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Endothelins are endothelium-derived vasoconstrictor peptides.

Below are the list of possible Endothelin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.


 Endothelin-1 ELISA Kit
 Endothelin-1 Recombinant
 Endothelin-1 Antibody
Also known as Endothelin-1 (ET-1).
Endothelins are endothelium-derived vasoconstrictor peptides.
 EDN1 Recombinant
 EDN1 Antibody
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 Endothelin-2 ELISA Kit
 Endothelin-2 Recombinant
 Endothelin-2 Antibody
Also known as Endothelin-2 (ET-2) (Preproendothelin-2) (PPET2).
Endothelins are endothelium-derived vasoconstrictor peptides.
 EDN2 Recombinant
 EDN2 Antibody
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 Endothelin-3 ELISA Kit
 Endothelin-3 Recombinant
 Endothelin-3 Antibody
Also known as Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3).
EDN3: Endothelins are endothelium-derived vasoconstrictor peptides. Defects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4); also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal o
bstruction. Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B); also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). Belongs to the endothelin/sarafotoxin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.2-q13.3

Cellular Component: extracellular region; extracellular space

Molecular Function: endothelin B receptor binding; hormone activity; receptor binding

Biological Process: artery smooth muscle contraction; blood circulation; cell surface receptor linked signal transduction; cell-cell signaling; inositol phosphate-mediated signaling; multicellular organismal development; neutrophil chemotaxis; peptide hormone secretion; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of heart rate; positive regulation of hormone secretion; positive regulation of leukocyte chemotaxis; positive regulation of MAP kinase activity; positive regulation of mitosis; regulation of gene expression; regulation of systemic arterial blood pressure by endothelin; signal transduction; vasoconstriction; vein smooth muscle contraction

Disease: Central Hypoventilation Syndrome, Congenital; Hirschsprung Disease, Susceptibility To, 4; Waardenburg Syndrome, Type 4b
 EDN3 Recombinant
 EDN3 Antibody
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