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F-box/WD repeat-containing protein

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Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1 (By similarity).

Below are the list of possible F-box/WD repeat-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

F-box/WD repeat-containing protein 10

 F-box/WD repeat-containing protein 10 ELISA Kit
 F-box/WD repeat-containing protein 10 Recombinant
 F-box/WD repeat-containing protein 10 Antibody
Also known as F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10).
FBXW10: Probable substrate-recognition component of a SCF (SKP1- CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. 4 isoforms of the human pro
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tein are produced by alternative splicing.
 Fbxw10 ELISA Kit
 Fbxw10 Recombinant
 Fbxw10 Antibody
Table BarTOPTable Bar
 

F-box/WD repeat-containing protein 11

 F-box/WD repeat-containing protein 11 ELISA Kit
 F-box/WD repeat-containing protein 11 Recombinant
 F-box/WD repeat-containing protein 11 Antibody
Also known as F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS).
FBW1B: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described.

Protein type: Ubiquitin conjugating system

Cellular Component: centrosome; cytoplasm; cytosol; nucleus; SCF ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin-protein ligase activity
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>Biological Process: negative regulation of NF-kappaB import into nucleus; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid dephosphorylation; protein destabilization; protein polyubiquitination; protein ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
 Fbxw11 ELISA Kit
 Fbxw11 Recombinant
 Fbxw11 Antibody
 Btrcp2 ELISA Kit
 Btrcp2 Recombinant
 Btrcp2 Antibody
 Fbw1b ELISA Kit
 Fbw1b Recombinant
 Fbw1b Antibody
 Fbxw1b ELISA Kit
 Fbxw1b Recombinant
 Fbxw1b Antibody
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F-box/WD repeat-containing protein 12

 F-box/WD repeat-containing protein 12 ELISA Kit
 F-box/WD repeat-containing protein 12 Recombinant
 F-box/WD repeat-containing protein 12 Antibody
Also known as F-box/WD repeat-containing protein 12 (F-box and WD-40 domain-containing protein 12) (F-box only protein 35).
FBXW12: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 3p21.31
 FBXW12 ELISA Kit
 FBXW12 Recombinant
 FBXW12 Antibody
 FBW12 ELISA Kit
 FBW12 Recombinant
 FBW12 Antibody
 FBXO12 ELISA Kit
 FBXO12 Recombinant
 FBXO12 Antibody
 FBXO35 ELISA Kit
 FBXO35 Recombinant
 FBXO35 Antibody
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F-box/WD repeat-containing protein 1A

 F-box/WD repeat-containing protein 1A ELISA Kit
 F-box/WD repeat-containing protein 1A Recombinant
 F-box/WD repeat-containing protein 1A Antibody
Also known as F-box/WD repeat-containing protein 1A (Beta-TrCP protein E3RS-IkappaB) (Beta-transducin repeat-containing protein) (Beta-TrCP) (E3RSIkappaB) (mE3RS-IkappaB) (F-box and WD repeats protein beta-TrCP) (HOS) (Ubiquitin ligase FWD1) (pIkappaB-E3 receptor subunit).
BTRC: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Regulates the stability of CTNNB1 and participates in Wnt signaling. Interacts directly with SKP1 i
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n the SCF complex. Interacts specifically with phosphorylated CTNNB1 and NFKBIA, ubiquitination substrates. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system

Cellular Component: cytoplasm; nucleus; SCF ubiquitin ligase complex

Molecular Function: beta-catenin binding; protein binding; protein phosphorylated amino acid binding; ubiquitin-protein ligase activity

Biological Process: mammary gland epithelial cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid dephosphorylation; protein catabolic process; protein destabilization; protein polyubiquitination; protein ubiquitination; regulation of cell cycle; regulation of circadian rhythm; regulation of I-kappaB kinase/NF-kappaB cascade; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process
 Btrc ELISA Kit
 Btrc Recombinant
 Btrc Antibody
 Fbw1 ELISA Kit
 Fbw1 Recombinant
 Fbw1 Antibody
 Fbxw1 ELISA Kit
 Fbxw1 Recombinant
 Fbxw1 Antibody
 Fwd1 ELISA Kit
 Fwd1 Recombinant
 Fwd1 Antibody
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F-box/WD repeat-containing protein 2

 F-box/WD repeat-containing protein 2 ELISA Kit
 F-box/WD repeat-containing protein 2 Recombinant
 F-box/WD repeat-containing protein 2 Antibody
Also known as F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2).
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
 FBXW2 ELISA Kit
 FBXW2 Recombinant
 FBXW2 Antibody
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F-box/WD repeat-containing protein 4

 F-box/WD repeat-containing protein 4 ELISA Kit
 F-box/WD repeat-containing protein 4 Recombinant
 F-box/WD repeat-containing protein 4 Antibody
Also known as F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4).
FBXW4: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling. Defects in FBXW4 are a cause of split-hand/foot malformation type 3 (SHFM3). SHFM3 is an autosomal dominant disorder characterized by hypoplasia/aplasia of the central digits with fusion of the remaining digits.

