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Double-stranded RNA-specific editase

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Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can inhibit cell proliferation and migration and can stimulate exocytosis.

Below are the list of possible Double-stranded RNA-specific editase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Double-stranded RNA-specific editase 1

 Double-stranded RNA-specific editase 1 ELISA Kit
 Double-stranded RNA-specific editase 1 Recombinant
 Double-stranded RNA-specific editase 1 Antibody
Also known as Double-stranded RNA-specific editase 1 (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase).
RED1: Editing of the messenger RNAs for glutamate receptor (GluR) subunits by site-selective adenosine deamination. Edits both the GluR-B Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.4.37; Hydrolase; Nucleolus; RNA-binding

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus

Molecular Function: d
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ouble-stranded RNA adenosine deaminase activity; double-stranded RNA binding; protein homodimerization activity; RNA binding

Biological Process: adenosine to inosine editing; base conversion or substitution editing; mRNA modification; negative regulation of cell migration; negative regulation of cell proliferation; positive regulation of mRNA processing; positive regulation of viral genome replication; regulation of cell cycle; RNA processing
 Adarb1 ELISA Kit
 Adarb1 Recombinant
 Adarb1 Antibody
 Adar2 ELISA Kit
 Adar2 Recombinant
 Adar2 Antibody
 Red1 ELISA Kit
 Red1 Recombinant
 Red1 Antibody
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Double-stranded RNA-specific editase Adar

 Double-stranded RNA-specific editase Adar ELISA Kit
 Double-stranded RNA-specific editase Adar Recombinant
 Double-stranded RNA-specific editase Adar Antibody
Also known as Double-stranded RNA-specific editase Adar (Adenosine deaminase that act on RNA) (Pre-mRNA adenosine deaminase) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dADAR) (dsRNA adenosine deaminase).
Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing
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of ion channels as targets.
 Adar ELISA Kit
 Adar Recombinant
 Adar Antibody
 hypnos-2 ELISA Kit
 hypnos-2 Recombinant
 hypnos-2 Antibody
 CG12598 ELISA Kit
 CG12598 Recombinant
 CG12598 Antibody
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Double-stranded RNA-specific editase B2

 Double-stranded RNA-specific editase B2 ELISA Kit
 Double-stranded RNA-specific editase B2 Recombinant
 Double-stranded RNA-specific editase B2 Antibody
Also known as Double-stranded RNA-specific editase B2 (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2).
ADARB2: Does not act on glutamate receptor or on serotonin receptor subtype 2C. Capable of binding to dsRNA but also to ssRNA.

Protein type: EC 3.5.-.-; Hydrolase; RNA-binding

Chromosomal Location of Human Ortholog: 10p15.3

Molecular Function: double-stranded RNA binding; single-stranded RNA binding
 ADARB2 ELISA Kit
 ADARB2 Recombinant
 ADARB2 Antibody
 ADAR3 ELISA Kit
 ADAR3 Recombinant
 ADAR3 Antibody
 RED2 ELISA Kit
 RED2 Recombinant
 RED2 Antibody
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