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DNA topoisomerase

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Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.

Below are the list of possible DNA topoisomerase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DNA topoisomerase 1

 DNA topoisomerase 1 ELISA Kit
 DNA topoisomerase 1 Recombinant
 DNA topoisomerase 1 Antibody
Also known as DNA topoisomerase 1 (DNA topoisomerase I).
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the
>>>
enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.
 TOP1 ELISA Kit
 TOP1 Recombinant
 TOP1 Antibody
 TOP-1 ELISA Kit
 TOP-1 Recombinant
 TOP-1 Antibody
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DNA topoisomerase 1 alpha

 DNA topoisomerase 1 alpha ELISA Kit
 DNA topoisomerase 1 alpha Recombinant
 DNA topoisomerase 1 alpha Antibody
Also known as DNA topoisomerase 1 alpha (DNA topoisomerase 1) (DNA topoisomerase I) (Protein FASCIATA 5) (Protein MGOUN1).
Encodes a type-I DNA topoisomerase I. Disruptions in this gene affect phyllotaxis and plant architecture suggesting that the gene plays a critical role in the maintenance of a regular pattern of organ initiation. Isolated as a protein oxidized during seed germination; proteomics approach revealed differences in de novo synthesis levels of this protein in condition with vs. without salicylic acid in the period from 0 to 40 hrs. following seed imbibition. Functions in ste
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m cell maintenance at all stages of shoot and floral meristems and in the regulation of gene silencing.
 TOP1A ELISA Kit
 TOP1A Recombinant
 TOP1A Antibody
 FAS5 ELISA Kit
 FAS5 Recombinant
 FAS5 Antibody
 MGO1 ELISA Kit
 MGO1 Recombinant
 MGO1 Antibody
 TOP1 ELISA Kit
 TOP1 Recombinant
 TOP1 Antibody
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DNA topoisomerase 1 beta

 DNA topoisomerase 1 beta ELISA Kit
 DNA topoisomerase 1 beta Recombinant
 DNA topoisomerase 1 beta Antibody
Also known as DNA topoisomerase 1 beta (DNA topoisomerase 1).
Encodes one of two Arabidopsis type-I DNA topoisomerase I genes. Reducing the level of expression of this gene in a top1alpha (At5g55300) mutant background causes seedling lethality.
 TOP1B ELISA Kit
 TOP1B Recombinant
 TOP1B Antibody
 TOP1 ELISA Kit
 TOP1 Recombinant
 TOP1 Antibody
 TOP1BETA ELISA Kit
 TOP1BETA Recombinant
 TOP1BETA Antibody
 At5g55310 ELISA Kit
 At5g55310 Recombinant
 At5g55310 Antibody
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DNA topoisomerase 1 type prokaryotic

 DNA topoisomerase 1 type prokaryotic ELISA Kit
 DNA topoisomerase 1 type prokaryotic Recombinant
 DNA topoisomerase 1 type prokaryotic Antibody
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-
>>>
phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone ().
 TOP1P ELISA Kit
 TOP1P Recombinant
 TOP1P Antibody
 MIMI_L221 ELISA Kit
 MIMI_L221 Recombinant
 MIMI_L221 Antibody
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DNA topoisomerase 1B

 DNA topoisomerase 1B ELISA Kit
 DNA topoisomerase 1B Recombinant
 DNA topoisomerase 1B Antibody
Also known as DNA topoisomerase 1B (TopIB) (DNA topoisomerase I) (Late protein H6).
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA stran
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d then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
 TOP1 ELISA Kit
 TOP1 Recombinant
 TOP1 Antibody
 VACWR104 ELISA Kit
 VACWR104 Recombinant
 VACWR104 Antibody
 H6R ELISA Kit
 H6R Recombinant
 H6R Antibody
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DNA topoisomerase 2

 DNA topoisomerase 2 ELISA Kit
 DNA topoisomerase 2 Recombinant
 DNA topoisomerase 2 Antibody
Also known as DNA topoisomerase 2 (DNA topoisomerase II).
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks ().
 TOP2 ELISA Kit
 TOP2 Recombinant
 TOP2 Antibody
 CAGL0J05610g ELISA Kit
 CAGL0J05610g Recombinant
 CAGL0J05610g Antibody
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DNA topoisomerase 2-alpha

 DNA topoisomerase 2-alpha ELISA Kit
 DNA topoisomerase 2-alpha Recombinant
 DNA topoisomerase 2-alpha Antibody
Also known as DNA topoisomerase 2-alpha (DNA topoisomerase II, alpha isozyme).
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillati
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on.
 TOP2A ELISA Kit
 TOP2A Recombinant
 TOP2A Antibody
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DNA topoisomerase 2-beta

