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Dystrophin

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Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.

Below are the list of possible Dystrophin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Dystrophin

 Dystrophin ELISA Kit
 Dystrophin Recombinant
 Dystrophin Antibody
dystrophin: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin- associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synapt
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ic transmission. Defects in DMD are the cause of Duchenne muscular dystrophy (DMD). DMD is the most common form of muscular dystrophy; a sex-linked recessive disorder. It typically presents in boys aged 3 to 7 year as proximal muscle weakness causing waddling gait, toe-walking, lordosis, frequent falls, and difficulty in standing up and climbing up stairs. The pelvic girdle is affected first, then the shoulder girdle. Progression is steady and most patients are confined to a wheelchair by age of 10 or 12. Flexion contractures and scoliosis ultimately occur. About 50% of patients have a lower IQ than their genetic expectations would suggest. There is no treatment. Defects in DMD are the cause of Becker muscular dystrophy (BMD). BMD resembles DMD in hereditary and clinical features but is later in onset and more benign. Defects in DMD are a cause of cardiomyopathy dilated X- linked type 3B (CMD3B); also known as X-linked dilated cardiomyopathy (XLCM). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xp21.2

Cellular Component: cell surface; cell-matrix junction; costamere; cytosol; dystrophin-associated glycoprotein complex; filopodium; filopodium membrane; lateral plasma membrane; lipid raft; protein complex; sarcolemma; synapse; syntrophin complex; Z disc

Molecular Function: actin binding; myosin binding; nitric-oxide synthase binding; protein binding; structural constituent of muscle; vinculin binding

Biological Process: cardiac muscle contraction; cellular protein complex assembly; muscle fiber development; muscle filament sliding; muscle maintenance; negative regulation of peptidyl-serine phosphorylation; peptide biosynthetic process; regulation of heart rate; regulation of skeletal muscle contraction; regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion

Disease: Cardiomyopathy, Dilated, 3b; Muscular Dystrophy, Becker Type; Muscular Dystrophy, Duchenne Type
 DMD ELISA Kit
 DMD Recombinant
 DMD Antibody
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Dystrophin, isoform B

 Dystrophin, isoform B ELISA Kit
 Dystrophin, isoform B Recombinant
 Dystrophin, isoform B Antibody
Also known as Dystrophin, isoform B (Protein detached).
Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. May play a role in anchoring the cytoskeleton to the plasma membrane.
 Dys ELISA Kit
 Dys Recombinant
 Dys Antibody
 det ELISA Kit
 det Recombinant
 det Antibody
 CG34157 ELISA Kit
 CG34157 Recombinant
 CG34157 Antibody
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Dystrophin, isoform D

 Dystrophin, isoform D ELISA Kit
 Dystrophin, isoform D Recombinant
 Dystrophin, isoform D Antibody
Also known as Dystrophin, isoform D (Protein detached).
Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. May play a role in anchoring the cytoskeleton to the plasma membrane.
 Dys ELISA Kit
 Dys Recombinant
 Dys Antibody
 det ELISA Kit
 det Recombinant
 det Antibody
 CG34157 ELISA Kit
 CG34157 Recombinant
 CG34157 Antibody
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Dystrophin, isoform E

 Dystrophin, isoform E ELISA Kit
 Dystrophin, isoform E Recombinant
 Dystrophin, isoform E Antibody
Also known as Dystrophin, isoform E (Protein detached).
Specifically required for survival and integrity of the larval musculature: the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. May play a role in anchoring the cytoskeleton to the plasma membrane.
 Dys ELISA Kit
 Dys Recombinant
 Dys Antibody
 det ELISA Kit
 det Recombinant
 det Antibody
 CG34157 ELISA Kit
 CG34157 Recombinant
 CG34157 Antibody
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Dystrophin, isoforms A/C/F/G/H

 Dystrophin, isoforms A/C/F/G/H ELISA Kit
 Dystrophin, isoforms A/C/F/G/H Recombinant
 Dystrophin, isoforms A/C/F/G/H Antibody
Also known as Dystrophin, isoforms A/C/F/G/H (DmDYS) (Protein detached).
Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. Both det and Dg are required for maintenance of early dpp signaling in the presumptive crossvein. Isoform A is not required to maintain muscle integrity, but plays a role in neuromuscular homeostasis by regulating neurotransmitter release. May play a role in anchoring the cytoskeleton to the plasma membrane.
 Dys ELISA Kit
 Dys Recombinant
 Dys Antibody
 det ELISA Kit
 det Recombinant
 det Antibody
 CG34157 ELISA Kit
 CG34157 Recombinant
 CG34157 Antibody
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Dystrophin-1

 Dystrophin-1 ELISA Kit
 Dystrophin-1 Recombinant
 Dystrophin-1 Antibody
Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning.
 dys-1 ELISA Kit
 dys-1 Recombinant
 dys-1 Antibody
 F15D3.1 ELISA Kit
 F15D3.1 Recombinant
 F15D3.1 Antibody
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