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Double-strand break repair protein

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Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).

Below are the list of possible Double-strand break repair protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Double-strand break repair protein MRE11

 Double-strand break repair protein MRE11 ELISA Kit
 Double-strand break repair protein MRE11 Recombinant
 Double-strand break repair protein MRE11 Antibody
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate se
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arches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation ().
 MRE11 ELISA Kit
 MRE11 Recombinant
 MRE11 Antibody
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Double-strand break repair protein mre-11

 Double-strand break repair protein mre-11 ELISA Kit
 Double-strand break repair protein mre-11 Recombinant
 Double-strand break repair protein mre-11 Antibody
Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
 mre-11 ELISA Kit
 mre-11 Recombinant
 mre-11 Antibody
 ZC302.1 ELISA Kit
 ZC302.1 Recombinant
 ZC302.1 Antibody
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Double-strand break repair protein MRE11A

 Double-strand break repair protein MRE11A ELISA Kit
 Double-strand break repair protein MRE11A Recombinant
 Double-strand break repair protein MRE11A Antibody
Also known as Double-strand break repair protein MRE11A (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A).
MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms
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a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.

Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease

Cellular Component: chromosome, telomeric region; condensed nuclear chromosome; Mre11 complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body

Molecular Function: 3'-5' exonuclease activity; ATP-dependent DNA helicase activity; DNA binding; endodeoxyribonuclease activity; protein binding; protein C-terminus binding; single-stranded DNA specific endodeoxyribonuclease activity

Biological Process: cell proliferation; chromosome organization and biogenesis; DNA duplex unwinding; double-strand break repair; double-strand break repair via nonhomologous end joining; heart development; intra-S DNA damage checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of apoptosis; negative regulation of DNA endoreduplication; negative regulation of virion penetration into host cell; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; response to DNA damage stimulus; sister chromatid cohesion; synapsis; telomeric 3' overhang formation
 Mre11a ELISA Kit
 Mre11a Recombinant
 Mre11a Antibody
 Mre11 ELISA Kit
 Mre11 Recombinant
 Mre11 Antibody
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Double-strand break repair protein mus-23

 Double-strand break repair protein mus-23 ELISA Kit
 Double-strand break repair protein mus-23 Recombinant
 Double-strand break repair protein mus-23 Antibody
Also known as Double-strand break repair protein mus-23 (Recombinational repair protein mus-23).
Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing ().
 mus-23 ELISA Kit
 mus-23 Recombinant
 mus-23 Antibody
 B11O9.50 ELISA Kit
 B11O9.50 Recombinant
 B11O9.50 Antibody
 NCU08730 ELISA Kit
 NCU08730 Recombinant
 NCU08730 Antibody
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Double-strand-break repair protein rad21 homolog

 Double-strand-break repair protein rad21 homolog ELISA Kit
 Double-strand-break repair protein rad21 homolog Recombinant
 Double-strand-break repair protein rad21 homolog Antibody
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. Plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. The cohesin complex is r
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equired for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis ().
 RAD21 ELISA Kit
 RAD21 Recombinant
 RAD21 Antibody
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