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E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Below are the list of possible E3 SUMO-protein ligase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. |
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E3 SUMO-protein ligase CBX4 ELISA Kit E3 SUMO-protein ligase CBX4 Recombinant E3 SUMO-protein ligase CBX4 Antibody | Also known as E3 SUMO-protein ligase CBX4 (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2). CBX4: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. 2 isoforms of the human protein are p >>> roduced by alternative splicing.
Protein type: EC 6.3.2.-; SUMO ligase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; nucleus; PcG protein complex
Molecular Function: enzyme binding; protein binding; SUMO binding; SUMO ligase activity; transcription corepressor activity
Biological Process: negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein sumoylation |
CBX4 ELISA Kit CBX4 Recombinant CBX4 Antibody |
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E3 SUMO-protein ligase EGR2 ELISA Kit E3 SUMO-protein ligase EGR2 Recombinant E3 SUMO-protein ligase EGR2 Antibody | Also known as E3 SUMO-protein ligase EGR2 (AT591) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20). EGR2: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Defects in EGR2 are a cause of congenital hypomyelination neuropathy (CHN). Inheritance can be autosomal dominant or recessive. Recessive CHN i >>> s also known as Charcot- Marie-Tooth disease type 4E (CMT4E). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness, and very slow nerve conduction velocities. Defects in EGR2 are a cause of Charcot-Marie-Tooth disease type 1D (CMT1D). CMT1D is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. Defects in EGR2 are a cause of Dejerine-Sottas syndrome (DSS); also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie- Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome. Belongs to the EGR C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; DNA-binding; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 10q21.1
Cellular Component: cytoplasm; nucleus
Molecular Function: chromatin binding; protein binding; transcription factor activity; ubiquitin protein ligase binding
Biological Process: brain development; fat cell differentiation; peripheral nervous system development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein export from nucleus; transcription from RNA polymerase II promoter
Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1d; Hypertrophic Neuropathy Of Dejerine-sottas; Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive |
EGR2 ELISA Kit EGR2 Recombinant EGR2 Antibody | KROX20 ELISA Kit KROX20 Recombinant KROX20 Antibody |
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E3 SUMO-protein ligase NSE2 ELISA Kit E3 SUMO-protein ligase NSE2 Recombinant E3 SUMO-protein ligase NSE2 Antibody | Also known as E3 SUMO-protein ligase NSE2 (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog). NSMCE2: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of >>> telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression. Belongs to the NSE2 family.
Protein type: EC 6.-.-.-; EC 6.3.2.-; Ligase; SUMO conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component: chromosome, telomeric region; nucleoplasm; nucleus; PML body
Molecular Function: protein binding; SUMO ligase activity
Biological Process: double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; positive regulation of maintenance of mitotic sister chromatid cohesion; positive regulation of mitotic metaphase/anaphase transition; protein sumoylation; telomere maintenance via recombination |
NSMCE2 ELISA Kit NSMCE2 Recombinant NSMCE2 Antibody | C8orf36 ELISA Kit C8orf36 Recombinant C8orf36 Antibody |
MMS21 ELISA Kit MMS21 Recombinant MMS21 Antibody |
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E3 SUMO-protein ligase PIAS1 ELISA Kit E3 SUMO-protein ligase PIAS1 Recombinant E3 SUMO-protein ligase PIAS1 Antibody | Also known as E3 SUMO-protein ligase PIAS1 (DEAD/H box-binding protein 1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein). PIAS1: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional co >>> regulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Interacts with NCOA2 and AR. Interacts with NR2C1; the interaction promotes its sumoylation. Interacts with DDX21, CSRP2, AXIN1, JUN, UBE2I, SUMO1, SATB2, PLAG1, TP53 and STAT1 (dimer), following IFNA1-stimulation. Interacts with SP3 (preferentially when SUMO-modified). Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase. Interacts with STAT1. Interacts with CHUK/IKKA; this interaction induces PIAS1 phosphorylation. Interacts with PTK2/FAK1; the interaction promotes its sumoylation. Interacts with DDX5. Expressed in numerous tissues with highest level in testis. Belongs to the PIAS family.
Protein type: EC 6.3.2.-; Nuclear receptor co-regulator; SUMO conjugating system; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 15q
Cellular Component: nucleoplasm; nucleus; PML body
Molecular Function: enzyme binding; protein binding; SUMO ligase activity; transcription corepressor activity
Biological Process: JAK-STAT cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein sumoylation; protein sumoylation; regulation of cell proliferation |
PIAS1 ELISA Kit PIAS1 Recombinant PIAS1 Antibody | DDXBP1 ELISA Kit DDXBP1 Recombinant DDXBP1 Antibody |
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E3 SUMO-protein ligase PIAS2 ELISA Kit E3 SUMO-protein ligase PIAS2 Recombinant E3 SUMO-protein ligase PIAS2 Antibody | Also known as E3 SUMO-protein ligase PIAS2 (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activ. This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play imp >>> ortant roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011] |
PIAS2 ELISA Kit PIAS2 Recombinant PIAS2 Antibody | PIASX ELISA Kit PIASX Recombinant PIASX Antibody |
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E3 SUMO-protein ligase PIAS3 ELISA Kit E3 SUMO-protein ligase PIAS3 Recombinant E3 SUMO-protein ligase PIAS3 Antibody | Also known as E3 SUMO-protein ligase PIAS3 (KChAP) (Potassium channel-associated protein) (Protein inhibitor of activated STAT protein 3). PIAS3: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, incl >>> uding the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Monomer. Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2. Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3- mediated transcriptional activity. Interacts with AR, PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. By dihydrotestosterone (DHT) in prostate cancer cells. Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells. Belongs to the PIAS family.
Protein type: EC 6.3.2.-; Nuclear receptor co-regulator; SUMO conjugating system
Cellular Component: cytoplasm; dendrite; nucleus; synapse
Molecular Function: enzyme binding; potassium channel regulator activity; protein binding; protein C-terminus binding; protein N-terminus binding; SUMO ligase activity
Biological Process: negative regulation of protein sumoylation; positive regulation of membrane potential; positive regulation of protein sumoylation; protein sumoylation; response to hormone stimulus |
Pias3 ELISA Kit Pias3 Recombinant Pias3 Antibody |
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E3 SUMO-protein ligase PIAS4 ELISA Kit E3 SUMO-protein ligase PIAS4 Recombinant E3 SUMO-protein ligase PIAS4 Antibody | Also known as E3 SUMO-protein ligase PIAS4 (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma). PIAS4: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in vario >>> us cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Interacts with AR, AXIN1, GATA2, LEF1, TP53 and STAT1 (IFNG-induced). Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs). Interacts with TICAM1. Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase. Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. Belongs to the PIAS family.
Protein type: EC 6.3.2.-; Nuclear receptor co-regulator; SUMO conjugating system; Transcription, coactivator/corepressor
Cellular Component: cytoplasm; nuclear matrix; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding; protein C-terminus binding; SUMO ligase activity; transcription corepressor activity; ubiquitin protein ligase binding
Biological Process: inhibition of NF-kappaB transcription factor; JAK-STAT cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of protein sumoylation; protein sumoylation |
Pias4 ELISA Kit Pias4 Recombinant Pias4 Antibody | Piasg ELISA Kit Piasg Recombinant Piasg Antibody |
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