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Fanconi anemia group I protein

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Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.

Below are the list of possible Fanconi anemia group I protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Fanconi anemia group I protein

 Fanconi anemia group I protein ELISA Kit
 Fanconi anemia group I protein Recombinant
 Fanconi anemia group I protein Antibody
Also known as Fanconi anemia group I protein (Protein FACI).
FANCI: Plays an essential role in the repair of DNA double- strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branch
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ed DNA: binds both single- stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. Defects in FANCI are a cause of Fanconi anemia complementation group I (FANCI). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; DNA repair, damage

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: cytoplasm; membrane; nucleoplasm

Molecular Function: protein binding

Biological Process: mitotic cell cycle G2/M transition DNA damage checkpoint; positive regulation of protein ubiquitination

Disease: Fanconi Anemia, Complementation Group I; Tracheoesophageal Fistula With Or Without Esophageal Atresia
 FANCI ELISA Kit
 FANCI Recombinant
 FANCI Antibody
 KIAA1794 ELISA Kit
 KIAA1794 Recombinant
 KIAA1794 Antibody
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Fanconi anemia group I protein homolog

 Fanconi anemia group I protein homolog ELISA Kit
 Fanconi anemia group I protein homolog Recombinant
 Fanconi anemia group I protein homolog Antibody
Also known as Fanconi anemia group I protein homolog (Protein FACI).
FANCI: Plays an essential role in the repair of DNA double- strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically bind
>>>
s branched DNA: binds both single- stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. Defects in FANCI are a cause of Fanconi anemia complementation group I (FANCI). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; DNA repair, damage

Cellular Component: cytoplasm; membrane; nucleoplasm

Biological Process: mitotic cell cycle G2/M transition DNA damage checkpoint; positive regulation of protein ubiquitination
 Fanci ELISA Kit
 Fanci Recombinant
 Fanci Antibody
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