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Fanconi anemia group M protein

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DNA-dependent ATPase component of the Fanconi anemia (FA) core complex .

Below are the list of possible Fanconi anemia group M protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Fanconi anemia group M protein

 Fanconi anemia group M protein ELISA Kit
 Fanconi anemia group M protein Recombinant
 Fanconi anemia group M protein Antibody
Also known as Fanconi anemia group M protein (Protein FACM) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).
FANCM: ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such
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lesions. Defects in FANCM are a cause of Fanconi anemia complementation group M (FANCM). FANCM is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Belongs to the DEAD box helicase family. DEAH subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.13; Helicase

Chromosomal Location of Human Ortholog: 14q21.2

Cellular Component: nucleoplasm

Molecular Function: chromatin binding; protein binding

Biological Process: replication fork processing; resolution of meiotic joint molecules as recombinants

Disease: Fanconi Anemia, Complementation Group M; Tracheoesophageal Fistula With Or Without Esophageal Atresia
 FANCM ELISA Kit
 FANCM Recombinant
 FANCM Antibody
 KIAA1596 ELISA Kit
 KIAA1596 Recombinant
 KIAA1596 Antibody
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Fanconi anemia group M protein homolog

 Fanconi anemia group M protein homolog ELISA Kit
 Fanconi anemia group M protein homolog Recombinant
 Fanconi anemia group M protein homolog Antibody
Also known as Fanconi anemia group M protein homolog (Protein FACM) (ATP-dependent RNA helicase FANCM).
FANCM: ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Defects in FANCM are a cause of Fanconi anemia complementation grou
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p M (FANCM). FANCM is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Belongs to the DEAD box helicase family. DEAH subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.13; Helicase

Cellular Component: nucleoplasm

Molecular Function: chromatin binding

Biological Process: replication fork processing; resolution of meiotic joint molecules as recombinants
 Fancm ELISA Kit
 Fancm Recombinant
 Fancm Antibody
 Kiaa1596 ELISA Kit
 Kiaa1596 Recombinant
 Kiaa1596 Antibody
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