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Disintegrin and metalloproteinase domain-containing protein

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May be involved in sperm-egg fusion.

Below are the list of possible Disintegrin and metalloproteinase domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Disintegrin and metalloproteinase domain-containing protein 1

 Disintegrin and metalloproteinase domain-containing protein 1 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 1 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 1 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 1 (ADAM 1) (Fertilin subunit alpha).
ADAM1A: May be involved in sperm-egg fusion.

Protein type: EC 3.4.24.-; Endoplasmic reticulum; Membrane protein, integral; Protease

Cellular Component: lipid raft

Biological Process: binding of sperm to zona pellucida; male gonad development
 Adam1 ELISA Kit
 Adam1 Recombinant
 Adam1 Antibody
 Adam1a ELISA Kit
 Adam1a Recombinant
 Adam1a Antibody
 Ftna ELISA Kit
 Ftna Recombinant
 Ftna Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 10

 Disintegrin and metalloproteinase domain-containing protein 10 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 10 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 10 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c).
ADAM10: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyl
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oid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Protein type: Cell adhesion; Cell surface; EC 3.4.24.81; Membrane protein, integral; Motility/polarity/chemotaxis; Protease; Vesicle

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi apparatus; Golgi-associated vesicle; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane

Molecular Function: endopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein homodimerization activity; protein kinase binding

Biological Process: constitutive protein ectodomain proteolysis; ephrin receptor signaling pathway; extracellular matrix disassembly; in utero embryonic development; membrane protein ectodomain proteolysis; monocyte activation; negative regulation of cell adhesion; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; protein amino acid phosphorylation

Disease: Alzheimer Disease 18; Reticulate Acropigmentation Of Kitamura
 ADAM10 ELISA Kit
 ADAM10 Recombinant
 ADAM10 Antibody
 KUZ ELISA Kit
 KUZ Recombinant
 KUZ Antibody
 MADM ELISA Kit
 MADM Recombinant
 MADM Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 11

 Disintegrin and metalloproteinase domain-containing protein 11 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 11 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 11 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (MDC11.1) (Metalloprotease-disintegrin MDC11a) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).
Probable ligand for integrin in the brain. This is a non-catalytic metalloprotease-like protein.
 adam11 ELISA Kit
 adam11 Recombinant
 adam11 Antibody
 mdc11a ELISA Kit
 mdc11a Recombinant
 mdc11a Antibody
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Disintegrin and metalloproteinase domain-containing protein 12

 Disintegrin and metalloproteinase domain-containing protein 12 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 12 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 12 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (Meltrin-alpha).
ADAM12: contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative
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splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Cellular Component: mitochondrion; nucleoplasm; plasma membrane

Molecular Function: SH3 domain binding
 Adam12 ELISA Kit
 Adam12 Recombinant
 Adam12 Antibody
 Mltna ELISA Kit
 Mltna Recombinant
 Mltna Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 15

 Disintegrin and metalloproteinase domain-containing protein 15 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 15 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 15 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (AD56) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin).
ADAM15: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial
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cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Cellular Component: cell surface

Molecular Function: integrin binding; metallopeptidase activity; protein binding; SH3 domain binding

Biological Process: innate immune response; integrin-mediated signaling pathway; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell-matrix adhesion
 Adam15 ELISA Kit
 Adam15 Recombinant
 Adam15 Antibody
 Mdc15 ELISA Kit
 Mdc15 Recombinant
 Mdc15 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 17

 Disintegrin and metalloproteinase domain-containing protein 17 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 17 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 17 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b).
TACE: a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor ne
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crosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described.

Protein type: EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: actin cytoskeleton; apical plasma membrane; cell surface; cytoplasm; focal adhesion; integral to plasma membrane; intercellular junction; lipid raft; membrane; plasma membrane

Molecular Function: integrin binding; interleukin-6 receptor binding; metalloendopeptidase activity; metallopeptidase activity; Notch binding; PDZ domain binding; protein binding

Biological Process: B cell differentiation; cell adhesion; cell adhesion mediated by integrin; cell motility involved in cell locomotion; defense response to Gram-positive bacterium; epidermal growth factor receptor signaling pathway; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; germinal center formation; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway; neutrophil mediated immunity; Notch receptor processing; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of epidermal growth factor receptor activity; positive regulation of leukocyte chemotaxis; positive regulation of protein amino acid phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; proteolysis; regulation of mast cell apoptosis; response to drug; response to high density lipoprotein stimulus; response to hypoxia; response to lipopolysaccharide; spleen development; T cell differentiation in the thymus; tumor necrosis factor-mediated signaling pathway; wound healing, spreading of epidermal cells

