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Dual-specificity protein phosphatase

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Mediates dephosphorylation of MAPK substrates such as SLT2, acquiring enhanced catalytic activity under oxidative conditions.

Below are the list of possible Dual-specificity protein phosphatase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Dual specificity protein phosphatase

 Dual specificity protein phosphatase ELISA Kit
 Dual specificity protein phosphatase Recombinant
 Dual specificity protein phosphatase Antibody
Could be involved in tyrosine phosphatase signalling pathways, having MAP-kinases as substrates.
 VH-PTP13 ELISA Kit
 VH-PTP13 Recombinant
 VH-PTP13 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 1

 Dual specificity protein phosphatase 1 ELISA Kit
 Dual specificity protein phosphatase 1 Recombinant
 Dual specificity protein phosphatase 1 Antibody
Also known as Dual specificity protein phosphatase 1 (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100).
MKP-1: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP1 specifically inactivates mitogen-activated protein (MAP) kinase in v
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itro by the concomitant dephosphorylation. It is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Contains 1 rhodanese domain.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: cytoplasm; nucleus

Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein binding

Biological Process: endoderm formation; inactivation of MAPK activity; negative regulation of MAP kinase activity; negative regulation of MAPKKK cascade; negative regulation of meiotic cell cycle; regulation of apoptosis; response to oxidative stress
 DUSP1 ELISA Kit
 DUSP1 Recombinant
 DUSP1 Antibody
 CL100 ELISA Kit
 CL100 Recombinant
 CL100 Antibody
 MKP1 ELISA Kit
 MKP1 Recombinant
 MKP1 Antibody
 PTPN10 ELISA Kit
 PTPN10 Recombinant
 PTPN10 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 10

 Dual specificity protein phosphatase 10 ELISA Kit
 Dual specificity protein phosphatase 10 Recombinant
 Dual specificity protein phosphatase 10 Antibody
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
 DUSP10 ELISA Kit
 DUSP10 Recombinant
 DUSP10 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 12

 Dual specificity protein phosphatase 12 ELISA Kit
 Dual specificity protein phosphatase 12 Recombinant
 Dual specificity protein phosphatase 12 Antibody
Also known as Dual specificity protein phosphatase 12 (Dual specificity phosphatase T-DSP4) (Dual specificity phosphatase VH1).
DUSP12: is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated p
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rotein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Cellular Component: cytoplasm; nucleus

Molecular Function: kinase binding; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; zinc ion binding

Biological Process: dephosphorylation; positive regulation of glucokinase activity; protein amino acid dephosphorylation
 Dusp12 ELISA Kit
 Dusp12 Recombinant
 Dusp12 Antibody
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Dual specificity protein phosphatase 13 isoform A

 Dual specificity protein phosphatase 13 isoform A ELISA Kit
 Dual specificity protein phosphatase 13 isoform A Recombinant
 Dual specificity protein phosphatase 13 isoform A Antibody
Also known as Dual specificity protein phosphatase 13 isoform A (DUSP13A) (Branching-enzyme interacting DSP) (Muscle-restricted DSP) (MDSP).
DUSP13 iso5: May be involved in the regulation of meiosis and/or differentiation of testicular germ cells during spermatogenesis. Exhibits intrinsic phosphatase activity towards both phospho- seryl/threonyl and -tyrosyl residues of myelin basic protein, with similar specific activities in vitro. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 5 isoforms of the human protein are produced by alternative
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promoter.

Protein type: Cell cycle regulation; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 10q22.2

Molecular Function: phosphoric monoester hydrolase activity; protein binding

Biological Process: dephosphorylation; meiosis; protein amino acid dephosphorylation; spermatogenesis
 DUSP13 ELISA Kit
 DUSP13 Recombinant
 DUSP13 Antibody
 BEDP ELISA Kit
 BEDP Recombinant
 BEDP Antibody
 DUSP13A ELISA Kit
 DUSP13A Recombinant
 DUSP13A Antibody
 MDSP ELISA Kit
 MDSP Recombinant
 MDSP Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 13 isoform B

 Dual specificity protein phosphatase 13 isoform B ELISA Kit
 Dual specificity protein phosphatase 13 isoform B Recombinant
 Dual specificity protein phosphatase 13 isoform B Antibody
Also known as Dual specificity protein phosphatase 13 isoform B (DUSP13B) (Dual specificity phosphatase SKRP4) (Testis- and skeletal-muscle-specific DSP).
DUSP13: May be involved in the regulation of meiosis and/or differentiation of testicular germ cells during spermatogenesis. Exhibits intrinsic phosphatase activity towards both phospho- seryl/threonyl and -tyrosyl residues of myelin basic protein, with similar specific activities in vitro. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 5 isoforms of the human protein are produced by alt
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ernative promoter.

