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E3 ubiquitin/ISG15 ligase

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 .

Below are the list of possible E3 ubiquitin/ISG15 ligase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

E3 ubiquitin/ISG15 ligase TRIM25

 E3 ubiquitin/ISG15 ligase TRIM25 ELISA Kit
 E3 ubiquitin/ISG15 ligase TRIM25 Recombinant
 E3 ubiquitin/ISG15 ligase TRIM25 Antibody
Also known as E3 ubiquitin/ISG15 ligase TRIM25 (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc fin.
TRIM25: a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.

Protein type: EC; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; nucleoplasm

Molecular Function: protein binding; transcription factor activity; ubiquitin-protein ligase activity

Biological Process: activation of NF-kappaB transcription factor; bypass DNA synthesis; innate immune response; negative regulation of interferon type I production; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; protein monoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of virion penetration into host cell; response to estrogen stimulus
 TRIM25 Recombinant
 TRIM25 Antibody
 EFP Recombinant
 EFP Antibody
 RNF147 Recombinant
 RNF147 Antibody
 ZNF147 Recombinant
 ZNF147 Antibody
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