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Endothelial PAS domain-containing protein

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Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Below are the list of possible Endothelial PAS domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Endothelial PAS domain-containing protein 1

 Endothelial PAS domain-containing protein 1 ELISA Kit
 Endothelial PAS domain-containing protein 1 Recombinant
 Endothelial PAS domain-containing protein 1 Antibody
Also known as Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2).
HIF2A: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be impli
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cated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBBP. Interacts with EGLN1. Interacts with VHL. Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2p21-p16

Cellular Component: cytosol; nucleoplasm; transcription factor complex

Molecular Function: DNA binding; histone acetyltransferase binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor binding

Biological Process: myoblast cell fate commitment; positive regulation of transcription from RNA polymerase II promoter; response to hypoxia; signal transduction; somatic stem cell maintenance; transcription from RNA polymerase II promoter

Disease: Erythrocytosis, Familial, 4
 EPAS1 ELISA Kit
 EPAS1 Recombinant
 EPAS1 Antibody
 BHLHE73 ELISA Kit
 BHLHE73 Recombinant
 BHLHE73 Antibody
 HIF2A ELISA Kit
 HIF2A Recombinant
 HIF2A Antibody
 MOP2 ELISA Kit
 MOP2 Recombinant
 MOP2 Antibody
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