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E3 ubiquitin-protein ligase

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E3 ubiquitin-protein ligase that acts as a negative regulator of abscisic acid (ABA) signaling. Mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ABI3.

Below are the list of possible E3 ubiquitin-protein ligase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

E3 ubiquitin protein ligase DRIP1

 E3 ubiquitin protein ligase DRIP1 ELISA Kit
 E3 ubiquitin protein ligase DRIP1 Recombinant
 E3 ubiquitin protein ligase DRIP1 Antibody
Also known as E3 ubiquitin protein ligase DRIP1 (DREB2A-interacting protein 1).
Encodes a C3HC4 RING-domain-containing ubiquitin E3 ligase capable of interacting with DREB2A. The DRIP1-GFP fusion protein is nuclear-localized. DRIP1 seems to be involved in regulating stress-related transcriptional changes and drought tolerance.
 DRIP1 ELISA Kit
 DRIP1 Recombinant
 DRIP1 Antibody
 At1g06770 ELISA Kit
 At1g06770 Recombinant
 At1g06770 Antibody
 F4H5.14 ELISA Kit
 F4H5.14 Recombinant
 F4H5.14 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin protein ligase DRIP2

 E3 ubiquitin protein ligase DRIP2 ELISA Kit
 E3 ubiquitin protein ligase DRIP2 Recombinant
 E3 ubiquitin protein ligase DRIP2 Antibody
Also known as E3 ubiquitin protein ligase DRIP2 (DREB2A-interacting protein 2).
Encodes a C3HC4 RING-domain-containing ubiquitin E3 ligase capable of interacting with DREB2A. DRIP2 seems to be involved in regulating stress-related transcriptional changes and drought tolerance.
 DRIP2 ELISA Kit
 DRIP2 Recombinant
 DRIP2 Antibody
 At2g30580 ELISA Kit
 At2g30580 Recombinant
 At2g30580 Antibody
 T6B20.7 ELISA Kit
 T6B20.7 Recombinant
 T6B20.7 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin protein ligase RIE1

 E3 ubiquitin protein ligase RIE1 ELISA Kit
 E3 ubiquitin protein ligase RIE1 Recombinant
 E3 ubiquitin protein ligase RIE1 Antibody
Also known as E3 ubiquitin protein ligase RIE1 (Protein RING-FINGER FOR EMBRYOGENESIS 1).
encodes a RING-H2 zinc finger protein essential for seed development.
 RIE1 ELISA Kit
 RIE1 Recombinant
 RIE1 Antibody
 At2g01735 ELISA Kit
 At2g01735 Recombinant
 At2g01735 Antibody
 T8O11 ELISA Kit
 T8O11 Recombinant
 T8O11 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin protein ligase RIN2

 E3 ubiquitin protein ligase RIN2 ELISA Kit
 E3 ubiquitin protein ligase RIN2 Recombinant
 E3 ubiquitin protein ligase RIN2 Antibody
Also known as E3 ubiquitin protein ligase RIN2 (AMF receptor-like protein 1A) (RPM1-interacting protein 2).
RPM1 interacting protein 2, has a CUE domain which is sufficient for the interaction with RPM1.Positive regulator of RPM1 and PRS2 mediated hypersensitive response.Functions as ubiquitin ligase and binds to RPM1.
 RIN2 ELISA Kit
 RIN2 Recombinant
 RIN2 Antibody
 AMFR-1A ELISA Kit
 AMFR-1A Recombinant
 AMFR-1A Antibody
 At4g25230 ELISA Kit
 At4g25230 Recombinant
 At4g25230 Antibody
 F24A6.70 ELISA Kit
 F24A6.70 Recombinant
 F24A6.70 Antibody
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E3 ubiquitin protein ligase RIN3

 E3 ubiquitin protein ligase RIN3 ELISA Kit
 E3 ubiquitin protein ligase RIN3 Recombinant
 E3 ubiquitin protein ligase RIN3 Antibody
Also known as E3 ubiquitin protein ligase RIN3 (RPM1-interacting protein 3).
Encodes RING-finger type ubiquitin ligases.
 RIN3 ELISA Kit
 RIN3 Recombinant
 RIN3 Antibody
 At5g51450 ELISA Kit
 At5g51450 Recombinant
 At5g51450 Antibody
 MFG13.16 ELISA Kit
 MFG13.16 Recombinant
 MFG13.16 Antibody
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E3 ubiquitin-protein ligase AIP2

 E3 ubiquitin-protein ligase AIP2 ELISA Kit
 E3 ubiquitin-protein ligase AIP2 Recombinant
 E3 ubiquitin-protein ligase AIP2 Antibody
Also known as E3 ubiquitin-protein ligase AIP2 (ABI3-interacting protein 2) (RING-type E3 ubiquitin transferase AIP2).
Encodes an E3 ligase that can interact with and polyubiquitinate ABI3 in vitro. AIP2 likely negatively regulates ABA signaling by targeting ABI3 for post-translational destruction.
 AIP2 ELISA Kit
 AIP2 Recombinant
 AIP2 Antibody
 At5g20910 ELISA Kit
 At5g20910 Recombinant
 At5g20910 Antibody
 F22D1.80 ELISA Kit
 F22D1.80 Recombinant
 F22D1.80 Antibody
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E3 ubiquitin-protein ligase AMFR

 E3 ubiquitin-protein ligase AMFR ELISA Kit
 E3 ubiquitin-protein ligase AMFR Recombinant
 E3 ubiquitin-protein ligase AMFR Antibody
Also known as E3 ubiquitin-protein ligase AMFR (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (RING-type E3 ubiquitin transferase AMFR) (gp78).
AMFR: E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in
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the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis. Interacts with RNF5. Also forms an ERAD complex containing VCP/p97, NGLY1; PSMC1; SAKS1 AND RAD23B required for coupling retrotranslocation, ubiquitination and deglycosylation. Interacts with DRL1. Interacts (through a region distinct from the RING finger) with UBE2G2/UBC7. Component of the VCP/p97-AMFR/gp78 complex that enhances VCP/p97 binding to polyubiquitinated proteins for their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway. Interacts (via the VIM) with VCP/p97. Interacts (via its membrane domain) with INSIG1; the interaction initiates the sterol-mediated ubiquitination and degradation of HMGCR by the ERAD pathway. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Endoplasmic reticulum; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, misc.; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; protein complex

Molecular Function: chaperone binding; protein binding; protein binding, bridging; receptor activity; ubiquitin-protein ligase activity

Biological Process: cell motility; ER-associated protein catabolic process; positive regulation of protein binding; protein autoubiquitination; protein oligomerization; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; signal transduction; ubiquitin-dependent protein catabolic process; unfolded protein response
 AMFR ELISA Kit
 AMFR Recombinant
 AMFR Antibody
 RNF45 ELISA Kit
 RNF45 Recombinant
 RNF45 Antibody
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E3 ubiquitin-protein ligase arc-1

 E3 ubiquitin-protein ligase arc-1 ELISA Kit
 E3 ubiquitin-protein ligase arc-1 Recombinant
 E3 ubiquitin-protein ligase arc-1 Antibody
Also known as E3 ubiquitin-protein ligase arc-1 (Putative GTP-binding protein trim-23 homolog).
Acts as an E3 ubiquitin-protein ligase.
 arc-1 ELISA Kit
 arc-1 Recombinant
 arc-1 Antibody
 arl-4 ELISA Kit
 arl-4 Recombinant
 arl-4 Antibody
 ZK1320.6 ELISA Kit
 ZK1320.6 Recombinant
 ZK1320.6 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase ARIH1

 E3 ubiquitin-protein ligase ARIH1 ELISA Kit
 E3 ubiquitin-protein ligase ARIH1 Recombinant
 E3 ubiquitin-protein ligase ARIH1 Antibody
Also known as E3 ubiquitin-protein ligase ARIH1 (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1).
ARIH1: E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation. Belongs to the RBR family. Ariadne subfamily.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin
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conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: Cul2-RING ubiquitin ligase complex; cytoplasm; cytosol; nuclear body; SCF ubiquitin ligase complex; ubiquitin ligase complex

Molecular Function: protein binding; small conjugating protein ligase activity; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process
 ARIH1 ELISA Kit
 ARIH1 Recombinant
 ARIH1 Antibody
 ARI ELISA Kit
 ARI Recombinant
 ARI Antibody
 MOP6 ELISA Kit
 MOP6 Recombinant
 MOP6 Antibody
 UBCH7BP ELISA Kit
 UBCH7BP Recombinant
 UBCH7BP Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase arih1l

 E3 ubiquitin-protein ligase arih1l ELISA Kit
 E3 ubiquitin-protein ligase arih1l Recombinant
 E3 ubiquitin-protein ligase arih1l Antibody
Also known as E3 ubiquitin-protein ligase arih1l (RING-type E3 ubiquitin transferase arih1l).
E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3.
 arih1l ELISA Kit
 arih1l Recombinant
 arih1l Antibody
 zgc:85905 ELISA Kit
 zgc:85905 Recombinant
 zgc:85905 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase ARIH2

 E3 ubiquitin-protein ligase ARIH2 ELISA Kit
 E3 ubiquitin-protein ligase ARIH2 Recombinant
 E3 ubiquitin-protein ligase ARIH2 Antibody
Also known as E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein).
ARIH2: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys- 63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis. Belongs to the RBR family. Ariadne subfamily.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: Cul5-RING ubiquitin ligase complex; cytoplasm; nucl
>>>
eus; ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity

Biological Process: developmental cell growth; multicellular organismal development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 ARIH2 ELISA Kit
 ARIH2 Recombinant
 ARIH2 Antibody
 ARI2 ELISA Kit
 ARI2 Recombinant
 ARI2 Antibody
 TRIAD1 ELISA Kit
 TRIAD1 Recombinant
 TRIAD1 Antibody
 HT005 ELISA Kit
 HT005 Recombinant
 HT005 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase Arkadia

 E3 ubiquitin-protein ligase Arkadia ELISA Kit
 E3 ubiquitin-protein ligase Arkadia Recombinant
 E3 ubiquitin-protein ligase Arkadia Antibody
Also known as E3 ubiquitin-protein ligase Arkadia (RING finger protein 111).
Acts in the Nodal pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activat
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es Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme ().
 RNF111 ELISA Kit
 RNF111 Recombinant
 RNF111 Antibody
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E3 ubiquitin-protein ligase arkadia-A

 E3 ubiquitin-protein ligase arkadia-A ELISA Kit
 E3 ubiquitin-protein ligase arkadia-A Recombinant
 E3 ubiquitin-protein ligase arkadia-A Antibody
Also known as E3 ubiquitin-protein ligase arkadia-A (RING finger protein 111-A).
Acts in the nodal-related pathway of mesoderm patterning during embryonic development. Enhances signaling of the subset of TGF-beta factors responsible for the formation of dorso-anterior tissues of Spemann's organizer. May act as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-co
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njugating enzymes and then transfers it to substrates.
 rnf111-a ELISA Kit
 rnf111-a Recombinant
 rnf111-a Antibody
 arkadia ELISA Kit
 arkadia Recombinant
 arkadia Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase arkadia-B

 E3 ubiquitin-protein ligase arkadia-B ELISA Kit
 E3 ubiquitin-protein ligase arkadia-B Recombinant
 E3 ubiquitin-protein ligase arkadia-B Antibody
Also known as E3 ubiquitin-protein ligase arkadia-B (RING finger protein 111-B).
Acts in the nodal-related pathway of mesoderm patterning during embryonic development. Enhances signaling of the subset of TGF-beta factors responsible for the formation of dorso-anterior tissues of Spemann's organizer. May act as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-co
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njugating enzymes and then transfers it to substrates ().
 rnf111-b ELISA Kit
 rnf111-b Recombinant
 rnf111-b Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase arkadia-C

 E3 ubiquitin-protein ligase arkadia-C ELISA Kit
 E3 ubiquitin-protein ligase arkadia-C Recombinant
 E3 ubiquitin-protein ligase arkadia-C Antibody
Also known as E3 ubiquitin-protein ligase arkadia-C (RING finger protein 111-C).
Acts in the nodal-related pathway of mesoderm patterning during embryonic development. Enhances signaling of the subset of TGF-beta factors responsible for the formation of dorso-anterior tissues of Spemann's organizer. May act as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-co
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njugating enzymes and then transfers it to substrates ().
 rnf111-c ELISA Kit
 rnf111-c Recombinant
 rnf111-c Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase At1g12760

 E3 ubiquitin-protein ligase At1g12760 ELISA Kit
 E3 ubiquitin-protein ligase At1g12760 Recombinant
 E3 ubiquitin-protein ligase At1g12760 Antibody
Also known as E3 ubiquitin-protein ligase At1g12760 (RING finger protein At1g12760).
Mediates E2-dependent protein ubiquitination in vitro.
 At1g12760 ELISA Kit
 At1g12760 Recombinant
 At1g12760 Antibody
 T12C24.29 ELISA Kit
 T12C24.29 Recombinant
 T12C24.29 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase At1g63170

 E3 ubiquitin-protein ligase At1g63170 ELISA Kit
 E3 ubiquitin-protein ligase At1g63170 Recombinant
 E3 ubiquitin-protein ligase At1g63170 Antibody
Also known as E3 ubiquitin-protein ligase At1g63170 (RING finger protein At1g63170).
Mediates E2-dependent protein ubiquitination.
 At1g63170 ELISA Kit
 At1g63170 Recombinant
 At1g63170 Antibody
 F16M19.7 ELISA Kit
 F16M19.7 Recombinant
 F16M19.7 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase At3g02290

 E3 ubiquitin-protein ligase At3g02290 ELISA Kit
 E3 ubiquitin-protein ligase At3g02290 Recombinant
 E3 ubiquitin-protein ligase At3g02290 Antibody
Also known as E3 ubiquitin-protein ligase At3g02290 (RING finger protein At3g02290).
Mediates E2-dependent protein ubiquitination.
 At3g02290 ELISA Kit
 At3g02290 Recombinant
 At3g02290 Antibody
 At3g02291 ELISA Kit
 At3g02291 Recombinant
 At3g02291 Antibody
 F14P3.6 ELISA Kit
 F14P3.6 Recombinant
 F14P3.6 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase At4g11680

 E3 ubiquitin-protein ligase At4g11680 ELISA Kit
 E3 ubiquitin-protein ligase At4g11680 Recombinant
 E3 ubiquitin-protein ligase At4g11680 Antibody
Also known as E3 ubiquitin-protein ligase At4g11680 (RING finger protein At4g11680).
Mediates E2-dependent protein ubiquitination in vitro.
 At4g11680 ELISA Kit
 At4g11680 Recombinant
 At4g11680 Antibody
 T5C23.110 ELISA Kit
 T5C23.110 Recombinant
 T5C23.110 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase ATL15

 E3 ubiquitin-protein ligase ATL15 ELISA Kit
 E3 ubiquitin-protein ligase ATL15 Recombinant
 E3 ubiquitin-protein ligase ATL15 Antibody
Also known as E3 ubiquitin-protein ligase ATL15 (RING-H2 finger protein ATL15) (RING-type E3 ubiquitin transferase ATL15).
Gene encodes a putative C3HC4-type RING zinc finger factor. it is induced in response to light and ascorbate stimulus.
 ATL15 ELISA Kit
 ATL15 Recombinant
 ATL15 Antibody
 At1g22500 ELISA Kit
 At1g22500 Recombinant
 At1g22500 Antibody
 F12K8.15 ELISA Kit
 F12K8.15 Recombinant
 F12K8.15 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase ATL23

 E3 ubiquitin-protein ligase ATL23 ELISA Kit
 E3 ubiquitin-protein ligase ATL23 Recombinant
 E3 ubiquitin-protein ligase ATL23 Antibody
Also known as E3 ubiquitin-protein ligase ATL23 (RING-H2 finger protein ATL23) (RING-type E3 ubiquitin transferase ATL23).
E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8, UBC10, UBC11, UBC28 and UBC29 in vitro.
 ATL23 ELISA Kit
 ATL23 Recombinant
 ATL23 Antibody
 At5g42200 ELISA Kit
 At5g42200 Recombinant
 At5g42200 Antibody
 MJC20.31 ELISA Kit
 MJC20.31 Recombinant
 MJC20.31 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase ATL31

 E3 ubiquitin-protein ligase ATL31 ELISA Kit
 E3 ubiquitin-protein ligase ATL31 Recombinant
 E3 ubiquitin-protein ligase ATL31 Antibody
Also known as E3 ubiquitin-protein ligase ATL31 (Protein CARBON/NITROGEN INSENSITIVE 1) (Protein SUPER SURVIVAL 1) (RING-H2 finger protein ATL31) (RING-type E3 ubiquitin transferase ATL31).
Encodes CNI1 (Carbon/Nitrogen Insensitive1) (also named as ATL31), a RING type ubiquitin ligase that functions in the Carbon/Nitrogen response for growth phase transition in Arabidopsis seedlings.
 ATL31 ELISA Kit
 ATL31 Recombinant
 ATL31 Antibody
 CNI1 ELISA Kit
 CNI1 Recombinant
 CNI1 Antibody
 SSV1 ELISA Kit
 SSV1 Recombinant
 SSV1 Antibody
 At5g27420 ELISA Kit
 At5g27420 Recombinant
 At5g27420 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase ATL4

 E3 ubiquitin-protein ligase ATL4 ELISA Kit
 E3 ubiquitin-protein ligase ATL4 Recombinant
 E3 ubiquitin-protein ligase ATL4 Antibody
Also known as E3 ubiquitin-protein ligase ATL4 (Protein ARABIDOPSIS TOXICOS EN LEVADURA 4) (Protein ATL4) (RING-H2 finger X1a) (RING-H2 zinc finger protein ATL4) (RING-H2 zinc finger protein RHX1a) (RING-type E3 ubiquitin transferase ATL4).
Encodes a putative RING-H2 zinc finger protein ATL4 (ATL4).
 ATL4 ELISA Kit
 ATL4 Recombinant
 ATL4 Antibody
 RHX1A ELISA Kit
 RHX1A Recombinant
 RHX1A Antibody
 At3g60220 ELISA Kit
 At3g60220 Recombinant
 At3g60220 Antibody
 F27H5_10 ELISA Kit
 F27H5_10 Recombinant
 F27H5_10 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase ATL41

 E3 ubiquitin-protein ligase ATL41 ELISA Kit
 E3 ubiquitin-protein ligase ATL41 Recombinant
 E3 ubiquitin-protein ligase ATL41 Antibody
Also known as E3 ubiquitin-protein ligase ATL41 (RING-H2 finger protein ATL41) (RING-type E3 ubiquitin transferase ATL41).
E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8, UBC10, UBC11, UBC28, UBC29, UBC30, UBC35 and UBC36 in vitro.
 ATL41 ELISA Kit
 ATL41 Recombinant
 ATL41 Antibody
 At2g42360 ELISA Kit
 At2g42360 Recombinant
 At2g42360 Antibody
 MHK10.8 ELISA Kit
 MHK10.8 Recombinant
 MHK10.8 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase ATL42

 E3 ubiquitin-protein ligase ATL42 ELISA Kit
 E3 ubiquitin-protein ligase ATL42 Recombinant
 E3 ubiquitin-protein ligase ATL42 Antibody
Also known as E3 ubiquitin-protein ligase ATL42 (RING-H2 finger protein ATL42) (RING-type E3 ubiquitin transferase ATL42).
E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8 in vitro.
 ATL42 ELISA Kit
 ATL42 Recombinant
 ATL42 Antibody
 At4g28890 ELISA Kit
 At4g28890 Recombinant
 At4g28890 Antibody
 F25O24.10 ELISA Kit
 F25O24.10 Recombinant
 F25O24.10 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase ATL59

 E3 ubiquitin-protein ligase ATL59 ELISA Kit
 E3 ubiquitin-protein ligase ATL59 Recombinant
 E3 ubiquitin-protein ligase ATL59 Antibody
Also known as E3 ubiquitin-protein ligase ATL59 (RING-H2 finger protein ATL59) (RING-type E3 ubiquitin transferase ATL59).
E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8, UBC10, UBC11, and UBC34 in vitro.
 ATL59 ELISA Kit
 ATL59 Recombinant
 ATL59 Antibody
 At4g10160 ELISA Kit
 At4g10160 Recombinant
 At4g10160 Antibody
 F28M11.80 ELISA Kit
 F28M11.80 Recombinant
 F28M11.80 Antibody
 T9A4.20 ELISA Kit
 T9A4.20 Recombinant
 T9A4.20 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase ATL6

 E3 ubiquitin-protein ligase ATL6 ELISA Kit
 E3 ubiquitin-protein ligase ATL6 Recombinant
 E3 ubiquitin-protein ligase ATL6 Antibody
Also known as E3 ubiquitin-protein ligase ATL6 (RING-H2 finger protein ATL6) (RING-type E3 ubiquitin transferase ATL6).
Encodes a putative RING-H2 zinc finger protein ATL6 (ATL6).
 ATL6 ELISA Kit
 ATL6 Recombinant
 ATL6 Antibody
 At3g05200 ELISA Kit
 At3g05200 Recombinant
 At3g05200 Antibody
 T12H1.17 ELISA Kit
 T12H1.17 Recombinant
 T12H1.17 Antibody
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E3 ubiquitin-protein ligase ATL76

 E3 ubiquitin-protein ligase ATL76 ELISA Kit
 E3 ubiquitin-protein ligase ATL76 Recombinant
 E3 ubiquitin-protein ligase ATL76 Antibody
Also known as E3 ubiquitin-protein ligase ATL76 (RING-H2 finger protein ATL76) (RING-type E3 ubiquitin transferase ATL76).
E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8 in vitro.
 ATL76 ELISA Kit
 ATL76 Recombinant
 ATL76 Antibody
 At1g49210 ELISA Kit
 At1g49210 Recombinant
 At1g49210 Antibody
 F27J15.3 ELISA Kit
 F27J15.3 Recombinant
 F27J15.3 Antibody
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E3 ubiquitin-protein ligase ATL9

 E3 ubiquitin-protein ligase ATL9 ELISA Kit
 E3 ubiquitin-protein ligase ATL9 Recombinant
 E3 ubiquitin-protein ligase ATL9 Antibody
Also known as E3 ubiquitin-protein ligase ATL9 (RING-H2 finger protein ATL9) (RING-type E3 ubiquitin transferase ATL9).
E3 ligase-like protein induced by chitin oligomers.
 ATL9 ELISA Kit
 ATL9 Recombinant
 ATL9 Antibody
 At2g35000 ELISA Kit
 At2g35000 Recombinant
 At2g35000 Antibody
 F19I3.23 ELISA Kit
 F19I3.23 Recombinant
 F19I3.23 Antibody
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E3 ubiquitin-protein ligase BAH1

 E3 ubiquitin-protein ligase BAH1 ELISA Kit
 E3 ubiquitin-protein ligase BAH1 Recombinant
 E3 ubiquitin-protein ligase BAH1 Antibody
Also known as E3 ubiquitin-protein ligase BAH1 (Protein BENZOIC ACID HYPERSENSITIVE 1) (Protein NITROGEN LIMITATION ADAPTATION) (RING-type E3 ubiquitin transferase BAH1).
Encodes a ubiquitin E3 ligase with RING and SPX domains that is involved in mediating immune responses and mediates degradation of PHT1s at plasma membranes. Targeted by MIR827. Ubiquitinates PHT1;3, PHT1;2, PHT1;1/AtPT1 and PHT1;4/AtPT2.
 BAH1 ELISA Kit
 BAH1 Recombinant
 BAH1 Antibody
 NLA ELISA Kit
 NLA Recombinant
 NLA Antibody
 At1g02860 ELISA Kit
 At1g02860 Recombinant
 At1g02860 Antibody
 F22D16.14 ELISA Kit
 F22D16.14 Recombinant
 F22D16.14 Antibody
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E3 ubiquitin-protein ligase BOI

 E3 ubiquitin-protein ligase BOI ELISA Kit
 E3 ubiquitin-protein ligase BOI Recombinant
 E3 ubiquitin-protein ligase BOI Antibody
Also known as E3 ubiquitin-protein ligase BOI (Inhibitor of apoptosis (IAP)-like protein) (AtILP) (Protein BOTRYTIS SUSCEPTIBLE 1 INTERACTOR) (AtBOI) (RING-type E3 ubiquitin transferase BOI).
Encodes BOI (Botrytis Susceptible 1 Interactor). Has E3 ubiquitin ligase activity. Interacts with and ubiquitinates BOS1 (Botrytis Susceptible 1). It prevents caspase activation and attenuates cell death.
 BOI ELISA Kit
 BOI Recombinant
 BOI Antibody
 ILP ELISA Kit
 ILP Recombinant
 ILP Antibody
 At4g19700 ELISA Kit
 At4g19700 Recombinant
 At4g19700 Antibody
 T16H5.60 ELISA Kit
 T16H5.60 Recombinant
 T16H5.60 Antibody
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E3 ubiquitin-protein ligase BRE1

 E3 ubiquitin-protein ligase BRE1 ELISA Kit
 E3 ubiquitin-protein ligase BRE1 Recombinant
 E3 ubiquitin-protein ligase BRE1 Antibody
Also known as E3 ubiquitin-protein ligase BRE1 (Brefeldin A-sensitivity protein 1) (RING-type E3 ubiquitin transferase BRE1).
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme RAD6/UBC2. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, an
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d is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. Also modulates the formation of double-strand breaks during meiosis.
 BRE1 ELISA Kit
 BRE1 Recombinant
 BRE1 Antibody
 YDL074C ELISA Kit
 YDL074C Recombinant
 YDL074C Antibody
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E3 ubiquitin-protein ligase bre-1

 E3 ubiquitin-protein ligase bre-1 ELISA Kit
 E3 ubiquitin-protein ligase bre-1 Recombinant
 E3 ubiquitin-protein ligase bre-1 Antibody
Also known as E3 ubiquitin-protein ligase bre-1 (RING finger protein rfp-1) (RING-type E3 ubiquitin transferase bre-1).
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
 rfp-1 ELISA Kit
 rfp-1 Recombinant
 rfp-1 Antibody
 bre-1 ELISA Kit
 bre-1 Recombinant
 bre-1 Antibody
 CBG18162 ELISA Kit
 CBG18162 Recombinant
 CBG18162 Antibody
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E3 ubiquitin-protein ligase BRE1A

 E3 ubiquitin-protein ligase BRE1A ELISA Kit
 E3 ubiquitin-protein ligase BRE1A Recombinant
 E3 ubiquitin-protein ligase BRE1A Antibody
Also known as E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A).
RNF20: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-
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4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with p53/TP53 and WAC. Interacts with PAF1; the interaction mediates the association of the PAF1 and RNF20/40 complexes which is a prerequsite for recruitment of UBE2A/B. Belongs to the BRE1 family.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: nucleolus; nucleoplasm; nucleus; ubiquitin ligase complex

Molecular Function: histone binding; mRNA 3'-UTR binding; p53 binding; protein binding; transcription coactivator activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: histone H2B ubiquitination; histone monoubiquitination; negative regulation of cell migration; positive regulation of transcription, DNA-dependent; protein polyubiquitination; regulation of mitotic cell cycle; regulation of transcription, DNA-dependent; ubiquitin-dependent protein catabolic process
 RNF20 ELISA Kit
 RNF20 Recombinant
 RNF20 Antibody
 BRE1A ELISA Kit
 BRE1A Recombinant
 BRE1A Antibody
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E3 ubiquitin-protein ligase BRE1B

 E3 ubiquitin-protein ligase BRE1B ELISA Kit
 E3 ubiquitin-protein ligase BRE1B Recombinant
 E3 ubiquitin-protein ligase BRE1B Antibody
Also known as E3 ubiquitin-protein ligase BRE1B (BRE1-B) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B).
RNF40: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex for
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ms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1 and WAC. Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine. Belongs to the BRE1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 16p11.2-p11.1

Cellular Component: membrane; neuron projection; nucleoplasm; nucleus; ubiquitin ligase complex

Molecular Function: mRNA 3'-UTR binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: histone H2B ubiquitination; histone monoubiquitination; regulation of mitotic cell cycle; ubiquitin-dependent protein catabolic process
 RNF40 ELISA Kit
 RNF40 Recombinant
 RNF40 Antibody
 BRE1B ELISA Kit
 BRE1B Recombinant
 BRE1B Antibody
 KIAA0661 ELISA Kit
 KIAA0661 Recombinant
 KIAA0661 Antibody
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E3 ubiquitin-protein ligase BRE1-like 1

 E3 ubiquitin-protein ligase BRE1-like 1 ELISA Kit
 E3 ubiquitin-protein ligase BRE1-like 1 Recombinant
 E3 ubiquitin-protein ligase BRE1-like 1 Antibody
Also known as E3 ubiquitin-protein ligase BRE1-like 1 (AtBRE1) (Protein HISTONE MONOUBIQUITINATION 1) (AtHUB1) (Protein REDUCED DORMANCY 4) (RING-type E3 ubiquitin transferase BRE1-like 1).
The gene encodes one of two orthologous E3 ubiquitin ligases in Arabidopsis that are involved in monoubiquitination of histone H2B.
 HUB1 ELISA Kit
 HUB1 Recombinant
 HUB1 Antibody
 BRE1A ELISA Kit
 BRE1A Recombinant
 BRE1A Antibody
 RDO4 ELISA Kit
 RDO4 Recombinant
 RDO4 Antibody
 At2g44950/At2g44960 ELISA Kit
 At2g44950/At2g44960 Recombinant
 At2g44950/At2g44960 Antibody
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E3 ubiquitin-protein ligase BRE1-like 2

 E3 ubiquitin-protein ligase BRE1-like 2 ELISA Kit
 E3 ubiquitin-protein ligase BRE1-like 2 Recombinant
 E3 ubiquitin-protein ligase BRE1-like 2 Antibody
Also known as E3 ubiquitin-protein ligase BRE1-like 2 (Protein HISTONE MONOUBIQUITINATION 2) (AtHUB2) (RING-type E3 ubiquitin transferase BRE1-like 2).
Encodes one of two orthologous E3 ubiquitin ligases in Arabidopsis that are involved in monoubiquitination of histone H2B.
 HUB2 ELISA Kit
 HUB2 Recombinant
 HUB2 Antibody
 BRE1B ELISA Kit
 BRE1B Recombinant
 BRE1B Antibody
 At1g55250/At1g55255 ELISA Kit
 At1g55250/At1g55255 Recombinant
 At1g55250/At1g55255 Antibody
 F7A10.17 ELISA Kit
 F7A10.17 Recombinant
 F7A10.17 Antibody
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E3 ubiquitin-protein ligase brl1

 E3 ubiquitin-protein ligase brl1 ELISA Kit
 E3 ubiquitin-protein ligase brl1 Recombinant
 E3 ubiquitin-protein ligase brl1 Antibody
Also known as E3 ubiquitin-protein ligase brl1 (BRE1-like protein 1) (RING finger protein 2) (RING-type E3 ubiquitin transferase brl1).
E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
 brl1 ELISA Kit
 brl1 Recombinant
 brl1 Antibody
 rfp2 ELISA Kit
 rfp2 Recombinant
 rfp2 Antibody
 SPCC1919.15 ELISA Kit
 SPCC1919.15 Recombinant
 SPCC1919.15 Antibody
 SPCC790.01 ELISA Kit
 SPCC790.01 Recombinant
 SPCC790.01 Antibody
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E3 ubiquitin-protein ligase brl2

 E3 ubiquitin-protein ligase brl2 ELISA Kit
 E3 ubiquitin-protein ligase brl2 Recombinant
 E3 ubiquitin-protein ligase brl2 Antibody
Also known as E3 ubiquitin-protein ligase brl2 (BRE1-like protein 2) (RING finger protein 1) (RING-type E3 ubiquitin transferase brl2).
E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
 brl2 ELISA Kit
 brl2 Recombinant
 brl2 Antibody
 rfp1 ELISA Kit
 rfp1 Recombinant
 rfp1 Antibody
 SPCC970.10c ELISA Kit
 SPCC970.10c Recombinant
 SPCC970.10c Antibody
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E3 ubiquitin-protein ligase CBL

 E3 ubiquitin-protein ligase CBL ELISA Kit
 E3 ubiquitin-protein ligase CBL Recombinant
 E3 ubiquitin-protein ligase CBL Antibody
Also known as E3 ubiquitin-protein ligase CBL (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (Signal transduction protein CBL).
CBL: an adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminate
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s signaling. Participates in signal transduction in hematopoietic cells.