Protein type: Cell cycle regulation; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 10q22.2

Molecular Function: phosphoric monoester hydrolase activity; protein binding

Biological Process: dephosphorylation; meiosis; protein amino acid dephosphorylation; spermatogenesis
 DUSP13 ELISA Kit
 DUSP13 Recombinant
 DUSP13 Antibody
 DUSP13B ELISA Kit
 DUSP13B Recombinant
 DUSP13B Antibody
 TMDP ELISA Kit
 TMDP Recombinant
 TMDP Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 14

 Dual specificity protein phosphatase 14 ELISA Kit
 Dual specificity protein phosphatase 14 Recombinant
 Dual specificity protein phosphatase 14 Antibody
Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases ().
 DUSP14 ELISA Kit
 DUSP14 Recombinant
 DUSP14 Antibody
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Dual specificity protein phosphatase 15

 Dual specificity protein phosphatase 15 ELISA Kit
 Dual specificity protein phosphatase 15 Recombinant
 Dual specificity protein phosphatase 15 Antibody
Also known as Dual specificity protein phosphatase 15 (Dual specificity protein phosphatase T-DSP10).
DUSP15: belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants encodin
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g two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Molecular Function: phosphoric monoester hydrolase activity

Biological Process: dephosphorylation; positive regulation of JNK cascade; regulation of cell proliferation; transforming growth factor beta receptor signaling pathway
 Dusp15 ELISA Kit
 Dusp15 Recombinant
 Dusp15 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 16

 Dual specificity protein phosphatase 16 ELISA Kit
 Dual specificity protein phosphatase 16 Recombinant
 Dual specificity protein phosphatase 16 Antibody
Also known as Dual specificity protein phosphatase 16 (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).
MKP-7: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP16 suppresses MAPK activation in the order of selectivity, JNK >> p38 > ERK, but interacts with ERK as well as JNK and p38. Overexpression of
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DUSP16 in BCR-ABL-transformed fibroblasts reduces their transforming capacity in vitro and in vivo via down regulation of BCR-ABL-induced JNK activation. DUSP16 might be haploinsufficient for tumor suppression. Contains 1 rhodanese domain.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity

Biological Process: dephosphorylation; inactivation of MAPK activity; MAPK export from nucleus; MAPK phosphatase export from nucleus, leptomycin B sensitive
 DUSP16 ELISA Kit
 DUSP16 Recombinant
 DUSP16 Antibody
 KIAA1700 ELISA Kit
 KIAA1700 Recombinant
 KIAA1700 Antibody
 MKP7 ELISA Kit
 MKP7 Recombinant
 MKP7 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 18

 Dual specificity protein phosphatase 18 ELISA Kit
 Dual specificity protein phosphatase 18 Recombinant
 Dual specificity protein phosphatase 18 Antibody
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
 DUSP18 ELISA Kit
 DUSP18 Recombinant
 DUSP18 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 19

 Dual specificity protein phosphatase 19 ELISA Kit
 Dual specificity protein phosphatase 19 Recombinant
 Dual specificity protein phosphatase 19 Antibody
Also known as Dual specificity protein phosphatase 19 (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating pho.
DUSP19: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specifi
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city

Chromosomal Location of Human Ortholog: 2q32.1

Molecular Function: JUN kinase phosphatase activity; MAP-kinase scaffold activity; mitogen-activated protein kinase kinase kinase binding; protein binding; protein kinase activator activity; protein kinase inhibitor activity

Biological Process: negative regulation of JNK activity; negative regulation of JNK cascade; negative regulation of protein kinase activity; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; positive regulation of protein kinase activity
 DUSP19 ELISA Kit
 DUSP19 Recombinant
 DUSP19 Antibody
 DUSP17 ELISA Kit
 DUSP17 Recombinant
 DUSP17 Antibody
 LMWDSP3 ELISA Kit
 LMWDSP3 Recombinant
 LMWDSP3 Antibody
 SKRP1 ELISA Kit
 SKRP1 Recombinant
 SKRP1 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 1-A

 Dual specificity protein phosphatase 1-A ELISA Kit
 Dual specificity protein phosphatase 1-A Recombinant
 Dual specificity protein phosphatase 1-A Antibody
Also known as Dual specificity protein phosphatase 1-A (XCL100) (XCL100-alfa).
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-188' and 'Tyr-190', regulating its activity during the meiotic cell cycle.
 dusp1-a ELISA Kit
 dusp1-a Recombinant
 dusp1-a Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 1-B

 Dual specificity protein phosphatase 1-B ELISA Kit
 Dual specificity protein phosphatase 1-B Recombinant
 Dual specificity protein phosphatase 1-B Antibody
Also known as Dual specificity protein phosphatase 1-B (XCL100-beta).
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-188' and 'Tyr-190', regulating its activity during the meiotic cell cycle.
 dusp1-b ELISA Kit
 dusp1-b Recombinant
 dusp1-b Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 1B

 Dual specificity protein phosphatase 1B ELISA Kit
 Dual specificity protein phosphatase 1B Recombinant
 Dual specificity protein phosphatase 1B Antibody
Also known as Dual specificity protein phosphatase 1B (AtDsPTP1B) (MAPK phosphatase 2) (AtMKP2).
Encodes a nuclear-localized MAP kinase phosphatase. Plants with reduced levels of MKP2 transcripts are hypersensitive to ozone and ozone-mediated activation of MPK3 and MPK6 is prolonged in these plants.
 DSPTP1B ELISA Kit
 DSPTP1B Recombinant
 DSPTP1B Antibody
 MKP2 ELISA Kit
 MKP2 Recombinant
 MKP2 Antibody
 At3g06110 ELISA Kit
 At3g06110 Recombinant
 At3g06110 Antibody
 F28L1.5 ELISA Kit
 F28L1.5 Recombinant
 F28L1.5 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 2

 Dual specificity protein phosphatase 2 ELISA Kit
 Dual specificity protein phosphatase 2 Recombinant
 Dual specificity protein phosphatase 2 Antibody
Also known as Dual specificity protein phosphatase 2 (Dual specificity protein phosphatase PAC-1).
DUSP2: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP2 is induced by mitogens, inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. Contains 1 rhodanese domain.

Protein type: E
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C 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Molecular Function: mitogen-activated protein kinase binding; phosphoprotein phosphatase activity

Biological Process: endoderm formation; protein amino acid dephosphorylation
 Dusp2 ELISA Kit
 Dusp2 Recombinant
 Dusp2 Antibody
 Pac-1 ELISA Kit
 Pac-1 Recombinant
 Pac-1 Antibody
 Pac1 ELISA Kit
 Pac1 Recombinant
 Pac1 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 21

 Dual specificity protein phosphatase 21 ELISA Kit
 Dual specificity protein phosphatase 21 Recombinant
 Dual specificity protein phosphatase 21 Antibody
Also known as Dual specificity protein phosphatase 21 (Low molecular weight dual specificity phosphatase 21) (LMW-DSP21).
DUSP21: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
>>>
r>Protein type: EC 3.1.3.16; EC 3.1.3.48; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: Xp11.4-p11.23

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; protein tyrosine phosphatase activity
 DUSP21 ELISA Kit
 DUSP21 Recombinant
 DUSP21 Antibody
 LMWDSP21 ELISA Kit
 LMWDSP21 Recombinant
 LMWDSP21 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 22

 Dual specificity protein phosphatase 22 ELISA Kit
 Dual specificity protein phosphatase 22 Recombinant
 Dual specificity protein phosphatase 22 Antibody
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) ().
 dusp22 ELISA Kit
 dusp22 Recombinant
 dusp22 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 22-A

 Dual specificity protein phosphatase 22-A ELISA Kit
 Dual specificity protein phosphatase 22-A Recombinant
 Dual specificity protein phosphatase 22-A Antibody
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) ().
 dusp22a ELISA Kit
 dusp22a Recombinant
 dusp22a Antibody
 dusp22 ELISA Kit
 dusp22 Recombinant
 dusp22 Antibody
 si:dkey-190g1.1 ELISA Kit
 si:dkey-190g1.1 Recombinant
 si:dkey-190g1.1 Antibody
 zgc:92816 ELISA Kit
 zgc:92816 Recombinant
 zgc:92816 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 22-B

 Dual specificity protein phosphatase 22-B ELISA Kit
 Dual specificity protein phosphatase 22-B Recombinant
 Dual specificity protein phosphatase 22-B Antibody
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) ().
 dusp22b ELISA Kit
 dusp22b Recombinant
 dusp22b Antibody
 dusp22 ELISA Kit
 dusp22 Recombinant
 dusp22 Antibody
 si:ch73-170d1.1 ELISA Kit
 si:ch73-170d1.1 Recombinant
 si:ch73-170d1.1 Antibody
 zgc:112536 ELISA Kit
 zgc:112536 Recombinant
 zgc:112536 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 23

 Dual specificity protein phosphatase 23 ELISA Kit
 Dual specificity protein phosphatase 23 Recombinant
 Dual specificity protein phosphatase 23 Antibody
Also known as Dual specificity protein phosphatase 23 (Low molecular mass dual specificity phosphatase 3) (LDP-3).
DUSP23: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). Belongs to the protein-
>>>
tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Cellular Component: cytoplasm; nucleus

Molecular Function: phosphoric monoester hydrolase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity

Biological Process: dephosphorylation
 Dusp23 ELISA Kit
 Dusp23 Recombinant
 Dusp23 Antibody
 Ldp3 ELISA Kit
 Ldp3 Recombinant
 Ldp3 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 26

 Dual specificity protein phosphatase 26 ELISA Kit
 Dual specificity protein phosphatase 26 Recombinant
 Dual specificity protein phosphatase 26 Antibody
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity.
 DUSP26 ELISA Kit
 DUSP26 Recombinant
 DUSP26 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 3

 Dual specificity protein phosphatase 3 ELISA Kit
 Dual specificity protein phosphatase 3 Recombinant
 Dual specificity protein phosphatase 3 Antibody
Also known as Dual specificity protein phosphatase 3 (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR).
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate
>>>
members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
 DUSP3 ELISA Kit
 DUSP3 Recombinant
 DUSP3 Antibody
 VHR ELISA Kit
 VHR Recombinant
 VHR Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 4

 Dual specificity protein phosphatase 4 ELISA Kit
 Dual specificity protein phosphatase 4 Recombinant
 Dual specificity protein phosphatase 4 Antibody
MKP-2: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in
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the nucleus. Induced by hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) in human endothelial cells. Two alternatively spliced isoforms have been described. In addition, multiple polyadenylation sites have been reported. Contains 1 rhodanese domain.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity

Cellular Component: nucleoplasm; nucleus

Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity

Biological Process: dephosphorylation; endoderm formation; inactivation of MAPK activity; protein amino acid dephosphorylation
 Dusp4 ELISA Kit
 Dusp4 Recombinant
 Dusp4 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 5

 Dual specificity protein phosphatase 5 ELISA Kit
 Dual specificity protein phosphatase 5 Recombinant
 Dual specificity protein phosphatase 5 Antibody
Also known as Dual specificity protein phosphatase 5 (Dual specificity protein phosphatase hVH3).
DUSP5: a dual-specificity protein phosphatase containing one Rhodanese domain. Is a direct transcriptional target of p53. Targets include phosphorylated MAP kinases. Overexpression suppresses the growth of several types of human cancer cells. Induced by IL-2, IL-7, and IL-15 but not IL-4 in T cells
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.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: nucleoplasm

Molecular Function: phosphoric monoester hydrolase activity; protein binding; protein tyrosine/serine/threonine phosphatase activity