Disease: Inflammatory Skin And Bowel Disease, Neonatal, 1
 ADAM17 ELISA Kit
 ADAM17 Recombinant
 ADAM17 Antibody
 CSVP ELISA Kit
 CSVP Recombinant
 CSVP Antibody
 TACE ELISA Kit
 TACE Recombinant
 TACE Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 18

 Disintegrin and metalloproteinase domain-containing protein 18 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 18 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 18 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 18 (ADAM 18) (Disintegrin and metalloproteinase domain-containing protein 27) (ADAM 27) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III) (tMDC III).
ADAM18: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Molecular Fun
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ction: integrin binding
 Adam18 ELISA Kit
 Adam18 Recombinant
 Adam18 Antibody
 Adam27 ELISA Kit
 Adam27 Recombinant
 Adam27 Antibody
 Dtgn3 ELISA Kit
 Dtgn3 Recombinant
 Dtgn3 Antibody
 Tmdc3 ELISA Kit
 Tmdc3 Recombinant
 Tmdc3 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 19

 Disintegrin and metalloproteinase domain-containing protein 19 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 19 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 19 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (Meltrin-beta).
ADAM19: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in
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bone. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Cellular Component: external side of plasma membrane; Golgi apparatus

Molecular Function: protein binding

Biological Process: heart development; membrane protein ectodomain proteolysis
 Adam19 ELISA Kit
 Adam19 Recombinant
 Adam19 Antibody
 Mltnb ELISA Kit
 Mltnb Recombinant
 Mltnb Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 1a

 Disintegrin and metalloproteinase domain-containing protein 1a ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 1a Recombinant
 Disintegrin and metalloproteinase domain-containing protein 1a Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 1a (ADAM 1a) (Fertilin subunit alpha-a).
ADAM1A: May be involved in sperm-egg fusion.

Protein type: EC 3.4.24.-; Endoplasmic reticulum; Membrane protein, integral; Protease

Cellular Component: lipid raft

Molecular Function: protein binding

Biological Process: binding of sperm to zona pellucida
 Adam1a ELISA Kit
 Adam1a Recombinant
 Adam1a Antibody
 Adam1 ELISA Kit
 Adam1 Recombinant
 Adam1 Antibody
 Ftna ELISA Kit
 Ftna Recombinant
 Ftna Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 1b

 Disintegrin and metalloproteinase domain-containing protein 1b ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 1b Recombinant
 Disintegrin and metalloproteinase domain-containing protein 1b Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 1b (ADAM 1b) (Fertilin subunit alpha-b).
ADAM1B: May play a role in spermatogenesis and sperm maturation.

Protein type: Cell surface; EC 3.4.24.-; Membrane protein, integral; Protease

Molecular Function: protein binding
 Adam1b ELISA Kit
 Adam1b Recombinant
 Adam1b Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 2

 Disintegrin and metalloproteinase domain-containing protein 2 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 2 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 2 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 2 (ADAM 2) (Cancer/testis antigen 15) (CT15) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta).
ADAM2: a member of the ADAM (a disintegrin and metalloprotease domain) family of Cancer-Testis Antigen (CTAs) . CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were o
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nce thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovary cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. A sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from RefSeq and UniProtKB

Protein type: Cancer Testis Antigen (CTA); Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: integrin binding; metallopeptidase activity

Biological Process: binding of sperm to zona pellucida; fusion of sperm to egg plasma membrane
 ADAM2 ELISA Kit
 ADAM2 Recombinant
 ADAM2 Antibody
 FTNB ELISA Kit
 FTNB Recombinant
 FTNB Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 20

 Disintegrin and metalloproteinase domain-containing protein 20 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 20 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 20 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 20 (ADAM 20).
ADAM20: May be involved in sperm maturation and/or fertilization.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: plasma membrane

Molecular Function: metallopeptidase
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activity

Biological Process: binding of sperm to zona pellucida; single fertilization
 ADAM20 ELISA Kit
 ADAM20 Recombinant
 ADAM20 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 21

 Disintegrin and metalloproteinase domain-containing protein 21 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 21 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 21 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 21 (ADAM 21).
ADAM21: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Lo
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cation of Human Ortholog: 14q24.1

Cellular Component: plasma membrane

Molecular Function: metallopeptidase activity

Biological Process: binding of sperm to zona pellucida; single fertilization
 ADAM21 ELISA Kit
 ADAM21 Recombinant
 ADAM21 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 22

 Disintegrin and metalloproteinase domain-containing protein 22 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 22 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 22 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22).
ADAM22: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing.

