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Enhanced intracellular survival protein

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Effector that is released into the host cell and affects host immune responses; it negatively modulates inflammation, macrophage autophagy, and cell death through redox-dependent signaling. Acts as an acetyltransferase. Acetylates 'Lys-55' of dual-specificity protein phosphatase 16 (DUSP16)/mitogen-activated protein kinase phosphatase-7 (MKP-7), a JNK-specific phosphatase; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis. Inhibits Con A-mediated T-cell proliferation in vitro. Treatment of T-cells with Eis inhibits ERK1/2, JAK pathway, and subsequent production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-4 (IL-4); on the contrary, there is increased production of interferon-gamma (IFN-gamma) and interleukin-10 (IL-10), which indicates that immunity in response to Eis treatment is skewed away from a protective T(H)1 response and Eis disturbs the cross regulation of T-cells. When expressed in M.smegmatis, enhances intracellular survival of the bacteria in host macrophages during infection.

Below are the list of possible Enhanced intracellular survival protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Enhanced intracellular survival protein

 Enhanced intracellular survival protein ELISA Kit
 Enhanced intracellular survival protein Recombinant
 Enhanced intracellular survival protein Antibody
May participate in pathogenesis, possibly by enhancing survival of the bacteria in host macrophages during infection.
 eis ELISA Kit
 eis Recombinant
 eis Antibody
 MT2489 ELISA Kit
 MT2489 Recombinant
 MT2489 Antibody
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