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Ectonucleotide pyrophosphatase/phosphodiesterase family

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Appears to modulate insulin sensitivity (By similarity). By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling.

Below are the list of possible Ectonucleotide pyrophosphatase/phosphodiesterase family products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ELISA Kit
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Recombinant
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Antibody
Also known as Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Lymphocyte antigen 41) (Ly-41) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1).
ENPP1: Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine pol
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yphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity. Homodimer; disulfide-linked. Interacts with INSR. Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis. At low concentrations of ATP, a phosphorylated intermediate is formed which inhibits further hydrolysis. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Protein type: Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.4.1; EC 3.6.1.9; Membrane protein, integral; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Phosphatase (non-protein); Phosphodiesterase

Cellular Component: cell surface; extracellular space; integral to membrane; integral to plasma membrane; lysosomal membrane; plasma membrane

Molecular Function: ATP binding; calcium ion binding; insulin receptor binding; nucleoside-triphosphate diphosphatase activity; nucleotide diphosphatase activity; phosphodiesterase I activity; protein homodimerization activity; zinc ion binding

Biological Process: 3'-phosphoadenosine 5'-phosphosulfate metabolic process; bone remodeling; cellular phosphate ion homeostasis; cellular response to insulin stimulus; generation of precursor metabolites and energy; inorganic diphosphate transport; negative regulation of cell growth; negative regulation of fat cell differentiation; negative regulation of glucose import; negative regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; negative regulation of ossification; negative regulation of protein amino acid autophosphorylation; nucleoside triphosphate catabolic process; phosphate metabolic process; sequestering of triacylglycerol
 Enpp1 ELISA Kit
 Enpp1 Recombinant
 Enpp1 Antibody
 Npps ELISA Kit
 Npps Recombinant
 Npps Antibody
 Pc1 ELISA Kit
 Pc1 Recombinant
 Pc1 Antibody
 Pdnp1 ELISA Kit
 Pdnp1 Recombinant
 Pdnp1 Antibody
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 ELISA Kit
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Recombinant
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Antibody
Also known as Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) (Autotaxin) (Extracellular lysophospholipase D) (LysoPLD).
ENPP2: Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic facto
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r by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.39; Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis; Phosphodiesterase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q24.1

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: calcium ion binding; hydrolase activity; lysophospholipase activity; transcription factor binding; zinc ion binding

Biological Process: cell motility; G-protein coupled receptor protein signaling pathway; phosphate metabolic process; phospholipid catabolic process; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell migration
 ENPP2 ELISA Kit
 ENPP2 Recombinant
 ENPP2 Antibody
 ATX ELISA Kit
 ATX Recombinant
 ATX Antibody
 PDNP2 ELISA Kit
 PDNP2 Recombinant
 PDNP2 Antibody
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 ELISA Kit
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 Recombinant
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 Antibody
Also known as Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (B10) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (RB13-6 antigen) (CD antigen CD203c).
ENPP3: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD. Belongs to the nucleotide pyrophosphatase/phosphodi
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esterase family.

Protein type: Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.4.1; EC 3.6.1.9; Membrane protein, integral; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Phosphodiesterase

Cellular Component: cell surface; perinuclear region of cytoplasm

Molecular Function: nucleoside-triphosphate diphosphatase activity; nucleotide diphosphatase activity; phosphodiesterase I activity

Biological Process: inorganic diphosphate transport; nucleoside triphosphate catabolic process; phosphate metabolic process
 Enpp3 ELISA Kit
 Enpp3 Recombinant
 Enpp3 Antibody
 Pdnp3 ELISA Kit
 Pdnp3 Recombinant
 Pdnp3 Antibody
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 5

 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 ELISA Kit
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Recombinant
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Antibody
Also known as Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5).
ENPP5: May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Protein type: EC 3.1.-.-; Hydrolase; Membrane protein, integral; Motility/polarity/chemotaxis

Cellu
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lar Component: integral to plasma membrane; plasma membrane

Molecular Function: nucleotide diphosphatase activity

Biological Process: cell communication; nucleotide catabolic process
 Enpp5 ELISA Kit
 Enpp5 Recombinant
 Enpp5 Antibody
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 6

 Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 ELISA Kit
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 Recombinant
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 Antibody
Also known as Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (E-NPP 6) (NPP-6) (Choline-specific glycerophosphodiester phosphodiesterase) (Glycerophosphocholine choline phosphodiesterase) (GPC-Cpde).
Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin. Also hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol
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and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid ().
 ENPP6 ELISA Kit
 ENPP6 Recombinant
 ENPP6 Antibody
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

 Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 ELISA Kit
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 Recombinant
 Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 Antibody
Also known as Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).
Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.
 Enpp7 ELISA Kit
 Enpp7 Recombinant
 Enpp7 Antibody
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Proteins Root Name Listing
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