Protein type: Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; flotillin complex; lipid raft; plasma membrane

Molecular Function: ephrin receptor binding; protein binding; receptor tyrosine kinase binding; SH3 domain binding; transcription factor activity; ubiquitin-protein ligase activity

Biological Process: cell surface receptor linked signal transduction; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; negative regulation of apoptosis; negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of receptor-mediated endocytosis; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; transforming growth factor beta receptor signaling pathway

Disease: Juvenile Myelomonocytic Leukemia; Noonan Syndrome-like Disorder With Or Without Juvenile Myelomonocytic Leukemia
 CBL ELISA Kit
 CBL Recombinant
 CBL Antibody
 CBL2 ELISA Kit
 CBL2 Recombinant
 CBL2 Antibody
 RNF55 ELISA Kit
 RNF55 Recombinant
 RNF55 Antibody
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E3 ubiquitin-protein ligase cblA

 E3 ubiquitin-protein ligase cblA ELISA Kit
 E3 ubiquitin-protein ligase cblA Recombinant
 E3 ubiquitin-protein ligase cblA Antibody
Also known as E3 ubiquitin-protein ligase cblA (Cbl-like protein A) (RING finger protein cblA).
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Upregulates STATc tyrosine phosphorylation via an inhibitory effect on ptpC accumulation. Recognizes activated receptor tyrosine kinases, RTKs and terminates signaling.
 cblA-1 ELISA Kit
 cblA-1 Recombinant
 cblA-1 Antibody
 DDB_G0273141 ELISA Kit
 DDB_G0273141 Recombinant
 DDB_G0273141 Antibody
 cblA-2 ELISA Kit
 cblA-2 Recombinant
 cblA-2 Antibody
 DDB_G0273609 ELISA Kit
 DDB_G0273609 Recombinant
 DDB_G0273609 Antibody
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E3 ubiquitin-protein ligase CBL-B

 E3 ubiquitin-protein ligase CBL-B ELISA Kit
 E3 ubiquitin-protein ligase CBL-B Recombinant
 E3 ubiquitin-protein ligase CBL-B Antibody
Also known as E3 ubiquitin-protein ligase CBL-B (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B).
Cbl-b: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement
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and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization. Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. May interact with CBL. Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3q13.11

Cellular Component: cytoplasm; cytosol; lipid raft; nucleoplasm; plasma membrane

Molecular Function: protein binding; receptor tyrosine kinase binding; SH3 domain binding; ubiquitin-protein ligase activity

Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor activity; NLS-bearing substrate import into nucleus; protein polyubiquitination; proteolysis; signal transduction
 CBLB ELISA Kit
 CBLB Recombinant
 CBLB Antibody
 RNF56 ELISA Kit
 RNF56 Recombinant
 RNF56 Antibody
 Nbla00127 ELISA Kit
 Nbla00127 Recombinant
 Nbla00127 Antibody
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E3 ubiquitin-protein ligase CBL-B-A

 E3 ubiquitin-protein ligase CBL-B-A ELISA Kit
 E3 ubiquitin-protein ligase CBL-B-A Recombinant
 E3 ubiquitin-protein ligase CBL-B-A Antibody
Also known as E3 ubiquitin-protein ligase CBL-B-A (SH3-binding protein CBL-B-A) (Signal transduction protein CBL-B-A).
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
 cblb-a ELISA Kit
 cblb-a Recombinant
 cblb-a Antibody
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E3 ubiquitin-protein ligase CBL-B-B

 E3 ubiquitin-protein ligase CBL-B-B ELISA Kit
 E3 ubiquitin-protein ligase CBL-B-B Recombinant
 E3 ubiquitin-protein ligase CBL-B-B Antibody
Also known as E3 ubiquitin-protein ligase CBL-B-B (SH3-binding protein CBL-B-B) (Signal transduction protein CBL-B-B).
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
 cblb-b ELISA Kit
 cblb-b Recombinant
 cblb-b Antibody
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E3 ubiquitin-protein ligase CBL-C

 E3 ubiquitin-protein ligase CBL-C ELISA Kit
 E3 ubiquitin-protein ligase CBL-C Recombinant
 E3 ubiquitin-protein ligase CBL-C Antibody
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Inhibits EGF stimulated MAPK1 act
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ivation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
 Cblc ELISA Kit
 Cblc Recombinant
 Cblc Antibody
 Cbl-3 ELISA Kit
 Cbl-3 Recombinant
 Cbl-3 Antibody
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E3 ubiquitin-protein ligase CCNB1IP1

 E3 ubiquitin-protein ligase CCNB1IP1 ELISA Kit
 E3 ubiquitin-protein ligase CCNB1IP1 Recombinant
 E3 ubiquitin-protein ligase CCNB1IP1 Antibody
Also known as E3 ubiquitin-protein ligase CCNB1IP1 (Cyclin-B1-interacting protein 1).
CCNB1IP1: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

Protein type: Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: condensed nuclear chromosome; synaptonemal complex

Molecular Function: ubiquitin-protein ligase activity

Biological Pr
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ocess: blastocyst formation; chiasma formation; meiotic recombination; protein ubiquitination; spermatid development
 Ccnb1ip1 ELISA Kit
 Ccnb1ip1 Recombinant
 Ccnb1ip1 Antibody
 Gm288 ELISA Kit
 Gm288 Recombinant
 Gm288 Antibody
 Hei10 ELISA Kit
 Hei10 Recombinant
 Hei10 Antibody
 Mei4 ELISA Kit
 Mei4 Recombinant
 Mei4 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase CCNB1IP1 homolog

 E3 ubiquitin-protein ligase CCNB1IP1 homolog ELISA Kit
 E3 ubiquitin-protein ligase CCNB1IP1 homolog Recombinant
 E3 ubiquitin-protein ligase CCNB1IP1 homolog Antibody
Also known as E3 ubiquitin-protein ligase CCNB1IP1 homolog (RING finger-containing protein HEI10).
Ubiquitin E3 ligase required for class I crossing-over (CO) formation during meiosis.
 HEI10 ELISA Kit
 HEI10 Recombinant
 HEI10 Antibody
 Os02g0232100 ELISA Kit
 Os02g0232100 Recombinant
 Os02g0232100 Antibody
 LOC_Os02g13810 ELISA Kit
 LOC_Os02g13810 Recombinant
 LOC_Os02g13810 Antibody
 OJ1705_E12.17 ELISA Kit
 OJ1705_E12.17 Recombinant
 OJ1705_E12.17 Antibody
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E3 ubiquitin-protein ligase CHFR

 E3 ubiquitin-protein ligase CHFR ELISA Kit
 E3 ubiquitin-protein ligase CHFR Recombinant
 E3 ubiquitin-protein ligase CHFR Antibody
Also known as E3 ubiquitin-protein ligase CHFR (Checkpoint with forkhead and RING finger domains protein).
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Pro
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bably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress ().
 chfr ELISA Kit
 chfr Recombinant
 chfr Antibody
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E3 ubiquitin-protein ligase CHIP

 E3 ubiquitin-protein ligase CHIP ELISA Kit
 E3 ubiquitin-protein ligase CHIP Recombinant
 E3 ubiquitin-protein ligase CHIP Antibody
Also known as E3 ubiquitin-protein ligase CHIP (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (STIP1 homology and U box-containing protein 1).
CHIP: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chapero
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ne complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Homodimer. Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1. Interacts with MKKS. Interacts with DYX1C1 and POLB. Interacts (via TPR repeats) with HSP90AA1. Interacts (when monoubiquitinated) with ATXN3. Interacts with UBE2W. Interacts (via the U-box domain) with the UBE2V2- UBE2N heterodimer; the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with DNAJB6. Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; intermediate filament cytoskeleton; nuclear inclusion body; nucleoplasm; plasma membrane; ubiquitin conjugating enzyme complex; ubiquitin ligase complex

Molecular Function: enzyme binding; G-protein-coupled receptor binding; Hsp70 protein binding; Hsp90 protein binding; kinase binding; misfolded protein binding; protein binding; protein binding, bridging; protein homodimerization activity; SMAD binding; TPR domain binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: misfolded or incompletely synthesized protein catabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein maturation; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of glucocorticoid metabolic process; regulation of protein stability; ubiquitin-dependent protein catabolic process; ubiquitin-dependent SMAD protein catabolic process

Disease: Spinocerebellar Ataxia, Autosomal Recessive 16
 STUB1 ELISA Kit
 STUB1 Recombinant
 STUB1 Antibody
 CHIP ELISA Kit
 CHIP Recombinant
 CHIP Antibody
 PP1131 ELISA Kit
 PP1131 Recombinant
 PP1131 Antibody
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E3 ubiquitin-protein ligase CIP8

 E3 ubiquitin-protein ligase CIP8 ELISA Kit
 E3 ubiquitin-protein ligase CIP8 Recombinant
 E3 ubiquitin-protein ligase CIP8 Antibody
Also known as E3 ubiquitin-protein ligase CIP8 (COP1-interacting protein 8).
Encodes a RING-H2 protein that interacts with the RING finger domain of COP1. CIP8 exhibits a strong interaction with the E2 ubiquitin conjugating enzyme AtUBC8 through its N-terminal domain and promotes ubiquitination in an E2-dependent fashion in vitro. It is possible that the AtUBC8-CIP8 module might interact with COP1 in vivo, thereby participating in proteasome-mediated degradation of HY5.
 CIP8 ELISA Kit
 CIP8 Recombinant
 CIP8 Antibody
 At5g64920 ELISA Kit
 At5g64920 Recombinant
 At5g64920 Antibody
 MXK3.15 ELISA Kit
 MXK3.15 Recombinant
 MXK3.15 Antibody
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E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

 E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 ELISA Kit
 E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 Recombinant
 E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 Antibody
Also known as E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 (Hexose metabolism-related protein HEX3) (Synthetic lethal of unknown function protein 5).
Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Promotes UBC4-dependent ubiquitination that mediates the proteolytic down-regulation of sumoylated proteins. Involved in the stimulation of ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal c
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ell cycle progression. Has a role in localizing the DNA damage protein DCD2. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression. Along with SIR2, promotes silencing of genes at telomeric or ribosomal DNA (rDNA) loci.
 SLX5 ELISA Kit
 SLX5 Recombinant
 SLX5 Antibody
 HEX3 ELISA Kit
 HEX3 Recombinant
 HEX3 Antibody
 YDL013W ELISA Kit
 YDL013W Recombinant
 YDL013W Antibody
 D2875 ELISA Kit
 D2875 Recombinant
 D2875 Antibody
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E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

 E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 ELISA Kit
 E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 Recombinant
 E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 Antibody
Also known as E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 (Synthetic lethal of unknown function protein 8).
Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Promotes UBC4-dependent ubiquitination that mediates the proteolytic down-regulation of sumoylated proteins. Involved in the stimulation of ubi
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quitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Has a role in localizing the DNA damage protein DCD2. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression. Inhibits RAD51-independent recombination via modulating the sumoylation of DNA repair proteins.
 SLX8 ELISA Kit
 SLX8 Recombinant
 SLX8 Antibody
 YER116C ELISA Kit
 YER116C Recombinant
 YER116C Antibody
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E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1

 E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1 ELISA Kit
 E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1 Recombinant
 E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1 Antibody
Also known as E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1 (Meiotically up-regulated gene 140 protein) (RING finger protein 1).
Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage. Has a role in meiosis.
 rfp1 ELISA Kit
 rfp1 Recombinant
 rfp1 Antibody
 mug140 ELISA Kit
 mug140 Recombinant
 mug140 Antibody
 SPAC19A8.10 ELISA Kit
 SPAC19A8.10 Recombinant
 SPAC19A8.10 Antibody
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E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2

 E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2 ELISA Kit
 E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2 Recombinant
 E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2 Antibody
Also known as E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2 (RING finger protein 2).
Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage.
 rfp2 ELISA Kit
 rfp2 Recombinant
 rfp2 Antibody
 SPAC343.18 ELISA Kit
 SPAC343.18 Recombinant
 SPAC343.18 Antibody
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E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8

 E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8 ELISA Kit
 E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8 Recombinant
 E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8 Antibody
Also known as E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8 (RING finger protein slx8) (RING-dependent E3 ubiquitin-protein ligase slx8) (Synthetic lethal of unknown function protein 8).
Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Acts as a critical suppressor of gross chromosomal rearrangements (
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GCRs) during normal cell cycle progression. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression ().
 slx8 ELISA Kit
 slx8 Recombinant
 slx8 Antibody
 SPBC3D6.11c ELISA Kit
 SPBC3D6.11c Recombinant
 SPBC3D6.11c Antibody
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E3 ubiquitin-protein ligase COP1

 E3 ubiquitin-protein ligase COP1 ELISA Kit
 E3 ubiquitin-protein ligase COP1 Recombinant
 E3 ubiquitin-protein ligase COP1 Antibody
Also known as E3 ubiquitin-protein ligase COP1 (Constitutive photomorphogenesis protein 1).
E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses ph
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otomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways ().
 COP1 ELISA Kit
 COP1 Recombinant
 COP1 Antibody
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E3 ubiquitin-protein ligase dbl4

 E3 ubiquitin-protein ligase dbl4 ELISA Kit
 E3 ubiquitin-protein ligase dbl4 Recombinant
 E3 ubiquitin-protein ligase dbl4 Antibody
Also known as E3 ubiquitin-protein ligase dbl4 (DNA-break-localizing protein 4) (Histone E3 ligase 1).
Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
 dbl4 ELISA Kit
 dbl4 Recombinant
 dbl4 Antibody
 SPAC328.02 ELISA Kit
 SPAC328.02 Recombinant
 SPAC328.02 Antibody
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E3 ubiquitin-protein ligase DMA1

 E3 ubiquitin-protein ligase DMA1 ELISA Kit
 E3 ubiquitin-protein ligase DMA1 Recombinant
 E3 ubiquitin-protein ligase DMA1 Antibody
Also known as E3 ubiquitin-protein ligase DMA1 (Checkpoint forkhead associated with RING domains-containing protein 1) (Defective in mitotic arrest protein 1).
E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjonction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugationg enzymes (PubMed:18202552). Involved in nutritional control of the cell cycle (PubMed:15319434). Targets the G1 cyclin PCL1 for destruction (PubMed:23264631). Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck (PubMed:15146058).
 DMA1 ELISA Kit
 DMA1 Recombinant
 DMA1 Antibody
 CHF1 ELISA Kit
 CHF1 Recombinant
 CHF1 Antibody
 YHR115C ELISA Kit
 YHR115C Recombinant
 YHR115C Antibody
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E3 ubiquitin-protein ligase DMA2

 E3 ubiquitin-protein ligase DMA2 ELISA Kit
 E3 ubiquitin-protein ligase DMA2 Recombinant
 E3 ubiquitin-protein ligase DMA2 Antibody
Also known as E3 ubiquitin-protein ligase DMA2 (Checkpoint forkhead associated with RING domains-containing protein 1) (Defective in mitotic arrest protein 2).
E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjonction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugationg enzymes. Involved in nutritional control of the cell cycle. Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck ().
 DMA2 ELISA Kit
 DMA2 Recombinant
 DMA2 Antibody
 CHF2 ELISA Kit
 CHF2 Recombinant
 CHF2 Antibody
 SCY_4678 ELISA Kit
 SCY_4678 Recombinant
 SCY_4678 Antibody
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E3 ubiquitin-protein ligase DTX1

 E3 ubiquitin-protein ligase DTX1 ELISA Kit
 E3 ubiquitin-protein ligase DTX1 Recombinant
 E3 ubiquitin-protein ligase DTX1 Antibody
Also known as E3 ubiquitin-protein ligase DTX1 (FXI-T1) (Protein deltex-1) (Deltex1) (mDTX1).
DTX1: Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulate
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s a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. Belongs to the Deltex family.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: nucleus

Molecular Function: Notch binding; protein binding; ubiquitin protein ligase binding

Biological Process: glial cell differentiation; negative regulation of neuron differentiation; negative regulation of T cell differentiation; Notch signaling pathway; regulation of Notch signaling pathway
 Dtx1 ELISA Kit
 Dtx1 Recombinant
 Dtx1 Antibody
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E3 ubiquitin-protein ligase DTX3L

 E3 ubiquitin-protein ligase DTX3L ELISA Kit
 E3 ubiquitin-protein ligase DTX3L Recombinant
 E3 ubiquitin-protein ligase DTX3L Antibody
Also known as E3 ubiquitin-protein ligase DTX3L (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2).
DTX3L: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a l
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icensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3q21.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: histone binding; protein binding; ubiquitin-protein ligase activity

Biological Process: double-strand break repair; histone monoubiquitination; protein polyubiquitination; response to DNA damage stimulus
 DTX3L ELISA Kit
 DTX3L Recombinant
 DTX3L Antibody
 BBAP ELISA Kit
 BBAP Recombinant
 BBAP Antibody
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E3 ubiquitin-protein ligase DTX4

 E3 ubiquitin-protein ligase DTX4 ELISA Kit
 E3 ubiquitin-protein ligase DTX4 Recombinant
 E3 ubiquitin-protein ligase DTX4 Antibody
Also known as E3 ubiquitin-protein ligase DTX4 (Protein deltex-4) (Deltex4).
DTX4: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interactio
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n with NLRP4. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ubiquitin conjugating system
 Dtx4 ELISA Kit
 Dtx4 Recombinant
 Dtx4 Antibody
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E3 ubiquitin-protein ligase DZIP3

 E3 ubiquitin-protein ligase DZIP3 ELISA Kit
 E3 ubiquitin-protein ligase DZIP3 Recombinant
 E3 ubiquitin-protein ligase DZIP3 Antibody
Also known as E3 ubiquitin-protein ligase DZIP3 (DAZ-interacting protein 3 homolog).
DZIP3: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically b
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ind RNA. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; RNA-binding; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm

Molecular Function: phosphatase binding; polyubiquitin binding; RNA binding; ubiquitin-protein ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 Dzip3 ELISA Kit
 Dzip3 Recombinant
 Dzip3 Antibody
 Kiaa0675 ELISA Kit
 Kiaa0675 Recombinant
 Kiaa0675 Antibody
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E3 ubiquitin-protein ligase E3D

 E3 ubiquitin-protein ligase E3D ELISA Kit
 E3 ubiquitin-protein ligase E3D Recombinant
 E3 ubiquitin-protein ligase E3D Antibody
Also known as E3 ubiquitin-protein ligase E3D (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein).
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
 UBE3D ELISA Kit
 UBE3D Recombinant
 UBE3D Antibody
 H10BH ELISA Kit
 H10BH Recombinant
 H10BH Antibody
 UBE2CBP ELISA Kit
 UBE2CBP Recombinant
 UBE2CBP Antibody
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E3 ubiquitin-protein ligase EL5

 E3 ubiquitin-protein ligase EL5 ELISA Kit
 E3 ubiquitin-protein ligase EL5 Recombinant
 E3 ubiquitin-protein ligase EL5 Antibody
Also known as E3 ubiquitin-protein ligase EL5 (Protein ELICITOR 5).
Functions as a E3 ubiquitin-protein ligase in cooperation with the E2 ubiquitin conjugating enzymes UBC5A and UBC5B. Involved in root development. Required for the maintenance of cell viability after the initiation of root primordial formation. May mediate the degradation of cytotoxic proteins produced in root cells after the actions of auxin, cytokinin and jasmonic acid. Mediates 'Lys-48'-linked polyubiquitination of MBP in vitro.
 EL5.1 ELISA Kit
 EL5.1 Recombinant
 EL5.1 Antibody
 EL5 ELISA Kit
 EL5 Recombinant
 EL5 Antibody
 Os02g0559800 ELISA Kit
 Os02g0559800 Recombinant
 Os02g0559800 Antibody
 LOC_Os02g35329 ELISA Kit
 LOC_Os02g35329 Recombinant
 LOC_Os02g35329 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase FANCL

 E3 ubiquitin-protein ligase FANCL ELISA Kit
 E3 ubiquitin-protein ligase FANCL Recombinant
 E3 ubiquitin-protein ligase FANCL Antibody
Also known as E3 ubiquitin-protein ligase FANCL (Fanconi anemia group L protein homolog) (Proliferation of germ cells protein).
FANCL: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. Defects in FANCL are the cause of Fanconi anemia complementation group L (FANCL). FANCL is a disor
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der affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: nuclear envelope; nucleus

Molecular Function: protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: DNA repair; gamete generation; protein monoubiquitination; protein ubiquitination; regulation of cell proliferation; response to DNA damage stimulus
 Fancl ELISA Kit
 Fancl Recombinant
 Fancl Antibody
 Phf9 ELISA Kit
 Phf9 Recombinant
 Phf9 Antibody
 Pog ELISA Kit
 Pog Recombinant
 Pog Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase HACE1

 E3 ubiquitin-protein ligase HACE1 ELISA Kit
 E3 ubiquitin-protein ligase HACE1 Recombinant
 E3 ubiquitin-protein ligase HACE1 Antibody
Also known as E3 ubiquitin-protein ligase HACE1 (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1).
HACE1: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates p
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ostmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. Defects in HACE1 are a cause of Wilms tumor (WT). WT is a pediatric malignancy of kidney and one of the most common solid cancers in childhood. HACE1 is epigenetically down-regulated in sporadic Wilms tumor. Moreover, a t(5;6)(q21;q21) translocation that truncates HACE1 has been found in a child with bilateral, young-onset Wilms tumor. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 6q16.3

Cellular Component: Golgi membrane; nucleus

Molecular Function: protein binding; Rab GTPase binding; Rac GTPase binding; ubiquitin-protein ligase activity

Biological Process: Golgi organization and biogenesis; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; Rac protein signal transduction; regulation of cell migration

Disease: Spastic Paraplegia And Psychomotor Retardation With Or Without Seizures
 HACE1 ELISA Kit
 HACE1 Recombinant
 HACE1 Antibody
 KIAA1320 ELISA Kit
 KIAA1320 Recombinant
 KIAA1320 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase Hakai

 E3 ubiquitin-protein ligase Hakai ELISA Kit
 E3 ubiquitin-protein ligase Hakai Recombinant
 E3 ubiquitin-protein ligase Hakai Antibody
Also known as E3 ubiquitin-protein ligase Hakai (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1).
Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation ().
 CBLL1 ELISA Kit
 CBLL1 Recombinant
 CBLL1 Antibody
 HAKAI ELISA Kit
 HAKAI Recombinant
 HAKAI Antibody
 QtsA-15158 ELISA Kit
 QtsA-15158 Recombinant
 QtsA-15158 Antibody
 QtsA-17111 ELISA Kit
 QtsA-17111 Recombinant
 QtsA-17111 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase HECTD1

 E3 ubiquitin-protein ligase HECTD1 ELISA Kit
 E3 ubiquitin-protein ligase HECTD1 Recombinant
 E3 ubiquitin-protein ligase HECTD1 Antibody
Also known as E3 ubiquitin-protein ligase HECTD1 (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECTD1).
HECTD1: a ubiquitin-protein ligase required for development of the head mesenchyme and neural tube closure. Accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ub
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iquitin to targeted substrates.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process
 HECTD1 ELISA Kit
 HECTD1 Recombinant
 HECTD1 Antibody
 KIAA1131 ELISA Kit
 KIAA1131 Recombinant
 KIAA1131 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase HECTD3

 E3 ubiquitin-protein ligase HECTD3 ELISA Kit
 E3 ubiquitin-protein ligase HECTD3 Recombinant
 E3 ubiquitin-protein ligase HECTD3 Antibody
Also known as E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3).
HECTD3: E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facil
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iting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: cytoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process
 HECTD3 ELISA Kit
 HECTD3 Recombinant
 HECTD3 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase HECW1

 E3 ubiquitin-protein ligase HECW1 ELISA Kit
 E3 ubiquitin-protein ligase HECW1 Recombinant
 E3 ubiquitin-protein ligase HECW1 Antibody
Also known as E3 ubiquitin-protein ligase HECW1 (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1).
HECW1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chr
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omosomal Location of Human Ortholog: 7p13

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: ubiquitin-protein ligase activity

Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process
 HECW1 ELISA Kit
 HECW1 Recombinant
 HECW1 Antibody
 KIAA0322 ELISA Kit
 KIAA0322 Recombinant
 KIAA0322 Antibody
 NEDL1 ELISA Kit
 NEDL1 Recombinant
 NEDL1 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase HECW2

 E3 ubiquitin-protein ligase HECW2 ELISA Kit
 E3 ubiquitin-protein ligase HECW2 Recombinant
 E3 ubiquitin-protein ligase HECW2 Antibody
Also known as E3 ubiquitin-protein ligase HECW2 (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2).
HECW2: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; nucleus

Molecular Function: ubiquitin-protein ligase ac
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tivity

Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process
 Hecw2 ELISA Kit
 Hecw2 Recombinant
 Hecw2 Antibody
 Kiaa1301 ELISA Kit
 Kiaa1301 Recombinant
 Kiaa1301 Antibody
 Nedl2 ELISA Kit
 Nedl2 Recombinant
 Nedl2 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase HEL2

 E3 ubiquitin-protein ligase HEL2 ELISA Kit
 E3 ubiquitin-protein ligase HEL2 Recombinant
 E3 ubiquitin-protein ligase HEL2 Antibody
Also known as E3 ubiquitin-protein ligase HEL2 (Histone E3 ligase 2).
Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
 HEL1 ELISA Kit
 HEL1 Recombinant
 HEL1 Antibody
 YKR017C ELISA Kit
 YKR017C Recombinant
 YKR017C Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase HERC2

 E3 ubiquitin-protein ligase HERC2 ELISA Kit
 E3 ubiquitin-protein ligase HERC2 Recombinant
 E3 ubiquitin-protein ligase HERC2 Antibody
Also known as E3 ubiquitin-protein ligase HERC2 (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2).
HERC2: E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promot
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ing DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. Interacts (when phosphorylated at Thr-4827) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment. Interacts with XPA.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Mitochondrial; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 15q13