Protein type: Cell cycle regul
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ation; Cell development/differentiation

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: SCF ubiquitin ligase complex

Molecular Function: protein binding

Biological Process: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Disease: Split-hand/foot Malformation 3
 FBXW4 ELISA Kit
 FBXW4 Recombinant
 FBXW4 Antibody
 FBW4 ELISA Kit
 FBW4 Recombinant
 FBW4 Antibody
 SHFM3 ELISA Kit
 SHFM3 Recombinant
 SHFM3 Antibody
Table BarTOPTable Bar
 

F-box/WD repeat-containing protein 5

 F-box/WD repeat-containing protein 5 ELISA Kit
 F-box/WD repeat-containing protein 5 Recombinant
 F-box/WD repeat-containing protein 5 Antibody
Also known as F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5).
FBXW5: Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subse
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quent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Belongs to the FBXW5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cytoplasm; SCF ubiquitin ligase complex

Molecular Function: protein binding; protein kinase binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
 FBXW5 ELISA Kit
 FBXW5 Recombinant
 FBXW5 Antibody
 FBW5 ELISA Kit
 FBW5 Recombinant
 FBW5 Antibody
 PP3971 ELISA Kit
 PP3971 Recombinant
 PP3971 Antibody
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F-box/WD repeat-containing protein 7

 F-box/WD repeat-containing protein 7 ELISA Kit
 F-box/WD repeat-containing protein 7 Recombinant
 F-box/WD repeat-containing protein 7 Antibody
Also known as F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4).
FBXW7: a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including MYC, cyclin E, NOTCH1-released notch intracellular domain (NICD), JUN, and probably PSEN1. Recognizes and binds to phosphorylated target proteins. Other components of the SCF(FBXW7) complex are sCUL1, RBX1, and SKP1A.
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Defects in FBXW7 may be a cause of breast cancer. The homolog of Cdc4, one of the yeast genes that regulate sister chromatid cohesion. Down-regulation or disruption of FBXW7 resulted in abnormal sister chromatid cohesion in human cells. Four alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Nucleolus; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 4q31.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; SCF ubiquitin ligase complex

Molecular Function: cyclin binding; identical protein binding; phosphothreonine binding; protein binding; protein binding, bridging; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: lipid homeostasis; negative regulation of DNA endoreduplication; negative regulation of Notch signaling pathway; positive regulation of epidermal growth factor receptor activity; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein ligase activity; protein polyubiquitination; protein stabilization; protein ubiquitination; regulation of protein localization; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; sister chromatid cohesion; vasculature development
 FBXW7 ELISA Kit
 FBXW7 Recombinant
 FBXW7 Antibody
 FBW7 ELISA Kit
 FBW7 Recombinant
 FBW7 Antibody
 FBX30 ELISA Kit
 FBX30 Recombinant
 FBX30 Antibody
 SEL10 ELISA Kit
 SEL10 Recombinant
 SEL10 Antibody
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F-box/WD repeat-containing protein 8

 F-box/WD repeat-containing protein 8 ELISA Kit
 F-box/WD repeat-containing protein 8 Recombinant
 F-box/WD repeat-containing protein 8 Antibody
Also known as F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8).
FBXW8: Substrate-recognition component of a SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type
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: Cell development/differentiation; Ubiquitin conjugating system

Cellular Component: cytoplasm; Golgi apparatus; perinuclear region of cytoplasm; SCF ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: cell proliferation; Golgi organization and biogenesis; positive regulation of dendrite morphogenesis; protein ubiquitination; ubiquitin-dependent protein catabolic process
 Fbxw8 ELISA Kit
 Fbxw8 Recombinant
 Fbxw8 Antibody
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F-box/WD repeat-containing protein 9

 F-box/WD repeat-containing protein 9 ELISA Kit
 F-box/WD repeat-containing protein 9 Recombinant
 F-box/WD repeat-containing protein 9 Antibody
Also known as F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9).
FBXW9: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19p13.2

Molecular Function: protein binding
 FBXW9 ELISA Kit
 FBXW9 Recombinant
 FBXW9 Antibody
 FBW9 ELISA Kit
 FBW9 Recombinant
 FBW9 Antibody
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F-box/WD repeat-containing protein A

