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Fanconi-associated nuclease

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Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates .

Below are the list of possible Fanconi-associated nuclease products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Fanconi-associated nuclease 1

 Fanconi-associated nuclease 1 ELISA Kit
 Fanconi-associated nuclease 1 Recombinant
 Fanconi-associated nuclease 1 Antibody
Also known as Fanconi-associated nuclease 1 (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15).
FAN1: Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activit
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y toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap- specific enzymes to unhook the ICL by cleaving the lagging-strand template. Belongs to the FAN1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; Deoxyribonuclease; EC 3.1.4.1; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 15q13.2-q13.3

Cellular Component: cytoplasm; intercellular bridge; nucleoplasm; nucleus

Molecular Function: 5'-3' exonuclease activity; 5'-flap endonuclease activity; magnesium ion binding; protein binding; ubiquitin binding

Biological Process: DNA repair; double-strand break repair via homologous recombination; nucleotide-excision repair; nucleotide-excision repair, DNA incision

Disease: Interstitial Nephritis, Karyomegalic
 FAN1 ELISA Kit
 FAN1 Recombinant
 FAN1 Antibody
 KIAA1018 ELISA Kit
 KIAA1018 Recombinant
 KIAA1018 Antibody
 MTMR15 ELISA Kit
 MTMR15 Recombinant
 MTMR15 Antibody
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Fanconi-associated nuclease 1 homolog

 Fanconi-associated nuclease 1 homolog ELISA Kit
 Fanconi-associated nuclease 1 homolog Recombinant
 Fanconi-associated nuclease 1 homolog Antibody
Nuclease required for the repair of DNA interstrand cross-links (ICL) (PubMed:24192486, PubMed:25319828). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions ().
 SPBC146.06c ELISA Kit
 SPBC146.06c Recombinant
 SPBC146.06c Antibody
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