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus

Molecular Function: protein binding; SUMO binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: double-strand break repair via nonhomologous end joining; protein sumoylation; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; response to DNA damage stimulus

Disease: Mental Retardation, Autosomal Recessive 38; Prader-willi Syndrome; Skin/hair/eye Pigmentation, Variation In, 1
 HERC2 ELISA Kit
 HERC2 Recombinant
 HERC2 Antibody
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E3 ubiquitin-protein ligase highwire

 E3 ubiquitin-protein ligase highwire ELISA Kit
 E3 ubiquitin-protein ligase highwire Recombinant
 E3 ubiquitin-protein ligase highwire Antibody
Also known as E3 ubiquitin-protein ligase highwire (Protein pam/highwire/rpm-1).
E3 ubiquitin-protein ligases mediate ubiquitination and subsequent proteasomal degradation of target proteins. Has a role during synaptogenesis; negative regulator of synaptic growth.
 hiw ELISA Kit
 hiw Recombinant
 hiw Antibody
 CG32592 ELISA Kit
 CG32592 Recombinant
 CG32592 Antibody
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E3 ubiquitin-protein ligase HOS1

 E3 ubiquitin-protein ligase HOS1 ELISA Kit
 E3 ubiquitin-protein ligase HOS1 Recombinant
 E3 ubiquitin-protein ligase HOS1 Antibody
Also known as E3 ubiquitin-protein ligase HOS1 (Protein HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1) (RING finger protein HOS1).
A novel protein with a RING finger motif near the amino terminus. Negative regulator of cold responses. Functions as an E3 ligase required for the ubiquitination of ICE1. HOS1 physically interacts with ICE1 and mediates the ubiquitination of ICE1 both in vitro and in vivo. Overexpression represses the expression of CBFs and their downstream genes and confers increased sensitivity to freezing stress.
 HOS1 ELISA Kit
 HOS1 Recombinant
 HOS1 Antibody
 At2g39810 ELISA Kit
 At2g39810 Recombinant
 At2g39810 Antibody
 T5I7.11 ELISA Kit
 T5I7.11 Recombinant
 T5I7.11 Antibody
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E3 ubiquitin-protein ligase HRD1

 E3 ubiquitin-protein ligase HRD1 ELISA Kit
 E3 ubiquitin-protein ligase HRD1 Recombinant
 E3 ubiquitin-protein ligase HRD1 Antibody
Also known as E3 ubiquitin-protein ligase HRD1 (Septin-interacting protein 3) (Synoviolin).
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induce
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d apoptosis. Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
 sip3 ELISA Kit
 sip3 Recombinant
 sip3 Antibody
 Syno ELISA Kit
 Syno Recombinant
 Syno Antibody
 CG1937 ELISA Kit
 CG1937 Recombinant
 CG1937 Antibody
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E3 ubiquitin-protein ligase hrd-1

 E3 ubiquitin-protein ligase hrd-1 ELISA Kit
 E3 ubiquitin-protein ligase hrd-1 Recombinant
 E3 ubiquitin-protein ligase hrd-1 Antibody
Also known as E3 ubiquitin-protein ligase hrd-1 (Suppressor/enhancer of lin-12).
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER s
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tress-induced apoptosis. Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation ().
 sel-11 ELISA Kit
 sel-11 Recombinant
 sel-11 Antibody
 hrd-1 ELISA Kit
 hrd-1 Recombinant
 hrd-1 Antibody
 CBG23271 ELISA Kit
 CBG23271 Recombinant
 CBG23271 Antibody
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E3 ubiquitin-protein ligase HUWE1

 E3 ubiquitin-protein ligase HUWE1 ELISA Kit
 E3 ubiquitin-protein ligase HUWE1 Recombinant
 E3 ubiquitin-protein ligase HUWE1 Antibody
Also known as E3 ubiquitin-protein ligase HUWE1 (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large struct.
HUWE1: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision
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repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Interacts with isoform p14ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity. Interacts with MYCN, POLB and CDC6. Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas. Belongs to the TOM1/PTR1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus

Molecular Function: DNA binding; protein binding; ubiquitin-protein ligase activity

Biological Process: base-excision repair; histone ubiquitination; protein monoubiquitination; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process

Disease: Mental Retardation, X-linked, Syndromic, Turner Type
 HUWE1 ELISA Kit
 HUWE1 Recombinant
 HUWE1 Antibody
 KIAA0312 ELISA Kit
 KIAA0312 Recombinant
 KIAA0312 Antibody
 KIAA1578 ELISA Kit
 KIAA1578 Recombinant
 KIAA1578 Antibody
 UREB1 ELISA Kit
 UREB1 Recombinant
 UREB1 Antibody
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E3 ubiquitin-protein ligase hyd

 E3 ubiquitin-protein ligase hyd ELISA Kit
 E3 ubiquitin-protein ligase hyd Recombinant
 E3 ubiquitin-protein ligase hyd Antibody
Also known as E3 ubiquitin-protein ligase hyd (HECT-type E3 ubiquitin transferase hyd) (Protein hyperplastic discs).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (). Required for regulation of cell proliferation in imaginal disks and germ cells. Acts as a negative regulator of hh, ci and dpp expression in the anterior of the eye disk.
 hyd ELISA Kit
 hyd Recombinant
 hyd Antibody
 l(3)C43 ELISA Kit
 l(3)C43 Recombinant
 l(3)C43 Antibody
 CG9484 ELISA Kit
 CG9484 Recombinant
 CG9484 Antibody
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E3 ubiquitin-protein ligase IAP-3

 E3 ubiquitin-protein ligase IAP-3 ELISA Kit
 E3 ubiquitin-protein ligase IAP-3 Recombinant
 E3 ubiquitin-protein ligase IAP-3 Antibody
Also known as E3 ubiquitin-protein ligase IAP-3 (IAP-3).
RING-finger E3 ubiquitin ligase required to prevent cellular apoptosis in infected cells. Ubiquitinates and subsquently targets host pro-apoptotic cellular proteins such as HID for degradation by the proteasome.
 IAP3 ELISA Kit
 IAP3 Recombinant
 IAP3 Antibody
 IAP ELISA Kit
 IAP Recombinant
 IAP Antibody
 ORF35 ELISA Kit
 ORF35 Recombinant
 ORF35 Antibody
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E3 ubiquitin-protein ligase ICP0

 E3 ubiquitin-protein ligase ICP0 ELISA Kit
 E3 ubiquitin-protein ligase ICP0 Recombinant
 E3 ubiquitin-protein ligase ICP0 Antibody
Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bo
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dies by degrading host PML and SP100.
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E3 ubiquitin-protein ligase IE2

 E3 ubiquitin-protein ligase IE2 ELISA Kit
 E3 ubiquitin-protein ligase IE2 Recombinant
 E3 ubiquitin-protein ligase IE2 Antibody
Also known as E3 ubiquitin-protein ligase IE2 (Immediate-early protein IE2).
RING-finger E3 ubiquitin ligase that plays an important regulatory role during the initial stages of infection. Migrates to specific nuclear foci early in infection supposely to prepare the sites for viral transcription and replication by targeting and ubiquitinating host proteins. Acts as a transcriptional activator a
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nd activates a number of viral promoters including itself, IE1 and the promoter of 39K gene.
 IE2 ELISA Kit
 IE2 Recombinant
 IE2 Antibody
 ORF151 ELISA Kit
 ORF151 Recombinant
 ORF151 Antibody
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E3 ubiquitin-protein ligase IE61

 E3 ubiquitin-protein ligase IE61 ELISA Kit
 E3 ubiquitin-protein ligase IE61 Recombinant
 E3 ubiquitin-protein ligase IE61 Antibody
Also known as E3 ubiquitin-protein ligase IE61 (Immediate-early protein 61) (IE61).
RING-finger E3 ubiquitin ligase that degrades host SP100, one of the major components of ND10 nuclear bodies, the
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reby disrupting the organization of these bodies. Acts as a transcriptional activator of viral promoters and enhances infectivity.
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E3 ubiquitin-protein ligase ipaH3

 E3 ubiquitin-protein ligase ipaH3 ELISA Kit
 E3 ubiquitin-protein ligase ipaH3 Recombinant
 E3 ubiquitin-protein ligase ipaH3 Antibody
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Synthesizes a 'Lys-48'-linked ubiquitin chain, which requires non-covalent binding between ubiquitin and the host ubiquitin-conjugating enzyme UBE2D1.
 ipaH3 ELISA Kit
 ipaH3 Recombinant
 ipaH3 Antibody
 SF1383 ELISA Kit
 SF1383 Recombinant
 SF1383 Antibody
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E3 ubiquitin-protein ligase ipaH9.8

 E3 ubiquitin-protein ligase ipaH9.8 ELISA Kit
 E3 ubiquitin-protein ligase ipaH9.8 Recombinant
 E3 ubiquitin-protein ligase ipaH9.8 Antibody
Also known as E3 ubiquitin-protein ligase ipaH9.8 (Invasion plasmid antigen ipaH9.8).
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell ().
 ipaH9.8 ELISA Kit
 ipaH9.8 Recombinant
 ipaH9.8 Antibody
 SFxv_5076 ELISA Kit
 SFxv_5076 Recombinant
 SFxv_5076 Antibody
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E3 ubiquitin-protein ligase Itchy

 E3 ubiquitin-protein ligase Itchy ELISA Kit
 E3 ubiquitin-protein ligase Itchy Recombinant
 E3 ubiquitin-protein ligase Itchy Antibody
Also known as E3 ubiquitin-protein ligase Itchy (HECT-type E3 ubiquitin transferase Itchy homolog).
ITCH: an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the cont
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rol of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways. Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response. Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation. Ubiquitinates SNX9. Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway. It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation. Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP. Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination. Monomer Interacts (via its WW domains) with OCNL, NOTCH1 AND JUN. Interacts with JUNB; the interaction promotes ITCH-mediated ubiquitination and degradation of JUNB. Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase and may induce its recruitment to exosomes. Interacts with ARHGEF7. Interacts with RNF11. Interacts (via the WW 1 domain) with NFE2 (via the PXY motif 1); the interaction promotes 'Lys-63'-linked ubiquitination of NFE2, retains it in the cytoplasm and prevents its transactivation activity. Interacts with FYN; the interaction phosphorylates ITCH on Tyr-420 decreasing binding of JUNB. Interacts (via WW domains) with CXCR4 (via C-terminus); the interaction depends on CXCR4 phosphorylation. Interacts (via WW domains) with PCBP2 within a complex containing ITCH, MAVS and PCBP2. Interacts (via WW domains) with TXNIP (via C-terminus). Interacts with ERBB4, DTX1, SPG20, SNX9 and SNX18. Interacts (via its WW domains) with ATN1. Interacts with Epstein-Barr virus LMP2A. Interacts (via WW domains) with SGK3. Widely expressed. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cell cortex; cytoplasm; cytoplasmic vesicle; membrane; nucleus; plasma membrane; ubiquitin ligase complex

Molecular Function: CXCR chemokine receptor binding; ligase activity; protein binding; ribonucleoprotein binding; ubiquitin-protein ligase activity

Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of alpha-beta T cell proliferation; negative regulation of apoptosis; negative regulation of defense response to virus; negative regulation of JNK cascade; positive regulation of protein catabolic process; positive regulation of T cell anergy; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process
 Itch ELISA Kit
 Itch Recombinant
 Itch Antibody
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E3 ubiquitin-protein ligase Itchy homolog

 E3 ubiquitin-protein ligase Itchy homolog ELISA Kit
 E3 ubiquitin-protein ligase Itchy homolog Recombinant
 E3 ubiquitin-protein ligase Itchy homolog Antibody
Also known as E3 ubiquitin-protein ligase Itchy homolog (Itch) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1).
ITCH: an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It cat
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alyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways. Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response. Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation. Ubiquitinates SNX9. Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway. It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation. Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP. Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination. Monomer Interacts (via its WW domains) with OCNL, NOTCH1 AND JUN. Interacts with JUNB; the interaction promotes ITCH-mediated ubiquitination and degradation of JUNB. Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase and may induce its recruitment to exosomes. Interacts with ARHGEF7. Interacts with RNF11. Interacts (via the WW 1 domain) with NFE2 (via the PXY motif 1); the interaction promotes 'Lys-63'-linked ubiquitination of NFE2, retains it in the cytoplasm and prevents its transactivation activity. Interacts with FYN; the interaction phosphorylates ITCH on Tyr-420 decreasing binding of JUNB. Interacts (via WW domains) with CXCR4 (via C-terminus); the interaction depends on CXCR4 phosphorylation. Interacts (via WW domains) with PCBP2 within a complex containing ITCH, MAVS and PCBP2. Interacts (via WW domains) with TXNIP (via C-terminus). Interacts with ERBB4, DTX1, SPG20, SNX9 and SNX18. Interacts (via its WW domains) with ATN1. Interacts with Epstein-Barr virus LMP2A. Interacts (via WW domains) with SGK3. Widely expressed. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: cytoplasm; cytosol; membrane; nucleus; plasma membrane

Molecular Function: CXCR chemokine receptor binding; protein binding; ribonucleoprotein binding; small conjugating protein ligase activity; ubiquitin-protein ligase activity

Biological Process: entry of virus into host cell; inhibition of NF-kappaB transcription factor; negative regulation of apoptosis; negative regulation of defense response to virus; negative regulation of interferon type I production; negative regulation of JNK cascade; Notch signaling pathway; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process

Disease: Autoimmune Disease, Multisystem, With Facial Dysmorphism
 ITCH ELISA Kit
 ITCH Recombinant
 ITCH Antibody
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E3 ubiquitin-protein ligase itt1

 E3 ubiquitin-protein ligase itt1 ELISA Kit
 E3 ubiquitin-protein ligase itt1 Recombinant
 E3 ubiquitin-protein ligase itt1 Antibody
Also known as E3 ubiquitin-protein ligase itt1 (RING finger protein itt1).
 itt1 ELISA Kit
 itt1 Recombinant
 itt1 Antibody
 SPAC1002.14 ELISA Kit
 SPAC1002.14 Recombinant
 SPAC1002.14 Antibody
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E3 ubiquitin-protein ligase KCMF1

 E3 ubiquitin-protein ligase KCMF1 ELISA Kit
 E3 ubiquitin-protein ligase KCMF1 Recombinant
 E3 ubiquitin-protein ligase KCMF1 Antibody
Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
 kcmf1 ELISA Kit
 kcmf1 Recombinant
 kcmf1 Antibody
 si:ch211-220b11.7 ELISA Kit
 si:ch211-220b11.7 Recombinant
 si:ch211-220b11.7 Antibody
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E3 ubiquitin-protein ligase KEG

 E3 ubiquitin-protein ligase KEG ELISA Kit
 E3 ubiquitin-protein ligase KEG Recombinant
 E3 ubiquitin-protein ligase KEG Antibody
Also known as E3 ubiquitin-protein ligase KEG (Protein KEEP ON GOING) (RING finger protein KEG).
Encodes KEEP ON GOING (KEG), a RING E3 ligase involved in abscisic acid signaling. KEG is essential for Arabidopsis growth and development. ABA promotes KEG degradation via the ubiquitin dependent 26S proteasome pathway.
 KEG ELISA Kit
 KEG Recombinant
 KEG Antibody
 At5g13530 ELISA Kit
 At5g13530 Recombinant
 At5g13530 Antibody
 T6I14.60 ELISA Kit
 T6I14.60 Recombinant
 T6I14.60 Antibody
 T6I14.70 ELISA Kit
 T6I14.70 Recombinant
 T6I14.70 Antibody
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E3 ubiquitin-protein ligase LAP

 E3 ubiquitin-protein ligase LAP ELISA Kit
 E3 ubiquitin-protein ligase LAP Recombinant
 E3 ubiquitin-protein ligase LAP Antibody
Also known as E3 ubiquitin-protein ligase LAP (Leukemia associated protein) (LAP).
E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. Binds target molecules through transmembrane interaction. The result of this ubiquitination is the enhancement
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of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed ().
 LAP ELISA Kit
 LAP Recombinant
 LAP Antibody
 C7L ELISA Kit
 C7L Recombinant
 C7L Antibody
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E3 ubiquitin-protein ligase listerin

 E3 ubiquitin-protein ligase listerin ELISA Kit
 E3 ubiquitin-protein ligase listerin Recombinant
 E3 ubiquitin-protein ligase listerin Antibody
E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product.
 At5g58410 ELISA Kit
 At5g58410 Recombinant
 At5g58410 Antibody
 MCK7.28 ELISA Kit
 MCK7.28 Recombinant
 MCK7.28 Antibody
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E3 ubiquitin-protein ligase LNX

 E3 ubiquitin-protein ligase LNX ELISA Kit
 E3 ubiquitin-protein ligase LNX Recombinant
 E3 ubiquitin-protein ligase LNX Antibody
Also known as E3 ubiquitin-protein ligase LNX (Ligand of Numb protein X 1) (Ligand of Numb-binding protein 1) (Numb-binding protein 1).
LNX1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to
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targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm

Molecular Function: PDZ domain binding; protein binding; ubiquitin-protein ligase activity

Biological Process: protein homooligomerization; protein ubiquitination during ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process
 Lnx1 ELISA Kit
 Lnx1 Recombinant
 Lnx1 Antibody
 Lnx ELISA Kit
 Lnx Recombinant
 Lnx Antibody
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E3 ubiquitin-protein ligase LRSAM1

 E3 ubiquitin-protein ligase LRSAM1 ELISA Kit
 E3 ubiquitin-protein ligase LRSAM1 Recombinant
 E3 ubiquitin-protein ligase LRSAM1 Antibody
Also known as E3 ubiquitin-protein ligase LRSAM1 (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).
LRSAM1: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Defects in LRSAM1 are a cause of
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Charcot-Marie-Tooth disease type 2P (CMT2P). CMT2P is an axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; membrane

Molecular Function: ubiquitin-protein ligase activity

Biological Process: negative regulation of endocytosis; non-lytic virus budding; protein autoubiquitination; protein catabolic process; protein polyubiquitination
 Lrsam1 ELISA Kit
 Lrsam1 Recombinant
 Lrsam1 Antibody
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E3 ubiquitin-protein ligase LubX

 E3 ubiquitin-protein ligase LubX ELISA Kit
 E3 ubiquitin-protein ligase LubX Recombinant
 E3 ubiquitin-protein ligase LubX Antibody
Also known as E3 ubiquitin-protein ligase LubX (Legionella U-box protein).
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway ().
 lubX ELISA Kit
 lubX Recombinant
 lubX Antibody
 lpp2887 ELISA Kit
 lpp2887 Recombinant
 lpp2887 Antibody
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E3 ubiquitin-protein ligase makorin

 E3 ubiquitin-protein ligase makorin ELISA Kit
 E3 ubiquitin-protein ligase makorin Recombinant
 E3 ubiquitin-protein ligase makorin Antibody
Also known as E3 ubiquitin-protein ligase makorin (Zinc finger CCCH domain-containing protein 35) (AtC3H35).
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
 MKRN ELISA Kit
 MKRN Recombinant
 MKRN Antibody
 At3g08505 ELISA Kit
 At3g08505 Recombinant
 At3g08505 Antibody
 T8G24.6 ELISA Kit
 T8G24.6 Recombinant
 T8G24.6 Antibody
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E3 ubiquitin-protein ligase makorin-1

 E3 ubiquitin-protein ligase makorin-1 ELISA Kit
 E3 ubiquitin-protein ligase makorin-1 Recombinant
 E3 ubiquitin-protein ligase makorin-1 Antibody
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-d
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ependent transcription ().
 MKRN1 ELISA Kit
 MKRN1 Recombinant
 MKRN1 Antibody
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E3 ubiquitin-protein ligase MARCH1

 E3 ubiquitin-protein ligase MARCH1 ELISA Kit
 E3 ubiquitin-protein ligase MARCH1 Recombinant
 E3 ubiquitin-protein ligase MARCH1 Antibody
Also known as E3 ubiquitin-protein ligase MARCH1 (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I).
MARCH1: E3 ubiquitin-protein ligase that mediates ubi
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quitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: early endosome membrane; endoplasmic reticulum membrane; endosome; late endosome membrane; lysosomal membrane; lysosome; plasma membrane; trans-Golgi network membrane

Molecular Function: MHC protein binding; ubiquitin-protein ligase activity

Biological Process: antigen processing and presentation of peptide antigen via MHC class II; immune response; protein polyubiquitination; protein ubiquitination
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E3 ubiquitin-protein ligase MARCH11

 E3 ubiquitin-protein ligase MARCH11 ELISA Kit
 E3 ubiquitin-protein ligase MARCH11 Recombinant
 E3 ubiquitin-protein ligase MARCH11 Antibody
Also known as E3 ubiquitin-protein ligase MARCH11 (Membrane-associated RING finger protein 11) (Membrane-associated RING-CH protein XI) (MARCH-XI).
MARCH11: E3 ubiquitin-protein ligase that mediate
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s polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase; Vesicle

Chromosomal Location of Human Ortholog: 5p15.1
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E3 ubiquitin-protein ligase MARCH2

 E3 ubiquitin-protein ligase MARCH2 ELISA Kit
 E3 ubiquitin-protein ligase MARCH2 Recombinant
 E3 ubiquitin-protein ligase MARCH2 Antibody
Also known as E3 ubiquitin-protein ligase MARCH2 (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II).
E3 ubiquitin-protein ligase that may mediate ubiqui
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tination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
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E3 ubiquitin-protein ligase MARCH3

 E3 ubiquitin-protein ligase MARCH3 ELISA Kit
 E3 ubiquitin-protein ligase MARCH3 Recombinant
 E3 ubiquitin-protein ligase MARCH3 Antibody
Also known as E3 ubiquitin-protein ligase MARCH3 (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III).
MARCH3: E3 ubiquitin-protein ligase which may be
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involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: endosome; lysosome
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E3 ubiquitin-protein ligase MARCH4

 E3 ubiquitin-protein ligase MARCH4 ELISA Kit
 E3 ubiquitin-protein ligase MARCH4 Recombinant
 E3 ubiquitin-protein ligase MARCH4 Antibody
Also known as E3 ubiquitin-protein ligase MARCH4 (Membrane-associated RING finger protein 4) (Membrane-associated RING-CH protein IV) (MARCH-IV).
E3 ubiquitin-protein ligase. E3 ubiquitin ligases a
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ccept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates ().
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E3 ubiquitin-protein ligase MARCH5

 E3 ubiquitin-protein ligase MARCH5 ELISA Kit
 E3 ubiquitin-protein ligase MARCH5 Recombinant
 E3 ubiquitin-protein ligase MARCH5 Antibody
Also known as E3 ubiquitin-protein ligase MARCH5 (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V).
Mitochondrial E3 ubiquitin-protein ligase that plays
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a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control ().
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E3 ubiquitin-protein ligase MARCH6

 E3 ubiquitin-protein ligase MARCH6 ELISA Kit
 E3 ubiquitin-protein ligase MARCH6 Recombinant
 E3 ubiquitin-protein ligase MARCH6 Antibody
Also known as E3 ubiquitin-protein ligase MARCH6 (Doa10 homolog) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) (Protein TEB-4) (RING finger protein 176).
MARCH6: E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane pro
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tein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 5p15.2

Cellular Component: integral to endoplasmic reticulum membrane; integral to membrane; membrane

Molecular Function: enzyme binding; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity

Biological Process: ER-associated protein catabolic process; proteasomal protein catabolic process
 RNF176 ELISA Kit
 RNF176 Recombinant
 RNF176 Antibody
 TEB4 ELISA Kit
 TEB4 Recombinant
 TEB4 Antibody
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E3 ubiquitin-protein ligase MARCH7

 E3 ubiquitin-protein ligase MARCH7 ELISA Kit
 E3 ubiquitin-protein ligase MARCH7 Recombinant
 E3 ubiquitin-protein ligase MARCH7 Antibody
Also known as E3 ubiquitin-protein ligase MARCH7 (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII).
MARCH7: E3 ubiquitin-protein ligase
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which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Biological Process: negative regulation of T cell proliferation; regulation of tolerance induction
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E3 ubiquitin-protein ligase MARCH8

 E3 ubiquitin-protein ligase MARCH8 ELISA Kit
 E3 ubiquitin-protein ligase MARCH8 Recombinant
 E3 ubiquitin-protein ligase MARCH8 Antibody
Also known as E3 ubiquitin-protein ligase MARCH8 (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII).
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MARCH8: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: endosome; lysosome

Molecular Function: MHC class II protein binding; ubiquitin-protein ligase activity

Biological Process: antigen processing and presentation of peptide antigen via MHC class II; negative regulation of MHC class II biosynthetic process; protein polyubiquitination; protein ubiquitination
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E3 ubiquitin-protein ligase MARCH9

 E3 ubiquitin-protein ligase MARCH9 ELISA Kit
 E3 ubiquitin-protein ligase MARCH9 Recombinant
 E3 ubiquitin-protein ligase MARCH9 Antibody
Also known as E3 ubiquitin-protein ligase MARCH9 (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX).
MARCH9: E3 ubiquitin-protein ligase that may mediat
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e ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: Golgi stack; trans-Golgi network
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E3 ubiquitin-protein ligase MBR1

 E3 ubiquitin-protein ligase MBR1 ELISA Kit
 E3 ubiquitin-protein ligase MBR1 Recombinant
 E3 ubiquitin-protein ligase MBR1 Antibody
Also known as E3 ubiquitin-protein ligase MBR1 (MED25-binding RING-H2 protein 1) (RING-H2 finger MBR1).
E3 ubiquitin-protein ligase that functions as regulator of MED25 stability by targeting MED25 for degradation in a RING-H2-dependent way. Proteasome-dependent degradation of MED25 seems to activate its function as positive regulator of FLOWERING LOCUS T (FT) and is important to induce the expression of FT and consequently to promote flowering.
 MBR1 ELISA Kit
 MBR1 Recombinant
 MBR1 Antibody
 At2g15530 ELISA Kit
 At2g15530 Recombinant
 At2g15530 Antibody
 F9O13 ELISA Kit
 F9O13 Recombinant
 F9O13 Antibody
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E3 ubiquitin-protein ligase MBR2

 E3 ubiquitin-protein ligase MBR2 ELISA Kit
 E3 ubiquitin-protein ligase MBR2 Recombinant
 E3 ubiquitin-protein ligase MBR2 Antibody
Also known as E3 ubiquitin-protein ligase MBR2 (HAL3-interacting protein 1 homolog) (AtHIP1) (MED25-binding RING-H2 protein 2) (RING-H2 finger MBR2).
E3 ubiquitin-protein ligase that functions as regulator of MED25 stability by targeting MED25 for degradation in a RING-H2-dependent way. Proteasome-dependent degradation of MED25 seems to activate its function as positive regulator of FLOWERING LOCUS T (FT) and is important to induce the expression of FT and consequently to promote flowering. May function downstream of HAL3 and be required for HAL3-regulated plant growth. Activation of MBR2 b
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y HAL3 may lead to the degradation of cell cycle suppressors, resulting in enhancement of cell division and plant growth.
 MBR2 ELISA Kit
 MBR2 Recombinant
 MBR2 Antibody
 HIP1 ELISA Kit
 HIP1 Recombinant
 HIP1 Antibody
 At4g34040 ELISA Kit
 At4g34040 Recombinant
 At4g34040 Antibody
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E3 ubiquitin-protein ligase Mdm2

 E3 ubiquitin-protein ligase Mdm2 ELISA Kit
 E3 ubiquitin-protein ligase Mdm2 Recombinant
 E3 ubiquitin-protein ligase Mdm2 Antibody
Also known as E3 ubiquitin-protein ligase Mdm2 (Double minute 2 protein) (Cdm2) (p53-binding protein Mdm2).
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself a
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nd ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells ().
 MDM2 ELISA Kit
 MDM2 Recombinant
 MDM2 Antibody
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E3 ubiquitin-protein ligase MGRN1

 E3 ubiquitin-protein ligase MGRN1 ELISA Kit
 E3 ubiquitin-protein ligase MGRN1 Recombinant
 E3 ubiquitin-protein ligase MGRN1 Antibody
Also known as E3 ubiquitin-protein ligase MGRN1 (Mahogunin RING finger protein 1).
MGRN1: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-i
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nduced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; early endosome; membrane; nucleus

Molecular Function: ubiquitin-protein ligase activity

Biological Process: endosome to lysosome transport; negative regulation of G-protein coupled receptor protein signaling pathway; protein monoubiquitination; protein polyubiquitination
 Mgrn1 ELISA Kit
 Mgrn1 Recombinant
 Mgrn1 Antibody
 Kiaa0544 ELISA Kit
 Kiaa0544 Recombinant
 Kiaa0544 Antibody
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E3 ubiquitin-protein ligase MIB1

 E3 ubiquitin-protein ligase MIB1 ELISA Kit
 E3 ubiquitin-protein ligase MIB1 Recombinant
 E3 ubiquitin-protein ligase MIB1 Antibody
Also known as E3 ubiquitin-protein ligase MIB1 (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1).
MIB1: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis. Mediates 'Lys-63'-linked polyubiquitination o
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f TBK1, which probably participates in kinase activation. Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: centrosome; cytoplasmic vesicle; postsynaptic density

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: blood vessel development; heart development; heart looping; in utero embryonic development; negative regulation of neuron differentiation; neural tube formation; Notch signaling pathway; positive regulation of endocytosis; somitogenesis
 Mib1 ELISA Kit
 Mib1 Recombinant
 Mib1 Antibody
 Dip1 ELISA Kit
 Dip1 Recombinant
 Dip1 Antibody
 Kiaa1323 ELISA Kit
 Kiaa1323 Recombinant
 Kiaa1323 Antibody
 Mib ELISA Kit
 Mib Recombinant
 Mib Antibody
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E3 ubiquitin-protein ligase MIB2

 E3 ubiquitin-protein ligase MIB2 ELISA Kit
 E3 ubiquitin-protein ligase MIB2 Recombinant
 E3 ubiquitin-protein ligase MIB2 Antibody
Also known as E3 ubiquitin-protein ligase MIB2 (Dystrophin-like protein) (Dyslike) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin).
MIB2: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delt
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a receptors. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: early endosome; ubiquitin ligase complex

Molecular Function: signal transducer activity; ubiquitin-protein ligase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; protein ubiquitination
 Mib2 ELISA Kit
 Mib2 Recombinant
 Mib2 Antibody
 Skd ELISA Kit
 Skd Recombinant
 Skd Antibody
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E3 ubiquitin-protein ligase Midline-1

 E3 ubiquitin-protein ligase Midline-1 ELISA Kit
 E3 ubiquitin-protein ligase Midline-1 Recombinant
 E3 ubiquitin-protein ligase Midline-1 Antibody
Also known as E3 ubiquitin-protein ligase Midline-1 (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (Tripartite motif-containing protein 18).
MID1: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1). A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypos
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padias in males and splayed labia in females, lip-palate- laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. MID1 mutations produce proteins with a decreased affinity for microtubules. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: cytoplasmic microtubule; cytosol; microtubule; microtubule associated complex

Molecular Function: identical protein binding; microtubule binding; phosphoprotein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; ubiquitin protein ligase binding

Biological Process: microtubule cytoskeleton organization and biogenesis; pattern specification process; positive regulation of stress-activated MAPK cascade

Disease: Opitz Gbbb Syndrome, X-linked; Tracheoesophageal Fistula With Or Without Esophageal Atresia
 MID1 ELISA Kit
 MID1 Recombinant
 MID1 Antibody
 FXY ELISA Kit
 FXY Recombinant
 FXY Antibody
 RNF59 ELISA Kit
 RNF59 Recombinant
 RNF59 Antibody
 TRIM18 ELISA Kit
 TRIM18 Recombinant
 TRIM18 Antibody
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E3 ubiquitin-protein ligase MIEL1

 E3 ubiquitin-protein ligase MIEL1 ELISA Kit
 E3 ubiquitin-protein ligase MIEL1 Recombinant
 E3 ubiquitin-protein ligase MIEL1 Antibody
Also known as E3 ubiquitin-protein ligase MIEL1 (MYB30-interacting E3 ligase 1).
Encodes a RING-type E3 ubiquitin ligase that interacts with and ubiquitinates MYB30, leads to MYB30 proteasomal degradation and downregulation of its transcriptional activity. Since MYB30 is a positive regulator of Arabidopsis HR and defence responses, MIEL1 is involved in the negative regulation of these processes.
 MIEL1 ELISA Kit
 MIEL1 Recombinant
 MIEL1 Antibody
 At5g18650 ELISA Kit
 At5g18650 Recombinant
 At5g18650 Antibody
 T1A4.30 ELISA Kit
 T1A4.30 Recombinant
 T1A4.30 Antibody
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E3 ubiquitin-protein ligase mind-bomb

 E3 ubiquitin-protein ligase mind-bomb ELISA Kit
 E3 ubiquitin-protein ligase mind-bomb Recombinant
 E3 ubiquitin-protein ligase mind-bomb Antibody
Also known as E3 ubiquitin-protein ligase mind-bomb (Mind bomb homolog) (D-mib).
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibitio
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n, a neur- and Dl-dependent signaling event, suggesting a distinct but partially complementary function with neur.
 mib1 ELISA Kit
 mib1 Recombinant
 mib1 Antibody
 mind-bomb ELISA Kit
 mind-bomb Recombinant
 mind-bomb Antibody
 CG5841 ELISA Kit
 CG5841 Recombinant
 CG5841 Antibody
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E3 ubiquitin-protein ligase MIR1

 E3 ubiquitin-protein ligase MIR1 ELISA Kit
 E3 ubiquitin-protein ligase MIR1 Recombinant
 E3 ubiquitin-protein ligase MIR1 Antibody
Also known as E3 ubiquitin-protein ligase MIR1 (IE1B protein) (Modulator of immune recognition 1) (ORF K3).
E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes. Binds target molecules through transmembrane interaction. E3 ubiquitin-protein ligases accept ub
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iquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Induces ubiquitination not only on lysines, but also on cysteine residues.
 K3 ELISA Kit
 K3 Recombinant
 K3 Antibody
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E3 ubiquitin-protein ligase MIR2

 E3 ubiquitin-protein ligase MIR2 ELISA Kit
 E3 ubiquitin-protein ligase MIR2 Recombinant
 E3 ubiquitin-protein ligase MIR2 Antibody
Also known as E3 ubiquitin-protein ligase MIR2 (IE1A protein) (Modulator of immune recognition 2) (ORF K5).
E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I, CD86, ICAM1 and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. Binds target molecules through transmembrane interaction. E3 ubiquitin-
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protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Specific for HLA-A and HLA-B2 alleles.
 K5 ELISA Kit
 K5 Recombinant
 K5 Antibody
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E3 ubiquitin-protein ligase MSL2

 E3 ubiquitin-protein ligase MSL2 ELISA Kit
 E3 ubiquitin-protein ligase MSL2 Recombinant
 E3 ubiquitin-protein ligase MSL2 Antibody
Also known as E3 ubiquitin-protein ligase MSL2 (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184).
MSL2: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Belongs to the MSL2 family.

Protein type: Ubiquitin conjugating system
 Msl2 ELISA Kit
 Msl2 Recombinant
 Msl2 Antibody
 Kiaa1585 ELISA Kit
 Kiaa1585 Recombinant
 Kiaa1585 Antibody
 Msl2l1 ELISA Kit
 Msl2l1 Recombinant
 Msl2l1 Antibody
 Rnf184 ELISA Kit
 Rnf184 Recombinant
 Rnf184 Antibody
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E3 ubiquitin-protein ligase msl-2

 E3 ubiquitin-protein ligase msl-2 ELISA Kit
 E3 ubiquitin-protein ligase msl-2 Recombinant
 E3 ubiquitin-protein ligase msl-2 Antibody
Also known as E3 ubiquitin-protein ligase msl-2 (Protein male-specific lethal-2).
The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B.
 msl-2 ELISA Kit
 msl-2 Recombinant
 msl-2 Antibody
 CG3241 ELISA Kit
 CG3241 Recombinant
 CG3241 Antibody
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E3 ubiquitin-protein ligase MYCBP2

 E3 ubiquitin-protein ligase MYCBP2 ELISA Kit
 E3 ubiquitin-protein ligase MYCBP2 Recombinant
 E3 ubiquitin-protein ligase MYCBP2 Antibody
Also known as E3 ubiquitin-protein ligase MYCBP2 (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc).
MYCBP2: Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis. Belongs to the highwire family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

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Cellular Component: axon; membrane; microtubule cytoskeleton

Molecular Function: protein binding; protein homodimerization activity

Biological Process: branchiomotor neuron axon guidance; central nervous system projection neuron axonogenesis; motor axon guidance; negative regulation of protein catabolic process; neuron morphogenesis during differentiation; regulation of cytoskeleton organization and biogenesis; regulation of protein localization
 Mycbp2 ELISA Kit
 Mycbp2 Recombinant
 Mycbp2 Antibody
 Pam ELISA Kit
 Pam Recombinant
 Pam Antibody
 Phr1 ELISA Kit
 Phr1 Recombinant
 Phr1 Antibody
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E3 ubiquitin-protein ligase MYLIP

 E3 ubiquitin-protein ligase MYLIP ELISA Kit
 E3 ubiquitin-protein ligase MYLIP Recombinant
 E3 ubiquitin-protein ligase MYLIP Antibody
Also known as E3 ubiquitin-protein ligase MYLIP (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR).
MYLIP: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a
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sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: cytoskeleton; cytosol; intracellular

Molecular Function: cytoskeletal protein binding; protein binding; structural constituent of cytoskeleton; ubiquitin-protein ligase activity

Biological Process: actomyosin structure organization and biogenesis; cell motility; nervous system development; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 MYLIP ELISA Kit
 MYLIP Recombinant
 MYLIP Antibody
 BZF1 ELISA Kit
 BZF1 Recombinant
 BZF1 Antibody
 IDOL ELISA Kit
 IDOL Recombinant
 IDOL Antibody
 BM-023 ELISA Kit
 BM-023 Recombinant
 BM-023 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase MYLIP-A

 E3 ubiquitin-protein ligase MYLIP-A ELISA Kit
 E3 ubiquitin-protein ligase MYLIP-A Recombinant
 E3 ubiquitin-protein ligase MYLIP-A Antibody
Also known as E3 ubiquitin-protein ligase MYLIP-A (Myosin regulatory light chain-interacting protein A) (MIR-A).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway.
 mylipa ELISA Kit
 mylipa Recombinant
 mylipa Antibody
 mir ELISA Kit
 mir Recombinant
 mir Antibody
 mylip ELISA Kit
 mylip Recombinant
 mylip Antibody
 si:ch211-266j17.1 ELISA Kit
 si:ch211-266j17.1 Recombinant
 si:ch211-266j17.1 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase MYLIP-B

 E3 ubiquitin-protein ligase MYLIP-B ELISA Kit
 E3 ubiquitin-protein ligase MYLIP-B Recombinant
 E3 ubiquitin-protein ligase MYLIP-B Antibody
Also known as E3 ubiquitin-protein ligase MYLIP-B (Myosin regulatory light chain-interacting protein B) (MIR-B).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway ().
 mylipb ELISA Kit
 mylipb Recombinant
 mylipb Antibody
 zgc:153767 ELISA Kit
 zgc:153767 Recombinant
 zgc:153767 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase NEDD4

 E3 ubiquitin-protein ligase NEDD4 ELISA Kit
 E3 ubiquitin-protein ligase NEDD4 Recombinant
 E3 ubiquitin-protein ligase NEDD4 Antibody
Also known as E3 ubiquitin-protein ligase NEDD4 (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4).
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the r
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egulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
 NEDD4 ELISA Kit
 NEDD4 Recombinant
 NEDD4 Antibody
 KIAA0093 ELISA Kit
 KIAA0093 Recombinant
 KIAA0093 Antibody
 NEDD4-1 ELISA Kit
 NEDD4-1 Recombinant
 NEDD4-1 Antibody
 PIG53 ELISA Kit
 PIG53 Recombinant
 PIG53 Antibody
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E3 ubiquitin-protein ligase Nedd-4

 E3 ubiquitin-protein ligase Nedd-4 ELISA Kit
 E3 ubiquitin-protein ligase Nedd-4 Recombinant
 E3 ubiquitin-protein ligase Nedd-4 Antibody
Also known as E3 ubiquitin-protein ligase Nedd-4 (DNedd4) (HECT-type E3 ubiquitin transferase NEDD4).
Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradat
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ion.
 Nedd4 ELISA Kit
 Nedd4 Recombinant
 Nedd4 Antibody
 CG7555 ELISA Kit
 CG7555 Recombinant
 CG7555 Antibody
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E3 ubiquitin-protein ligase NEDD4-like

 E3 ubiquitin-protein ligase NEDD4-like ELISA Kit
 E3 ubiquitin-protein ligase NEDD4-like Recombinant
 E3 ubiquitin-protein ligase NEDD4-like Antibody
Also known as E3 ubiquitin-protein ligase NEDD4-like (HECT-type E3 ubiquitin transferase NED4L).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Pro
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motes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes.
 NEDD4L ELISA Kit
 NEDD4L Recombinant
 NEDD4L Antibody
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E3 ubiquitin-protein ligase NEURL1

 E3 ubiquitin-protein ligase NEURL1 ELISA Kit
 E3 ubiquitin-protein ligase NEURL1 Recombinant
 E3 ubiquitin-protein ligase NEURL1 Antibody
Also known as E3 ubiquitin-protein ligase NEURL1 (Neuralized-like protein 1A) (h-neu) (h-neuralized 1) (RING finger protein 67).
NEURL1: May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 10q25.1

Cellular Component: dendritic spi
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ne; perikaryon; plasma membrane; postsynaptic density

Molecular Function: translation factor activity, non-nucleic acid binding; ubiquitin-protein ligase activity

Biological Process: negative regulation of cell proliferation; negative regulation of Notch signaling pathway; nervous system development; positive regulation of apoptosis; positive regulation of filopodium formation; positive regulation of long-term neuronal synaptic plasticity; protein monoubiquitination
 NEURL1 ELISA Kit
 NEURL1 Recombinant
 NEURL1 Antibody
 NEURL ELISA Kit
 NEURL Recombinant
 NEURL Antibody
 NEURL1A ELISA Kit
 NEURL1A Recombinant
 NEURL1A Antibody
 RNF67 ELISA Kit
 RNF67 Recombinant
 RNF67 Antibody
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E3 ubiquitin-protein ligase NEURL1B

 E3 ubiquitin-protein ligase NEURL1B ELISA Kit
 E3 ubiquitin-protein ligase NEURL1B Recombinant
 E3 ubiquitin-protein ligase NEURL1B Antibody
Also known as E3 ubiquitin-protein ligase NEURL1B (Neuralized-2) (NEUR2) (Neuralized-like protein 1B) (Neuralized-like protein 2) (Neuralized-like protein 3).
NEURL1B: E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ligase

Cellular Component: early endosome

Molecular Function: ligase activity; protein binding
 Neurl1b ELISA Kit
 Neurl1b Recombinant
 Neurl1b Antibody
 Neurl2 ELISA Kit
 Neurl2 Recombinant
 Neurl2 Antibody
 Neurl3 ELISA Kit
 Neurl3 Recombinant
 Neurl3 Antibody
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E3 ubiquitin-protein ligase NEURL3

 E3 ubiquitin-protein ligase NEURL3 ELISA Kit
 E3 ubiquitin-protein ligase NEURL3 Recombinant
 E3 ubiquitin-protein ligase NEURL3 Antibody
Also known as E3 ubiquitin-protein ligase NEURL3 (Lung-inducible neuralized-related C3CH4 RING domain protein) (Neuralized-like protein 3).
E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation ().
 Neurl3 ELISA Kit
 Neurl3 Recombinant
 Neurl3 Antibody
 Lincr ELISA Kit
 Lincr Recombinant
 Lincr Antibody
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E3 ubiquitin-protein ligase NHLRC1

 E3 ubiquitin-protein ligase NHLRC1 ELISA Kit
 E3 ubiquitin-protein ligase NHLRC1 Recombinant
 E3 ubiquitin-protein ligase NHLRC1 Antibody
Also known as E3 ubiquitin-protein ligase NHLRC1 (Malin) (NHL repeat-containing protein 1).
human homolog is a putative E3 ubiquitin ligase associated with Lafora progressive myoclonus epilepsy and possibly involved in clearance of polyglucosans from dendrites [RGD, Feb 2006]
 Nhlrc1 ELISA Kit
 Nhlrc1 Recombinant
 Nhlrc1 Antibody
 Epm2b ELISA Kit
 Epm2b Recombinant
 Epm2b Antibody
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E3 ubiquitin-protein ligase NRDP1

 E3 ubiquitin-protein ligase NRDP1 ELISA Kit
 E3 ubiquitin-protein ligase NRDP1 Recombinant
 E3 ubiquitin-protein ligase NRDP1 Antibody
Also known as E3 ubiquitin-protein ligase NRDP1 (RING finger protein 41).
RNF41: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cel
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l differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Molecular Function: erythropoietin receptor binding; interleukin-3 receptor binding; protein binding; Ral GTPase binding; ubiquitin-protein ligase activity

Biological Process: negative regulation of cell migration; negative regulation of cell proliferation; positive regulation of transcription factor activity; proteasomal protein catabolic process; protein autoubiquitination; protein polyubiquitination; protein ubiquitination; regulation of gene expression; regulation of lymphocyte differentiation; regulation of MAPKKK cascade; regulation of myeloid cell differentiation; regulation of protein kinase B signaling cascade
 Rnf41 ELISA Kit
 Rnf41 Recombinant
 Rnf41 Antibody
 Flrf ELISA Kit
 Flrf Recombinant
 Flrf Antibody
 Nrdp1 ELISA Kit
 Nrdp1 Recombinant
 Nrdp1 Antibody
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E3 ubiquitin-protein ligase ORTHRUS 1

 E3 ubiquitin-protein ligase ORTHRUS 1 ELISA Kit
 E3 ubiquitin-protein ligase ORTHRUS 1 Recombinant
 E3 ubiquitin-protein ligase ORTHRUS 1 Antibody
Also known as E3 ubiquitin-protein ligase ORTHRUS 1 (Protein VARIANT IN METHYLATION 3).
Encodes the VIM3/ORTH1 protein that is similar to VIM1. This protein has an N-terminal PHD domain and two RING domains surrounding an SRA domain. The protein has been shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the former. This protein functions as an E3 ubiquitin ligase in vitro with members of the UBC8 family E2s. Either of the two RING domains present in the protein can promote ubiquitylation in vitro, but, not the PHD domain. Over-expres
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sion of ORTH1/VIM3 leads to decreased levels of FWA methylation, increased levels of FWA transcripts, and delayed flowering. Cen180 repeats are also hypomethylated in plants overexpressing this protein.
 ORTH1 ELISA Kit
 ORTH1 Recombinant
 ORTH1 Antibody
 VIM3 ELISA Kit
 VIM3 Recombinant
 VIM3 Antibody
 At5g39550 ELISA Kit
 At5g39550 Recombinant
 At5g39550 Antibody
 MIJ24.3 ELISA Kit
 MIJ24.3 Recombinant
 MIJ24.3 Antibody
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E3 ubiquitin-protein ligase ORTHRUS 2

 E3 ubiquitin-protein ligase ORTHRUS 2 ELISA Kit
 E3 ubiquitin-protein ligase ORTHRUS 2 Recombinant
 E3 ubiquitin-protein ligase ORTHRUS 2 Antibody
Also known as E3 ubiquitin-protein ligase ORTHRUS 2 (Protein VARIANT IN METHYLATION 1).
Encodes a 645-amino acid methylcytosine-binding protein with a PHD domain, two RING finger domains, and an SRA domain that is involved in centromere heterochromatinization. This protein functions as an E3 ubiquitin ligase in vitro. The protein has been shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the former. It plays a role in the establishment/maintenance of chromatin structure during cell division and is localized in the nucleus. Plants ove
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r-expressing VIM1/ORTH2 show an inhibition in root growth and a delay in flowering. Both over-expression of GFP:ORTH2 and loss of ORTH2/VIM1 lead to decreased levels of DNA methylation. GFP:ORTH2 over-expressers also have increased levels of FWA transcripts.
 ORTH2 ELISA Kit
 ORTH2 Recombinant
 ORTH2 Antibody
 VIM1 ELISA Kit
 VIM1 Recombinant
 VIM1 Antibody
 At1g57820 ELISA Kit
 At1g57820 Recombinant
 At1g57820 Antibody
 F12K22.14 ELISA Kit
 F12K22.14 Recombinant
 F12K22.14 Antibody
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E3 ubiquitin-protein ligase ORTHRUS 3

 E3 ubiquitin-protein ligase ORTHRUS 3 ELISA Kit
 E3 ubiquitin-protein ligase ORTHRUS 3 Recombinant
 E3 ubiquitin-protein ligase ORTHRUS 3 Antibody
Also known as E3 ubiquitin-protein ligase ORTHRUS 3 (Protein VARIANT IN METHYLATION 5).
predicted to encode a protein with an N-terminal PHD domain and two RING domains surrounding an SRA domain. Attempts to isolate ORTH3/VIM5 cDNA through RT-PCR were unsuccessful and only one Arabidopsis EST is associated with this locus. A paternally expressed imprinted gene.
 ORTH3 ELISA Kit
 ORTH3 Recombinant
 ORTH3 Antibody
 VIM5 ELISA Kit
 VIM5 Recombinant
 VIM5 Antibody
 At1g57800 ELISA Kit
 At1g57800 Recombinant
 At1g57800 Antibody
 F12K22.15 ELISA Kit
 F12K22.15 Recombinant
 F12K22.15 Antibody
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E3 ubiquitin-protein ligase ORTHRUS 5

 E3 ubiquitin-protein ligase ORTHRUS 5 ELISA Kit
 E3 ubiquitin-protein ligase ORTHRUS 5 Recombinant
 E3 ubiquitin-protein ligase ORTHRUS 5 Antibody
Also known as E3 ubiquitin-protein ligase ORTHRUS 5 (Protein VARIANT IN METHYLATION 2).
Encodes a protein that is similar to VIM1 but is not involved in cytosine methylation. This protein has an N-terminal PHD domain and two RING domains surrounding an SRA domain. ORTH5/VIM2 has E3 ubiquitin ligase activity in vitro.
 ORTH5 ELISA Kit
 ORTH5 Recombinant
 ORTH5 Antibody
 VIM2 ELISA Kit
 VIM2 Recombinant
 VIM2 Antibody
 At1g66050 ELISA Kit
 At1g66050 Recombinant
 At1g66050 Antibody
 F15E12.5 ELISA Kit
 F15E12.5 Recombinant
 F15E12.5 Antibody
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E3 ubiquitin-protein ligase ORTHRUS-LIKE 1

 E3 ubiquitin-protein ligase ORTHRUS-LIKE 1 ELISA Kit
 E3 ubiquitin-protein ligase ORTHRUS-LIKE 1 Recombinant
 E3 ubiquitin-protein ligase ORTHRUS-LIKE 1 Antibody
Also known as E3 ubiquitin-protein ligase ORTHRUS-LIKE 1 (ORTH-LIKE 1) (Protein VARIANT IN METHYLATION 6).
E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11.
 ORTHL ELISA Kit
 ORTHL Recombinant
 ORTHL Antibody
 ORL1 ELISA Kit
 ORL1 Recombinant
 ORL1 Antibody
 VIM6 ELISA Kit
 VIM6 Recombinant
 VIM6 Antibody
 At4g08590 ELISA Kit
 At4g08590 Recombinant
 At4g08590 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase Os03g0188200

 E3 ubiquitin-protein ligase Os03g0188200 ELISA Kit
 E3 ubiquitin-protein ligase Os03g0188200 Recombinant
 E3 ubiquitin-protein ligase Os03g0188200 Antibody
Also known as E3 ubiquitin-protein ligase Os03g0188200 (RING-H2 finger protein Os03g0188200) (RING-type E3 ubiquitin transferase Os03g0188200).
Possesses E3 ubiquitin-protein ligase in vitro.
 Os03g0188200 ELISA Kit
 Os03g0188200 Recombinant
 Os03g0188200 Antibody
 LOC_Os03g08920 ELISA Kit
 LOC_Os03g08920 Recombinant
 LOC_Os03g08920 Antibody
 OJ1217B09.7 ELISA Kit
 OJ1217B09.7 Recombinant
 OJ1217B09.7 Antibody
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E3 ubiquitin-protein ligase Os04g0590900

 E3 ubiquitin-protein ligase Os04g0590900 ELISA Kit
 E3 ubiquitin-protein ligase Os04g0590900 Recombinant
 E3 ubiquitin-protein ligase Os04g0590900 Antibody
Also known as E3 ubiquitin-protein ligase Os04g0590900 (RING-H2 finger protein Os04g0590900) (RING-type E3 ubiquitin transferase Os04g0590900).
Possesses E3 ubiquitin-protein ligase in vitro.
 Os04g0590900 ELISA Kit
 Os04g0590900 Recombinant
 Os04g0590900 Antibody
 LOC_Os04g50100 ELISA Kit
 LOC_Os04g50100 Recombinant
 LOC_Os04g50100 Antibody
 OsJ_15972 ELISA Kit
 OsJ_15972 Recombinant
 OsJ_15972 Antibody
 OSJNBa0086O06.21 ELISA Kit
 OSJNBa0086O06.21 Recombinant
 OSJNBa0086O06.21 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase Os06g0535400

 E3 ubiquitin-protein ligase Os06g0535400 ELISA Kit
 E3 ubiquitin-protein ligase Os06g0535400 Recombinant
 E3 ubiquitin-protein ligase Os06g0535400 Antibody
Also known as E3 ubiquitin-protein ligase Os06g0535400 (RING-H2 finger protein Os06g0535400) (RING-type E3 ubiquitin transferase Os06g0535400).
Possesses E3 ubiquitin-protein ligase in vitro.
 Os06g0535400 ELISA Kit
 Os06g0535400 Recombinant
 Os06g0535400 Antibody
 LOC_Os06g34450 ELISA Kit
 LOC_Os06g34450 Recombinant
 LOC_Os06g34450 Antibody
 OSJNBa0001B21.23 ELISA Kit
 OSJNBa0001B21.23 Recombinant
 OSJNBa0001B21.23 Antibody
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E3 ubiquitin-protein ligase p28

 E3 ubiquitin-protein ligase p28 ELISA Kit
 E3 ubiquitin-protein ligase p28 Recombinant
 E3 ubiquitin-protein ligase p28 Antibody
RING-finger E3 ubiquitin ligase which catalyzes the formation of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Plays an important role in virulence by acting as an anti-apoptotic factor.
 p28 ELISA Kit
 p28 Recombinant
 p28 Antibody
 EVM1012 ELISA Kit
 EVM1012 Recombinant
 EVM1012 Antibody
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E3 ubiquitin-protein ligase p28-like

 E3 ubiquitin-protein ligase p28-like ELISA Kit
 E3 ubiquitin-protein ligase p28-like Recombinant
 E3 ubiquitin-protein ligase p28-like Antibody
RING-finger E3 ubiquitin ligase which catalyzes the formation of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Plays an important role in virulence by acting as an anti-apoptotic factor ().
 p28 ELISA Kit
 p28 Recombinant
 p28 Antibody
 m8008R ELISA Kit
 m8008R Recombinant
 m8008R Antibody
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E3 ubiquitin-protein ligase parkin

 E3 ubiquitin-protein ligase parkin ELISA Kit
 E3 ubiquitin-protein ligase parkin Recombinant
 E3 ubiquitin-protein ligase parkin Antibody
PARK2: a component of a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. P
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articipates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'- linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria. Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in role in regulation of neuron death. Limits the production of reactive oxygen species (ROS). Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Regulates cyclin-E during neuronal apoptosis. May represent a tumor suppressor gene. Forms an E3 ubiquitin ligase complex with UBE2L3 or UBE2L6. Mediates 'Lys-63'-linked polyubiquitination by associating with UBE2V1. Part of a SCF-like complex, consisting of PARK2, CUL1 and FBXW7. Part of a complex, including STUB1, HSP70 and GPR37. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2 and GPR37, thus facilitating PARK2-mediated GPR37 ubiquitination. HSP70 transiently associates with unfolded GPR37 and inhibits the E3 activity of PARK2, whereas, STUB1 enhances the E3 activity of PARK2 through promotion of dissociation of HSP70 from PARK2-GPR37 complexes. Interacts with PSMD4 and PACRG. Interacts with LRRK2. Interacts with RANBP2. Interacts with SUMO1 but not SUMO2, which promotes nuclear localization and autoubiquitination. Interacts (via first RING- type domain) with AIMP2 (via N-terminus). Interacts with PSMA7 and RNF41. Interacts with PINK1. Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons from kainate-mediated apoptosis. Found in serum. Belongs to the RBR family. Parkin subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; intracellular; lipid raft; mitochondrion; neuron projection; nucleus; perinuclear region of cytoplasm; postsynaptic density; protein complex; SCF ubiquitin ligase complex; synapse; synaptic vesicle; synaptic vesicle membrane; terminal button; ubiquitin ligase complex

Molecular Function: actin binding; beta-catenin binding; chaperone binding; enzyme binding; G-protein-coupled receptor binding; heat shock protein binding; histone deacetylase binding; Hsp70 protein binding; identical protein binding; kinase binding; PDZ domain binding; phospholipase binding; protein binding; protein complex binding; protein kinase binding; tubulin binding; ubiquitin binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: adult locomotory behavior; cellular protein catabolic process; dopamine metabolic process; dopamine uptake; learning; locomotory behavior; macromitophagy; mitochondrial fission; mitochondrion degradation; mitochondrion localization; mitochondrion organization and biogenesis; negative regulation of actin filament bundle formation; negative regulation of glucokinase activity; negative regulation of insulin secretion; negative regulation of JNK cascade; negative regulation of neuron apoptosis; negative regulation of protein amino acid phosphorylation; negative regulation of synaptic transmission, glutamatergic; negative regulation of transcription from RNA polymerase II promoter; neuron maturation; norepinephrine metabolic process; positive regulation of DNA binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of neurotransmitter uptake; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; proteasomal protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein destabilization; protein metabolic process; protein modification process; protein monoubiquitination; protein polyubiquitination; protein stabilization; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of apoptosis; regulation of autophagy; regulation of dopamine metabolic process; regulation of mitochondrial membrane potential; regulation of neurotransmitter secretion; regulation of protein ubiquitination; regulation of synaptic transmission; response to corticosterone stimulus; response to drug; response to oxidative stress; response to unfolded protein; startle response; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; ubiquitin-dependent protein catabolic process; zinc ion homeostasis
 Park2 ELISA Kit
 Park2 Recombinant
 Park2 Antibody
 Prkn ELISA Kit
 Prkn Recombinant
 Prkn Antibody
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E3 ubiquitin-protein ligase PDZRN3

 E3 ubiquitin-protein ligase PDZRN3 ELISA Kit
 E3 ubiquitin-protein ligase PDZRN3 Recombinant
 E3 ubiquitin-protein ligase PDZRN3 Antibody
Also known as E3 ubiquitin-protein ligase PDZRN3 (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3).
PDZRN3: E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system;
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Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3p13

Cellular Component: neuromuscular junction

Molecular Function: ubiquitin-protein ligase activity

Biological Process: neuromuscular junction development; protein ubiquitination
 PDZRN3 ELISA Kit
 PDZRN3 Recombinant
 PDZRN3 Antibody
 KIAA1095 ELISA Kit
 KIAA1095 Recombinant
 KIAA1095 Antibody
 LNX3 ELISA Kit
 LNX3 Recombinant
 LNX3 Antibody
 SEMCAP3 ELISA Kit
 SEMCAP3 Recombinant
 SEMCAP3 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase pellino homolog 1

 E3 ubiquitin-protein ligase pellino homolog 1 ELISA Kit
 E3 ubiquitin-protein ligase pellino homolog 1 Recombinant
 E3 ubiquitin-protein ligase pellino homolog 1 Antibody
Also known as E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1).
PELI1: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Fou
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nd in a complex containing TRAF6, IRAK1 and IRAK4. Interacts with MAP3K7. Belongs to the pellino family.

