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Embryonic growth/differentiation factor

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May mediate cell differentiation events during embryonic development.

Below are the list of possible Embryonic growth/differentiation factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Embryonic growth/differentiation factor 1

 Embryonic growth/differentiation factor 1 ELISA Kit
 Embryonic growth/differentiation factor 1 Recombinant
 Embryonic growth/differentiation factor 1 Antibody
Also known as Embryonic growth/differentiation factor 1 (GDF-1).
GDF1: May mediate cell differentiation events during embryonic development. Defects in GDF1 are a cause of conotruncal heart malformations (CTHM). A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncu
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s arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Defects in GDF1 are the cause of transposition of the great arteries dextro-looped type 3 (DTGA3). A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients with transposition of the great arteries. Defects in GDF1 are a cause of tetralogy of Fallot (TOF). A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: extracellular space

Molecular Function: cytokine activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; cell development; regulation of apoptosis; regulation of MAPKKK cascade

Disease: Conotruncal Heart Malformations; Right Atrial Isomerism; Tetralogy Of Fallot; Transposition Of The Great Arteries, Dextro-looped 3
 GDF1 ELISA Kit
 GDF1 Recombinant
 GDF1 Antibody
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