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DNA-binding protein inhibitor

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Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Below are the list of possible DNA-binding protein inhibitor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DNA-binding protein inhibitor ID-1

 DNA-binding protein inhibitor ID-1 ELISA Kit
 DNA-binding protein inhibitor ID-1 Recombinant
 DNA-binding protein inhibitor ID-1 Antibody
Also known as DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1).
ID1: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 20q11

Cellular Component: Golgi apparatus; nucleoplasm; nucleus
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Molecular Function: protein binding

Biological Process: angiogenesis; blood vessel endothelial cell migration; blood vessel morphogenesis; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway
 ID1 ELISA Kit
 ID1 Recombinant
 ID1 Antibody
 BHLHB24 ELISA Kit
 BHLHB24 Recombinant
 BHLHB24 Antibody
 ID ELISA Kit
 ID Recombinant
 ID Antibody
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DNA-binding protein inhibitor ID-2

 DNA-binding protein inhibitor ID-2 ELISA Kit
 DNA-binding protein inhibitor ID-2 Recombinant
 DNA-binding protein inhibitor ID-2 Antibody
Also known as DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2).
ID2: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.
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Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system.

Protein type: DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: centrosome; cytoplasm; cytosol; nucleoplasm; nucleus; protein complex

Molecular Function: protein binding

Biological Process: circadian regulation of gene expression; embryonic digestive tract morphogenesis; entrainment of circadian clock by photoperiod; locomotor rhythm; mammary gland epithelial cell proliferation; multicellular organismal development; negative regulation of neuron differentiation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; neuron fate commitment; positive regulation of blood pressure; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; regulation of circadian rhythm; regulation of lipid metabolic process
 ID2 ELISA Kit
 ID2 Recombinant
 ID2 Antibody
 BHLHB26 ELISA Kit
 BHLHB26 Recombinant
 BHLHB26 Antibody
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DNA-binding protein inhibitor ID-2-A

 DNA-binding protein inhibitor ID-2-A ELISA Kit
 DNA-binding protein inhibitor ID-2-A Recombinant
 DNA-binding protein inhibitor ID-2-A Antibody
Also known as DNA-binding protein inhibitor ID-2-A (Inhibitor of DNA binding 2-A) (XId2) (Inhibitor of differentiation 2-A).
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Inhibits the activity of both neurogeni
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c (neurod1/neuroD) and myogenic (myod1/myoD) bHLH factors. May play a role in the regulation of the circadian clock.
 id2-a ELISA Kit
 id2-a Recombinant
 id2-a Antibody
 id2 ELISA Kit
 id2 Recombinant
 id2 Antibody
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DNA-binding protein inhibitor ID-2-B

 DNA-binding protein inhibitor ID-2-B ELISA Kit
 DNA-binding protein inhibitor ID-2-B Recombinant
 DNA-binding protein inhibitor ID-2-B Antibody
Also known as DNA-binding protein inhibitor ID-2-B (Inhibitor of DNA binding 2-B) (Inhibitor of differentiation 2-B).
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Inhibits the activity of both neurogenic (neur
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od1/neuroD) and myogenic (myod1/myoD) bHLH factors. May play a role in the regulation of the circadian clock ().
 id2-b ELISA Kit
 id2-b Recombinant
 id2-b Antibody
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DNA-binding protein inhibitor ID-3

 DNA-binding protein inhibitor ID-3 ELISA Kit
 DNA-binding protein inhibitor ID-3 Recombinant
 DNA-binding protein inhibitor ID-3 Antibody
Also known as DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3).
ID3: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors. Induced by phorbol 12-myristate 13-acetate (
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PMA). Interacts with COPS5 and COPS7A. Homodimer, and heterodimer with other HLH proteins.

Protein type: DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1p36.13-p36.12

Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus

Molecular Function: protein binding; transcription corepressor activity

Biological Process: multicellular organismal development; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent
 ID3 ELISA Kit
 ID3 Recombinant
 ID3 Antibody
 1R21 ELISA Kit
 1R21 Recombinant
 1R21 Antibody
 BHLHB25 ELISA Kit
 BHLHB25 Recombinant
 BHLHB25 Antibody
 HEIR1 ELISA Kit
 HEIR1 Recombinant
 HEIR1 Antibody
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DNA-binding protein inhibitor ID-3-A

 DNA-binding protein inhibitor ID-3-A ELISA Kit
 DNA-binding protein inhibitor ID-3-A Recombinant
 DNA-binding protein inhibitor ID-3-A Antibody
Also known as DNA-binding protein inhibitor ID-3-A (Inhibitor of DNA binding 3) (XId3) (XIdI) (XIdIa) (XIdIb) (XIdx) (Inhibitor of differentiation 3-A).
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Influences
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cell fate decisions in the embryo by sequestering and blocking the activity of the bHLH transcription factors that control these decisions. Inhibits the binding of myogenic bHLH-containing complexes to E-box DNA, thereby preventing activation of muscle-specific target genes. Also inhibits the activity of neurogenic factor neurod1/neuroD. Plays a role in cell cycle progression and survival of neural crest progenitors; binding to either hes4-B/hairy2b or stat3 blocks the formation of transcription factor complexes and the repressor function of hes4-B/hairy2B, to allow neural crest progenitors to differentiate. May play a role in the regulation of the circadian rhythm.
 id3-a ELISA Kit
 id3-a Recombinant
 id3-a Antibody
 id3 ELISA Kit
 id3 Recombinant
 id3 Antibody
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DNA-binding protein inhibitor ID-3-B

 DNA-binding protein inhibitor ID-3-B ELISA Kit
 DNA-binding protein inhibitor ID-3-B Recombinant
 DNA-binding protein inhibitor ID-3-B Antibody
Also known as DNA-binding protein inhibitor ID-3-B (Inhibitor of DNA binding 3-B) (XIdIIa) (Inhibitor of differentiation 3-B).
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Influences cell fate decisions in the
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embryo by sequestering and blocking the activity of the bHLH transcription factors that control these decisions. Inhibits the binding of myogenic bHLH-containing complexes to E-box DNA, thereby preventing activation of muscle-specific target genes. Also inhibits the activity of neurogenic factor neurod1/neuroD. Plays a role in cell cycle progression and survival of neural crest progenitors; binding to either hes4-B/hairy2b or stat3 blocks the formation of transcription factor complexes and the repressor function of hes4-B/hairy2B, to allow neural crest progenitors to differentiate. May play a role in the regulation of the circadian rhythm ().
 id3-b ELISA Kit
 id3-b Recombinant
 id3-b Antibody
 id3 ELISA Kit
 id3 Recombinant
 id3 Antibody
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DNA-binding protein inhibitor ID-4

 DNA-binding protein inhibitor ID-4 ELISA Kit
 DNA-binding protein inhibitor ID-4 Recombinant
 DNA-binding protein inhibitor ID-4 Antibody
Also known as DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4).
ID4: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.

Protein type: Transcription, coactivator/corepressor<
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Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: nucleus

Molecular Function: protein binding; transcription corepressor activity

Biological Process: negative regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter
 ID4 ELISA Kit
 ID4 Recombinant
 ID4 Antibody
 BHLHB27 ELISA Kit
 BHLHB27 Recombinant
 BHLHB27 Antibody
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