Prot
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ein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: axon; integral to membrane

Molecular Function: protein binding

Biological Process: adult locomotory behavior; gliogenesis; myelination in the peripheral nervous system; Schwann cell differentiation
 Adam22 ELISA Kit
 Adam22 Recombinant
 Adam22 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 23

 Disintegrin and metalloproteinase domain-containing protein 23 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 23 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 23 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).
ADAM23: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Me
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mbrane protein, integral; Motility/polarity/chemotaxis

Molecular Function: protein binding
 Adam23 ELISA Kit
 Adam23 Recombinant
 Adam23 Antibody
 Mdc3 ELISA Kit
 Mdc3 Recombinant
 Mdc3 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 24

 Disintegrin and metalloproteinase domain-containing protein 24 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 24 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 24 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 24 (ADAM 24) (Testase-1).
ADAM24:

Protein type: Protease

Molecular Function: integrin binding; metallopeptidase activity
 Adam24 ELISA Kit
 Adam24 Recombinant
 Adam24 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 25

 Disintegrin and metalloproteinase domain-containing protein 25 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 25 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 25 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 25 (ADAM 25) (Testase-2).
ADAM25: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization.

Protein type: EC 3.4.24.-; Membrane protein, integral; Protease

Molecular Function: integrin binding; metallopeptidase activity
 Adam25 ELISA Kit
 Adam25 Recombinant
 Adam25 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 26A

 Disintegrin and metalloproteinase domain-containing protein 26A ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 26A Recombinant
 Disintegrin and metalloproteinase domain-containing protein 26A Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 26A (ADAM 26A) (Testase-3).
ADAM26A:

Protein type: EC 3.4.24.-

Molecular Function: integrin binding; metallopeptidase activity
 Adam26a ELISA Kit
 Adam26a Recombinant
 Adam26a Antibody
 Adam26 ELISA Kit
 Adam26 Recombinant
 Adam26 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 28

 Disintegrin and metalloproteinase domain-containing protein 28 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 28 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 28 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II).
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in
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sperm maturation.
 ADAM28 ELISA Kit
 ADAM28 Recombinant
 ADAM28 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 29

 Disintegrin and metalloproteinase domain-containing protein 29 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 29 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 29 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 29 (ADAM 29).
ADAM29: a member of the ADAM (a disintegrin and metalloprotease domain) family of Cancer-Testis Antigen (CTAs). CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in
>>>
fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins. May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein. Has been found to be frequently mutated in melanoma. Mutations may play a role in melanoma progression and metastasis. Expressed in leukemias at the mRNA level. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); Membrane protein, integral; Motility/polarity/chemotaxis; Protease
 Adam29 ELISA Kit
 Adam29 Recombinant
 Adam29 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 30

 Disintegrin and metalloproteinase domain-containing protein 30 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 30 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 30 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 30 (ADAM 30).
ADAM30: May be involved in spermatogenesis and fertilization. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 1p12

Cellular Componen
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t: plasma membrane

Molecular Function: metallopeptidase activity; zinc ion binding

Biological Process: binding of sperm to zona pellucida
 ADAM30 ELISA Kit
 ADAM30 Recombinant
 ADAM30 Antibody
 UNQ2509/PRO5997 ELISA Kit
 UNQ2509/PRO5997 Recombinant
 UNQ2509/PRO5997 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 32

 Disintegrin and metalloproteinase domain-containing protein 32 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 32 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 32 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 32 (ADAM 32).
ADAM32: May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 8p11.22
 ADAM32 ELISA Kit
 ADAM32 Recombinant
 ADAM32 Antibody
 UNQ5982/PRO21340 ELISA Kit
 UNQ5982/PRO21340 Recombinant
 UNQ5982/PRO21340 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 33