Protein type: Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: nucleus

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of T cell activation; negative regulation of T cell proliferation; positive regulation of B cell activation; positive regulation of B cell proliferation; positive regulation of cytokine production; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein ubiquitination; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; protein polyubiquitination; response to dsRNA; response to lipopolysaccharide
 Peli1 ELISA Kit
 Peli1 Recombinant
 Peli1 Antibody
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E3 ubiquitin-protein ligase pellino homolog 2

 E3 ubiquitin-protein ligase pellino homolog 2 ELISA Kit
 E3 ubiquitin-protein ligase pellino homolog 2 Recombinant
 E3 ubiquitin-protein ligase pellino homolog 2 Antibody
Also known as E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2).
PELI2: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate the MAP (mitogen activated prote
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in) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation. Belongs to the pellino family.

Protein type: Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytosol; membrane; protein complex

Molecular Function: protein binding

Biological Process: positive regulation of MAPKKK cascade; positive regulation of protein amino acid phosphorylation
 Peli2 ELISA Kit
 Peli2 Recombinant
 Peli2 Antibody
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E3 ubiquitin-protein ligase pellino homolog 3

 E3 ubiquitin-protein ligase pellino homolog 3 ELISA Kit
 E3 ubiquitin-protein ligase pellino homolog 3 Recombinant
 E3 ubiquitin-protein ligase pellino homolog 3 Antibody
Also known as E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3).
PELI3: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required f
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or NF-kappa-B activation. Belongs to the pellino family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: cytosol

Molecular Function: protein binding
 PELI3 ELISA Kit
 PELI3 Recombinant
 PELI3 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase PEP5

 E3 ubiquitin-protein ligase PEP5 ELISA Kit
 E3 ubiquitin-protein ligase PEP5 Recombinant
 E3 ubiquitin-protein ligase PEP5 Antibody
Also known as E3 ubiquitin-protein ligase PEP5 (Carboxypeptidase Y-deficient protein 5) (Histone E3 ligase PEP5) (Vacuolar biogenesis protein END1) (Vacuolar morphogenesis protein 1) (Vacuolar protein sorting-associated protein 11) (Vacuolar protein-target.
Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. It is required for gluconeogenic growth of yeast. Acts as component of the HOPS complex that acts during the docking
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stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion (PubMed:3062374, PubMed:10978279, PubMed:10944212, PubMed:16601699). Acts as component of the CORVET complex that is required for transport between endosome and vacuole. CORVET is an effector for the endosomal Rab GTPase VPS21 (PubMed:17488625). Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation (PubMed:22570702).
 PEP5 ELISA Kit
 PEP5 Recombinant
 PEP5 Antibody
 END1 ELISA Kit
 END1 Recombinant
 END1 Antibody
 VAM1 ELISA Kit
 VAM1 Recombinant
 VAM1 Antibody
 VPL9 ELISA Kit
 VPL9 Recombinant
 VPL9 Antibody
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E3 ubiquitin-protein ligase PIB1

 E3 ubiquitin-protein ligase PIB1 ELISA Kit
 E3 ubiquitin-protein ligase PIB1 Recombinant
 E3 ubiquitin-protein ligase PIB1 Antibody
Also known as E3 ubiquitin-protein ligase PIB1 (Phosphatidylinositol 3-phosphate-binding protein 1).
Functions as an E3 ubiquitin-protein ligase. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate.
 PIB1 ELISA Kit
 PIB1 Recombinant
 PIB1 Antibody
 YDR313C ELISA Kit
 YDR313C Recombinant
 YDR313C Antibody
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E3 ubiquitin-protein ligase Praja-1

 E3 ubiquitin-protein ligase Praja-1 ELISA Kit
 E3 ubiquitin-protein ligase Praja-1 Recombinant
 E3 ubiquitin-protein ligase Praja-1 Antibody
Also known as E3 ubiquitin-protein ligase Praja-1 (Praja1).
PJA1: Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiq
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uitin ligase

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: protein catabolic process; protein ubiquitination
 Pja1 ELISA Kit
 Pja1 Recombinant
 Pja1 Antibody
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E3 ubiquitin-protein ligase Praja-2

 E3 ubiquitin-protein ligase Praja-2 ELISA Kit
 E3 ubiquitin-protein ligase Praja-2 Recombinant
 E3 ubiquitin-protein ligase Praja-2 Antibody
Also known as E3 ubiquitin-protein ligase Praja-2 (Praja2).
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes ().
 PJA2 ELISA Kit
 PJA2 Recombinant
 PJA2 Antibody
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E3 ubiquitin-protein ligase PRT1

 E3 ubiquitin-protein ligase PRT1 ELISA Kit
 E3 ubiquitin-protein ligase PRT1 Recombinant
 E3 ubiquitin-protein ligase PRT1 Antibody
Also known as E3 ubiquitin-protein ligase PRT1 (Proteolysis 1 protein).
Contains two ring finger domains and one ZZ domain. Week similarity to yeast Rad18p. Putative component of the N-end rule pathway (ubiquitin-dependent proteolysis).
 PRT1 ELISA Kit
 PRT1 Recombinant
 PRT1 Antibody
 At3g24800 ELISA Kit
 At3g24800 Recombinant
 At3g24800 Antibody
 K7P8.9 ELISA Kit
 K7P8.9 Recombinant
 K7P8.9 Antibody
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E3 ubiquitin-protein ligase PRT6

 E3 ubiquitin-protein ligase PRT6 ELISA Kit
 E3 ubiquitin-protein ligase PRT6 Recombinant
 E3 ubiquitin-protein ligase PRT6 Antibody
Also known as E3 ubiquitin-protein ligase PRT6 (Protein PROTEOLYSIS 6).
Encodes PROTEOLYSIS6 (PRT6), a component of the N-end rule pathway that targets protein degradation through the identity of the amino-terminal residue of specific protein substrates. Another component of the N-end rule pathway is arginyl-tRNA:protein arginyltransferase (ATE). Arabidopsis contains two ATE genes: At5g05700/ATE1, At3g11240/ATE2. PRT6 and ATE were shown to regulate seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination.
 PRT6 ELISA Kit
 PRT6 Recombinant
 PRT6 Antibody
 CER3 ELISA Kit
 CER3 Recombinant
 CER3 Antibody
 At5g02310 ELISA Kit
 At5g02310 Recombinant
 At5g02310 Antibody
 T1E22.60 ELISA Kit
 T1E22.60 Recombinant
 T1E22.60 Antibody
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E3 ubiquitin-protein ligase ptr1

 E3 ubiquitin-protein ligase ptr1 ELISA Kit
 E3 ubiquitin-protein ligase ptr1 Recombinant
 E3 ubiquitin-protein ligase ptr1 Antibody
Also known as E3 ubiquitin-protein ligase ptr1 (HECT-type E3 ubiquitin transferase ptr1) (Poly(A)+ RNA transport protein 1).
Probable ubiquitin ligase protein involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Probably participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins su
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ch as rae1.
 ptr1 ELISA Kit
 ptr1 Recombinant
 ptr1 Antibody
 SPAC19D5.04 ELISA Kit
 SPAC19D5.04 Recombinant
 SPAC19D5.04 Antibody
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E3 ubiquitin-protein ligase pub1

 E3 ubiquitin-protein ligase pub1 ELISA Kit
 E3 ubiquitin-protein ligase pub1 Recombinant
 E3 ubiquitin-protein ligase pub1 Antibody
Also known as E3 ubiquitin-protein ligase pub1 (HECT-type E3 ubiquitin transferase pub1).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Regulates ubiquitination of cdc25.
 pub1 ELISA Kit
 pub1 Recombinant
 pub1 Antibody
 SPAC11G7.02 ELISA Kit
 SPAC11G7.02 Recombinant
 SPAC11G7.02 Antibody
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E3 ubiquitin-protein ligase pub2

 E3 ubiquitin-protein ligase pub2 ELISA Kit
 E3 ubiquitin-protein ligase pub2 Recombinant
 E3 ubiquitin-protein ligase pub2 Antibody
Also known as E3 ubiquitin-protein ligase pub2 (HECT-type E3 ubiquitin transferase pub2).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Has a role in the G2/M transition.
 pub2 ELISA Kit
 pub2 Recombinant
 pub2 Antibody
 SPAC1805.15c ELISA Kit
 SPAC1805.15c Recombinant
 SPAC1805.15c Antibody
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E3 ubiquitin-protein ligase PUB22

 E3 ubiquitin-protein ligase PUB22 ELISA Kit
 E3 ubiquitin-protein ligase PUB22 Recombinant
 E3 ubiquitin-protein ligase PUB22 Antibody
Also known as E3 ubiquitin-protein ligase PUB22 (Plant U-box protein 22) (U-box domain-containing protein 22).
Encodes a cytoplasmically localized U-box domain E3 ubiquitin ligase protein that is involved in the response to water stress and acts as a negative regulator of PAMP-triggered immunity.
 PUB22 ELISA Kit
 PUB22 Recombinant
 PUB22 Antibody
 At3g52450 ELISA Kit
 At3g52450 Recombinant
 At3g52450 Antibody
 F22O6_170 ELISA Kit
 F22O6_170 Recombinant
 F22O6_170 Antibody
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E3 ubiquitin-protein ligase PUB23

 E3 ubiquitin-protein ligase PUB23 ELISA Kit
 E3 ubiquitin-protein ligase PUB23 Recombinant
 E3 ubiquitin-protein ligase PUB23 Antibody
Also known as E3 ubiquitin-protein ligase PUB23 (Plant U-box protein 23) (U-box domain-containing protein 23).
Encodes a cytoplasmically localized U-box domain containing E3 ubiquitin ligase that is involved in the response to water stress and acts as a negative regulator of PAMP-triggered immunity.
 PUB23 ELISA Kit
 PUB23 Recombinant
 PUB23 Antibody
 At2g35930 ELISA Kit
 At2g35930 Recombinant
 At2g35930 Antibody
 F11F19.16 ELISA Kit
 F11F19.16 Recombinant
 F11F19.16 Antibody
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E3 ubiquitin-protein ligase PUB24

 E3 ubiquitin-protein ligase PUB24 ELISA Kit
 E3 ubiquitin-protein ligase PUB24 Recombinant
 E3 ubiquitin-protein ligase PUB24 Antibody
Also known as E3 ubiquitin-protein ligase PUB24 (Plant U-box protein 24) (U-box domain-containing protein 24).
Encodes a U-box-domain-containing E3 ubiquitin ligase that acts as a negative regulator of PAMP-triggered immunity.
 PUB24 ELISA Kit
 PUB24 Recombinant
 PUB24 Antibody
 At3g11840 ELISA Kit
 At3g11840 Recombinant
 At3g11840 Antibody
 F26K24.13 ELISA Kit
 F26K24.13 Recombinant
 F26K24.13 Antibody
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E3 ubiquitin-protein ligase pub3

 E3 ubiquitin-protein ligase pub3 ELISA Kit
 E3 ubiquitin-protein ligase pub3 Recombinant
 E3 ubiquitin-protein ligase pub3 Antibody
Also known as E3 ubiquitin-protein ligase pub3 (HECT-type E3 ubiquitin transferase pub3).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 pub3 ELISA Kit
 pub3 Recombinant
 pub3 Antibody
 SPBC16E9.11c ELISA Kit
 SPBC16E9.11c Recombinant
 SPBC16E9.11c Antibody
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E3 ubiquitin-protein ligase RAD18

 E3 ubiquitin-protein ligase RAD18 ELISA Kit
 E3 ubiquitin-protein ligase RAD18 Recombinant
 E3 ubiquitin-protein ligase RAD18 Antibody
Also known as E3 ubiquitin-protein ligase RAD18 (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73).
RAD18: a structural maintenance of chromosomes (SMC) protein involved in postreplication repair of UV-damaged DNA. Has ssDNA binding activity. Interacts with Rad6 through a conserved ring-finger motif. Rad6 is an ubiquitin-conjugating enzyme required for post-replica
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tion repair of damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.

Protein type: DNA repair, damage; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: centrosome; nuclear inclusion body; nucleoplasm; nucleus; replication fork

Molecular Function: identical protein binding; polyubiquitin binding; protein binding; protein complex binding; single-stranded DNA-dependent ATPase activity; ubiquitin protein ligase binding; Y-form DNA binding

Biological Process: DNA damage response, detection of DNA damage; positive regulation of chromosome segregation; postreplication repair; protein autoubiquitination; protein monoubiquitination; response to DNA damage stimulus; response to UV
 RAD18 ELISA Kit
 RAD18 Recombinant
 RAD18 Antibody
 RNF73 ELISA Kit
 RNF73 Recombinant
 RNF73 Antibody
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E3 ubiquitin-protein ligase RBBP6

 E3 ubiquitin-protein ligase RBBP6 ELISA Kit
 E3 ubiquitin-protein ligase RBBP6 Recombinant
 E3 ubiquitin-protein ligase RBBP6 Antibody
Also known as E3 ubiquitin-protein ligase RBBP6 (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis).
RBBP6: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. 4 isoforms of the human p
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rotein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Nucleolus; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: nucleoplasm

Molecular Function: ubiquitin-protein ligase activity

Biological Process: embryonic organ development; in utero embryonic development; multicellular organism growth; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of DNA replication; response to DNA damage stimulus
 Rbbp6 ELISA Kit
 Rbbp6 Recombinant
 Rbbp6 Antibody
 P2pr ELISA Kit
 P2pr Recombinant
 P2pr Antibody
 Pact ELISA Kit
 Pact Recombinant
 Pact Antibody
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E3 ubiquitin-protein ligase RBX1

 E3 ubiquitin-protein ligase RBX1 ELISA Kit
 E3 ubiquitin-protein ligase RBX1 Recombinant
 E3 ubiquitin-protein ligase RBX1 Antibody
Also known as E3 ubiquitin-protein ligase RBX1 (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1).
RBX1: E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognitio
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n components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of CBC(VHL) complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 or CUL5 and VHL. Part of the CSA complex (DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Part of multisubunit E3 ubiquitin ligase complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 and MED8; elongin BC complex (TCEB1 and TCEB2), CUL5 and MUF1. Part of multisubunit complexes with elongin BC complex (TCEB1 and TCEB2), elongin A/TCEB3 or SOCS1 or WSB1 and CUL5. Interacts directly with CUL1 and probably also with CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7. Probably interacts with CDC34. Interacts with COPS6. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Part of an E3 ligase complex composed of RBX1, DDB1, DDB2 and CUL4A or CUL4B. Interacts with UBE2M. Part of a SCF complex consisting of CUL1, FBXO3, RBX1 and SKP1; this complex interacts with PML via FBXO3. Interacts with human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongation reaction of ubiquitin chains by the SCF(FBW7) complex. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Widely expressed. Belongs to the RING-box family.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; cullin-RING ubiquitin ligase complex; cytosol; nucleoplasm; SCF ubiquitin ligase complex

Molecular Function: NEDD8 ligase activity; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: DNA damage response, detection of DNA damage; MAPKKK cascade; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; proteasomal ubiquitin-dependent protein catabolic process; protein monoubiquitination; protein neddylation; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transcription-coupled nucleotide-excision repair; Wnt receptor signaling pathway
 RBX1 ELISA Kit
 RBX1 Recombinant
 RBX1 Antibody
 RNF75 ELISA Kit
 RNF75 Recombinant
 RNF75 Antibody
 ROC1 ELISA Kit
 ROC1 Recombinant
 ROC1 Antibody
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E3 ubiquitin-protein ligase RDUF1

 E3 ubiquitin-protein ligase RDUF1 ELISA Kit
 E3 ubiquitin-protein ligase RDUF1 Recombinant
 E3 ubiquitin-protein ligase RDUF1 Antibody
Also known as E3 ubiquitin-protein ligase RDUF1 (RING and DUF1117 domain-containing protein 1) (AtRDUF1).
Encodes an ABA- and drought-induced RING-DUF1117 gene whose mutation results in hyposensitive phenotypes toward ABA in terms of germination rate and stomatal closure and markedly reduced tolerance to drought stress relative to wild-type plants.
 RDUF1 ELISA Kit
 RDUF1 Recombinant
 RDUF1 Antibody
 At3g46620 ELISA Kit
 At3g46620 Recombinant
 At3g46620 Antibody
 F12A12.140 ELISA Kit
 F12A12.140 Recombinant
 F12A12.140 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RDUF2

 E3 ubiquitin-protein ligase RDUF2 ELISA Kit
 E3 ubiquitin-protein ligase RDUF2 Recombinant
 E3 ubiquitin-protein ligase RDUF2 Antibody
Also known as E3 ubiquitin-protein ligase RDUF2 (RING and DUF1117 domain-containing protein 2) (AtRDUF2).
E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid-dependent drought stress responses. Possesses E3 ubiquitin ligase activity in vitro.
 DURF2 ELISA Kit
 DURF2 Recombinant
 DURF2 Antibody
 At5g59550 ELISA Kit
 At5g59550 Recombinant
 At5g59550 Antibody
 F2O15.22 ELISA Kit
 F2O15.22 Recombinant
 F2O15.22 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RFWD2

 E3 ubiquitin-protein ligase RFWD2 ELISA Kit
 E3 ubiquitin-protein ligase RFWD2 Recombinant
 E3 ubiquitin-protein ligase RFWD2 Antibody
Also known as E3 ubiquitin-protein ligase RFWD2 (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200).
COP1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abo
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lishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Homodimer. Homodimerization is mediated by the coiled coil domain. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Isoform 2 does not interact with CUL4A but still binds to RBX1, suggesting that the interaction may be mediated by another culllin protein. Isoform 1 and isoform 2 interact with CUL5 but not with CUL1, CUL2 not CUL3. Interacts with bZIP transcription factors JUN, JUNB and JUND but not with FOS, ATF2 nor XBP1. Interacts with p53 (TP53). By p53/TP53. Ubiquitously expressed at low level. Expressed at higher level in testis, placenta, skeletal muscle and heart. Belongs to the COP1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1q25.1-q25.2

Cellular Component: centrosome; cytoplasm; cytosol; focal adhesion; nucleoplasm

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; response to ionizing radiation
 RFWD2 ELISA Kit
 RFWD2 Recombinant
 RFWD2 Antibody
 COP1 ELISA Kit
 COP1 Recombinant
 COP1 Antibody
 RNF200 ELISA Kit
 RNF200 Recombinant
 RNF200 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RFWD3

 E3 ubiquitin-protein ligase RFWD3 ELISA Kit
 E3 ubiquitin-protein ligase RFWD3 Recombinant
 E3 ubiquitin-protein ligase RFWD3 Antibody
Also known as E3 ubiquitin-protein ligase RFWD3 (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201).
E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from exte
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nding polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair ().
 RFWD3 ELISA Kit
 RFWD3 Recombinant
 RFWD3 Antibody
 RNF201 ELISA Kit
 RNF201 Recombinant
 RNF201 Antibody
 PANDA_016934 ELISA Kit
 PANDA_016934 Recombinant
 PANDA_016934 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RGLG1

 E3 ubiquitin-protein ligase RGLG1 ELISA Kit
 E3 ubiquitin-protein ligase RGLG1 Recombinant
 E3 ubiquitin-protein ligase RGLG1 Antibody
Also known as E3 ubiquitin-protein ligase RGLG1 (RING domain ligase 1).
Encodes RGLG1 (RING domain ligase 1), a RING domain ubiquitin E3 ligase that negatively regulates the drought stress response by mediating ERF53 transcriptional activity.
 RGLG1 ELISA Kit
 RGLG1 Recombinant
 RGLG1 Antibody
 At3g01650 ELISA Kit
 At3g01650 Recombinant
 At3g01650 Antibody
 F4P13.19 ELISA Kit
 F4P13.19 Recombinant
 F4P13.19 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RGLG2

 E3 ubiquitin-protein ligase RGLG2 ELISA Kit
 E3 ubiquitin-protein ligase RGLG2 Recombinant
 E3 ubiquitin-protein ligase RGLG2 Antibody
Also known as E3 ubiquitin-protein ligase RGLG2 (RING domain ligase 2).
Encodes RGLG2 (RING domain ligase 2), a RING domain ubiquitin E3 ligase that negatively regulates the drought stress response by mediating ERF53 transcriptional activity.
 RGLG2 ELISA Kit
 RGLG2 Recombinant
 RGLG2 Antibody
 At5g14420 ELISA Kit
 At5g14420 Recombinant
 At5g14420 Antibody
 F18O22.210 ELISA Kit
 F18O22.210 Recombinant
 F18O22.210 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RHA1B

 E3 ubiquitin-protein ligase RHA1B ELISA Kit
 E3 ubiquitin-protein ligase RHA1B Recombinant
 E3 ubiquitin-protein ligase RHA1B Antibody
Also known as E3 ubiquitin-protein ligase RHA1B (RING-H2 finger A1b) (RING-H2 zinc finger protein RHA1b).
Encodes a putative RING-H2 finger protein RHA1b.
 RHA1B ELISA Kit
 RHA1B Recombinant
 RHA1B Antibody
 At4g11360 ELISA Kit
 At4g11360 Recombinant
 At4g11360 Antibody
 F8L21.150 ELISA Kit
 F8L21.150 Recombinant
 F8L21.150 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RHA2A

 E3 ubiquitin-protein ligase RHA2A ELISA Kit
 E3 ubiquitin-protein ligase RHA2A Recombinant
 E3 ubiquitin-protein ligase RHA2A Antibody
Also known as E3 ubiquitin-protein ligase RHA2A (RING-H2 finger A2a) (RING-H2 zinc finger protein RHA2a).
Encodes a putative RING-H2 finger protein RHA2a.
 RHA2A ELISA Kit
 RHA2A Recombinant
 RHA2A Antibody
 At1g15100 ELISA Kit
 At1g15100 Recombinant
 At1g15100 Antibody
 F9L1.3 ELISA Kit
 F9L1.3 Recombinant
 F9L1.3 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RHA2B

 E3 ubiquitin-protein ligase RHA2B ELISA Kit
 E3 ubiquitin-protein ligase RHA2B Recombinant
 E3 ubiquitin-protein ligase RHA2B Antibody
Also known as E3 ubiquitin-protein ligase RHA2B (RING-H2 finger A2b) (RING-H2 zinc finger protein RHA2b).
E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid (ABA) signaling and responses to salt and osmotic stresses during seed germination and early seedling development. Acts additively with RHA2A in regulating ABA signaling and drought response. Possesses E3 ubiquitin ligase activity in vitro.
 RHA2B ELISA Kit
 RHA2B Recombinant
 RHA2B Antibody
 At2g01150 ELISA Kit
 At2g01150 Recombinant
 At2g01150 Antibody
 F10A8.3 ELISA Kit
 F10A8.3 Recombinant
 F10A8.3 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RHF1A

 E3 ubiquitin-protein ligase RHF1A ELISA Kit
 E3 ubiquitin-protein ligase RHF1A Recombinant
 E3 ubiquitin-protein ligase RHF1A Antibody
Also known as E3 ubiquitin-protein ligase RHF1A (RING-H2 finger F1a) (RING-H2 zinc finger protein RHF1a).
encodes a RING-type E3 ubiquitin ligase implicated in gametogenesis. RHF1a can interact with the cell cycle inhibitor ICK4/KRP6 in vitro. It apppears to target ICK4KRP6 for degradation following meiosis in order to allow the mitoses associated with megagametogenesis and microgametogenesis to occur. RHF1a is expressed in the carpels throughout floral development. It is expressed in various tissues of the anthers during the early stages of anther development but not in stage 12 flowers an
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d beyond.
 RHF1A ELISA Kit
 RHF1A Recombinant
 RHF1A Antibody
 At4g14220 ELISA Kit
 At4g14220 Recombinant
 At4g14220 Antibody
 dl3150w ELISA Kit
 dl3150w Recombinant
 dl3150w Antibody
 FCAALL.146 ELISA Kit
 FCAALL.146 Recombinant
 FCAALL.146 Antibody
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E3 ubiquitin-protein ligase RHF2A

 E3 ubiquitin-protein ligase RHF2A ELISA Kit
 E3 ubiquitin-protein ligase RHF2A Recombinant
 E3 ubiquitin-protein ligase RHF2A Antibody
Also known as E3 ubiquitin-protein ligase RHF2A (RING-H2 finger F2a) (RING-H2 zinc finger protein RHF2a).
encodes a RING-type E3 ubiquitin ligase implicated in gametogenesis. Double mutant analyses with RHF1a suggests that RHF2a may be involved in targetting ICK4KRP6 for degradation following meiosis in order to allow the mitoses associated with megagametogenesis and microgametogenesis to occur. RHF2a is expressed in all four floral whorls and is present at ~8-fold higher levels than RHF1a in inflorescences by RT-PCR analyses.
 RHF2A ELISA Kit
 RHF2A Recombinant
 RHF2A Antibody
 At5g22000 ELISA Kit
 At5g22000 Recombinant
 At5g22000 Antibody
 T6G21.110 ELISA Kit
 T6G21.110 Recombinant
 T6G21.110 Antibody
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E3 ubiquitin-protein ligase rififylin

 E3 ubiquitin-protein ligase rififylin ELISA Kit
 E3 ubiquitin-protein ligase rififylin Recombinant
 E3 ubiquitin-protein ligase rififylin Antibody
Also known as E3 ubiquitin-protein ligase rififylin (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger prot.
RFFL: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating
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system; Ubiquitin ligase; Vesicle

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytoplasm; endosome membrane; Golgi membrane; lysosome; membrane; nucleoplasm; plasma membrane

Molecular Function: p53 binding; protease binding; protein binding; protein kinase binding; ubiquitin protein ligase binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway; ubiquitin-dependent protein catabolic process
 RFFL ELISA Kit
 RFFL Recombinant
 RFFL Antibody
 RNF189 ELISA Kit
 RNF189 Recombinant
 RNF189 Antibody
 RNF34L ELISA Kit
 RNF34L Recombinant
 RNF34L Antibody
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E3 ubiquitin-protein ligase RING1

 E3 ubiquitin-protein ligase RING1 ELISA Kit
 E3 ubiquitin-protein ligase RING1 Recombinant
 E3 ubiquitin-protein ligase RING1 Antibody
Also known as E3 ubiquitin-protein ligase RING1 (Polycomb complex protein RING1) (RING finger protein 1).
RING1: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and partici
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pates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity)

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; nuclear body; nucleoplasm; nucleus; PcG protein complex; sex chromatin; ubiquitin ligase complex

Molecular Function: chromatin binding

Biological Process: anterior/posterior pattern formation; camera-type eye morphogenesis; histone ubiquitination; negative regulation of transcription, DNA-dependent; regulation of catalytic activity
 Ring1 ELISA Kit
 Ring1 Recombinant
 Ring1 Antibody
 Rnf1 ELISA Kit
 Rnf1 Recombinant
 Rnf1 Antibody
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E3 ubiquitin-protein ligase RING1-like

 E3 ubiquitin-protein ligase RING1-like ELISA Kit
 E3 ubiquitin-protein ligase RING1-like Recombinant
 E3 ubiquitin-protein ligase RING1-like Antibody
Also known as E3 ubiquitin-protein ligase RING1-like (RING finger protein 1).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Promotes polyubiquitination of target proteins ().
 At3g19950 ELISA Kit
 At3g19950 Recombinant
 At3g19950 Antibody
 MPN9.19 ELISA Kit
 MPN9.19 Recombinant
 MPN9.19 Antibody
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E3 ubiquitin-protein ligase RING2

 E3 ubiquitin-protein ligase RING2 ELISA Kit
 E3 ubiquitin-protein ligase RING2 Recombinant
 E3 ubiquitin-protein ligase RING2 Antibody
Also known as E3 ubiquitin-protein ligase RING2 (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1).
RNF2: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of bot
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h imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin- protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. Component of chromatin-associated Polycomb (PcG) complexes. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2, MBLR, L3MBTL2 and YAF2. Component of a PRC1-like complex. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with RYBP, HIP2 and TFCP2. Association to the chromosomal DNA is cell-cycle dependent. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RING1. Interacts with Interacts with PCGF2, CBX4, CBX6, CBX7 and CBX8. Interacts with CBX2, BMI and PHC2. Interacts with RYBP, HIP2 and TFCP2.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1q25.3

Cellular Component: nucleoplasm; nucleus; PcG protein complex; ubiquitin ligase complex

Molecular Function: chromatin binding; protein binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; protein sumoylation
 RNF2 ELISA Kit
 RNF2 Recombinant
 RNF2 Antibody
 BAP1 ELISA Kit
 BAP1 Recombinant
 BAP1 Antibody
 DING ELISA Kit
 DING Recombinant
 DING Antibody
 HIPI3 ELISA Kit
 HIPI3 Recombinant
 HIPI3 Antibody
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E3 ubiquitin-protein ligase RING2-A

 E3 ubiquitin-protein ligase RING2-A ELISA Kit
 E3 ubiquitin-protein ligase RING2-A Recombinant
 E3 ubiquitin-protein ligase RING2-A Antibody
Also known as E3 ubiquitin-protein ligase RING2-A (RING finger protein 1B-A) (RING1b-A) (RING finger protein 2-A).
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inacti
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vation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility ().
 rnf2-a ELISA Kit
 rnf2-a Recombinant
 rnf2-a Antibody
 ring1b-a ELISA Kit
 ring1b-a Recombinant
 ring1b-a Antibody
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E3 ubiquitin-protein ligase RING2-B

 E3 ubiquitin-protein ligase RING2-B ELISA Kit
 E3 ubiquitin-protein ligase RING2-B Recombinant
 E3 ubiquitin-protein ligase RING2-B Antibody
Also known as E3 ubiquitin-protein ligase RING2-B (RING finger protein 1B-B) (RING1b-B) (RING finger protein 2-B).
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inacti
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vation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility ().
 rnf2-b ELISA Kit
 rnf2-b Recombinant
 rnf2-b Antibody
 ring1b-b ELISA Kit
 ring1b-b Recombinant
 ring1b-b Antibody
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E3 ubiquitin-protein ligase RKP

 E3 ubiquitin-protein ligase RKP ELISA Kit
 E3 ubiquitin-protein ligase RKP Recombinant
 E3 ubiquitin-protein ligase RKP Antibody
Also known as E3 ubiquitin-protein ligase RKP (AtKPC1) (Protein RELATED TO KPC1).
Encodes a protein predicted to act as a RING E3 ubiquitin ligase. It appears to regulate the stability of the KRP1/ICK1 cyclin dependent kinase inhibitor. Induced by beet severe curly virus (BSCTV) C4 protein.
 RKP ELISA Kit
 RKP Recombinant
 RKP Antibody
 KPC1 ELISA Kit
 KPC1 Recombinant
 KPC1 Antibody
 At2g22010 ELISA Kit
 At2g22010 Recombinant
 At2g22010 Antibody
 F7D8.33 ELISA Kit
 F7D8.33 Recombinant
 F7D8.33 Antibody
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E3 ubiquitin-protein ligase RLIM

 E3 ubiquitin-protein ligase RLIM ELISA Kit
 E3 ubiquitin-protein ligase RLIM Recombinant
 E3 ubiquitin-protein ligase RLIM Antibody
Also known as E3 ubiquitin-protein ligase RLIM (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12).
RNF12: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitmen
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t the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex- related dosage differences of X-encoded genes in somatic cells of female placental mammals. Belongs to the RNF12 family.

