA4/ITGB1) and the alpha-5/beta-1 (ITGA5/ITGB1) integrins to VCAM-1 and fibronectin respecti
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vely with almost the same degree of specificity. Inhibition on alpha-IIb/beta-3 (ITGA2B/ITGB3) is low.
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Disintegrin Eo1 subunit 1

 Disintegrin Eo1 subunit 1 ELISA Kit
 Disintegrin Eo1 subunit 1 Recombinant
 Disintegrin Eo1 subunit 1 Antibody
Also known as Disintegrin Eo1 subunit 1 (Eo1-1).
Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (ITGA5/I
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TGB1) to immobilized fibronectin. Inhibition on alpha-IIb/beta-3 (ITGA2B/ITGB3) is low ().
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Disintegrin EO4A

 Disintegrin EO4A ELISA Kit
 Disintegrin EO4A Recombinant
 Disintegrin EO4A Antibody
Also known as Disintegrin EO4A (Dim-3 SP6) (Eo-10) (Eo-10c1).
Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/be
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ta-1 (ITGA5/ITGB1) to immobilized fibronectin. Inhibition on alpha-2b/beta-3 (ITGA2B/ITGB3) is low.
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Disintegrin EO5A

 Disintegrin EO5A ELISA Kit
 Disintegrin EO5A Recombinant
 Disintegrin EO5A Antibody
Also known as Disintegrin EO5A (Eo-12).
Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of the alpha-4/beta-1 (ITGA4/ITGB1) integrin to VCAM-1. Inhibition on alpha-IIb
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/beta-3 (ITGA2B/ITGB3) is low.
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Disintegrin EO5B

 Disintegrin EO5B ELISA Kit
 Disintegrin EO5B Recombinant
 Disintegrin EO5B Antibody
Also known as Disintegrin EO5B (EO4B).
Poor inhibitor of platelet aggregation. When it dimerizes with EO4A, it inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (I
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TGA5/ITGB1) to immobilized fibronectin. When it dimerizes with EO5A, it inhibits the adhesion of the alpha-4/beta-1 (ITGA4/ITGB1) integrin to VCAM-1. When it dimerizes either with EO4A or EO5A, the inhibition on alpha-IIb/beta-3 (ITGA2B/ITGB3) is low.
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Disintegrin isoform D-2

 Disintegrin isoform D-2 ELISA Kit
 Disintegrin isoform D-2 Recombinant
 Disintegrin isoform D-2 Antibody
Inhibits fibrinogen interaction with platelets. Acts by binding to the alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating fa
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ctor and collagen ().
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Disintegrin isoform D-3

 Disintegrin isoform D-3 ELISA Kit
 Disintegrin isoform D-3 Recombinant
 Disintegrin isoform D-3 Antibody
Inhibits fibrinogen interaction with platelets. Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor
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and collagen ().
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Disintegrin subunit alpha

 Disintegrin subunit alpha ELISA Kit
 Disintegrin subunit alpha Recombinant
 Disintegrin subunit alpha Antibody
Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits both ADP-induced platelet aggregation and platelet aggregate dissociation in human platelet-rich plasma.
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Disintegrin VA6

 Disintegrin VA6 ELISA Kit
 Disintegrin VA6 Recombinant
 Disintegrin VA6 Antibody
Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin. Inhibition on alph
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a-IIb/beta-3 (ITGA2B/ITGB3) is low, and there is no inhibition on alpha-1/beta-1 (ITGA1/ITGB1), alpha-2/beta-1 (ITGA2/ITGB1) and alpha-6/beta-1 (ITGA6/ITGB1).
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Disintegrin VB7A

 Disintegrin VB7A ELISA Kit
 Disintegrin VB7A Recombinant
 Disintegrin VB7A Antibody
Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin. Inhibition on alph
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a-2b/beta-3 (ITGA2B/ITGB3) is low.
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Disintegrin VB7B

 Disintegrin VB7B ELISA Kit
 Disintegrin VB7B Recombinant
 Disintegrin VB7B Antibody
Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin. Inhibition on alph
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a-IIb/beta-3 (ITGA2B/ITGB3) is low.
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Disintegrin VLO4

 Disintegrin VLO4 ELISA Kit
 Disintegrin VLO4 Recombinant
 Disintegrin VLO4 Antibody
Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin. Inhibition on alph
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a-2b/beta-3 (ITGA2B/ITGB3) is low.
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Disintegrin VLO5A

 Disintegrin VLO5A ELISA Kit
 Disintegrin VLO5A Recombinant
 Disintegrin VLO5A Antibody
Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of the alpha-4/beta-1 (ITGA4/ITGB1) integrin to VCAM-1. Inhibition on alpha-IIb/beta-3 (ITGA2B/ITGB3) is low.
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Disintegrin VLO5B

 Disintegrin VLO5B ELISA Kit
 Disintegrin VLO5B Recombinant
 Disintegrin VLO5B Antibody
Poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of the alpha-4/beta-1 (ITGA4/ITGB1) integrin to VCAM-1. Inhibition on alpha-2b/beta-3 (ITGA2B/ITGB3) is low.
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Proteins Root Name Listing
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