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Dual specificity tyrosine-phosphorylation-regulated kinase

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Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).

Below are the list of possible Dual specificity tyrosine-phosphorylation-regulated kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

 Dual specificity tyrosine-phosphorylation-regulated kinase 1A ELISA Kit
 Dual specificity tyrosine-phosphorylation-regulated kinase 1A Recombinant
 Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody
Also known as Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB).
DYRK1A: a dual-specificity protein kinase of the DYRK family. Contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. May play a significant role in a pathway regulating cell proliferation and may be involved in brain development. Its gene is localized in the Down syndrome (DS) critical region of chromosome 21, and is a stron
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g candidate gene for learning defects associated with Down syndrome. Overexpression in mice gives rise to neurological abnormalities similar to those observed in DS. Five splice-variant isoforms have been described.

Protein type: CMGC group; DYRK family; Dyrk1 subfamily; EC 2.7.12.2; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)

Chromosomal Location of Human Ortholog: 21q22.13

Cellular Component: nuclear speck; nucleoplasm; nucleus

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein self-association; protein serine/threonine kinase activity; protein-tyrosine kinase activity; tau protein binding

Biological Process: circadian rhythm; negative regulation of DNA damage response, signal transduction by p53 class mediator; nervous system development; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation

Disease: Mental Retardation, Autosomal Dominant 7
 DYRK1A ELISA Kit
 DYRK1A Recombinant
 DYRK1A Antibody
 DYRK ELISA Kit
 DYRK Recombinant
 DYRK Antibody
 MNB ELISA Kit
 MNB Recombinant
 MNB Antibody
 MNBH ELISA Kit
 MNBH Recombinant
 MNBH Antibody
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B

 Dual specificity tyrosine-phosphorylation-regulated kinase 1B ELISA Kit
 Dual specificity tyrosine-phosphorylation-regulated kinase 1B Recombinant
 Dual specificity tyrosine-phosphorylation-regulated kinase 1B Antibody
DYRK1B: a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in
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a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described.

Protein type: CMGC group; DYRK family; Dyrk1 subfamily; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)

Molecular Function: protein kinase activity; transcription coactivator activity

Biological Process: myoblast fusion; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation
 Dyrk1b ELISA Kit
 Dyrk1b Recombinant
 Dyrk1b Antibody
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Dual specificity tyrosine-phosphorylation-regulated kinase 2

 Dual specificity tyrosine-phosphorylation-regulated kinase 2 ELISA Kit
 Dual specificity tyrosine-phosphorylation-regulated kinase 2 Recombinant
 Dual specificity tyrosine-phosphorylation-regulated kinase 2 Antibody
DYRK2: a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Phosphorylates the translation initiation factor eIF2B at Ser539, priming it for phosphorylation by glycogen synthase kinase-3.

Protein type: CMGC group; DYRK family; Dyrk2 subfamily; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)

Chromosomal
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Location of Human Ortholog: 12q15

Cellular Component: cytoplasm; nucleoplasm; nucleus; ubiquitin ligase complex

Molecular Function: ATP binding; magnesium ion binding; manganese ion binding; protein binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity; ubiquitin binding

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of NFAT protein import into nucleus; positive regulation of glycogen biosynthetic process; protein amino acid phosphorylation; response to DNA damage stimulus; smoothened signaling pathway
 DYRK2 ELISA Kit
 DYRK2 Recombinant
 DYRK2 Antibody
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Dual specificity tyrosine-phosphorylation-regulated kinase 3

 Dual specificity tyrosine-phosphorylation-regulated kinase 3 ELISA Kit
 Dual specificity tyrosine-phosphorylation-regulated kinase 3 Recombinant
 Dual specificity tyrosine-phosphorylation-regulated kinase 3 Antibody
DYRK3: a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Expressed primarily in erythroid progenitor cells and regulates late erythropoiesis.

Protein type: CMGC group; DYRK family; Dyrk2 subfamily; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)

Cellular Component: nucleus

Molecular Function:
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ATP binding; magnesium ion binding; protein binding; protein kinase activity; protein-tyrosine kinase activity

Biological Process: erythrocyte differentiation; peptidyl-tyrosine phosphorylation; protein amino acid phosphorylation
 Dyrk3 ELISA Kit
 Dyrk3 Recombinant
 Dyrk3 Antibody
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Dual specificity tyrosine-phosphorylation-regulated kinase 4

 Dual specificity tyrosine-phosphorylation-regulated kinase 4 ELISA Kit
 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Recombinant
 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Antibody
DYRK4: a dual-specificity protein kinase of the DYRK family. Its expression is up-regulated by retinoic-acid-induced differentiation of a human neuronal precursor teratocarcinoma cell line.

Protein type: CMGC group; DYRK family; Dyrk2 subfamily; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)

Chromosomal Location of Human Ortholog:
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12p13.32

Cellular Component: intracellular membrane-bound organelle

Molecular Function: protein binding
 DYRK4 ELISA Kit
 DYRK4 Recombinant
 DYRK4 Antibody
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Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1

 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 ELISA Kit
 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 Recombinant
 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 Antibody
Also known as Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 (Dual specificity Yak1-related kinase mbk-1) (Minibrain Kinase 1).
Possible role in the function of olfactory neurons.
 mbk-1 ELISA Kit
 mbk-1 Recombinant
 mbk-1 Antibody
 CBG07597 ELISA Kit
 CBG07597 Recombinant
 CBG07597 Antibody
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Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2

 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 ELISA Kit
 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 Recombinant
 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 Antibody
Also known as Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 (Dual specificity Yak1-related kinase mbk-2) (Minibrain Kinase 2).
Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis (PubMed:16338136, PubMed:17869113, PubMed:18854162, PubMe
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d:18199581). Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos (PubMed:14697358). Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage (PubMed:18199581).
 mbk-2 ELISA Kit
 mbk-2 Recombinant
 mbk-2 Antibody
 F49E11.1 ELISA Kit
 F49E11.1 Recombinant
 F49E11.1 Antibody
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