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Fermitin family

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Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.

Below are the list of possible Fermitin family products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Fermitin family homolog 1

 Fermitin family homolog 1 ELISA Kit
 Fermitin family homolog 1 Recombinant
 Fermitin family homolog 1 Antibody
Also known as Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1).
kindlin-1: Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. Defects in FERMT1
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are the cause of Kindler syndrome (KINDS). An autosomal recessive skin disorder characterized by skin blistering, photosensitivity, progressive poikiloderma, and extensive skin atrophy. Additional clinical features include gingival erosions, ocular, esophageal, gastrointestinal and urogenital involvement, and an increased risk of mucocutaneous malignancy. Although most FERMT1 mutations are predicted to lead to premature termination of translation, and to loss of FERMT1 function, significant clinical variability is observed among patients. There is an association of FERMT1 missense and in-frame deletion mutations with milder disease phenotypes, and later onset of complications (PubMed:21936020). Belongs to the kindlin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20p12.3

Cellular Component: cell junction; cytosol

Biological Process: cell adhesion; keratinocyte migration; keratinocyte proliferation

Disease: Kindler Syndrome
 FERMT1 ELISA Kit
 FERMT1 Recombinant
 FERMT1 Antibody
 C20orf42 ELISA Kit
 C20orf42 Recombinant
 C20orf42 Antibody
 KIND1 ELISA Kit
 KIND1 Recombinant
 KIND1 Antibody
 URP1 ELISA Kit
 URP1 Recombinant
 URP1 Antibody
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Fermitin family homolog 2

 Fermitin family homolog 2 ELISA Kit
 Fermitin family homolog 2 Recombinant
 Fermitin family homolog 2 Antibody
Also known as Fermitin family homolog 2 (Kindlin-2).
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phosp
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holipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling (). Required for normal embryonic development, including normal heart morphogenesis and normal angiogenesis.
 fermt2 ELISA Kit
 fermt2 Recombinant
 fermt2 Antibody
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Fermitin family homolog 3

 Fermitin family homolog 3 ELISA Kit
 Fermitin family homolog 3 Recombinant
 Fermitin family homolog 3 Antibody
Also known as Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2).
kindlin-3: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3); also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome char
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acterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes. Belongs to the kindlin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: membrane; podosome

Molecular Function: integrin binding

Biological Process: integrin activation; integrin-mediated signaling pathway; leukocyte adhesion; positive regulation of cell migration; regulation of cell-cell adhesion mediated by integrin

Disease: Leukocyte Adhesion Deficiency, Type Iii
 FERMT3 ELISA Kit
 FERMT3 Recombinant
 FERMT3 Antibody
 KIND3 ELISA Kit
 KIND3 Recombinant
 KIND3 Antibody
 MIG2B ELISA Kit
 MIG2B Recombinant
 MIG2B Antibody
 URP2 ELISA Kit
 URP2 Recombinant
 URP2 Antibody
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Proteins Root Name Listing
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