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Dual specificity mitogen-activated protein kinase kinase

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Required for cAMP-mediated activation of guanylyl cyclase activity and plays an essential role in aggregation, morphogenesis, and chemotaxis. Appears to act upstream of erk1 but not erk2.

Below are the list of possible Dual specificity mitogen-activated protein kinase kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Dual specificity mitogen-activated protein kinase kinase 1

 Dual specificity mitogen-activated protein kinase kinase 1 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase 1 Recombinant
 Dual specificity mitogen-activated protein kinase kinase 1 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (DdMEK1) (MEK1) (MAPK/ERK kinase A) (MEKA).
Required for cAMP-mediated activation of guanylyl cyclase activity and plays an essential role in aggregation, morphogenesis, and chemotaxis. Appears to act upstream of erk1 but not erk2.
 mekA ELISA Kit
 mekA Recombinant
 mekA Antibody
 MEK1 ELISA Kit
 MEK1 Recombinant
 MEK1 Antibody
 DDB_G0269152 ELISA Kit
 DDB_G0269152 Recombinant
 DDB_G0269152 Antibody
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Dual specificity mitogen-activated protein kinase kinase 2

 Dual specificity mitogen-activated protein kinase kinase 2 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase 2 Recombinant
 Dual specificity mitogen-activated protein kinase kinase 2 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2).
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases ().
 MAP2K2 ELISA Kit
 MAP2K2 Recombinant
 MAP2K2 Antibody
 MEK2 ELISA Kit
 MEK2 Recombinant
 MEK2 Antibody
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Dual specificity mitogen-activated protein kinase kinase 3

 Dual specificity mitogen-activated protein kinase kinase 3 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase 3 Recombinant
 Dual specificity mitogen-activated protein kinase kinase 3 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3) (MEK 3).
MKK3: a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. A deletion and two point mutants found in colon cancer cell lines. Three splice-variant isoforms have been described.

Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; S
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TE7 family

Cellular Component: cytoplasm; cytosol; membrane

Molecular Function: MAP kinase kinase activity; protein binding; protein kinase binding; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of MAPK activity; cardiac muscle contraction; inflammatory response; MAPKKK cascade; positive regulation of protein kinase activity; positive regulation of transcription, DNA-dependent; regulation of cytokine biosynthetic process
 Map2k3 ELISA Kit
 Map2k3 Recombinant
 Map2k3 Antibody
 Mkk3 ELISA Kit
 Mkk3 Recombinant
 Mkk3 Antibody
 Prkmk3 ELISA Kit
 Prkmk3 Recombinant
 Prkmk3 Antibody
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Dual specificity mitogen-activated protein kinase kinase 4

 Dual specificity mitogen-activated protein kinase kinase 4 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase 4 Recombinant
 Dual specificity mitogen-activated protein kinase kinase 4 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1).
MKK4: dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction.

Protein type: EC 2.7.12.2; Kinase, prot
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ein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family

Cellular Component: axon; cytoplasm; cytosol; dendrite cytoplasm; nucleus; perikaryon

Molecular Function: ATP binding; JUN kinase kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of JNK activity; JNK cascade; MAPKKK cascade; positive regulation of apoptosis; positive regulation of DNA replication; positive regulation of neuron apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; response to wounding
 Map2k4 ELISA Kit
 Map2k4 Recombinant
 Map2k4 Antibody
 Jnkk1 ELISA Kit
 Jnkk1 Recombinant
 Jnkk1 Antibody
 Mek4 ELISA Kit
 Mek4 Recombinant
 Mek4 Antibody
 Mkk4 ELISA Kit
 Mkk4 Recombinant
 Mkk4 Antibody
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Dual specificity mitogen-activated protein kinase kinase 5

 Dual specificity mitogen-activated protein kinase kinase 5 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase 5 Recombinant
 Dual specificity mitogen-activated protein kinase kinase 5 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) (MEK 5).
MEK5: a dual specificity protein kinase of the STE7 family. Activates ERK5 and is itself phosphorylated and activated by MEKK3, as well as by atypical protein kinase C isoforms. Involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced isoforms have been described.

Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 fa
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mily

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: cytoplasm

Molecular Function: protein binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of MAPK activity; inhibition of NF-kappaB transcription factor; negative regulation of caspase activity; negative regulation of heterotypic cell-cell adhesion; negative regulation of interleukin-8 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; signal transduction
 MAP2K5 ELISA Kit
 MAP2K5 Recombinant
 MAP2K5 Antibody
 MEK5 ELISA Kit
 MEK5 Recombinant
 MEK5 Antibody
 MKK5 ELISA Kit
 MKK5 Recombinant
 MKK5 Antibody
 PRKMK5 ELISA Kit
 PRKMK5 Recombinant
 PRKMK5 Antibody
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Dual specificity mitogen-activated protein kinase kinase 6

 Dual specificity mitogen-activated protein kinase kinase 6 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase 6 Recombinant
 Dual specificity mitogen-activated protein kinase kinase 6 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (MEK 6).
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and
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MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases ().
 MAP2K6 ELISA Kit
 MAP2K6 Recombinant
 MAP2K6 Antibody
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Dual specificity mitogen-activated protein kinase kinase 7

 Dual specificity mitogen-activated protein kinase kinase 7 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase 7 Recombinant
 Dual specificity mitogen-activated protein kinase kinase 7 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-J
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un N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
 Map2k7 ELISA Kit
 Map2k7 Recombinant
 Map2k7 Antibody
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Dual specificity mitogen-activated protein kinase kinase dSOR1

