| F-box/WD repeat-containing protein 7 ELISA Kit|
F-box/WD repeat-containing protein 7 Recombinant
F-box/WD repeat-containing protein 7 Antibody
|Also known as F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4). |
FBXW7: a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including MYC, cyclin E, NOTCH1-released notch intracellular domain (NICD), JUN, and probably PSEN1. Recognizes and binds to phosphorylated target proteins. Other components of the SCF(FBXW7) complex are sCUL1, RBX1, and SKP1A.
Defects in FBXW7 may be a cause of breast cancer. The homolog of Cdc4, one of the yeast genes that regulate sister chromatid cohesion. Down-regulation or disruption of FBXW7 resulted in abnormal sister chromatid cohesion in human cells. Four alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Nucleolus; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4q31.3
Cellular Component: cytoplasm; cytosol; nucleoplasm; SCF ubiquitin ligase complex
Molecular Function: cyclin binding; identical protein binding; phosphothreonine binding; protein binding; protein binding, bridging; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: lipid homeostasis; negative regulation of DNA endoreduplication; negative regulation of Notch signaling pathway; positive regulation of epidermal growth factor receptor activity; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein ligase activity; protein polyubiquitination; protein stabilization; protein ubiquitination; regulation of protein localization; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; sister chromatid cohesion; vasculature development
| FBXW7 ELISA Kit|
| FBW7 ELISA Kit|
| FBX30 ELISA Kit|
| SEL10 ELISA Kit|