Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow E3 ISG15--protein ligase  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Anti-Insulin Receptor Antibody (AIRA) ELISA Kit
 • Prostaglandin E2 (PGE2) ELISA Kit
 • Jun B Proto Oncogene (JUNB) ELISA Kit
 • SAS10 Antibody
 • CD38 Antibody
 • Thyroglobulin (TG) Antibody
 • stathmin 1-oncoprotein 18 (STMN1) ELISA Kit
 • BLTR Antibody
 • Azaperone Chemical Reference
 • UBC3B (UBE2R2) Antibody
 • Cell division control protein 6 homolog (Cdc6) Recombinant Protein
 • mevalonate kinase (MVK) ELISA Kit
 • GluR6-7 Antibody
 • TREML1 Antibody
 downarrow more ...
separator

E3 ISG15--protein ligase

separator
Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.

Below are the list of possible E3 ISG15--protein ligase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

E3 ISG15--protein ligase HERC5

 E3 ISG15--protein ligase HERC5 ELISA Kit
 E3 ISG15--protein ligase HERC5 Recombinant
 E3 ISG15--protein ligase HERC5 Antibody
Also known as E3 ISG15--protein ligase HERC5 (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5).
HERC5: Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Makes part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylat
>>>
ion of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant- negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: ISG15 conjugating enzyme activity; protein binding; ubiquitin-protein ligase activity

Biological Process: ISG15-protein conjugation; negative regulation of interferon type I production; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of cyclin-dependent protein kinase activity; regulation of defense response to virus
 HERC5 ELISA Kit
 HERC5 Recombinant
 HERC5 Antibody
 CEB1 ELISA Kit
 CEB1 Recombinant
 CEB1 Antibody
 CEBP1 ELISA Kit
 CEBP1 Recombinant
 CEBP1 Antibody
Table BarTOPTable Bar
 

E3 ISG15--protein ligase Herc6

 E3 ISG15--protein ligase Herc6 ELISA Kit
 E3 ISG15--protein ligase Herc6 Recombinant
 E3 ISG15--protein ligase Herc6 Antibody
HERC6: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system

Cellular Component: cytoplasm; nucleus

Molecular Funct
>>>
ion: cyclin binding; ubiquitin-protein ligase activity

Biological Process: hemopoietic progenitor cell differentiation; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 Herc6 ELISA Kit
 Herc6 Recombinant
 Herc6 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions