Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow DNA topoisomerase 2-binding protein  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Allograft Inflammatory Factor 1 (AIF1) ELISA Kit
 • KLRG1 Antibody
 • NPM1 - NPM - Nucleophosmin Antibody
 • 3-Phosphoglyceric phosphokinase Antibody
 • KDSR Recombinant Protein
 • CCKA Receptor (Cckar) Peptide
 • E-selectin (SELE) Recombinant Protein
 • HBV X Recombinant Protein
 • heat shock 70kDa protein 12A (HSPA12A) ELISA Kit
 • Tyrosinase Antibody
 • Sex Hormone Binding Globulin (SHBG) ELISA Kit
 • Tumor Protein p53 Binding Protein 1 (TP53BP1) ELISA Kit
 • Fibroblast growth factor receptor 3 (FGFR3) Recombinant Protein
 • 2,4-Dienoyl CoA Reductase 1 (DECR1) Recombinant Protein
 downarrow more ...
separator

DNA topoisomerase 2-binding protein

separator
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR .

Below are the list of possible DNA topoisomerase 2-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

DNA topoisomerase 2-binding protein 1

 DNA topoisomerase 2-binding protein 1 ELISA Kit
 DNA topoisomerase 2-binding protein 1 Recombinant
 DNA topoisomerase 2-binding protein 1 Antibody
Also known as DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1).
TOPBP1: a DNA-binding protein and scaffolding protein that is required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. R
>>>
ecruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR. Contains 7 BRCT domains, which are characteristic of proteins involved in cell cycle checkpoint control in response to DNA damage. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase. Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Up-regulated during the S phase of the cell cycle. Up-regulated by E2F1 and interferon.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: actin cytoskeleton; centrosome; chromosome; cytoplasm; Golgi apparatus; nucleoplasm; nucleus; PML body

Molecular Function: identical protein binding; protein binding; protein C-terminus binding

Biological Process: DNA metabolic process; DNA replication; DNA replication initiation; mitotic cell cycle DNA replication checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; response to DNA damage stimulus; response to ionizing radiation
 TOPBP1 ELISA Kit
 TOPBP1 Recombinant
 TOPBP1 Antibody
 KIAA0259 ELISA Kit
 KIAA0259 Recombinant
 KIAA0259 Antibody
Table BarTOPTable Bar
 

DNA topoisomerase 2-binding protein 1-A

 DNA topoisomerase 2-binding protein 1-A ELISA Kit
 DNA topoisomerase 2-binding protein 1-A Recombinant
 DNA topoisomerase 2-binding protein 1-A Antibody
Also known as DNA topoisomerase 2-binding protein 1-A (Cut5 protein) (DNA topoisomerase II-binding protein 1-A) (TopBP1-A) (XtopBP).
Has dual roles in initiation of DNA replication, and regulation of checkpoint responses. Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages. Necessary for the loading of replication factors onto
>>>
chromatin, including gemc1, cdc45, DNA polymerases and components of the GINS complex such as ginsl/sld5. Binds chromatin in both S-phase cyclin-dependent kinase (S-CDK)-independent and S-CDK-dependent modes. Chromatin binding is required for the action of S-CDK, which in turn triggers the formation of preinitiation complexes of DNA replication. Its role in checkpoint activation is independent of the DNA replication role. In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the chek1 signaling pathway and block S-phase progression. Increases the kinase activity of atr to numerous substrates, and is required for the phosphorylation of Rad1.
 topbp1-A ELISA Kit
 topbp1-A Recombinant
 topbp1-A Antibody
 cut5 ELISA Kit
 cut5 Recombinant
 cut5 Antibody
Table BarTOPTable Bar
 

DNA topoisomerase 2-binding protein 1-B

 DNA topoisomerase 2-binding protein 1-B ELISA Kit
 DNA topoisomerase 2-binding protein 1-B Recombinant
 DNA topoisomerase 2-binding protein 1-B Antibody
Also known as DNA topoisomerase 2-binding protein 1-B (DNA topoisomerase II-binding protein 1-B) (TopBP1-B) (Xmus101).
Has dual roles in initiation of DNA replication, and regulation of checkpoint responses. Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages. Necessary for the loading of replication factors onto chromatin, inc
>>>
luding gemc1, cdc45, DNA polymerases and components of the GINS complex such as ginsl/sld5. Binds chromatin in both S-phase cyclin-dependent kinase (S-CDK)-independent and S-CDK-dependent modes. Chromatin binding is required for the action of S-CDK, which in turn triggers the formation of preinitiation complexes of DNA replication. Its role in checkpoint activation is independent of the DNA replication role. In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the chek1 signaling pathway and block S-phase progression. Increases the kinase activity of atr to numerous substrates, and is required for the phosphorylation of Rad1.
 topbp1-B ELISA Kit
 topbp1-B Recombinant
 topbp1-B Antibody
 mus101 ELISA Kit
 mus101 Recombinant
 mus101 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions