Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).
Below are the list of possible Dual specificity tyrosine-phosphorylation-regulated kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A ELISA Kit|
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Recombinant
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody
|Also known as Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB). |
DYRK1A: a dual-specificity protein kinase of the DYRK family. Contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. May play a significant role in a pathway regulating cell proliferation and may be involved in brain development. Its gene is localized in the Down syndrome (DS) critical region of chromosome 21, and is a stron
g candidate gene for learning defects associated with Down syndrome. Overexpression in mice gives rise to neurological abnormalities similar to those observed in DS. Five splice-variant isoforms have been described.
Protein type: CMGC group; DYRK family; Dyrk1 subfamily; EC 18.104.22.168; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of Human Ortholog: 21q22.13
Cellular Component: nuclear speck; nucleoplasm; nucleus
Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein self-association; protein serine/threonine kinase activity; protein-tyrosine kinase activity; tau protein binding
Biological Process: circadian rhythm; negative regulation of DNA damage response, signal transduction by p53 class mediator; nervous system development; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation
Disease: Mental Retardation, Autosomal Dominant 7
| DYRK1A ELISA Kit|
| DYRK ELISA Kit|
| MNB ELISA Kit|
| MNBH ELISA Kit|
| Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 ELISA Kit|
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 Recombinant
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 Antibody
|Also known as Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 (Dual specificity Yak1-related kinase mbk-2) (Minibrain Kinase 2). |
Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis (PubMed:16338136, PubMed:17869113, PubMed:18854162, PubMe
d:18199581). Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos (PubMed:14697358). Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage (PubMed:18199581).
| mbk-2 ELISA Kit|
| F49E11.1 ELISA Kit|