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Disks large

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Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction and cell proliferation (By similarity).

Below are the list of possible Disks large products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Disks large homolog 1

 Disks large homolog 1 ELISA Kit
 Disks large homolog 1 Recombinant
 Disks large homolog 1 Antibody
Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction and cell proliferation ().
 dlg1 ELISA Kit
 dlg1 Recombinant
 dlg1 Antibody
 TEgg018e06.1 ELISA Kit
 TEgg018e06.1 Recombinant
 TEgg018e06.1 Antibody
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Disks large homolog 2

 Disks large homolog 2 ELISA Kit
 Disks large homolog 2 Recombinant
 Disks large homolog 2 Antibody
Also known as Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93).
PSD-93: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying po
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tassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Belongs to the MAGUK family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: basolateral plasma membrane; cell junction; cell soma; cytoplasm; dendrite; ionotropic glutamate receptor complex; membrane; postsynaptic density; postsynaptic membrane; voltage-gated potassium channel complex

Molecular Function: guanylate kinase activity; ionotropic glutamate receptor binding; kinase binding; PDZ domain binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein phosphatase binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; neuronal ion channel clustering; receptor clustering; sensory perception of pain; synaptic transmission
 Dlg2 ELISA Kit
 Dlg2 Recombinant
 Dlg2 Antibody
 Dlgh2 ELISA Kit
 Dlgh2 Recombinant
 Dlgh2 Antibody
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Disks large homolog 3

 Disks large homolog 3 ELISA Kit
 Disks large homolog 3 Recombinant
 Disks large homolog 3 Antibody
Also known as Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR).
DLG3: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interact
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s through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: basolateral plasma membrane; extracellular space; ionotropic glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane

Molecular Function: guanylate kinase activity; ionotropic glutamate receptor binding; kinase binding; ligand-gated ion channel activity; phosphatase binding; protein binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; nervous system development; receptor clustering; synaptic transmission

Disease: Mental Retardation, X-linked 90
 DLG3 ELISA Kit
 DLG3 Recombinant
 DLG3 Antibody
 KIAA1232 ELISA Kit
 KIAA1232 Recombinant
 KIAA1232 Antibody
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Disks large homolog 4

 Disks large homolog 4 ELISA Kit
 Disks large homolog 4 Recombinant
 Disks large homolog 4 Antibody
Also known as Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95).
Plays a role in synapse assembly and function. Plays a role in synaptic plasticity.
 dlg4 ELISA Kit
 dlg4 Recombinant
 dlg4 Antibody
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Disks large homolog 5

 Disks large homolog 5 ELISA Kit
 Disks large homolog 5 Recombinant
 Disks large homolog 5 Antibody
Also known as Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG).
DLG5: May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton. Belongs to the MAGUK family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10q23

Cellular Component: cytoplasm

Molecular Function: beta-catenin binding; cytoskeletal protein binding; protein bindin
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g

Biological Process: negative regulation of cell proliferation; signal transduction

Disease: Inflammatory Bowel Disease 1
 DLG5 ELISA Kit
 DLG5 Recombinant
 DLG5 Antibody
 KIAA0583 ELISA Kit
 KIAA0583 Recombinant
 KIAA0583 Antibody
 PDLG ELISA Kit
 PDLG Recombinant
 PDLG Antibody
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