Biological Process: activation of MAPK activity; dephosphorylation; endoderm formation; MAPKKK cascade; protein amino acid dephosphorylation
 DUSP5 ELISA Kit
 DUSP5 Recombinant
 DUSP5 Antibody
 VH3 ELISA Kit
 VH3 Recombinant
 VH3 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 6

 Dual specificity protein phosphatase 6 ELISA Kit
 Dual specificity protein phosphatase 6 Recombinant
 Dual specificity protein phosphatase 6 Antibody
Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia.
 DUSP6 ELISA Kit
 DUSP6 Recombinant
 DUSP6 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 7

 Dual specificity protein phosphatase 7 ELISA Kit
 Dual specificity protein phosphatase 7 Recombinant
 Dual specificity protein phosphatase 7 Antibody
DUSP7: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). High levels observed in the active state of AML and ALL diseases and in other types of
>>>
cancer. 2 isoforms are produced by use of alternative promoters.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Cellular Component: cytosol

Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: negative regulation of MAP kinase activity
 Dusp7 ELISA Kit
 Dusp7 Recombinant
 Dusp7 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 8

 Dual specificity protein phosphatase 8 ELISA Kit
 Dual specificity protein phosphatase 8 Recombinant
 Dual specificity protein phosphatase 8 Antibody
Also known as Dual specificity protein phosphatase 8 (Dual specificity protein phosphatase hVH-5).
DUSP8: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insul
>>>
in.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 11p15.5

Molecular Function: phosphoric monoester hydrolase activity

Biological Process: dephosphorylation; inactivation of MAPK activity
 DUSP8 ELISA Kit
 DUSP8 Recombinant
 DUSP8 Antibody
 C11orf81 ELISA Kit
 C11orf81 Recombinant
 C11orf81 Antibody
 VH5 ELISA Kit
 VH5 Recombinant
 VH5 Antibody
Table BarTOPTable Bar
 

Dual specificity protein phosphatase 9

 Dual specificity protein phosphatase 9 ELISA Kit
 Dual specificity protein phosphatase 9 Recombinant
 Dual specificity protein phosphatase 9 Antibody
Also known as Dual specificity protein phosphatase 9 (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4).
DUSP9: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-acti
>>>
vated protein (MAP) kinase superfamily (ERK, JNK, p38). Shows selectivity for members of the ERK family, is expressed at high levels in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: phosphoprotein phosphatase activity; protein binding; protein tyrosine/serine/threonine phosphatase activity

Biological Process: activation of MAPK activity; JNK cascade; MAPKKK cascade; protein amino acid dephosphorylation
 DUSP9 ELISA Kit
 DUSP9 Recombinant
 DUSP9 Antibody
 MKP4 ELISA Kit
 MKP4 Recombinant
 MKP4 Antibody
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Dual specificity protein phosphatase CDC14A

 Dual specificity protein phosphatase CDC14A ELISA Kit
 Dual specificity protein phosphatase CDC14A Recombinant
 Dual specificity protein phosphatase CDC14A Antibody
Also known as Dual specificity protein phosphatase CDC14A (CDC14 cell division cycle 14 homolog A).
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle
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control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
 CDC14A ELISA Kit
 CDC14A Recombinant
 CDC14A Antibody
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Dual specificity protein phosphatase CDC14B

 Dual specificity protein phosphatase CDC14B ELISA Kit
 Dual specificity protein phosphatase CDC14B Recombinant
 Dual specificity protein phosphatase CDC14B Antibody
Also known as Dual specificity protein phosphatase CDC14B (CDC14 cell division cycle 14 homolog B).
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the rol
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e in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
 CDC14B ELISA Kit
 CDC14B Recombinant
 CDC14B Antibody
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Dual specificity protein phosphatase CDC14C

 Dual specificity protein phosphatase CDC14C ELISA Kit
 Dual specificity protein phosphatase CDC14C Recombinant
 Dual specificity protein phosphatase CDC14C Antibody
Also known as Dual specificity protein phosphatase CDC14C (CDC14 cell division cycle 14 homolog C).
Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases ().
 CDC14C ELISA Kit
 CDC14C Recombinant
 CDC14C Antibody
 CDC14B2 ELISA Kit
 CDC14B2 Recombinant
 CDC14B2 Antibody
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Dual specificity protein phosphatase H1

