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EGF-containing fibulin-like extracellular matrix protein

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Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.

Below are the list of possible EGF-containing fibulin-like extracellular matrix protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

EGF-containing fibulin-like extracellular matrix protein 1

 EGF-containing fibulin-like extracellular matrix protein 1 ELISA Kit
 EGF-containing fibulin-like extracellular matrix protein 1 Recombinant
 EGF-containing fibulin-like extracellular matrix protein 1 Antibody
Also known as EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3).
EFEMP1: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. Defects in EFEMP1 are a cause of Doyne honeycomb reti
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nal dystrophy (DHRD); also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium. Belongs to the fibulin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p16

Cellular Component: extracellular matrix; extracellular region; extracellular space

Molecular Function: epidermal growth factor receptor activity; epidermal growth factor receptor binding; protein binding

Biological Process: camera-type eye development; embryonic eye morphogenesis; epidermal growth factor receptor signaling pathway; negative regulation of chondrocyte differentiation; peptidyl-tyrosine phosphorylation; post-embryonic eye morphogenesis; regulation of transcription, DNA-dependent; visual perception

Disease: Doyne Honeycomb Retinal Dystrophy
 EFEMP1 ELISA Kit
 EFEMP1 Recombinant
 EFEMP1 Antibody
 FBLN3 ELISA Kit
 FBLN3 Recombinant
 FBLN3 Antibody
 FBNL ELISA Kit
 FBNL Recombinant
 FBNL Antibody
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EGF-containing fibulin-like extracellular matrix protein 2

 EGF-containing fibulin-like extracellular matrix protein 2 ELISA Kit
 EGF-containing fibulin-like extracellular matrix protein 2 Recombinant
 EGF-containing fibulin-like extracellular matrix protein 2 Antibody
Also known as EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1).
EFEMP2: Defects in EFEMP2 are the cause of cutis laxa, autosomal recessive, type 1B (ARCL1B). A connective tissue disorder characterized by characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. ARCL1B f
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eatures include emphysema, lethal pulmonary artery occlusion, aortic aneurysm, cardiopulmonary insufficiency, birth fractures, arachnodactyly, and fragility of blood vessels. Belongs to the fibulin family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: proteinaceous extracellular matrix
 Efemp2 ELISA Kit
 Efemp2 Recombinant
 Efemp2 Antibody
 Fbln4 ELISA Kit
 Fbln4 Recombinant
 Fbln4 Antibody
 Mbp1 ELISA Kit
 Mbp1 Recombinant
 Mbp1 Antibody
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