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Double-stranded RNA-specific adenosine deaminase

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Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Does not affect polyomavirus replication but provides protection against virus-induced cytopathic effects. Essential for embryonic development and cell survival and plays a critical role in the maintenance of hematopoietic stem cells (By similarity).

Below are the list of possible Double-stranded RNA-specific adenosine deaminase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Double-stranded RNA-specific adenosine deaminase

 Double-stranded RNA-specific adenosine deaminase ELISA Kit
 Double-stranded RNA-specific adenosine deaminase Recombinant
 Double-stranded RNA-specific adenosine deaminase Antibody
Also known as Double-stranded RNA-specific adenosine deaminase (DRADA).
ADAR: Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions
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to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site- selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. Isoform 1 is induced by interferon alpha. Isoform 5 is constitutively expressed. Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. 5 isoforms of the human protein are produced by alternative promoter.

Protein type: EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding

Cellular Component: cytoplasm; membrane; nuclear speck; nucleolus; nucleoplasm; nucleus

Molecular Function: double-stranded RNA adenosine deaminase activity

Biological Process: adenosine to inosine editing; base conversion or substitution editing; defense response to virus; erythrocyte differentiation; hemopoietic progenitor cell differentiation; in utero embryonic development; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, production of miRNAs; negative regulation of apoptosis; negative regulation of viral genome replication; osteoblast differentiation; positive regulation of viral genome replication; pre-microRNA processing; protein export from nucleus; protein import into nucleus; response to virus; somatic diversification of immune receptors via somatic mutation
 Adar ELISA Kit
 Adar Recombinant
 Adar Antibody
 Dsrad ELISA Kit
 Dsrad Recombinant
 Dsrad Antibody
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