Protein type: EC 6.3.2.-; Ligase; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; ubiquitin-dependent protein catabolic process
 Rlim ELISA Kit
 Rlim Recombinant
 Rlim Antibody
 Rnf12 ELISA Kit
 Rnf12 Recombinant
 Rnf12 Antibody
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E3 ubiquitin-protein ligase RMA1

 E3 ubiquitin-protein ligase RMA1 ELISA Kit
 E3 ubiquitin-protein ligase RMA1 Recombinant
 E3 ubiquitin-protein ligase RMA1 Antibody
Also known as E3 ubiquitin-protein ligase RMA1 (Protein RING membrane-anchor 1).
RMA1 encodes a novel 28 kDa protein with a RING finger motif and a C-terminal membrane-anchoring domain that is involved in the secretory pathway. Has E3 ubiquitin ligase activity.
 RMA1 ELISA Kit
 RMA1 Recombinant
 RMA1 Antibody
 At4g03510 ELISA Kit
 At4g03510 Recombinant
 At4g03510 Antibody
 F9H3.14 ELISA Kit
 F9H3.14 Recombinant
 F9H3.14 Antibody
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E3 ubiquitin-protein ligase RMA1H1

 E3 ubiquitin-protein ligase RMA1H1 ELISA Kit
 E3 ubiquitin-protein ligase RMA1H1 Recombinant
 E3 ubiquitin-protein ligase RMA1H1 Antibody
Also known as E3 ubiquitin-protein ligase RMA1H1 (Protein RING membrane-anchor 1 homolog 1).
E3 ubiquitin-protein ligase required for aquaporin levels regulation.
 RMA1H1 ELISA Kit
 RMA1H1 Recombinant
 RMA1H1 Antibody
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E3 ubiquitin-protein ligase RMA2

 E3 ubiquitin-protein ligase RMA2 ELISA Kit
 E3 ubiquitin-protein ligase RMA2 Recombinant
 E3 ubiquitin-protein ligase RMA2 Antibody
Also known as E3 ubiquitin-protein ligase RMA2 (Protein RING membrane-anchor 2).
Encodes a RING finger E3 ubiquitin ligase. Binds and ubiquitinates ABP1 in vivo and in vitro.
 RMA2 ELISA Kit
 RMA2 Recombinant
 RMA2 Antibody
 A-RZF ELISA Kit
 A-RZF Recombinant
 A-RZF Antibody
 At4g28270 ELISA Kit
 At4g28270 Recombinant
 At4g28270 Antibody
 F26K10.15 ELISA Kit
 F26K10.15 Recombinant
 F26K10.15 Antibody
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E3 ubiquitin-protein ligase RMA3

 E3 ubiquitin-protein ligase RMA3 ELISA Kit
 E3 ubiquitin-protein ligase RMA3 Recombinant
 E3 ubiquitin-protein ligase RMA3 Antibody
Also known as E3 ubiquitin-protein ligase RMA3 (Protein RING membrane-anchor 3).
Encodes a RING finger E3 ubiquitin ligase.
 RMA3 ELISA Kit
 RMA3 Recombinant
 RMA3 Antibody
 At4g27470 ELISA Kit
 At4g27470 Recombinant
 At4g27470 Antibody
 F27G19.70 ELISA Kit
 F27G19.70 Recombinant
 F27G19.70 Antibody
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E3 ubiquitin-protein ligase RNF103

 E3 ubiquitin-protein ligase RNF103 ELISA Kit
 E3 ubiquitin-protein ligase RNF103 Recombinant
 E3 ubiquitin-protein ligase RNF103 Antibody
Also known as E3 ubiquitin-protein ligase RNF103 (KF-1) (hKF-1) (RING finger protein 103) (Zinc finger protein 103 homolog) (Zfp-103).
RNF103: Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system;
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Ubiquitin ligase

Chromosomal Location of Human Ortholog: 2p11.2

Cellular Component: endoplasmic reticulum

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: central nervous system development; ER-associated protein catabolic process; protein ubiquitination
 RNF103 ELISA Kit
 RNF103 Recombinant
 RNF103 Antibody
 ZFP103 ELISA Kit
 ZFP103 Recombinant
 ZFP103 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RNF114

 E3 ubiquitin-protein ligase RNF114 ELISA Kit
 E3 ubiquitin-protein ligase RNF114 Recombinant
 E3 ubiquitin-protein ligase RNF114 Antibody
Also known as E3 ubiquitin-protein ligase RNF114 (RING finger protein 114) (Zinc finger protein 228) (Zinc finger protein 313).
ZNF313: May play a role in spermatogenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: cytosol; intracellular

Molecular Function: ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity

Biological Process: positive regulation of proteasoma
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l ubiquitin-dependent protein catabolic process; protein polyubiquitination
 RNF114 ELISA Kit
 RNF114 Recombinant
 RNF114 Antibody
 ZNF228 ELISA Kit
 ZNF228 Recombinant
 ZNF228 Antibody
 ZNF313 ELISA Kit
 ZNF313 Recombinant
 ZNF313 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RNF115

 E3 ubiquitin-protein ligase RNF115 ELISA Kit
 E3 ubiquitin-protein ligase RNF115 Recombinant
 E3 ubiquitin-protein ligase RNF115 Antibody
Also known as E3 ubiquitin-protein ligase RNF115 (RING finger protein 115) (Rabring 7) (Zinc finger protein 364).
ZNF364: Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1q21.1

Cellular Component
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: cytosol

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process via the multivesicular body pathway
 RNF115 ELISA Kit
 RNF115 Recombinant
 RNF115 Antibody
 ZNF364 ELISA Kit
 ZNF364 Recombinant
 ZNF364 Antibody
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E3 ubiquitin-protein ligase RNF12

 E3 ubiquitin-protein ligase RNF12 ELISA Kit
 E3 ubiquitin-protein ligase RNF12 Recombinant
 E3 ubiquitin-protein ligase RNF12 Antibody
Also known as E3 ubiquitin-protein ligase RNF12 (RING finger protein 12).
Acts as an E3 ubiquitin-protein ligase specific for ldb1, mediating ubiquitination and proteasome-dependent degradation of excess ldb1 in a RING-dependent manner. Does not degrade ldb1 bound to lhx1/lim1, nor lim1 itself and thus contributes to the establishment of proper ldb1-lhx1/lim1 stoichiometry and the formation of
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a ldb1-lhx1/lim1 complex. Interferes with Spemann organizer function and suppresses secondary axis formation induced by ldb1 and lhx1/lim1 ().
 rnf12 ELISA Kit
 rnf12 Recombinant
 rnf12 Antibody
 TGas054b08.1 ELISA Kit
 TGas054b08.1 Recombinant
 TGas054b08.1 Antibody
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E3 ubiquitin-protein ligase RNF123

 E3 ubiquitin-protein ligase RNF123 ELISA Kit
 E3 ubiquitin-protein ligase RNF123 Recombinant
 E3 ubiquitin-protein ligase RNF123 Antibody
Also known as E3 ubiquitin-protein ligase RNF123 (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).
RNF123: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity)

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; U
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biquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm
 Rnf123 ELISA Kit
 Rnf123 Recombinant
 Rnf123 Antibody
 Kpc1 ELISA Kit
 Kpc1 Recombinant
 Kpc1 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RNF125

 E3 ubiquitin-protein ligase RNF125 ELISA Kit
 E3 ubiquitin-protein ligase RNF125 Recombinant
 E3 ubiquitin-protein ligase RNF125 Antibody
Also known as E3 ubiquitin-protein ligase RNF125 (RING finger protein 125).
RNF125: E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component:
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intracellular

Molecular Function: ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity

Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination
 Rnf125 ELISA Kit
 Rnf125 Recombinant
 Rnf125 Antibody
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E3 ubiquitin-protein ligase RNF126

 E3 ubiquitin-protein ligase RNF126 ELISA Kit
 E3 ubiquitin-protein ligase RNF126 Recombinant
 E3 ubiquitin-protein ligase RNF126 Antibody
Also known as E3 ubiquitin-protein ligase RNF126 (RING finger protein 126).
E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degrada
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tion of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA.
 RNF126 ELISA Kit
 RNF126 Recombinant
 RNF126 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RNF126-A

 E3 ubiquitin-protein ligase RNF126-A ELISA Kit
 E3 ubiquitin-protein ligase RNF126-A Recombinant
 E3 ubiquitin-protein ligase RNF126-A Antibody
Also known as E3 ubiquitin-protein ligase RNF126-A (RING finger protein 126-A).
E3 ubiquitin-protein ligase that may regulate several biological processes through ubiquitination of various target proteins.
 rnf126-a ELISA Kit
 rnf126-a Recombinant
 rnf126-a Antibody
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E3 ubiquitin-protein ligase RNF126-B

 E3 ubiquitin-protein ligase RNF126-B ELISA Kit
 E3 ubiquitin-protein ligase RNF126-B Recombinant
 E3 ubiquitin-protein ligase RNF126-B Antibody
Also known as E3 ubiquitin-protein ligase RNF126-B (RING finger protein 126-B).
E3 ubiquitin-protein ligase that may regulate several biological processes through ubiquitination of various target proteins.
 rnf126-b ELISA Kit
 rnf126-b Recombinant
 rnf126-b Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RNF128

 E3 ubiquitin-protein ligase RNF128 ELISA Kit
 E3 ubiquitin-protein ligase RNF128 Recombinant
 E3 ubiquitin-protein ligase RNF128 Antibody
Also known as E3 ubiquitin-protein ligase RNF128 (Gene related to anergy in lymphocytes protein) (Goliath-related E3 ubiquitin-protein ligase 1) (RING finger protein 128).
RNF128: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural- inducing signals. 2 isoforms of
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the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: endoplasmic reticulum; Golgi apparatus; late endosome

Biological Process: negative regulation of cytokine biosynthetic process; protein ubiquitination; regulation of protein stability
 Rnf128 ELISA Kit
 Rnf128 Recombinant
 Rnf128 Antibody
 Grail ELISA Kit
 Grail Recombinant
 Grail Antibody
 Greul1 ELISA Kit
 Greul1 Recombinant
 Greul1 Antibody
 MNCb-3816 ELISA Kit
 MNCb-3816 Recombinant
 MNCb-3816 Antibody
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E3 ubiquitin-protein ligase RNF12-A

 E3 ubiquitin-protein ligase RNF12-A ELISA Kit
 E3 ubiquitin-protein ligase RNF12-A Recombinant
 E3 ubiquitin-protein ligase RNF12-A Antibody
Also known as E3 ubiquitin-protein ligase RNF12-A (RING finger protein 12-A) (XRnf12).
Acts as an E3 ubiquitin-protein ligase specific for ldb1, mediating ubiquitination and proteasome-dependent degradation of excess ldb1 in a RING-dependent manner. Does not degrade ldb1 bound to lhx1/lim1, nor lim1 itself and thus contributes to the establishment of proper ldb1-lhx1/lim1 stoichiometry and the
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formation of a ldb1-lhx1/lim1 complex. Interferes with Spemann organizer function and suppresses secondary axis formation induced by ldb1 and lhx1/lim1.
 rnf12-a ELISA Kit
 rnf12-a Recombinant
 rnf12-a Antibody
 rnf12 ELISA Kit
 rnf12 Recombinant
 rnf12 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RNF12-B

 E3 ubiquitin-protein ligase RNF12-B ELISA Kit
 E3 ubiquitin-protein ligase RNF12-B Recombinant
 E3 ubiquitin-protein ligase RNF12-B Antibody
Also known as E3 ubiquitin-protein ligase RNF12-B (RING finger protein 12-B) (XRnf12B).
Acts as an E3 ubiquitin-protein ligase specific for ldb1, mediating ubiquitination and proteasome-dependent degradation of excess ldb1 in a RING-dependent manner. Does not degrade ldb1 bound to lhx1/lim1, nor lim1 itself and thus contributes to the establishment of proper ldb1-lhx1/lim1 stoichiometry and the
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formation of a ldb1-lhx1/lim1 complex. Interferes with Spemann organizer function and suppresses secondary axis formation induced by ldb1 and lhx1/lim1 ().
 rnf12-b ELISA Kit
 rnf12-b Recombinant
 rnf12-b Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase RNF13

 E3 ubiquitin-protein ligase RNF13 ELISA Kit
 E3 ubiquitin-protein ligase RNF13 Recombinant
 E3 ubiquitin-protein ligase RNF13 Antibody
Also known as E3 ubiquitin-protein ligase RNF13 (C-RZF) (RING finger protein 13).
E3 ubiquitin-protein ligase. May play a role in controlling cell proliferation, including that of muscle cells.
 RNF13 ELISA Kit
 RNF13 Recombinant
 RNF13 Antibody
 RZF ELISA Kit
 RZF Recombinant
 RZF Antibody
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E3 ubiquitin-protein ligase RNF130

 E3 ubiquitin-protein ligase RNF130 ELISA Kit
 E3 ubiquitin-protein ligase RNF130 Recombinant
 E3 ubiquitin-protein ligase RNF130 Antibody
Also known as E3 ubiquitin-protein ligase RNF130 (G1-related zinc finger protein) (Goliath homolog) (RING finger protein 130).
RNF130: May have a role during the programmed cell death of hematopoietic cells. Acts as an E3 ubiquitin- protein ligase.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Com
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ponent: cytoplasm; nucleus

Molecular Function: ubiquitin-protein ligase activity

Biological Process: programmed cell death
 Rnf130 ELISA Kit
 Rnf130 Recombinant
 Rnf130 Antibody
 G1rp ELISA Kit
 G1rp Recombinant
 G1rp Antibody
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E3 ubiquitin-protein ligase RNF133

 E3 ubiquitin-protein ligase RNF133 ELISA Kit
 E3 ubiquitin-protein ligase RNF133 Recombinant
 E3 ubiquitin-protein ligase RNF133 Antibody
Also known as E3 ubiquitin-protein ligase RNF133 (Goliath-related E3 ubiquitin-protein ligase 2) (RING finger protein 133).
RNF133: Has E3 ubiquitin-protein ligase activity.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Endoplasmic reticulum; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: endoplasmic reticulum membrane

Biolog
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ical Process: protein autoubiquitination
 Rnf133 ELISA Kit
 Rnf133 Recombinant
 Rnf133 Antibody
 Greul2 ELISA Kit
 Greul2 Recombinant
 Greul2 Antibody
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E3 ubiquitin-protein ligase RNF135

 E3 ubiquitin-protein ligase RNF135 ELISA Kit
 E3 ubiquitin-protein ligase RNF135 Recombinant
 E3 ubiquitin-protein ligase RNF135 Antibody
Also known as E3 ubiquitin-protein ligase RNF135 (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (Riplet).
RNF135: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. Defects in RNF135 are the cause of macrocepha
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ly macrosomia facial dysmorphism syndrome (MMFD). MMFD is an autosomal dominant disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without renal dysfunction. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding; DNA replication; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cytoplasm; cytosol

Molecular Function: identical protein binding; protein binding; ribonucleoprotein binding; ubiquitin-protein ligase activity

Biological Process: innate immune response; negative regulation of interferon type I production; positive regulation of interferon-beta production; protein ubiquitination; regulation of innate immune response

Disease: Macrocephaly, Macrosomia, Facial Dysmorphism Syndrome
 RNF135 ELISA Kit
 RNF135 Recombinant
 RNF135 Antibody
 L13 ELISA Kit
 L13 Recombinant
 L13 Antibody
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E3 ubiquitin-protein ligase RNF138

 E3 ubiquitin-protein ligase RNF138 ELISA Kit
 E3 ubiquitin-protein ligase RNF138 Recombinant
 E3 ubiquitin-protein ligase RNF138 Antibody
Also known as E3 ubiquitin-protein ligase RNF138 (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138).
RNF138: E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubi
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quitin ligase

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: nucleus

Molecular Function: protein binding; protein kinase binding; single-stranded DNA binding; ubiquitin conjugating enzyme binding

Biological Process: double-strand break repair via homologous recombination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination
 RNF138 ELISA Kit
 RNF138 Recombinant
 RNF138 Antibody
 NARF ELISA Kit
 NARF Recombinant
 NARF Antibody
 HSD-4 ELISA Kit
 HSD-4 Recombinant
 HSD-4 Antibody
 HSD4 ELISA Kit
 HSD4 Recombinant
 HSD4 Antibody
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E3 ubiquitin-protein ligase RNF139

 E3 ubiquitin-protein ligase RNF139 ELISA Kit
 E3 ubiquitin-protein ligase RNF139 Recombinant
 E3 ubiquitin-protein ligase RNF139 Antibody
Also known as E3 ubiquitin-protein ligase RNF139 (RING finger protein 139) (Translocation in renal carcinoma on chromosome 8 protein).
RNF139: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the e
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ndoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. Defects in RNF139 may be a cause of renal cell carcinoma (RCC). It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. A chromosomal aberration involving RNF139 has been found in a lymphoblastoid cell line established from a family with renal cell carcinoma and thyroid carcinoma. Translocation (3;8)(q14.2;q24.1) with FHIT. RNF139 is found to be fused to FHIT and disrupted within the sterol-sensing domain. In contrast, the FHIT coding region is maintained and expressed. Sporadic cases of renal carcinoma, where an acquired mutation in RNF139 results in the duplication of 12 nucleotides in the 5'-UTR, has also been identified.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: endoplasmic reticulum

Molecular Function: protease binding; small conjugating protein ligase activity; ubiquitin-protein ligase activity

Biological Process: negative regulation of cell proliferation; negative regulation of translation; proteasomal ubiquitin-dependent protein catabolic process; protein destabilization; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of protein ubiquitination
 Rnf139 ELISA Kit
 Rnf139 Recombinant
 Rnf139 Antibody
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E3 ubiquitin-protein ligase RNF14

 E3 ubiquitin-protein ligase RNF14 ELISA Kit
 E3 ubiquitin-protein ligase RNF14 Recombinant
 E3 ubiquitin-protein ligase RNF14 Antibody
Also known as E3 ubiquitin-protein ligase RNF14 (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) (Triad2 protein).
RNF14: Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription. Belongs to the RBR family. RNF14 subfamily.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; Transcription, coactiva
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tor/corepressor; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 5q23.3-q31.1

Cellular Component: cytoplasm; nucleus; ubiquitin ligase complex

Molecular Function: androgen receptor binding; protein binding; small conjugating protein ligase activity; transcription coactivator activity; ubiquitin conjugating enzyme binding

Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription, DNA-dependent; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; signal transduction
 RNF14 ELISA Kit
 RNF14 Recombinant
 RNF14 Antibody
 ARA54 ELISA Kit
 ARA54 Recombinant
 ARA54 Antibody
 HRIHFB2038 ELISA Kit
 HRIHFB2038 Recombinant
 HRIHFB2038 Antibody
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E3 ubiquitin-protein ligase RNF144A

 E3 ubiquitin-protein ligase RNF144A ELISA Kit
 E3 ubiquitin-protein ligase RNF144A Recombinant
 E3 ubiquitin-protein ligase RNF144A Antibody
Also known as E3 ubiquitin-protein ligase RNF144A (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4).
RNF144A: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Belongs to the RBR family. RNF144 subfamily.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: Golgi apparatus; ubiqui
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tin ligase complex

Molecular Function: ubiquitin conjugating enzyme binding

Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 Rnf144a ELISA Kit
 Rnf144a Recombinant
 Rnf144a Antibody
 Kiaa0161 ELISA Kit
 Kiaa0161 Recombinant
 Kiaa0161 Antibody
 Rnf144 ELISA Kit
 Rnf144 Recombinant
 Rnf144 Antibody
 Ubce7ip4 ELISA Kit
 Ubce7ip4 Recombinant
 Ubce7ip4 Antibody
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E3 ubiquitin-protein ligase RNF144B

 E3 ubiquitin-protein ligase RNF144B ELISA Kit
 E3 ubiquitin-protein ligase RNF144B Recombinant
 E3 ubiquitin-protein ligase RNF144B Antibody
Also known as E3 ubiquitin-protein ligase RNF144B (IBR domain-containing protein 2) (RING finger protein 144B).
RNF144B: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a
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p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. Belongs to the RBR family. RNF144 subfamily.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; mitochondrial membrane; ubiquitin ligase complex

Molecular Function: ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity

Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 Rnf144b ELISA Kit
 Rnf144b Recombinant
 Rnf144b Antibody
 Ibrdc2 ELISA Kit
 Ibrdc2 Recombinant
 Ibrdc2 Antibody
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E3 ubiquitin-protein ligase RNF146

 E3 ubiquitin-protein ligase RNF146 ELISA Kit
 E3 ubiquitin-protein ligase RNF146 Recombinant
 E3 ubiquitin-protein ligase RNF146 Antibody
Also known as E3 ubiquitin-protein ligase RNF146 (Dactylidin) (Iduna) (RING finger protein 146).
RNF146: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signal
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ing pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys- 48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor- mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation. Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N- nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair. Defects in RNF146 are a cause of susceptibility to breast cancer. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 6q22.1-q22.33

Cellular Component: cytosol

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: protein autoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway
 RNF146 ELISA Kit
 RNF146 Recombinant
 RNF146 Antibody
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E3 ubiquitin-protein ligase RNF146-A

 E3 ubiquitin-protein ligase RNF146-A ELISA Kit
 E3 ubiquitin-protein ligase RNF146-A Recombinant
 E3 ubiquitin-protein ligase RNF146-A Antibody
Also known as E3 ubiquitin-protein ligase RNF146-A (RING finger protein 146-A).
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction c
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omplex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination ().
 RNF146A ELISA Kit
 RNF146A Recombinant
 RNF146A Antibody
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E3 ubiquitin-protein ligase RNF146-B

 E3 ubiquitin-protein ligase RNF146-B ELISA Kit
 E3 ubiquitin-protein ligase RNF146-B Recombinant
 E3 ubiquitin-protein ligase RNF146-B Antibody
Also known as E3 ubiquitin-protein ligase RNF146-B (RING finger protein 146-B).
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction c
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omplex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination ().
 RNF146B ELISA Kit
 RNF146B Recombinant
 RNF146B Antibody
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E3 ubiquitin-protein ligase RNF149

 E3 ubiquitin-protein ligase RNF149 ELISA Kit
 E3 ubiquitin-protein ligase RNF149 Recombinant
 E3 ubiquitin-protein ligase RNF149 Antibody
Also known as E3 ubiquitin-protein ligase RNF149 (DNA polymerase-transactivated protein 2) (RING finger protein 149).
RNF149: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 2q11.2 >>>
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Cellular Component: membrane
 RNF149 ELISA Kit
 RNF149 Recombinant
 RNF149 Antibody
 DNAPTP2 ELISA Kit
 DNAPTP2 Recombinant
 DNAPTP2 Antibody
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E3 ubiquitin-protein ligase rnf152

 E3 ubiquitin-protein ligase rnf152 ELISA Kit
 E3 ubiquitin-protein ligase rnf152 Recombinant
 E3 ubiquitin-protein ligase rnf152 Antibody
Also known as E3 ubiquitin-protein ligase rnf152 (RING finger protein 152).
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent target
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ing to the proteasome for degradation.
 rnf152 ELISA Kit
 rnf152 Recombinant
 rnf152 Antibody
 zgc:110537 ELISA Kit
 zgc:110537 Recombinant
 zgc:110537 Antibody
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E3 ubiquitin-protein ligase rnf152-A

 E3 ubiquitin-protein ligase rnf152-A ELISA Kit
 E3 ubiquitin-protein ligase rnf152-A Recombinant
 E3 ubiquitin-protein ligase rnf152-A Antibody
Also known as E3 ubiquitin-protein ligase rnf152-A (RING finger protein 152-A).
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent ta
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rgeting to the proteasome for degradation.
 rnf152-a ELISA Kit
 rnf152-a Recombinant
 rnf152-a Antibody
 rnf152 ELISA Kit
 rnf152 Recombinant
 rnf152 Antibody
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E3 ubiquitin-protein ligase rnf152-B

 E3 ubiquitin-protein ligase rnf152-B ELISA Kit
 E3 ubiquitin-protein ligase rnf152-B Recombinant
 E3 ubiquitin-protein ligase rnf152-B Antibody
Also known as E3 ubiquitin-protein ligase rnf152-B (RING finger protein 152-B).
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent ta
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rgeting to the proteasome for degradation.
 rnf152-b ELISA Kit
 rnf152-b Recombinant
 rnf152-b Antibody
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E3 ubiquitin-protein ligase RNF167

 E3 ubiquitin-protein ligase RNF167 ELISA Kit
 E3 ubiquitin-protein ligase RNF167 Recombinant
 E3 ubiquitin-protein ligase RNF167 Antibody
Also known as E3 ubiquitin-protein ligase RNF167 (RING finger protein 167).
RNF167: May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.

