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Docking protein

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DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).

Below are the list of possible Docking protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Docking protein 1

 Docking protein 1 ELISA Kit
 Docking protein 1 Recombinant
 Docking protein 1 Antibody
Also known as Docking protein 1 (Downstream of tyrosine kinase 1).
DOK1: a docking protein that interacts with receptor tyrosine kinases. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CM
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L. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; intracellular; nucleus

Molecular Function: receptor signaling protein activity

Biological Process: Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
 Dok1 ELISA Kit
 Dok1 Recombinant
 Dok1 Antibody
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Docking protein 2

 Docking protein 2 ELISA Kit
 Docking protein 2 Recombinant
 Docking protein 2 Antibody
Also known as Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2)).
DOK2: a member of the p62dok family of proteins that interact with receptor tyrosine kinases and mediate particular biological responses. Constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous l
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eukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/Abl), a chimeric protein whose presence is associated with CML. Contains a pleckstrin homology domain at the amino terminus, 13 potential tyrosine phosphorylation sites, and six PXXP SH3 recognition motifs. Binds p120 (RasGAP) from CML cells.

Protein type: Adaptor/scaffold

Cellular Component: intracellular

Molecular Function: receptor signaling protein activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: MAPKKK cascade; Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
 Dok2 ELISA Kit
 Dok2 Recombinant
 Dok2 Antibody
 Frip ELISA Kit
 Frip Recombinant
 Frip Antibody
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Docking protein 3

 Docking protein 3 ELISA Kit
 Docking protein 3 Recombinant
 Docking protein 3 Antibody
Also known as Docking protein 3 (Downstream of tyrosine kinase 3).
DOK3: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with SHIP. May modulate Abl function. Upon tyrosine phosphorylation, Dok3 interacts w
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ith CSK and SHIP via their SH2 domains. Both pY381 and pY398 are required for interaction with SHIP. Only pY381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Does not interact with RasGAP. Four isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q35.3

Molecular Function: protein binding
 DOK3 ELISA Kit
 DOK3 Recombinant
 DOK3 Antibody
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Docking protein 4

 Docking protein 4 ELISA Kit
 Docking protein 4 Recombinant
 Docking protein 4 Antibody
Also known as Docking protein 4 (Downstream of tyrosine kinase 4).
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (). Putative link with downstream effectors of RET in neu
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ronal differentiation. May be involved in the regulation of the immune response induced by T-cells ().
 DOK4 ELISA Kit
 DOK4 Recombinant
 DOK4 Antibody
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Docking protein 5

 Docking protein 5 ELISA Kit
 Docking protein 5 Recombinant
 Docking protein 5 Antibody
Also known as Docking protein 5 (Downstream of tyrosine kinase 5).
DOK5: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in Ret-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of Ret
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in neuronal differentiation. Interacts with phosphorylated Ret. In contrast to other DOK proteins, it does not interact with RASGAP. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Molecular Function: protein binding; receptor signaling protein activity

Biological Process: MAPKKK cascade; nervous system development; regulation of nerve growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
 Dok5 ELISA Kit
 Dok5 Recombinant
 Dok5 Antibody
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Docking protein 6

 Docking protein 6 ELISA Kit
 Docking protein 6 Recombinant
 Docking protein 6 Antibody
Also known as Docking protein 6 (Downstream of tyrosine kinase 6).
DOK6: ocking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Interacts via its PTB domain with phosphorylated Ret, promoting neurite growth. May have a role in brain development and/or maintenance. Highly expressed in fetal
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and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 18q22.2

Molecular Function: protein binding
 DOK6 ELISA Kit
 DOK6 Recombinant
 DOK6 Antibody
 DOK5L ELISA Kit
 DOK5L Recombinant
 DOK5L Antibody
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