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DNA annealing helicase and endonuclease

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DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

Below are the list of possible DNA annealing helicase and endonuclease products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DNA annealing helicase and endonuclease ZRANB3

 DNA annealing helicase and endonuclease ZRANB3 ELISA Kit
 DNA annealing helicase and endonuclease ZRANB3 Recombinant
 DNA annealing helicase and endonuclease ZRANB3 Antibody
Also known as DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3).
ZRANB3: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Rec
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ruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. Belongs to the SNF2/RAD54 helicase family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase

Chromosomal Location of Human Ortholog: 2q21.3

Cellular Component: nuclear replication fork; nucleus

Molecular Function: DNA helicase activity; endodeoxyribonuclease activity; protein binding

Biological Process: DNA repair; negative regulation of DNA recombination; replication fork processing; replication fork protection; response to DNA damage stimulus; response to UV
 ZRANB3 ELISA Kit
 ZRANB3 Recombinant
 ZRANB3 Antibody
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