 F-box/WD repeat-containing protein A ELISA Kit
 F-box/WD repeat-containing protein A Recombinant
 F-box/WD repeat-containing protein A Antibody
Also known as F-box/WD repeat-containing protein A (F-box protein A) (Protein cheater A).
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May target the cAMP phosphodiesterase regA for degradation leading to an increase in cAMP and PKA activity. Promotes development of prestalk cells as opposed to prespores within the developing fruiting body. Required for culmination and fruiting body development.
 fbxA ELISA Kit
 fbxA Recombinant
 fbxA Antibody
 chtA ELISA Kit
 chtA Recombinant
 chtA Antibody
 DDB_G0276887 ELISA Kit
 DDB_G0276887 Recombinant
 DDB_G0276887 Antibody
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F-box/WD repeat-containing protein lin-23

 F-box/WD repeat-containing protein lin-23 ELISA Kit
 F-box/WD repeat-containing protein lin-23 Recombinant
 F-box/WD repeat-containing protein lin-23 Antibody
Also known as F-box/WD repeat-containing protein lin-23 (Abnormal cell lineage protein 23).
Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation ().
 lin-23 ELISA Kit
 lin-23 Recombinant
 lin-23 Antibody
 K10B2.1 ELISA Kit
 K10B2.1 Recombinant
 K10B2.1 Antibody
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F-box/WD repeat-containing protein pof1

 F-box/WD repeat-containing protein pof1 ELISA Kit
 F-box/WD repeat-containing protein pof1 Recombinant
 F-box/WD repeat-containing protein pof1 Antibody
Also known as F-box/WD repeat-containing protein pof1 (Skp1-binding protein 1).
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Required for the inactivation of zip1 via ubiquitination.
 pof1 ELISA Kit
 pof1 Recombinant
 pof1 Antibody
 sbp1 ELISA Kit
 sbp1 Recombinant
 sbp1 Antibody
 SPAC57A10.05c ELISA Kit
 SPAC57A10.05c Recombinant
 SPAC57A10.05c Antibody
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F-box/WD repeat-containing protein pof10

 F-box/WD repeat-containing protein pof10 ELISA Kit
 F-box/WD repeat-containing protein pof10 Recombinant
 F-box/WD repeat-containing protein pof10 Antibody
Also known as F-box/WD repeat-containing protein pof10 (Skp1-binding protein 2).
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
 pof10 ELISA Kit
 pof10 Recombinant
 pof10 Antibody
 sbp2 ELISA Kit
 sbp2 Recombinant
 sbp2 Antibody
 SPBC1703.06 ELISA Kit
 SPBC1703.06 Recombinant
 SPBC1703.06 Antibody
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F-box/WD repeat-containing protein pof11

 F-box/WD repeat-containing protein pof11 ELISA Kit
 F-box/WD repeat-containing protein pof11 Recombinant
 F-box/WD repeat-containing protein pof11 Antibody
Also known as F-box/WD repeat-containing protein pof11 (Meiotically up-regulated gene 156 protein).
Has a role in meiosis.
 pof11 ELISA Kit
 pof11 Recombinant
 pof11 Antibody
 mug156 ELISA Kit
 mug156 Recombinant
 mug156 Antibody
 SPAC29E6.01 ELISA Kit
 SPAC29E6.01 Recombinant
 SPAC29E6.01 Antibody
 SPAC30.05 ELISA Kit
 SPAC30.05 Recombinant
 SPAC30.05 Antibody
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F-box/WD repeat-containing protein sel-10

 F-box/WD repeat-containing protein sel-10 ELISA Kit
 F-box/WD repeat-containing protein sel-10 Recombinant
 F-box/WD repeat-containing protein sel-10 Antibody
Also known as F-box/WD repeat-containing protein sel-10 (Egg laying defective protein 41) (Suppressor/enhancer of lin-12 protein 10).
Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates synapse elimination in early development in the motor neuron HSNL (PubMed:17626846). Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis (PubM
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ed:9389650). May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation (PubMed:9389650). Involved in sex determination by promoting female development (PubMed:15306688, PubMed:18718460). Potential regulator of presenilin (PubMed:9861048). May have a role in egg laying (PubMed:8293978, PubMed:15306688). Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis (PubMed:22623721). Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation (PubMed:23154983).
 sel-10 ELISA Kit
 sel-10 Recombinant
 sel-10 Antibody
 egl-41 ELISA Kit
 egl-41 Recombinant
 egl-41 Antibody
 F55B12.3 ELISA Kit
 F55B12.3 Recombinant
 F55B12.3 Antibody
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Proteins Root Name Listing
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