 Dual specificity protein phosphatase H1 ELISA Kit
 Dual specificity protein phosphatase H1 Recombinant
 Dual specificity protein phosphatase H1 Antibody
Also known as Dual specificity protein phosphatase H1 (Late protein H1).
Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.
 H1L ELISA Kit
 H1L Recombinant
 H1L Antibody
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Dual specificity protein phosphatase Mpk3

 Dual specificity protein phosphatase Mpk3 ELISA Kit
 Dual specificity protein phosphatase Mpk3 Recombinant
 Dual specificity protein phosphatase Mpk3 Antibody
Also known as Dual specificity protein phosphatase Mpk3 (Drosophila MKP3) (DMKP3) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3).
Negatively regulates the activity of members of the MAP kinase family in response to changes in the cellular environment. Has a specificity for the ERK family. Acts as negative regulator in a variety of developmental processes inc
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luding cell differentiation and proliferation controlled by the Ras/ERK pathway. Suppresses the photoreceptor cell differentiation and wing vein formation. Required for proper oogenesis and early embryogenesis. Functions autonomously in a subset of photoreceptor progenitor cells in eye imaginal disks. Appears also to be required in surrounding non-neuronal cells for ommatidial patterning and photoreceptor differentiation. Plays a role in the maintenance of epithelial integrity during tracheal development.
 Mkp3 ELISA Kit
 Mkp3 Recombinant
 Mkp3 Antibody
 CG14080 ELISA Kit
 CG14080 Recombinant
 CG14080 Antibody
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Dual specificity protein phosphatase PHS1

 Dual specificity protein phosphatase PHS1 ELISA Kit
 Dual specificity protein phosphatase PHS1 Recombinant
 Dual specificity protein phosphatase PHS1 Antibody
Also known as Dual specificity protein phosphatase PHS1 (Protein PROPYZAMIDE-HYPERSENSITIVE 1).
Encodes a protein tyrosine phosphatase Propyzamide-Hypersensitive 1 (PHS1). One of the mutant alleles, phs1-1, is hypersensitive to the microtubule-destabilizing drug propyzamide, suggesting that PHS1 may be involved in phosphorylation cascades that control the dynamics of cortical microtubules in plant cells. A second allele, phs1-3, is hypersensitive to abscisic acid, indicating a possible involvement of PHS1 in ABA signalling.
 PHS1 ELISA Kit
 PHS1 Recombinant
 PHS1 Antibody
 At5g23720 ELISA Kit
 At5g23720 Recombinant
 At5g23720 Antibody
 MQM1.1 ELISA Kit
 MQM1.1 Recombinant
 MQM1.1 Antibody
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Dual specificity protein phosphatase PPS1

 Dual specificity protein phosphatase PPS1 ELISA Kit
 Dual specificity protein phosphatase PPS1 Recombinant
 Dual specificity protein phosphatase PPS1 Antibody
Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle.
 PPS1 ELISA Kit
 PPS1 Recombinant
 PPS1 Antibody
 YBR276C ELISA Kit
 YBR276C Recombinant
 YBR276C Antibody
 YBR2013 ELISA Kit
 YBR2013 Recombinant
 YBR2013 Antibody
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Dual specificity protein phosphatase VP2

 Dual specificity protein phosphatase VP2 ELISA Kit
 Dual specificity protein phosphatase VP2 Recombinant
 Dual specificity protein phosphatase VP2 Antibody
May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication.
 VP2 ELISA Kit
 VP2 Recombinant
 VP2 Antibody
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Dual-specificity protein phosphatase SDP1

 Dual-specificity protein phosphatase SDP1 ELISA Kit
 Dual-specificity protein phosphatase SDP1 Recombinant
 Dual-specificity protein phosphatase SDP1 Antibody
Also known as Dual-specificity protein phosphatase SDP1 (Stress-inducible MAPK phosphatase).
Mediates dephosphorylation of MAPK substrates such as SLT2, acquiring enhanced catalytic activity under oxidative conditions.
 SDP1 ELISA Kit
 SDP1 Recombinant
 SDP1 Antibody
 YIL113W ELISA Kit
 YIL113W Recombinant
 YIL113W Antibody
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Proteins Root Name Listing
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