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Ficolin

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Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity).

Below are the list of possible Ficolin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Ficolin-1

 Ficolin-1 ELISA Kit
 Ficolin-1 Recombinant
 Ficolin-1 Antibody
Also known as Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin).
FCN1: Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2- 6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. Belongs to the ficolin lectin family.

Protein
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type: Secreted; Secreted, signal peptide

Molecular Function: protein binding

Biological Process: complement activation, lectin pathway
 Fcn1 ELISA Kit
 Fcn1 Recombinant
 Fcn1 Antibody
 Fcna ELISA Kit
 Fcna Recombinant
 Fcna Antibody
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Ficolin-2

 Ficolin-2 ELISA Kit
 Ficolin-2 Recombinant
 Ficolin-2 Antibody
Also known as Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35).
FCN2: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsoni
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c effect via the collagen region. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 9q34
 FCN2 ELISA Kit
 FCN2 Recombinant
 FCN2 Antibody
 FCNL ELISA Kit
 FCNL Recombinant
 FCNL Antibody
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Ficolin-3

 Ficolin-3 ELISA Kit
 Ficolin-3 Recombinant
 Ficolin-3 Antibody
Also known as Ficolin-3 (Collagen/fibrinogen domain-containing lectin 3 p35) (Collagen/fibrinogen domain-containing protein 3) (Hakata antigen).
FCN3: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D). FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fing
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ers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: extracellular region

Molecular Function: antigen binding; protein binding; serine-type endopeptidase activity

Biological Process: complement activation; complement activation, lectin pathway; defense response to virus; negative regulation of virion penetration into host cell; recognition of apoptotic cell

Disease: Immunodeficiency Due To Ficolin 3 Deficiency
 FCN3 ELISA Kit
 FCN3 Recombinant
 FCN3 Antibody
 FCNH ELISA Kit
 FCNH Recombinant
 FCNH Antibody
 HAKA1 ELISA Kit
 HAKA1 Recombinant
 HAKA1 Antibody
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