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Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

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Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity).

Below are the list of possible Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase ELISA Kit
 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Recombinant
 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Antibody
Also known as Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1).
MAN1B1: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from
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Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the glycosyl hydrolase 47 family.

Protein type: Calcium-binding; EC 3.2.1.113; Endoplasmic reticulum; Glycan Metabolism - N-glycan biosynthesis; Hydrolase; Membrane protein, integral

Cellular Component: endoplasmic reticulum; membrane

Molecular Function: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Biological Process: ER-associated protein catabolic process; N-glycan processing
 Man1b1 ELISA Kit
 Man1b1 Recombinant
 Man1b1 Antibody
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