 DNA topoisomerase 2-beta ELISA Kit
 DNA topoisomerase 2-beta Recombinant
 DNA topoisomerase 2-beta Antibody
Also known as DNA topoisomerase 2-beta (DNA topoisomerase II, beta isozyme).
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
 TOP2B ELISA Kit
 TOP2B Recombinant
 TOP2B Antibody
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DNA topoisomerase 3

 DNA topoisomerase 3 ELISA Kit
 DNA topoisomerase 3 Recombinant
 DNA topoisomerase 3 Antibody
Also known as DNA topoisomerase 3 (DNA topoisomerase III).
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic ty
>>>
rosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
 topB ELISA Kit
 topB Recombinant
 topB Antibody
 BT9727_0351 ELISA Kit
 BT9727_0351 Recombinant
 BT9727_0351 Antibody
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DNA topoisomerase 3-alpha

 DNA topoisomerase 3-alpha ELISA Kit
 DNA topoisomerase 3-alpha Recombinant
 DNA topoisomerase 3-alpha Antibody
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, t
>>>
he DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the resolution step of homologous recombination, in a process called Holliday Junction dissolution, to limit DNA crossover formation in cells ().
 TOP3A ELISA Kit
 TOP3A Recombinant
 TOP3A Antibody
 Os03g0165000 ELISA Kit
 Os03g0165000 Recombinant
 Os03g0165000 Antibody
 LOC_Os03g06900 ELISA Kit
 LOC_Os03g06900 Recombinant
 LOC_Os03g06900 Antibody
 OJ1123F12.5 ELISA Kit
 OJ1123F12.5 Recombinant
 OJ1123F12.5 Antibody
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DNA topoisomerase 3-beta

 DNA topoisomerase 3-beta ELISA Kit
 DNA topoisomerase 3-beta Recombinant
 DNA topoisomerase 3-beta Antibody
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, t
>>>
he DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone ().
 TOP3B ELISA Kit
 TOP3B Recombinant
 TOP3B Antibody
 Os09g0500600 ELISA Kit
 Os09g0500600 Recombinant
 Os09g0500600 Antibody
 LOC_Os09g32450 ELISA Kit
 LOC_Os09g32450 Recombinant
 LOC_Os09g32450 Antibody
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DNA topoisomerase 3-beta-1

 DNA topoisomerase 3-beta-1 ELISA Kit
 DNA topoisomerase 3-beta-1 Recombinant
 DNA topoisomerase 3-beta-1 Antibody
Also known as DNA topoisomerase 3-beta-1 (DNA topoisomerase III beta-1).
TOP3B: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the ca
>>>
talytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Possesses negatively supercoiled DNA relaxing activity. Belongs to the type IA topoisomerase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; EC 5.99.1.2; Topoisomerase

Cellular Component: condensed chromosome; cytosol; nucleus

Molecular Function: DNA topoisomerase activity

Biological Process: chromosome segregation; DNA topological change
 Top3b ELISA Kit
 Top3b Recombinant
 Top3b Antibody
 Top3b1 ELISA Kit
 Top3b1 Recombinant
 Top3b1 Antibody
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DNA topoisomerase 4 subunit A

 DNA topoisomerase 4 subunit A ELISA Kit
 DNA topoisomerase 4 subunit A Recombinant
 DNA topoisomerase 4 subunit A Antibody
Also known as DNA topoisomerase 4 subunit A (Topoisomerase IV subunit A).
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule ().
 parC ELISA Kit
 parC Recombinant
 parC Antibody
 BB_0035 ELISA Kit
 BB_0035 Recombinant
 BB_0035 Antibody
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DNA topoisomerase 4 subunit B

 DNA topoisomerase 4 subunit B ELISA Kit
 DNA topoisomerase 4 subunit B Recombinant
 DNA topoisomerase 4 subunit B Antibody
Also known as DNA topoisomerase 4 subunit B (Topoisomerase IV subunit B).
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule ().
 parE ELISA Kit
 parE Recombinant
 parE Antibody
 BB_0036 ELISA Kit
 BB_0036 Recombinant
 BB_0036 Antibody
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DNA topoisomerase 6 subunit A