 Disintegrin and metalloproteinase domain-containing protein 33 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 33 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 33 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33).
ADAM33: Genetic variations in ADAM33 are associated with susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. 3 isoforms of the human protein are produced by alternative
>>>
splicing.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 20p13
 ADAM33 ELISA Kit
 ADAM33 Recombinant
 ADAM33 Antibody
 C20orf153 ELISA Kit
 C20orf153 Recombinant
 C20orf153 Antibody
 UNQ873/PRO1891 ELISA Kit
 UNQ873/PRO1891 Recombinant
 UNQ873/PRO1891 Antibody
Table BarTOPTable Bar
 

Disintegrin and metalloproteinase domain-containing protein 5

 Disintegrin and metalloproteinase domain-containing protein 5 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 5 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 5 Antibody
This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion ().
 ADAM5 ELISA Kit
 ADAM5 Recombinant
 ADAM5 Antibody
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Disintegrin and metalloproteinase domain-containing protein 7

 Disintegrin and metalloproteinase domain-containing protein 7 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 7 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 7 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 7 (ADAM 7).
ADAM7: May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein. Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

Protein type: Mem
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brane protein, integral; Motility/polarity/chemotaxis; Protease

Cellular Component: apical part of cell; plasma membrane

Molecular Function: endopeptidase activity
 Adam7 ELISA Kit
 Adam7 Recombinant
 Adam7 Antibody
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Disintegrin and metalloproteinase domain-containing protein 8

 Disintegrin and metalloproteinase domain-containing protein 8 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 8 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 8 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (Cell surface antigen MS2) (CD antigen CD156a).
ADAM8: Possible involvement in extravasation of leukocytes.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: cell surface; cytopla
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sm; dense core granule membrane; integral to plasma membrane; plasma membrane; podosome; specific granule

Molecular Function: calcium ion binding; cell adhesion molecule binding; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding

Biological Process: activation of NF-kappaB transcription factor; angiogenesis; cell morphogenesis; extracellular matrix disassembly; inflammatory response; leukocyte migration during inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling cascade; positive regulation of protein secretion; positive regulation of T cell differentiation in the thymus; regulation of cell-cell adhesion
 ADAM8 ELISA Kit
 ADAM8 Recombinant
 ADAM8 Antibody
 MS2 ELISA Kit
 MS2 Recombinant
 MS2 Antibody
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Disintegrin and metalloproteinase domain-containing protein 9

 Disintegrin and metalloproteinase domain-containing protein 9 ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein 9 Recombinant
 Disintegrin and metalloproteinase domain-containing protein 9 Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase).
ADAM9: Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP. Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motili
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ty/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 8p11.22

Cellular Component: cell surface; extracellular space; focal adhesion

Molecular Function: collagen binding; integrin binding; laminin binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein kinase C binding; SH3 domain binding

Biological Process: activation of MAPKK activity; cell adhesion; cell adhesion mediated by integrin; cell migration; cell-cell adhesion mediated by integrin; cell-matrix adhesion; integrin-mediated signaling pathway; keratinocyte differentiation; membrane protein ectodomain proteolysis; monocyte activation; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell adhesion mediated by integrin; positive regulation of keratinocyte migration; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein secretion; response to calcium ion; response to glucocorticoid stimulus; response to hydrogen peroxide; response to manganese ion; transforming growth factor beta receptor signaling pathway

Disease: Cone-rod Dystrophy 9
 ADAM9 ELISA Kit
 ADAM9 Recombinant
 ADAM9 Antibody
 KIAA0021 ELISA Kit
 KIAA0021 Recombinant
 KIAA0021 Antibody
 MCMP ELISA Kit
 MCMP Recombinant
 MCMP Antibody
 MDC9 ELISA Kit
 MDC9 Recombinant
 MDC9 Antibody
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Disintegrin and metalloproteinase domain-containing protein B

 Disintegrin and metalloproteinase domain-containing protein B ELISA Kit
 Disintegrin and metalloproteinase domain-containing protein B Recombinant
 Disintegrin and metalloproteinase domain-containing protein B Antibody
Also known as Disintegrin and metalloproteinase domain-containing protein B (ADAM B).
Probable zinc protease.
 ADM-B ELISA Kit
 ADM-B Recombinant
 ADM-B Antibody
 TRV_04965 ELISA Kit
 TRV_04965 Recombinant
 TRV_04965 Antibody
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