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DNA excision repair protein

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Adapter protein for ddb1/cullin 4 ubiquitin ligases involved in transcription-coupled nucleotide excision repair.

Below are the list of possible DNA excision repair protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DNA excision repair protein ckn1

 DNA excision repair protein ckn1 ELISA Kit
 DNA excision repair protein ckn1 Recombinant
 DNA excision repair protein ckn1 Antibody
Adapter protein for ddb1/cullin 4 ubiquitin ligases involved in transcription-coupled nucleotide excision repair.
 ckn1 ELISA Kit
 ckn1 Recombinant
 ckn1 Antibody
 SPBC577.09 ELISA Kit
 SPBC577.09 Recombinant
 SPBC577.09 Antibody
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DNA excision repair protein CSB

 DNA excision repair protein CSB ELISA Kit
 DNA excision repair protein CSB Recombinant
 DNA excision repair protein CSB Antibody
Also known as DNA excision repair protein CSB (Cockayne syndrome protein CSB) (OsCSB).
Essential factor involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation.
 CSB ELISA Kit
 CSB Recombinant
 CSB Antibody
 Os01g0102800 ELISA Kit
 Os01g0102800 Recombinant
 Os01g0102800 Antibody
 LOC_Os01g01312 ELISA Kit
 LOC_Os01g01312 Recombinant
 LOC_Os01g01312 Antibody
 P0402A09.26 ELISA Kit
 P0402A09.26 Recombinant
 P0402A09.26 Antibody
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DNA excision repair protein ERCC-1

 DNA excision repair protein ERCC-1 ELISA Kit
 DNA excision repair protein ERCC-1 Recombinant
 DNA excision repair protein ERCC-1 Antibody
Structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair.
 ercc1 ELISA Kit
 ercc1 Recombinant
 ercc1 Antibody
 DDB_G0267682 ELISA Kit
 DDB_G0267682 Recombinant
 DDB_G0267682 Antibody
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DNA excision repair protein ERCC-6

 DNA excision repair protein ERCC-6 ELISA Kit
 DNA excision repair protein ERCC-6 Recombinant
 DNA excision repair protein ERCC-6 Antibody
Also known as DNA excision repair protein ERCC-6 (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB).
ERCC6: Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around it
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self, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions. Defects in ERCC6 are the cause of Cockayne syndrome type B (CSB). Cockayne syndrome is a rare disorder characterized by cutaneous sensitivity to sunlight, abnormal and slow growth, cachectic dwarfism, progeroid appearance, progressive pigmentary retinopathy and sensorineural deafness. There is delayed neural development and severe progressive neurologic degeneration resulting in mental retardation. Two clinical forms are recognized: in the classical form or Cockayne syndrome type 1, the symptoms are progressive and typically become apparent within the first few years or life; the less common Cockayne syndrome type 2 is characterized by more severe symptoms that manifest prenatally. Cockayne syndrome shows some overlap with certain forms of xeroderma pigmentosum. Unlike xeroderma pigmentosum, patients with Cockayne syndrome do not manifest increased freckling and other pigmentation abnormalities in the skin and have no significant increase in skin cancer. Defects in ERCC6 are the cause of cerebro-oculo-facio- skeletal syndrome type 1 (COFS1); also known as COFS syndrome or Pena-Shokeir syndrome type 2. COFS is a degenerative autosomal recessive disorder of prenatal onset affecting the brain, eye and spinal cord. After birth, it leads to brain atrophy, hypoplasia of the corpus callosum, hypotonia, cataracts, microcornea, optic atrophy, progressive joint contractures and growth failure. Facial dysmorphism is a constant feature. Abnormalities of the skull, eyes, limbs, heart and kidney also occur. Defects in ERCC6 are a cause of De Sanctis-Cacchione syndrome (DSC); also known as xerodermic idiocy. DSC is an autosomal recessive syndrome consisting of xeroderma pigmentosum associated with mental retardation, retarded growth, gonadal hypoplasia and sometimes neurologic complications. Defects in ERCC6 are the cause of susceptibility to age- related macular degeneration type 5 (ARMD5). A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Defects in ERCC6 are a cause of UV-sensitive syndrome type 1 (UVSS1). A rare autosomal recessive disorder characterized by photosensitivity and mild freckling but without neurological abnormalities or skin tumors. Patient exhibit a number of freckles, hypopigmented spots, telangiectases, and slightly dried skin in sun-exposed areas. Belongs to the SNF2/RAD54 helicase family.

Protein type: DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase; Transcription regulation

Chromosomal Location of Human Ortholog: 10q11.23

Cellular Component: nucleolus; nucleoplasm; nucleus; transcription elongation factor complex

Molecular Function: ATP binding; chromatin binding; DNA binding; DNA helicase activity; DNA-dependent ATPase activity; protein binding; protein C-terminus binding; protein complex binding; protein N-terminus binding; protein tyrosine kinase activator activity

Biological Process: base-excision repair; positive regulation of gene expression, epigenetic; positive regulation of RNA elongation; regulation of RNA elongation; response to oxidative stress; response to UV; transcription-coupled nucleotide-excision repair

Disease: Cerebrooculofacioskeletal Syndrome 1; Cockayne Syndrome B; De Sanctis-cacchione Syndrome; Lung Cancer; Macular Degeneration, Age-related, 5; Premature Ovarian Failure 11; Uv-sensitive Syndrome 1
 ERCC6 ELISA Kit
 ERCC6 Recombinant
 ERCC6 Antibody
 CSB ELISA Kit
 CSB Recombinant
 CSB Antibody
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DNA excision repair protein ERCC-6-like

 DNA excision repair protein ERCC-6-like ELISA Kit
 DNA excision repair protein ERCC-6-like Recombinant
 DNA excision repair protein ERCC-6-like Antibody
Also known as DNA excision repair protein ERCC-6-like (ATP-dependent helicase ERCC6-like).
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until
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it is resolved during anaphase ().
 ERCC6L ELISA Kit
 ERCC6L Recombinant
 ERCC6L Antibody
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DNA excision repair protein ERCC-6-like 2

 DNA excision repair protein ERCC-6-like 2 ELISA Kit
 DNA excision repair protein ERCC-6-like 2 Recombinant
 DNA excision repair protein ERCC-6-like 2 Antibody
May be involved in early DNA damage response.
 ERCC6L2 ELISA Kit
 ERCC6L2 Recombinant
 ERCC6L2 Antibody
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DNA excision repair protein ERCC-8

 DNA excision repair protein ERCC-8 ELISA Kit
 DNA excision repair protein ERCC-8 Recombinant
 DNA excision repair protein ERCC-8 Antibody
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-c
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oupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes ().
 ERCC8 ELISA Kit
 ERCC8 Recombinant
 ERCC8 Antibody
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DNA excision repair protein haywire

 DNA excision repair protein haywire ELISA Kit
 DNA excision repair protein haywire Recombinant
 DNA excision repair protein haywire Antibody
Also known as DNA excision repair protein haywire (ATP-dependent DNA helicase hay) (ERCC-3 homolog protein) (ERCC3Dm).
Probably an ATP-dependent DNA helicase involved in excision repair of DNA. May have a DNA unwinding function.
 hay ELISA Kit
 hay Recombinant
 hay Antibody
 ERCC3 ELISA Kit
 ERCC3 Recombinant
 ERCC3 Antibody
 CG8019 ELISA Kit
 CG8019 Recombinant
 CG8019 Antibody
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Proteins Root Name Listing
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