Protein type: EC 6.3.2.-
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; EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm

Molecular Function: ubiquitin-protein ligase activity

Biological Process: negative regulation of cell cycle; protein polyubiquitination
 Rnf167 ELISA Kit
 Rnf167 Recombinant
 Rnf167 Antibody
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E3 ubiquitin-protein ligase RNF168

 E3 ubiquitin-protein ligase RNF168 ELISA Kit
 E3 ubiquitin-protein ligase RNF168 Recombinant
 E3 ubiquitin-protein ligase RNF168 Antibody
Also known as E3 ubiquitin-protein ligase RNF168 (hRNF168) (RING finger protein 168).
RNF168: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the
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RNF8- dependent H2A ubiquitination, promoting the formation of 'Lys-63'- linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). Defects in RNF168 are the cause of Riddle syndrome (RIDDLES). Riddle syndrome is characterized by increased radiosensitivity, immunodeficiency, mild motor control and learning difficulties, facial dysmorphism, and short stature. Defects are probably due to impaired localization of TP53BP1 and BRCA1 at DNA lesions. Belongs to the RNF168 family.

Protein type: EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: cytoplasm; nucleoplasm; nucleus; protein complex; ubiquitin ligase complex

Molecular Function: chromatin binding; histone binding; nucleosome binding; protein binding; ubiquitin binding; ubiquitin-protein ligase activity

Biological Process: double-strand break repair; double-strand break repair via nonhomologous end joining; isotype switching; positive regulation of DNA repair; protein sumoylation; protein ubiquitination; response to DNA damage stimulus; response to ionizing radiation; ubiquitin-dependent protein catabolic process

Disease: Riddle Syndrome
 RNF168 ELISA Kit
 RNF168 Recombinant
 RNF168 Antibody
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E3 ubiquitin-protein ligase RNF169

 E3 ubiquitin-protein ligase RNF169 ELISA Kit
 E3 ubiquitin-protein ligase RNF169 Recombinant
 E3 ubiquitin-protein ligase RNF169 Antibody
Also known as E3 ubiquitin-protein ligase RNF169 (RING finger protein 169).
RNF169: Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby act
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ing as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair. Belongs to the RNF169 family.

Protein type: EC 6.3.2.-; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: nucleoplasm; nucleus

Molecular Function: nucleosome binding

Biological Process: response to DNA damage stimulus
 RNF169 ELISA Kit
 RNF169 Recombinant
 RNF169 Antibody
 KIAA1991 ELISA Kit
 KIAA1991 Recombinant
 KIAA1991 Antibody
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E3 ubiquitin-protein ligase RNF170

 E3 ubiquitin-protein ligase RNF170 ELISA Kit
 E3 ubiquitin-protein ligase RNF170 Recombinant
 E3 ubiquitin-protein ligase RNF170 Antibody
Also known as E3 ubiquitin-protein ligase RNF170 (Putative LAG1-interacting protein) (RING finger protein 170).
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degrada
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tion pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
 RNF170 ELISA Kit
 RNF170 Recombinant
 RNF170 Antibody
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E3 ubiquitin-protein ligase RNF180

 E3 ubiquitin-protein ligase RNF180 ELISA Kit
 E3 ubiquitin-protein ligase RNF180 Recombinant
 E3 ubiquitin-protein ligase RNF180 Antibody
Also known as E3 ubiquitin-protein ligase RNF180 (RING finger protein 180).
RNF180: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase >>>
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Cellular Component: intrinsic to endoplasmic reticulum membrane

Molecular Function: protein binding; ubiquitin conjugating enzyme binding

Biological Process: adult behavior; norepinephrine metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein polyubiquitination; regulation of catalytic activity; serotonin metabolic process
 Rnf180 ELISA Kit
 Rnf180 Recombinant
 Rnf180 Antibody
 Rines ELISA Kit
 Rines Recombinant
 Rines Antibody
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E3 ubiquitin-protein ligase RNF181

 E3 ubiquitin-protein ligase RNF181 ELISA Kit
 E3 ubiquitin-protein ligase RNF181 Recombinant
 E3 ubiquitin-protein ligase RNF181 Antibody
Also known as E3 ubiquitin-protein ligase RNF181 (RING finger protein 181).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 rnf181 ELISA Kit
 rnf181 Recombinant
 rnf181 Antibody
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E3 ubiquitin-protein ligase RNF181 homolog

 E3 ubiquitin-protein ligase RNF181 homolog ELISA Kit
 E3 ubiquitin-protein ligase RNF181 homolog Recombinant
 E3 ubiquitin-protein ligase RNF181 homolog Antibody
Also known as E3 ubiquitin-protein ligase RNF181 homolog (RING finger protein 181 homolog).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 CG7694 ELISA Kit
 CG7694 Recombinant
 CG7694 Antibody
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E3 ubiquitin-protein ligase RNF182

 E3 ubiquitin-protein ligase RNF182 ELISA Kit
 E3 ubiquitin-protein ligase RNF182 Recombinant
 E3 ubiquitin-protein ligase RNF182 Antibody
Also known as E3 ubiquitin-protein ligase RNF182 (RING finger protein 182).
E3 ubiquitin-protein ligase that mediates the ubiquitination of atp6v0c and targets it to degradation via the ubiquitin-proteasome pathway.
 rnf182 ELISA Kit
 rnf182 Recombinant
 rnf182 Antibody
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E3 ubiquitin-protein ligase RNF185

 E3 ubiquitin-protein ligase RNF185 ELISA Kit
 E3 ubiquitin-protein ligase RNF185 Recombinant
 E3 ubiquitin-protein ligase RNF185 Antibody
Also known as E3 ubiquitin-protein ligase RNF185 (RING finger protein 185).
RNF185: Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ligase; Membrane protein, integral; Membrane protein, multi-p
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ass; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: endoplasmic reticulum

Molecular Function: protein binding

Biological Process: ER-associated protein catabolic process; protein autoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 RNF185 ELISA Kit
 RNF185 Recombinant
 RNF185 Antibody
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E3 ubiquitin-protein ligase RNF187

 E3 ubiquitin-protein ligase RNF187 ELISA Kit
 E3 ubiquitin-protein ligase RNF187 Recombinant
 E3 ubiquitin-protein ligase RNF187 Antibody
Also known as E3 ubiquitin-protein ligase RNF187 (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187).
RNF187: E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase
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Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: ubiquitin-protein ligase activity

Biological Process: positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination
 Rnf187 ELISA Kit
 Rnf187 Recombinant
 Rnf187 Antibody
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E3 ubiquitin-protein ligase RNF19A

 E3 ubiquitin-protein ligase RNF19A ELISA Kit
 E3 ubiquitin-protein ligase RNF19A Recombinant
 E3 ubiquitin-protein ligase RNF19A Antibody
Also known as E3 ubiquitin-protein ligase RNF19A (Double ring-finger protein) (Dorfin) (Gametogenesis-expressed protein GEG-154) (RING finger protein 19A) (UBCM4-interacting protein 117) (UIP117) (XY body protein) (XYbp).
RNF19: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. Belongs to the RB
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R family. RNF19 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: centrosome; cytoplasm; ubiquitin ligase complex

Molecular Function: ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity

Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 Rnf19a ELISA Kit
 Rnf19a Recombinant
 Rnf19a Antibody
 Geg-154 ELISA Kit
 Geg-154 Recombinant
 Geg-154 Antibody
 Rnf19 ELISA Kit
 Rnf19 Recombinant
 Rnf19 Antibody
 Xybp ELISA Kit
 Xybp Recombinant
 Xybp Antibody
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E3 ubiquitin-protein ligase RNF19B

 E3 ubiquitin-protein ligase RNF19B ELISA Kit
 E3 ubiquitin-protein ligase RNF19B Recombinant
 E3 ubiquitin-protein ligase RNF19B Antibody
Also known as E3 ubiquitin-protein ligase RNF19B (IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B).
This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]
 RNF19B ELISA Kit
 RNF19B Recombinant
 RNF19B Antibody
 IBRDC3 ELISA Kit
 IBRDC3 Recombinant
 IBRDC3 Antibody
 NKLAM ELISA Kit
 NKLAM Recombinant
 NKLAM Antibody
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E3 ubiquitin-protein ligase RNF213

 E3 ubiquitin-protein ligase RNF213 ELISA Kit
 E3 ubiquitin-protein ligase RNF213 Recombinant
 E3 ubiquitin-protein ligase RNF213 Antibody
Also known as E3 ubiquitin-protein ligase RNF213 (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213).
RNF213: Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase activity. Defects in RNF213 are the cause of susceptibility to Moyamoya disease type 2 (MYMY2). A progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a 'puff of smoke' (moyamoya) on cerebral angiogram. Affected
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individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults. A chromosomal aberration involving ALO17 is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALK. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Oncoprotein; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: cytoplasm; cytosol; membrane; nucleolus

Molecular Function: ATPase activity; ubiquitin-protein ligase activity

Biological Process: angiogenesis; protein autoubiquitination; protein homooligomerization; protein polyubiquitination; protein ubiquitination; sprouting angiogenesis; ubiquitin-dependent protein catabolic process
 RNF213 ELISA Kit
 RNF213 Recombinant
 RNF213 Antibody
 ALO17 ELISA Kit
 ALO17 Recombinant
 ALO17 Antibody
 C17orf27 ELISA Kit
 C17orf27 Recombinant
 C17orf27 Antibody
 KIAA1554 ELISA Kit
 KIAA1554 Recombinant
 KIAA1554 Antibody
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E3 ubiquitin-protein ligase rnf213-alpha

 E3 ubiquitin-protein ligase rnf213-alpha ELISA Kit
 E3 ubiquitin-protein ligase rnf213-alpha Recombinant
 E3 ubiquitin-protein ligase rnf213-alpha Antibody
Also known as E3 ubiquitin-protein ligase rnf213-alpha (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha).
E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of proteins downstream of rspo3, leading to inhibit t
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he non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity (). Also involved in neuromuscular regulation (PubMed:26530008).
 rnf213a ELISA Kit
 rnf213a Recombinant
 rnf213a Antibody
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E3 ubiquitin-protein ligase rnf213-beta

 E3 ubiquitin-protein ligase rnf213-beta ELISA Kit
 E3 ubiquitin-protein ligase rnf213-beta Recombinant
 E3 ubiquitin-protein ligase rnf213-beta Antibody
Also known as E3 ubiquitin-protein ligase rnf213-beta (Mysterin-B) (Mysterin-beta) (RING finger protein 213-B) (RING finger protein 213-beta).
Has both E3 ubiquitin-protein ligase and ATPase activities.
 rnf213b ELISA Kit
 rnf213b Recombinant
 rnf213b Antibody
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E3 ubiquitin-protein ligase RNF216

 E3 ubiquitin-protein ligase RNF216 ELISA Kit
 E3 ubiquitin-protein ligase RNF216 Recombinant
 E3 ubiquitin-protein ligase RNF216 Antibody
Also known as E3 ubiquitin-protein ligase RNF216 (RING finger protein 216) (Triad domain-containing protein 3) (UbcM4-interacting protein 83) (Ubiquitin-conjugating enzyme 7-interacting protein 1).
TRIAD3: Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN i
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nhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: nucleus; ubiquitin ligase complex

Molecular Function: ubiquitin binding; ubiquitin-protein ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; regulation of defense response to virus by host; regulation of interferon-beta production
 Rnf216 ELISA Kit
 Rnf216 Recombinant
 Rnf216 Antibody
 Triad3 ELISA Kit
 Triad3 Recombinant
 Triad3 Antibody
 Ubce7ip1 ELISA Kit
 Ubce7ip1 Recombinant
 Ubce7ip1 Antibody
 Uip83 ELISA Kit
 Uip83 Recombinant
 Uip83 Antibody
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E3 ubiquitin-protein ligase RNF220

 E3 ubiquitin-protein ligase RNF220 ELISA Kit
 E3 ubiquitin-protein ligase RNF220 Recombinant
 E3 ubiquitin-protein ligase RNF220 Antibody
Also known as E3 ubiquitin-protein ligase RNF220 (RING finger protein 220).
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 and promotes Wnt signaling ().
 RNF220 ELISA Kit
 RNF220 Recombinant
 RNF220 Antibody
 QflA-23520 ELISA Kit
 QflA-23520 Recombinant
 QflA-23520 Antibody
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E3 ubiquitin-protein ligase RNF25

 E3 ubiquitin-protein ligase RNF25 ELISA Kit
 E3 ubiquitin-protein ligase RNF25 Recombinant
 E3 ubiquitin-protein ligase RNF25 Antibody
Also known as E3 ubiquitin-protein ligase RNF25 (RING finger protein 25).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2. Stimulates transcription mediated by NF-kappa-B ().
 RNF25 ELISA Kit
 RNF25 Recombinant
 RNF25 Antibody
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E3 ubiquitin-protein ligase RNF31

 E3 ubiquitin-protein ligase RNF31 ELISA Kit
 E3 ubiquitin-protein ligase RNF31 Recombinant
 E3 ubiquitin-protein ligase RNF31 Antibody
Also known as E3 ubiquitin-protein ligase RNF31 (HOIL-1-interacting protein) (HOIP) (Putative Ariadne-like ubiquitin ligase) (PAUL) (RING finger protein 31).
RNF31: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates line
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ar polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytosol; internal side of plasma membrane

Molecular Function: protein binding; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: activation of NF-kappaB transcription factor; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein polyubiquitination; protein ubiquitination; T cell receptor signaling pathway
 Rnf31 ELISA Kit
 Rnf31 Recombinant
 Rnf31 Antibody
 Paul ELISA Kit
 Paul Recombinant
 Paul Antibody
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E3 ubiquitin-protein ligase RNF34

 E3 ubiquitin-protein ligase RNF34 ELISA Kit
 E3 ubiquitin-protein ligase RNF34 Recombinant
 E3 ubiquitin-protein ligase RNF34 Antibody
Also known as E3 ubiquitin-protein ligase RNF34 (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger pr.
RNF34: Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Pr
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otects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate and phosphatidylinositol 3- phosphate. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane

Molecular Function: p53 binding; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 RNF34 ELISA Kit
 RNF34 Recombinant
 RNF34 Antibody
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E3 ubiquitin-protein ligase RNF38

 E3 ubiquitin-protein ligase RNF38 ELISA Kit
 E3 ubiquitin-protein ligase RNF38 Recombinant
 E3 ubiquitin-protein ligase RNF38 Antibody
Also known as E3 ubiquitin-protein ligase RNF38 (RING finger protein 38).
RNF38: 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: ubiquitin-protein ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic
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process; protein ubiquitination; regulation of transcription, DNA-dependent
 Rnf38 ELISA Kit
 Rnf38 Recombinant
 Rnf38 Antibody
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E3 ubiquitin-protein ligase RNF4

 E3 ubiquitin-protein ligase RNF4 ELISA Kit
 E3 ubiquitin-protein ligase RNF4 Recombinant
 E3 ubiquitin-protein ligase RNF4 Antibody
Also known as E3 ubiquitin-protein ligase RNF4 (RING finger protein 4).
RNF4: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including
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PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation.

Protein type: EC 6.3.2.-; Ligase; Nuclear receptor co-regulator; Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; PML body

Molecular Function: androgen receptor binding; DNA binding; estrogen receptor binding; nucleosome binding; progesterone receptor binding; protein binding; protein homodimerization activity; SUMO polymer binding; TATA-binding protein binding; transcription factor binding; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: negative regulation of protein sumoylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein ubiquitination; response to arsenic
 Rnf4 ELISA Kit
 Rnf4 Recombinant
 Rnf4 Antibody
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E3 ubiquitin-protein ligase RNF43

 E3 ubiquitin-protein ligase RNF43 ELISA Kit
 E3 ubiquitin-protein ligase RNF43 Recombinant
 E3 ubiquitin-protein ligase RNF43 Antibody
Also known as E3 ubiquitin-protein ligase RNF43 (RING finger protein 43).
RNF43: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal
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stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Belongs to the ZNRF3 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: integral to plasma membrane

Molecular Function: frizzled binding; ubiquitin-protein ligase activity

Biological Process: negative regulation of Wnt receptor signaling pathway; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 Rnf43 ELISA Kit
 Rnf43 Recombinant
 Rnf43 Antibody
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E3 ubiquitin-protein ligase RNF5

 E3 ubiquitin-protein ligase RNF5 ELISA Kit
 E3 ubiquitin-protein ligase RNF5 Recombinant
 E3 ubiquitin-protein ligase RNF5 Antibody
Also known as E3 ubiquitin-protein ligase RNF5 (Protein G16) (RING finger protein 5) (Ram1 homolog) (HsRma1).
RNF5: Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; th
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e ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 6p21.3

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: cellular protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process
 RNF5 ELISA Kit
 RNF5 Recombinant
 RNF5 Antibody
 G16 ELISA Kit
 G16 Recombinant
 G16 Antibody
 NG2 ELISA Kit
 NG2 Recombinant
 NG2 Antibody
 RMA1 ELISA Kit
 RMA1 Recombinant
 RMA1 Antibody
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E3 ubiquitin-protein ligase RNF6

 E3 ubiquitin-protein ligase RNF6 ELISA Kit
 E3 ubiquitin-protein ligase RNF6 Recombinant
 E3 ubiquitin-protein ligase RNF6 Antibody
RNF6: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a tra
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nscriptional regulator. Defects in RNF6 may be a cause of esophageal cancer (ESCR). A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Belongs to the RNF12 family.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 13q12.2

Cellular Component: axon; cytoplasm; intracellular membrane-bound organelle; nuclear membrane; nucleoplasm; nucleus

Molecular Function: androgen receptor binding; protein binding; ubiquitin-protein ligase activity

Biological Process: negative regulation of axon extension; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; regulation of transcription, DNA-dependent; ubiquitin-dependent protein catabolic process

Disease: Esophageal Cancer
 RNF6 ELISA Kit
 RNF6 Recombinant
 RNF6 Antibody
 SPG2 ELISA Kit
 SPG2 Recombinant
 SPG2 Antibody
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E3 ubiquitin-protein ligase RNF8

 E3 ubiquitin-protein ligase RNF8 ELISA Kit
 E3 ubiquitin-protein ligase RNF8 Recombinant
 E3 ubiquitin-protein ligase RNF8 Antibody
Also known as E3 ubiquitin-protein ligase RNF8 (ActA-interacting protein 37) (AIP37) (LaXp180) (RING finger protein 8).
RNF8: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'- linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by cat
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alyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin- conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggraving telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2. Belongs to the RNF8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; EC 6.3.2.-; EC 6.3.2.19; Histone-binding; Ligase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: chromosome, telomeric region; cytoplasm; nucleus; ubiquitin ligase complex

Molecular Function: chromatin binding; histone binding; protein homodimerization activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: double-strand break repair; double-strand break repair via nonhomologous end joining; histone exchange; histone H2A ubiquitination; histone H2B ubiquitination; isotype switching; positive regulation of DNA repair; protein autoubiquitination; response to DNA damage stimulus; response to ionizing radiation; spermatid development; ubiquitin-dependent protein catabolic process
 Rnf8 ELISA Kit
 Rnf8 Recombinant
 Rnf8 Antibody
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E3 ubiquitin-protein ligase rnf8-A

 E3 ubiquitin-protein ligase rnf8-A ELISA Kit
 E3 ubiquitin-protein ligase rnf8-A Recombinant
 E3 ubiquitin-protein ligase rnf8-A Antibody
Also known as E3 ubiquitin-protein ligase rnf8-A (RING finger protein 8-A).
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove ta
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rget proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53bp1 and brca1 ionizing radiation-induced foci (IRIF). H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.
 rnf8-A ELISA Kit
 rnf8-A Recombinant
 rnf8-A Antibody
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E3 ubiquitin-protein ligase rnf8-B

 E3 ubiquitin-protein ligase rnf8-B ELISA Kit
 E3 ubiquitin-protein ligase rnf8-B Recombinant
 E3 ubiquitin-protein ligase rnf8-B Antibody
Also known as E3 ubiquitin-protein ligase rnf8-B (RING finger protein 8-B).
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove ta
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rget proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53bp1 and brca1 ionizing radiation-induced foci (IRIF). H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.
 rnf8-B ELISA Kit
 rnf8-B Recombinant
 rnf8-B Antibody
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E3 ubiquitin-protein ligase rpm-1

 E3 ubiquitin-protein ligase rpm-1 ELISA Kit
 E3 ubiquitin-protein ligase rpm-1 Recombinant
 E3 ubiquitin-protein ligase rpm-1 Antibody
Also known as E3 ubiquitin-protein ligase rpm-1 (Pam/highwire/rpm-1 protein) (Regulator of presynaptic morphology protein 1) (Synapse defective protein 3).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1 (PubMed:10839353, PubMed:15707898). Negatively regulates a p38 MAP kinase pathway composed of dlk-1, mkk-4, and pmk-3 that functions presynaptically to regulate synaptic architecture (PubMed:15707898). Has a role during synaptogenesis; regulates neuronal morphology, specifically presynaptic differentiation.
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May regulate the spatial arrangement of presynaptic terminals or restrict their development (PubMed:10839354, PubMed:15208641, PubMed:15707898, PubMed:21968191). By targeting both dlk-1 and mlk-1 for degradation, may negatively regulate mlk-1/mek-1/kgb-1 and dlk-1/mkk-4/pmk-3 pathways which are involved in axon regeneration after injury (PubMed:21670305). Regulates axon termination in PLM and ALM neurons (PubMed:21968191).
 rpm-1 ELISA Kit
 rpm-1 Recombinant
 rpm-1 Antibody
 syd-3 ELISA Kit
 syd-3 Recombinant
 syd-3 Antibody
 C01B7.6 ELISA Kit
 C01B7.6 Recombinant
 C01B7.6 Antibody
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E3 ubiquitin-protein ligase RSP5

 E3 ubiquitin-protein ligase RSP5 ELISA Kit
 E3 ubiquitin-protein ligase RSP5 Recombinant
 E3 ubiquitin-protein ligase RSP5 Antibody
Also known as E3 ubiquitin-protein ligase RSP5 (HECT ubiquitin ligase A) (HECT-type E3 ubiquitin transferase RSP5).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization. Ubiquitinates
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'Lys-528' of the uric acid/xanthine transporter uapA at the cell membrane, leading to its internalization, sorting into the endosomal pathway to the vacuolar lumen where it is eventually degraded.
 hulA ELISA Kit
 hulA Recombinant
 hulA Antibody
 AN1339 ELISA Kit
 AN1339 Recombinant
 AN1339 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SDIR1

 E3 ubiquitin-protein ligase SDIR1 ELISA Kit
 E3 ubiquitin-protein ligase SDIR1 Recombinant
 E3 ubiquitin-protein ligase SDIR1 Antibody
Also known as E3 ubiquitin-protein ligase SDIR1 (Protein salt- and drought-induced RING finger1).
Encodes an intracellular membrane localized protein with E3 ligase activity that is involved in regulation of ABA signaling. Loss of function alleles show decreased sensitivity to ABA. Overexpression results in increased sensitivity to ABA.
 SDIR1 ELISA Kit
 SDIR1 Recombinant
 SDIR1 Antibody
 At3g55530 ELISA Kit
 At3g55530 Recombinant
 At3g55530 Antibody
 T22E16.190 ELISA Kit
 T22E16.190 Recombinant
 T22E16.190 Antibody
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E3 ubiquitin-protein ligase SGR9, amyloplastic

 E3 ubiquitin-protein ligase SGR9, amyloplastic ELISA Kit
 E3 ubiquitin-protein ligase SGR9, amyloplastic Recombinant
 E3 ubiquitin-protein ligase SGR9, amyloplastic Antibody
Also known as E3 ubiquitin-protein ligase SGR9, amyloplastic (Protein SHOOT GRAVITROPISM 9).
Encodes an E3 ligase, SHOOT GRAVITROPISM9. Modulates the interaction between statoliths and F-Actin in gravity sensing.
 SGR9 ELISA Kit
 SGR9 Recombinant
 SGR9 Antibody
 At5g02750 ELISA Kit
 At5g02750 Recombinant
 At5g02750 Antibody
 F9G14.60 ELISA Kit
 F9G14.60 Recombinant
 F9G14.60 Antibody
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E3 ubiquitin-protein ligase SH3RF1

 E3 ubiquitin-protein ligase SH3RF1 ELISA Kit
 E3 ubiquitin-protein ligase SH3RF1 Recombinant
 E3 ubiquitin-protein ligase SH3RF1 Antibody
Also known as E3 ubiquitin-protein ligase SH3RF1 (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2).
SH3RF1: Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). May be involved in targeting of HIV-1 GAG and GAG-POL polyp
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roteins to the plasma membrane. Belongs to the SH3RF family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 4q32.3

Cellular Component: cytosol

Molecular Function: protein binding

Biological Process: negative regulation of apoptosis; negative regulation of caspase activity
 SH3RF1 ELISA Kit
 SH3RF1 Recombinant
 SH3RF1 Antibody
 KIAA1494 ELISA Kit
 KIAA1494 Recombinant
 KIAA1494 Antibody
 POSH ELISA Kit
 POSH Recombinant
 POSH Antibody
 RNF142 ELISA Kit
 RNF142 Recombinant
 RNF142 Antibody
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E3 ubiquitin-protein ligase SHPRH

 E3 ubiquitin-protein ligase SHPRH ELISA Kit
 E3 ubiquitin-protein ligase SHPRH Recombinant
 E3 ubiquitin-protein ligase SHPRH Antibody
Also known as E3 ubiquitin-protein ligase SHPRH (SNF2, histone-linker, PHD and RING finger domain-containing helicase).
SHPRH: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin
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chains linked through 'Lys-63'. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.-; EC 3.6.4.-; EC 6.3.2.-; EC 6.3.2.19; Helicase; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Molecular Function: ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: protein polyubiquitination; response to DNA damage stimulus
 Shprh ELISA Kit
 Shprh Recombinant
 Shprh Antibody
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E3 ubiquitin-protein ligase siah-1

 E3 ubiquitin-protein ligase siah-1 ELISA Kit
 E3 ubiquitin-protein ligase siah-1 Recombinant
 E3 ubiquitin-protein ligase siah-1 Antibody
Also known as E3 ubiquitin-protein ligase siah-1 (Seven in absentia homolog 1).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiqu
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itin-mediated degradation of different substrates ().
 siah-1 ELISA Kit
 siah-1 Recombinant
 siah-1 Antibody
 Y37E11AR.2 ELISA Kit
 Y37E11AR.2 Recombinant
 Y37E11AR.2 Antibody
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E3 ubiquitin-protein ligase Siah1

 E3 ubiquitin-protein ligase Siah1 ELISA Kit
 E3 ubiquitin-protein ligase Siah1 Recombinant
 E3 ubiquitin-protein ligase Siah1 Antibody
Also known as E3 ubiquitin-protein ligase Siah1 (Seven in absentia homolog 1) (Siah-1).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers t
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he ubiquitin-mediated degradation of different substrates ().
 siah1 ELISA Kit
 siah1 Recombinant
 siah1 Antibody
 zgc:56026 ELISA Kit
 zgc:56026 Recombinant
 zgc:56026 Antibody
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E3 ubiquitin-protein ligase SIAH1A

 E3 ubiquitin-protein ligase SIAH1A ELISA Kit
 E3 ubiquitin-protein ligase SIAH1A Recombinant
 E3 ubiquitin-protein ligase SIAH1A Antibody
Also known as E3 ubiquitin-protein ligase SIAH1A (Seven in absentia homolog 1a) (Siah-1a) (Siah1a) (mSiah-1a).
SIAH1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted sub
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strates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S- nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins. Homodimer. Interacts with group 1 glutamate receptors GRM1 and GRM5. Interacts with DAB1, which may inhibit its activity. Interacts with UBE2E2. Interacts with PEG3. Interacts with GAPDH; leading to stabilize SIAH1. Component of some large E3 complex composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with UBE2I. Interacts with alpha- tubulin. Interacts with PEG10, which may inhibit its activity. Interacts with KHDRBS3. Interacts with SNCAIP and HIPK2. May be induced by p53/TP53, suggesting that it may be required to modulate p53/TP53 response. The relevance of such activity in vivo is however unclear and may not exist. Widely expressed at a low level. Down- regulated in advanced hepatocellular carcinomas. Inhibited by interaction with SNCAIP (isoform 2, but not isoform 1). May be inhibited by interaction with PEG10. Belongs to the SINA (Seven in absentia) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: beta-catenin destruction complex; cytoplasm; cytosol; early endosome; nucleus; plasma membrane

Molecular Function: protein binding; protein C-terminus binding; protein homodimerization activity; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: apoptosis; male meiosis I; neuron apoptosis; positive regulation of apoptosis; post-embryonic development; proteasomal ubiquitin-dependent protein catabolic process; protein catabolic process; protein destabilization; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of multicellular organism growth; spermatogenesis; ubiquitin-dependent protein catabolic process
 Siah1a ELISA Kit
 Siah1a Recombinant
 Siah1a Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SIAH1B