 Dual specificity mitogen-activated protein kinase kinase dSOR1 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase dSOR1 Recombinant
 Dual specificity mitogen-activated protein kinase kinase dSOR1 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase dSOR1 (Downstream of RAF) (MAPKK).
Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene p
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roducts, maybe via the ERK-A kinase.
 Dsor1 ELISA Kit
 Dsor1 Recombinant
 Dsor1 Antibody
 CG15793 ELISA Kit
 CG15793 Recombinant
 CG15793 Antibody
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Dual specificity mitogen-activated protein kinase kinase jkk-1

 Dual specificity mitogen-activated protein kinase kinase jkk-1 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase jkk-1 Recombinant
 Dual specificity mitogen-activated protein kinase kinase jkk-1 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase jkk-1 (MAP kinase kinase jkk-1) (JNK-1 activator kinase) (JNK kinase).
Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1 (PubMed:10393177, PubMed:15767565, PubMed:17894411). Plays a role in coordinating locomotion via D-type GABAergic motoneur
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ons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1 (PubMed:10393177, PubMed:11738026). Positively regulates lifespan (PubMed:15767565). Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1 (PubMed:15767565). Regulates germline cell apoptosis in response to heavy metals such as Cu2+ and to arsenite (PubMed:18597494, PubMed:19497412).
 jkk-1 ELISA Kit
 jkk-1 Recombinant
 jkk-1 Antibody
 F35C8.3 ELISA Kit
 F35C8.3 Recombinant
 F35C8.3 Antibody
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Dual specificity mitogen-activated protein kinase kinase mek-1

 Dual specificity mitogen-activated protein kinase kinase mek-1 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase mek-1 Recombinant
 Dual specificity mitogen-activated protein kinase kinase mek-1 Antibody
Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1 (PubMed:15116070, PubMed:18809575, PubMed:20008556). May also have a synergistic role with sek-1 in phosphorylating pmk-1 (PubMed:15256594, PubMed:18809575). Involved in the response to environmental stress including heavy metal ions (Cu2+ and Cd
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2+), oxidative stress and starvation (PubMed:11013217, PubMed:15116070, PubMed:18832074, PubMed:18809575). In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses (PubMed:16729024). Involved in resistance to pathogenic bacteria infection (PubMed:15256594). Involved in axon regeneration after injury (PubMed:21670305).
 mek-1 ELISA Kit
 mek-1 Recombinant
 mek-1 Antibody
 K08A8.1 ELISA Kit
 K08A8.1 Recombinant
 K08A8.1 Antibody
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Dual specificity mitogen-activated protein kinase kinase mek-2

 Dual specificity mitogen-activated protein kinase kinase mek-2 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase mek-2 Recombinant
 Dual specificity mitogen-activated protein kinase kinase mek-2 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase mek-2 (MAP kinase kinase mek-2).
Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation (PubMed:7729690). Required for progression of developing oocytes through the pachytene stage (PubMed:19826475). Plays a role
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in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Involved in fluid homeostasis (PubMed:11689700). Positively regulates lifespan upstream of mpk-1 (PubMed:20624915).
 mek-2 ELISA Kit
 mek-2 Recombinant
 mek-2 Antibody
 Y54E10BL.6 ELISA Kit
 Y54E10BL.6 Recombinant
 Y54E10BL.6 Antibody
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Dual specificity mitogen-activated protein kinase kinase sek-1

 Dual specificity mitogen-activated protein kinase kinase sek-1 ELISA Kit
 Dual specificity mitogen-activated protein kinase kinase sek-1 Recombinant
 Dual specificity mitogen-activated protein kinase kinase sek-1 Antibody
Also known as Dual specificity mitogen-activated protein kinase kinase sek-1 (MAP kinase kinase sek-1).
Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1 (PubMed:12142542, PubMed:16166371). Downstream of CaMKII unc-43 and adapter prot
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ein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons (PubMed:12142542, PubMed:11751572). Involved in resistance to pathogenic Gram-positive and Gram-negative bacterial and fungal infection (PubMed:12142542, PubMed:18394898, PubMed:22216003). Involved in resistance to the nematotoxic C.cinerea galectin Cgl2 (PubMed:20062796). Probably by promoting pmk-1-mediated activation of skn-1, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacterial infection (PubMed:22216003). Probably downstream of tir-1, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury (PubMed:18394898). Involved in the response to oxidative stress (PubMed:15888317, PubMed:22308034). May regulate transcription factor daf-16 localization during oxidative stress (PubMed:15888317). By phosphorylating pmk-1, regulates skn-1 localization during oxidative stress (PubMed:16166371). By phosphorylating and activating pmk-1, plays a role in the stabilization of transcription factor rnt-1 in the intestine during oxidative stress (PubMed:22308034). Up-regulates expression of gcs-1 in intestine upon arsenite treatment (PubMed:16166371). Regulates germline proliferation in response to osmotic stress, starvation and germline apoptosis induced by heavy metals, such as Cu2+ (PubMed:16729024, PubMed:19497412). In association with mek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses (PubMed:16729024). Plays a role downstream of tir-1/nsy-1 in regulating susceptibility to anoxia (PubMed:21212236). In males, by regulating pqn-41 expression, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development (PubMed:22363008). Involved in egg laying (PubMed:12142542).
 sek-1 ELISA Kit
 sek-1 Recombinant
 sek-1 Antibody
 R03G5.2 ELISA Kit
 R03G5.2 Recombinant
 R03G5.2 Antibody
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