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DNA damage-binding protein

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Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2 (By similarity).

Below are the list of possible DNA damage-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DNA damage-binding protein 1

 DNA damage-binding protein 1 ELISA Kit
 DNA damage-binding protein 1 Recombinant
 DNA damage-binding protein 1 Antibody
Also known as DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1).
Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds t
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o cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2 ().
 DDB1 ELISA Kit
 DDB1 Recombinant
 DDB1 Antibody
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DNA damage-binding protein 1a

 DNA damage-binding protein 1a ELISA Kit
 DNA damage-binding protein 1a Recombinant
 DNA damage-binding protein 1a Antibody
Also known as DNA damage-binding protein 1a (UV-damaged DNA-binding protein 1a) (DDB1a).
Structurally similar to damaged DNA binding proteins. DDB1a is part of a 350 KDa nuclear localized DET1 protein complex. This complex may physically interact with histone tails and while bound to chromatin- repress transcription of genes involved in photomorphogenesis. DDB1a is shown to be RUB-modified.
 DDB1A ELISA Kit
 DDB1A Recombinant
 DDB1A Antibody
 At4g05420 ELISA Kit
 At4g05420 Recombinant
 At4g05420 Antibody
 C6L9.100 ELISA Kit
 C6L9.100 Recombinant
 C6L9.100 Antibody
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DNA damage-binding protein 1b

 DNA damage-binding protein 1b ELISA Kit
 DNA damage-binding protein 1b Recombinant
 DNA damage-binding protein 1b Antibody
Also known as DNA damage-binding protein 1b (UV-damaged DNA-binding protein 1b) (DDB1b).
One of two closely related genes similar to a damaged DNA binding protein originally described in mammals. May form a complex with DET1 to regulate photomorphogenesis. Loss of function mutations are lethal. The DDB1b protein binds with a number of DWD-containing proteins and may form part of a CUL4-based E3 ubiquitin ligase.
 DDB1B ELISA Kit
 DDB1B Recombinant
 DDB1B Antibody
 At4g21100 ELISA Kit
 At4g21100 Recombinant
 At4g21100 Antibody
 F7J7.40 ELISA Kit
 F7J7.40 Recombinant
 F7J7.40 Antibody
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DNA damage-binding protein 2

 DNA damage-binding protein 2 ELISA Kit
 DNA damage-binding protein 2 Recombinant
 DNA damage-binding protein 2 Antibody
Also known as DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2).
Required for DNA repair. Binds to ddb1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate
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recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair ().
 ddb2 ELISA Kit
 ddb2 Recombinant
 ddb2 Antibody
 si:dkey-45f10.3 ELISA Kit
 si:dkey-45f10.3 Recombinant
 si:dkey-45f10.3 Antibody
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DNA damage-binding protein cmr1

 DNA damage-binding protein cmr1 ELISA Kit
 DNA damage-binding protein cmr1 Recombinant
 DNA damage-binding protein cmr1 Antibody
DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.
 AFUB_078330 ELISA Kit
 AFUB_078330 Recombinant
 AFUB_078330 Antibody
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