 E3 ubiquitin-protein ligase SIAH1B ELISA Kit
 E3 ubiquitin-protein ligase SIAH1B Recombinant
 E3 ubiquitin-protein ligase SIAH1B Antibody
Also known as E3 ubiquitin-protein ligase SIAH1B (Seven in absentia homolog 1b) (Siah-1b) (Siah1b).
This gene encodes a member of the seven in absentia homolog (Siah) family of E3 ubiquitin ligase enzymes that catalyze the transfer of ubiquitin to substrate proteins. The encoded protein targets Pard3A (partitioning defective 3A) protein for proteasome-mediated degradation during the exit of cer
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ebellar granule neurons from their germinal zone niche. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
 Siah1b ELISA Kit
 Siah1b Recombinant
 Siah1b Antibody
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E3 ubiquitin-protein ligase SIAH2

 E3 ubiquitin-protein ligase SIAH2 ELISA Kit
 E3 ubiquitin-protein ligase SIAH2 Recombinant
 E3 ubiquitin-protein ligase SIAH2 Antibody
Also known as E3 ubiquitin-protein ligase SIAH2 (Seven in absentia homolog 2) (Siah-2).
a synaptophysin binding protein and also interact with E2 ubiquitin-conjugating enzyme UbcH8; involved in the regulating the ubiquitination and degradation of synaptophysin [RGD, Feb 2006]
 Siah2 ELISA Kit
 Siah2 Recombinant
 Siah2 Antibody
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E3 ubiquitin-protein ligase sina

 E3 ubiquitin-protein ligase sina ELISA Kit
 E3 ubiquitin-protein ligase sina Recombinant
 E3 ubiquitin-protein ligase sina Antibody
Also known as E3 ubiquitin-protein ligase sina (Seven in absentia homolog) (SmSINA).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitin-me
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diated degradation of nuclear receptors for retinoids SmRXR1 and SmRXR2.
 SINA ELISA Kit
 SINA Recombinant
 SINA Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINA-like 1

 E3 ubiquitin-protein ligase SINA-like 1 ELISA Kit
 E3 ubiquitin-protein ligase SINA-like 1 Recombinant
 E3 ubiquitin-protein ligase SINA-like 1 Antibody
Also known as E3 ubiquitin-protein ligase SINA-like 1 (Seven in absentia-like protein 1).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers
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the ubiquitin-mediated degradation of different substrates ().
 At1g66610 ELISA Kit
 At1g66610 Recombinant
 At1g66610 Antibody
 T12I7.6 ELISA Kit
 T12I7.6 Recombinant
 T12I7.6 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINA-like 10

 E3 ubiquitin-protein ligase SINA-like 10 ELISA Kit
 E3 ubiquitin-protein ligase SINA-like 10 Recombinant
 E3 ubiquitin-protein ligase SINA-like 10 Antibody
Also known as E3 ubiquitin-protein ligase SINA-like 10 (Seven in absentia-like protein 10).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably trigge
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rs the ubiquitin-mediated degradation of different substrates ().
 At5g37930 ELISA Kit
 At5g37930 Recombinant
 At5g37930 Antibody
 K18L3.13 ELISA Kit
 K18L3.13 Recombinant
 K18L3.13 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINA-like 11

 E3 ubiquitin-protein ligase SINA-like 11 ELISA Kit
 E3 ubiquitin-protein ligase SINA-like 11 Recombinant
 E3 ubiquitin-protein ligase SINA-like 11 Antibody
Also known as E3 ubiquitin-protein ligase SINA-like 11 (Seven in absentia-like protein 11).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably trigge
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rs the ubiquitin-mediated degradation of different substrates ().
 At5g62800 ELISA Kit
 At5g62800 Recombinant
 At5g62800 Antibody
 MQB2.12 ELISA Kit
 MQB2.12 Recombinant
 MQB2.12 Antibody
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E3 ubiquitin-protein ligase SINA-like 2

 E3 ubiquitin-protein ligase SINA-like 2 ELISA Kit
 E3 ubiquitin-protein ligase SINA-like 2 Recombinant
 E3 ubiquitin-protein ligase SINA-like 2 Antibody
Also known as E3 ubiquitin-protein ligase SINA-like 2 (Seven in absentia-like protein 2).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers
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the ubiquitin-mediated degradation of different substrates ().
 At1g66620 ELISA Kit
 At1g66620 Recombinant
 At1g66620 Antibody
 T12I7.7 ELISA Kit
 T12I7.7 Recombinant
 T12I7.7 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINA-like 3

 E3 ubiquitin-protein ligase SINA-like 3 ELISA Kit
 E3 ubiquitin-protein ligase SINA-like 3 Recombinant
 E3 ubiquitin-protein ligase SINA-like 3 Antibody
Also known as E3 ubiquitin-protein ligase SINA-like 3 (Seven in absentia-like protein 3).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers
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the ubiquitin-mediated degradation of different substrates ().
 At1g66630 ELISA Kit
 At1g66630 Recombinant
 At1g66630 Antibody
 T12I7.8 ELISA Kit
 T12I7.8 Recombinant
 T12I7.8 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINA-like 4

 E3 ubiquitin-protein ligase SINA-like 4 ELISA Kit
 E3 ubiquitin-protein ligase SINA-like 4 Recombinant
 E3 ubiquitin-protein ligase SINA-like 4 Antibody
Also known as E3 ubiquitin-protein ligase SINA-like 4 (Seven in absentia-like protein 4).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates ().
 At1g66650 ELISA Kit
 At1g66650 Recombinant
 At1g66650 Antibody
 F4N21_21 ELISA Kit
 F4N21_21 Recombinant
 F4N21_21 Antibody
 T12I7.10 ELISA Kit
 T12I7.10 Recombinant
 T12I7.10 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINA-like 5

 E3 ubiquitin-protein ligase SINA-like 5 ELISA Kit
 E3 ubiquitin-protein ligase SINA-like 5 Recombinant
 E3 ubiquitin-protein ligase SINA-like 5 Antibody
Also known as E3 ubiquitin-protein ligase SINA-like 5 (Seven in absentia-like protein 5).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates ().
 At1g66660 ELISA Kit
 At1g66660 Recombinant
 At1g66660 Antibody
 F4N21_20 ELISA Kit
 F4N21_20 Recombinant
 F4N21_20 Antibody
 T12I7.11 ELISA Kit
 T12I7.11 Recombinant
 T12I7.11 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINA-like 7

 E3 ubiquitin-protein ligase SINA-like 7 ELISA Kit
 E3 ubiquitin-protein ligase SINA-like 7 Recombinant
 E3 ubiquitin-protein ligase SINA-like 7 Antibody
Also known as E3 ubiquitin-protein ligase SINA-like 7 (Seven in absentia-like protein 7).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers
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the ubiquitin-mediated degradation of different substrates ().
 At5g37890 ELISA Kit
 At5g37890 Recombinant
 At5g37890 Antibody
 K18L3.9 ELISA Kit
 K18L3.9 Recombinant
 K18L3.9 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINA-like 8

 E3 ubiquitin-protein ligase SINA-like 8 ELISA Kit
 E3 ubiquitin-protein ligase SINA-like 8 Recombinant
 E3 ubiquitin-protein ligase SINA-like 8 Antibody
Also known as E3 ubiquitin-protein ligase SINA-like 8 (Seven in absentia-like protein 8).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers
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the ubiquitin-mediated degradation of different substrates ().
 At5g37900 ELISA Kit
 At5g37900 Recombinant
 At5g37900 Antibody
 K18L3.10 ELISA Kit
 K18L3.10 Recombinant
 K18L3.10 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINAT2

 E3 ubiquitin-protein ligase SINAT2 ELISA Kit
 E3 ubiquitin-protein ligase SINAT2 Recombinant
 E3 ubiquitin-protein ligase SINAT2 Antibody
Also known as E3 ubiquitin-protein ligase SINAT2 (Seven in absentia homolog 2).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
 SINAT2 ELISA Kit
 SINAT2 Recombinant
 SINAT2 Antibody
 At3g58040 ELISA Kit
 At3g58040 Recombinant
 At3g58040 Antibody
 T10K17.250 ELISA Kit
 T10K17.250 Recombinant
 T10K17.250 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINAT3

 E3 ubiquitin-protein ligase SINAT3 ELISA Kit
 E3 ubiquitin-protein ligase SINAT3 Recombinant
 E3 ubiquitin-protein ligase SINAT3 Antibody
Also known as E3 ubiquitin-protein ligase SINAT3 (Seven in absentia homolog 3).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates ().
 SINAT3 ELISA Kit
 SINAT3 Recombinant
 SINAT3 Antibody
 At3g61790 ELISA Kit
 At3g61790 Recombinant
 At3g61790 Antibody
 F15G16.180 ELISA Kit
 F15G16.180 Recombinant
 F15G16.180 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINAT4

 E3 ubiquitin-protein ligase SINAT4 ELISA Kit
 E3 ubiquitin-protein ligase SINAT4 Recombinant
 E3 ubiquitin-protein ligase SINAT4 Antibody
Also known as E3 ubiquitin-protein ligase SINAT4 (Seven in absentia homolog 4).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates ().
 SINAT4 ELISA Kit
 SINAT4 Recombinant
 SINAT4 Antibody
 At4g27880 ELISA Kit
 At4g27880 Recombinant
 At4g27880 Antibody
 T27E11.120 ELISA Kit
 T27E11.120 Recombinant
 T27E11.120 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SINAT5

 E3 ubiquitin-protein ligase SINAT5 ELISA Kit
 E3 ubiquitin-protein ligase SINAT5 Recombinant
 E3 ubiquitin-protein ligase SINAT5 Antibody
Also known as E3 ubiquitin-protein ligase SINAT5 (Seven in absentia homolog 5).
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitin-mediated degradation of NAC021/NAC022, a transcription activator that functions downstream of the auxin signals, thereby acting as a down-regulator of auxin signals. Involved in the formation of lateral root
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s.
 SINAT5 ELISA Kit
 SINAT5 Recombinant
 SINAT5 Antibody
 At5g53360 ELISA Kit
 At5g53360 Recombinant
 At5g53360 Antibody
 K19E1.16 ELISA Kit
 K19E1.16 Recombinant
 K19E1.16 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SIS3

 E3 ubiquitin-protein ligase SIS3 ELISA Kit
 E3 ubiquitin-protein ligase SIS3 Recombinant
 E3 ubiquitin-protein ligase SIS3 Antibody
Also known as E3 ubiquitin-protein ligase SIS3 (Protein SUGAR INSENSITIVE 3).
E3 ubiquitin protein ligase that acts as positive regulator of sugar signaling during early seedling development. Possesses E3 ligase activity in vitro.
 SIS3 ELISA Kit
 SIS3 Recombinant
 SIS3 Antibody
 At3g47990 ELISA Kit
 At3g47990 Recombinant
 At3g47990 Antibody
 T17F15.140 ELISA Kit
 T17F15.140 Recombinant
 T17F15.140 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SlrP

 E3 ubiquitin-protein ligase SlrP ELISA Kit
 E3 ubiquitin-protein ligase SlrP Recombinant
 E3 ubiquitin-protein ligase SlrP Antibody
Also known as E3 ubiquitin-protein ligase SlrP (Secreted effector protein SlrP).
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin). Leads to significant decrease of thioredoxin activity and in
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crease of host cell death.
 slrP ELISA Kit
 slrP Recombinant
 slrP Antibody
 STM0800 ELISA Kit
 STM0800 Recombinant
 STM0800 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase Smurf1

 E3 ubiquitin-protein ligase Smurf1 ELISA Kit
 E3 ubiquitin-protein ligase Smurf1 Recombinant
 E3 ubiquitin-protein ligase Smurf1 Antibody
Also known as E3 ubiquitin-protein ligase Smurf1 (HECT-type E3 ubiquitin transferase Smurf1) (Lethal with a checkpoint kinase protein) (SMAD ubiquitination regulatory factor 1 homolog) (DSmurf).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Dpp signaling after gastrulation by promoting MAD ubiquitination and subsequent degradation.
 lack ELISA Kit
 lack Recombinant
 lack Antibody
 Smurf ELISA Kit
 Smurf Recombinant
 Smurf Antibody
 Smurf1 ELISA Kit
 Smurf1 Recombinant
 Smurf1 Antibody
 CG4943 ELISA Kit
 CG4943 Recombinant
 CG4943 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SMURF2

 E3 ubiquitin-protein ligase SMURF2 ELISA Kit
 E3 ubiquitin-protein ligase SMURF2 Recombinant
 E3 ubiquitin-protein ligase SMURF2 Antibody
Also known as E3 ubiquitin-protein ligase SMURF2 (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2).
SMURF2: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 a
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nd SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; nucleus; ubiquitin ligase complex

Molecular Function: identical protein binding; protein binding; SMAD binding; transforming growth factor beta receptor binding; ubiquitin-protein ligase activity

Biological Process: negative regulation of transforming growth factor beta receptor signaling pathway; protein ubiquitination during ubiquitin-dependent protein catabolic process; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process; ubiquitin-dependent SMAD protein catabolic process
 Smurf2 ELISA Kit
 Smurf2 Recombinant
 Smurf2 Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase SNT2

 E3 ubiquitin-protein ligase SNT2 ELISA Kit
 E3 ubiquitin-protein ligase SNT2 Recombinant
 E3 ubiquitin-protein ligase SNT2 Antibody
Also known as E3 ubiquitin-protein ligase SNT2 (Histone E3 ligase SNT2) (SANT domain-containing protein 2).
Transcriptional regulator that, together with ECM5, recruits histone deacetylase RPD3 to a small number of promoters of stress-response genes in response to oxidative stress (PubMed:23878396). Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation (PubMed:22570702).
 SNT2 ELISA Kit
 SNT2 Recombinant
 SNT2 Antibody
 YGL131C ELISA Kit
 YGL131C Recombinant
 YGL131C Antibody
 G2850 ELISA Kit
 G2850 Recombinant
 G2850 Antibody
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E3 ubiquitin-protein ligase SopA

 E3 ubiquitin-protein ligase SopA ELISA Kit
 E3 ubiquitin-protein ligase SopA Recombinant
 E3 ubiquitin-protein ligase SopA Antibody
Also known as E3 ubiquitin-protein ligase SopA (Salmonella outer protein A) (Secreted effector protein SopA).
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway ().
 sopA ELISA Kit
 sopA Recombinant
 sopA Antibody
 SeD_A2402 ELISA Kit
 SeD_A2402 Recombinant
 SeD_A2402 Antibody
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E3 ubiquitin-protein ligase SP1

 E3 ubiquitin-protein ligase SP1 ELISA Kit
 E3 ubiquitin-protein ligase SP1 Recombinant
 E3 ubiquitin-protein ligase SP1 Antibody
Also known as E3 ubiquitin-protein ligase SP1 (DIAP1-like protein 1) (Protein SUPPRESSOR OF PPI1 LOCUS 1).
Encodes a RING-type ubiquitin E3 ligase of the chloroplast outer membrane that associates with TOC complexes and mediated ubiquitination of TOC components, promoting their degradation.
 SP1 ELISA Kit
 SP1 Recombinant
 SP1 Antibody
 DIAL1 ELISA Kit
 DIAL1 Recombinant
 DIAL1 Antibody
 At1g63900 ELISA Kit
 At1g63900 Recombinant
 At1g63900 Antibody
 T12P18.8 ELISA Kit
 T12P18.8 Recombinant
 T12P18.8 Antibody
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E3 ubiquitin-protein ligase SPL1

 E3 ubiquitin-protein ligase SPL1 ELISA Kit
 E3 ubiquitin-protein ligase SPL1 Recombinant
 E3 ubiquitin-protein ligase SPL1 Antibody
Also known as E3 ubiquitin-protein ligase SPL1 (DIAP1-like protein 2) (SP1-like protein 1).
Possesses E3 ubiquitin-protein ligase activity.
 SPL1 ELISA Kit
 SPL1 Recombinant
 SPL1 Antibody
 DIAL2 ELISA Kit
 DIAL2 Recombinant
 DIAL2 Antibody
 ZCF61 ELISA Kit
 ZCF61 Recombinant
 ZCF61 Antibody
 At1g59560 ELISA Kit
 At1g59560 Recombinant
 At1g59560 Antibody
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E3 ubiquitin-protein ligase SPL11

 E3 ubiquitin-protein ligase SPL11 ELISA Kit
 E3 ubiquitin-protein ligase SPL11 Recombinant
 E3 ubiquitin-protein ligase SPL11 Antibody
Also known as E3 ubiquitin-protein ligase SPL11 (Cell death-related protein SPL11) (Protein spotted leaf 11).
E3 ubiquitin-protein ligase that negatively regulates programmed cell death and disease resistance. Participates in flowering time control by mediating ubiquitination and subsequent proteasomal degradation of SPIN1.
 SPL11 ELISA Kit
 SPL11 Recombinant
 SPL11 Antibody
 Os12g0570000 ELISA Kit
 Os12g0570000 Recombinant
 Os12g0570000 Antibody
 LOC_Os12g38210 ELISA Kit
 LOC_Os12g38210 Recombinant
 LOC_Os12g38210 Antibody
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E3 ubiquitin-protein ligase SPL2

 E3 ubiquitin-protein ligase SPL2 ELISA Kit
 E3 ubiquitin-protein ligase SPL2 Recombinant
 E3 ubiquitin-protein ligase SPL2 Antibody
Also known as E3 ubiquitin-protein ligase SPL2 (SP1-like protein 2).
Possesses E3 ubiquitin-protein ligase activity.
 SPL2 ELISA Kit
 SPL2 Recombinant
 SPL2 Antibody
 At1g54150 ELISA Kit
 At1g54150 Recombinant
 At1g54150 Antibody
 F15I1.25 ELISA Kit
 F15I1.25 Recombinant
 F15I1.25 Antibody
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E3 ubiquitin-protein ligase SspH1

 E3 ubiquitin-protein ligase SspH1 ELISA Kit
 E3 ubiquitin-protein ligase SspH1 Recombinant
 E3 ubiquitin-protein ligase SspH1 Antibody
Also known as E3 ubiquitin-protein ligase SspH1 (Salmonella secreted protein H1) (Secreted effector protein SspH1).
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin-protein ligase that interferes with the host's ubiquitination pathway and targets host proteins for proteasomal degradation. Can ubiquitinate ub
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iquitin, giving rise to polyubiquitin chains (in vitro). Polyubiquitinates host PKN1, leading to its proteasomal degradation. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression; this depends only partially on its E3 ubiquitin-protein ligase activity.
 sspH1 ELISA Kit
 sspH1 Recombinant
 sspH1 Antibody
 STM14_1483 ELISA Kit
 STM14_1483 Recombinant
 STM14_1483 Antibody
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E3 ubiquitin-protein ligase sspH2

 E3 ubiquitin-protein ligase sspH2 ELISA Kit
 E3 ubiquitin-protein ligase sspH2 Recombinant
 E3 ubiquitin-protein ligase sspH2 Antibody
Also known as E3 ubiquitin-protein ligase sspH2 (Salmonella secreted protein H2) (Secreted effector protein sspH2).
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway ().
 sspH2 ELISA Kit
 sspH2 Recombinant
 sspH2 Antibody
 STM2241 ELISA Kit
 STM2241 Recombinant
 STM2241 Antibody
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E3 ubiquitin-protein ligase Su

 E3 ubiquitin-protein ligase Su ELISA Kit
 E3 ubiquitin-protein ligase Su Recombinant
 E3 ubiquitin-protein ligase Su Antibody
Also known as E3 ubiquitin-protein ligase Su(dx) (HECT-type E3 ubiquitin transferase Su(dx)) (Protein suppressor of deltex).
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, e
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ndocytosis and degradation. Involved in wing growth and leg joint formation.
 Su(dx) ELISA Kit
 Su(dx) Recombinant
 Su(dx) Antibody
 CG4244 ELISA Kit
 CG4244 Recombinant
 CG4244 Antibody
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E3 ubiquitin-protein ligase synoviolin

 E3 ubiquitin-protein ligase synoviolin ELISA Kit
 E3 ubiquitin-protein ligase synoviolin Recombinant
 E3 ubiquitin-protein ligase synoviolin Antibody
Also known as E3 ubiquitin-protein ligase synoviolin (Synovial apoptosis inhibitor 1).
SYVN1: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER
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stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Belongs to the HRD1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Endoplasmic reticulum; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: endoplasmic reticulum; membrane; nucleoplasm; smooth endoplasmic reticulum; ubiquitin ligase complex

Molecular Function: ATPase binding; chaperone binding; protein binding; unfolded protein binding

Biological Process: ER-associated protein catabolic process; in utero embryonic development; protein amino acid N-linked glycosylation via asparagine; protein catabolic process; protein polyubiquitination; protein stabilization; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; response to unfolded protein; retrograde protein transport, ER to cytosol; unfolded protein response
 Syvn1 ELISA Kit
 Syvn1 Recombinant
 Syvn1 Antibody
 Hrd1 ELISA Kit
 Hrd1 Recombinant
 Hrd1 Antibody
 Kiaa1810 ELISA Kit
 Kiaa1810 Recombinant
 Kiaa1810 Antibody
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E3 ubiquitin-protein ligase synoviolin A

 E3 ubiquitin-protein ligase synoviolin A ELISA Kit
 E3 ubiquitin-protein ligase synoviolin A Recombinant
 E3 ubiquitin-protein ligase synoviolin A Antibody
Also known as E3 ubiquitin-protein ligase synoviolin A (Synovial apoptosis inhibitor-1-A).
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) in
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volved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis ().
 syvn1-a ELISA Kit
 syvn1-a Recombinant
 syvn1-a Antibody
 hrd1-a ELISA Kit
 hrd1-a Recombinant
 hrd1-a Antibody
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E3 ubiquitin-protein ligase synoviolin B

 E3 ubiquitin-protein ligase synoviolin B ELISA Kit
 E3 ubiquitin-protein ligase synoviolin B Recombinant
 E3 ubiquitin-protein ligase synoviolin B Antibody
Also known as E3 ubiquitin-protein ligase synoviolin B (Synovial apoptosis inhibitor 1-B).
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) in
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volved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis ().
 syvn1-b ELISA Kit
 syvn1-b Recombinant
 syvn1-b Antibody
 hrd1-b ELISA Kit
 hrd1-b Recombinant
 hrd1-b Antibody
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E3 ubiquitin-protein ligase TM129

 E3 ubiquitin-protein ligase TM129 ELISA Kit
 E3 ubiquitin-protein ligase TM129 Recombinant
 E3 ubiquitin-protein ligase TM129 Antibody
TMEM129: Belongs to the TMEM129 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: endoplasmic reticulum

Biological Process: ER-associated protein catabolic process; protein polyubiquitination; retrograde pr
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otein transport, ER to cytosol
 TMEM129 ELISA Kit
 TMEM129 Recombinant
 TMEM129 Antibody
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E3 ubiquitin-protein ligase TOM1

 E3 ubiquitin-protein ligase TOM1 ELISA Kit
 E3 ubiquitin-protein ligase TOM1 Recombinant
 E3 ubiquitin-protein ligase TOM1 Antibody
Also known as E3 ubiquitin-protein ligase TOM1 (HECT-type E3 ubiquitin transferase TOM1) (Suppressor of snRNA protein 2) (Temperature-dependent organization in mitotic nucleus protein 1).
Probable ubiquitin ligase protein involved in many cellular processes, such as transcription regulation, maintenance of nuclear structure, cell cycle, mRNA export and rRNA maturation. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Involved in transcription regulation by interacting, and probably mediating, ubiquitination of some subunit of the
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SAGA complex. Required for SPT7 ubiquitination. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins. Required for the shuttling of hnRNP protein NAB2, probably by mediating ubiquitination of a protein associated with NAB2. Also required for full induction of the general stress and heat-shock responses. Involved in 18S rRNA maturation by affecting several early steps in the rRNA processing pathway.
 TOM1 ELISA Kit
 TOM1 Recombinant
 TOM1 Antibody
 SSR2 ELISA Kit
 SSR2 Recombinant
 SSR2 Antibody
 YDR457W ELISA Kit
 YDR457W Recombinant
 YDR457W Antibody
 D8035.1 ELISA Kit
 D8035.1 Recombinant
 D8035.1 Antibody
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E3 ubiquitin-protein ligase TOM1-like

 E3 ubiquitin-protein ligase TOM1-like ELISA Kit
 E3 ubiquitin-protein ligase TOM1-like Recombinant
 E3 ubiquitin-protein ligase TOM1-like Antibody
Also known as E3 ubiquitin-protein ligase TOM1-like (HECT-type E3 ubiquitin transferase TOM1-like).
Probable ubiquitin ligase protein, which may be involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins.
 B11B22.010 ELISA Kit
 B11B22.010 Recombinant
 B11B22.010 Antibody
 NCU08501 ELISA Kit
 NCU08501 Recombinant
 NCU08501 Antibody
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E3 ubiquitin-protein ligase Topors

 E3 ubiquitin-protein ligase Topors ELISA Kit
 E3 ubiquitin-protein ligase Topors Recombinant
 E3 ubiquitin-protein ligase Topors Antibody
Also known as E3 ubiquitin-protein ligase Topors (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (dTopors).
Functions as a ubiquitin-protein E3 ligase. Negatively regulates the transcriptional repressor h/hairy by promoting its ubiquitination and subsequent degradation. Also directs the nuclear organization of
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the gypsy chromatin insulator. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them, and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may require the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may promote formation of nuclear insulator bodies by recruiting individual insulator complexes to the nuclear lamina.
 Topors ELISA Kit
 Topors Recombinant
 Topors Antibody
 CG15104 ELISA Kit
 CG15104 Recombinant
 CG15104 Antibody
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E3 ubiquitin-protein ligase TRAF7

 E3 ubiquitin-protein ligase TRAF7 ELISA Kit
 E3 ubiquitin-protein ligase TRAF7 Recombinant
 E3 ubiquitin-protein ligase TRAF7 Antibody
Also known as E3 ubiquitin-protein ligase TRAF7 (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7).
TRAF7: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Belongs to the WD repeat TRAF7 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquiti
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n ligase

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: intracellular membrane-bound organelle; plasma membrane; ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: activation of MAPKKK activity; apoptosis; positive regulation of MAPKKK cascade; protein ubiquitination
 TRAF7 ELISA Kit
 TRAF7 Recombinant
 TRAF7 Antibody
 RFWD1 ELISA Kit
 RFWD1 Recombinant
 RFWD1 Antibody
 RNF119 ELISA Kit
 RNF119 Recombinant
 RNF119 Antibody
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E3 ubiquitin-protein ligase TRAIP

 E3 ubiquitin-protein ligase TRAIP ELISA Kit
 E3 ubiquitin-protein ligase TRAIP Recombinant
 E3 ubiquitin-protein ligase TRAIP Antibody
Also known as E3 ubiquitin-protein ligase TRAIP (RING finger protein 206) (TRAF-interacting protein).
TRAIP: Inhibits activation of NF-kappa-B mediated by TNF.

Protein type: EC 6.3.2.-; Ligase; Nucleolus; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3p21.31

Molecular Function: protein binding

Biological Process: apoptosis; cell proliferation

Disease: Seckel Syndrome 9
 TRAIP ELISA Kit
 TRAIP Recombinant
 TRAIP Antibody
 RNF206 ELISA Kit
 RNF206 Recombinant
 RNF206 Antibody
 TRIP ELISA Kit
 TRIP Recombinant
 TRIP Antibody
Table BarTOPTable Bar
 

E3 ubiquitin-protein ligase TRIM11

 E3 ubiquitin-protein ligase TRIM11 ELISA Kit
 E3 ubiquitin-protein ligase TRIM11 Recombinant
 E3 ubiquitin-protein ligase TRIM11 Antibody
Also known as E3 ubiquitin-protein ligase TRIM11 (Protein BIA1) (RING finger protein 92) (Tripartite motif-containing protein 11).
TRIM11: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby m
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odulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: innate immune response; negative regulation of viral transcription; negative regulation of virion penetration into host cell; positive regulation of virion penetration into host cell
 TRIM11 ELISA Kit
 TRIM11 Recombinant
 TRIM11 Antibody
 RNF92 ELISA Kit
 RNF92 Recombinant
 RNF92 Antibody
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E3 ubiquitin-protein ligase TRIM13

 E3 ubiquitin-protein ligase TRIM13 ELISA Kit
 E3 ubiquitin-protein ligase TRIM13 Recombinant
 E3 ubiquitin-protein ligase TRIM13 Antibody
Also known as E3 ubiquitin-protein ligase TRIM13 (B-cell chronic lymphocytic leukemia tumor suppressor Leu5) (Leukemia-associated protein 5) (Putative tumor suppressor RFP2) (RING finger protein 77) (Ret finger protein 2) (Tripartite motif-containing prote.
TRIM13: E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53
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/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ligase; Membrane protein, integral; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: endoplasmic reticulum membrane

Molecular Function: protein binding; signal transducer activity; ubiquitin-protein ligase activity

Biological Process: activation of NF-kappaB transcription factor; anatomical structure morphogenesis; ER-associated protein catabolic process; innate immune response; negative regulation of viral transcription; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macroautophagy; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; response to gamma radiation
 TRIM13 ELISA Kit
 TRIM13 Recombinant
 TRIM13 Antibody
 LEU5 ELISA Kit
 LEU5 Recombinant
 LEU5 Antibody
 RFP2 ELISA Kit