 DNA topoisomerase 6 subunit A ELISA Kit
 DNA topoisomerase 6 subunit A Recombinant
 DNA topoisomerase 6 subunit A Antibody
Also known as DNA topoisomerase 6 subunit A (AtTOP6A) (Meiotic recombination protein SPO11-3) (AtSPO11-3) (Protein BRASSINOSTEROID INSENSITIVE 5) (Protein ROOT HAIRLESS 2).
Involved in the patterning and shape of leaf trichomes. Encodes the DNA topoisomerase VI SPO11-3, involved in endoreduplication
 TOP6A ELISA Kit
 TOP6A Recombinant
 TOP6A Antibody
 BIN5 ELISA Kit
 BIN5 Recombinant
 BIN5 Antibody
 RHL2 ELISA Kit
 RHL2 Recombinant
 RHL2 Antibody
 SPO11-3 ELISA Kit
 SPO11-3 Recombinant
 SPO11-3 Antibody
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DNA topoisomerase 6 subunit A3

 DNA topoisomerase 6 subunit A3 ELISA Kit
 DNA topoisomerase 6 subunit A3 Recombinant
 DNA topoisomerase 6 subunit A3 Antibody
Also known as DNA topoisomerase 6 subunit A3 (OsTOP6A3) (DNA topoisomerase 6 subunit A) (OsTOP6A) (Meiotic recombination protein SPO11-3).
Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity (). May be involved in cell proliferation and stress tolerance.
 TOP6A3 ELISA Kit
 TOP6A3 Recombinant
 TOP6A3 Antibody
 SPO11-3 ELISA Kit
 SPO11-3 Recombinant
 SPO11-3 Antibody
 TOP6A ELISA Kit
 TOP6A Recombinant
 TOP6A Antibody
 OsI_11065 ELISA Kit
 OsI_11065 Recombinant
 OsI_11065 Antibody
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DNA topoisomerase 6 subunit B

 DNA topoisomerase 6 subunit B ELISA Kit
 DNA topoisomerase 6 subunit B Recombinant
 DNA topoisomerase 6 subunit B Antibody
Also known as DNA topoisomerase 6 subunit B (AtTOP6B) (Protein BRASSINOSTEROID INSENSITIVE 3) (Protein ELONGATED HYPOCOTYL 6) (Protein ROOT HAIRLESS 3).
Encodes putative eukaryotic homolog of archaebacterial topoisomerase VI subunit B, TOP6B. Is essential for endoreduplication and is involved in cell expansion and cell proliferation. The hlq (harlequin) dwarf mutant has fewer root hair and leaf trichome. It has abnormal epidermal cell and accumulates callose.
 TOP6B ELISA Kit
 TOP6B Recombinant
 TOP6B Antibody
 BIN3 ELISA Kit
 BIN3 Recombinant
 BIN3 Antibody
 HYP6 ELISA Kit
 HYP6 Recombinant
 HYP6 Antibody
 RHL3 ELISA Kit
 RHL3 Recombinant
 RHL3 Antibody
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DNA topoisomerase I

 DNA topoisomerase I ELISA Kit
 DNA topoisomerase I Recombinant
 DNA topoisomerase I Antibody
Also known as DNA topoisomerase I, mitochondrial (TOP1mt).
TOP1MT: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine o
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f the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Belongs to the type IB topoisomerase family.

Protein type: EC 5.99.1.2; Mitochondrial; Topoisomerase

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: mitochondrion; nucleolus; nucleus

Molecular Function: DNA topoisomerase type I activity

Biological Process: chromatin remodeling; chromosome segregation; DNA replication; DNA topological change
 TOP1MT ELISA Kit
 TOP1MT Recombinant
 TOP1MT Antibody
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DNA topoisomerase I, plasmid

 DNA topoisomerase I, plasmid ELISA Kit
 DNA topoisomerase I, plasmid Recombinant
 DNA topoisomerase I, plasmid Antibody
Also known as DNA topoisomerase I, plasmid (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme).
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scis
>>>
sile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
 XF_a0003 ELISA Kit
 XF_a0003 Recombinant
 XF_a0003 Antibody
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DNA topoisomerase large subunit

 DNA topoisomerase large subunit ELISA Kit
 DNA topoisomerase large subunit Recombinant
 DNA topoisomerase large subunit Antibody
Also known as DNA topoisomerase large subunit (Protein Gp39).
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. T4 topoisomerase makes double-stran
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d breaks.
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DNA topoisomerase medium subunit

 DNA topoisomerase medium subunit ELISA Kit
 DNA topoisomerase medium subunit Recombinant
 DNA topoisomerase medium subunit Antibody
Also known as DNA topoisomerase medium subunit (Protein Gp52).
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. T4 topoisomerase makes double-stra
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nd breaks.
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DNA topoisomerase small subunit

 DNA topoisomerase small subunit ELISA Kit
 DNA topoisomerase small subunit Recombinant
 DNA topoisomerase small subunit Antibody
Also known as DNA topoisomerase small subunit (Protein Gp60).
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. T4 topoisomerase makes double-stran
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d breaks.
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