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Filamin

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Actin binding protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity). Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs .

Below are the list of possible Filamin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Filamin-A

 Filamin-A ELISA Kit
 Filamin-A Recombinant
 Filamin-A Antibody
Also known as Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin).
FLNA: a ubiquitous cytoskeletal protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Plays an essential role in embryonic cell migration. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interactions with filamin A may allow neuroblast migration from the ventricular zone into the corti
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cal plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.

Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Cellular Component: actin cytoskeleton; actin filament; actin filament bundle; brush border; cell soma; cell-cell adherens junction; cortical cytoskeleton; cytoplasm; cytosol; dendritic shaft; extracellular matrix; filamentous actin; focal adhesion; growth cone; intercellular junction; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; trans-Golgi network

Molecular Function: actin binding; actin filament binding; G-protein-coupled receptor binding; glycoprotein binding; GTPase binding; kinase binding; mu-type opioid receptor binding; protein binding; protein complex binding; protein homodimerization activity; protein kinase C binding; Rac GTPase binding; Ral GTPase binding; Rho GTPase binding; signal transducer activity; SMAD binding; small GTPase binding; transcription factor binding

Biological Process: actin crosslink formation; actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; angiogenesis; blood vessel remodeling; cytoplasmic sequestering of protein; dopamine receptor, adenylate cyclase inhibiting pathway; early endosome to late endosome transport; epithelial to mesenchymal transition; establishment of protein localization; heart morphogenesis; intercellular junction assembly and maintenance; mRNA transcription from RNA polymerase II promoter; negative regulation of apoptosis; negative regulation of protein catabolic process; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase I promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein stabilization; receptor clustering; regulation of actin filament bundle formation; regulation of cell migration
 Flna ELISA Kit
 Flna Recombinant
 Flna Antibody
 Fln ELISA Kit
 Fln Recombinant
 Fln Antibody
 Fln1 ELISA Kit
 Fln1 Recombinant
 Fln1 Antibody
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Filamin-B

 Filamin-B ELISA Kit
 Filamin-B Recombinant
 Filamin-B Antibody
Also known as Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP).
FLNB: a ubiquitous cytoskeletal protein that links actin filaments to membrane glycoproteins. Six alternatively spliced isoforms have been described. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoforms 1 and 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells, retina and skeletal muscle. Isoform 1 i
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s predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord and platelets. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer's disease. Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytoplasm; cytosol; extracellular matrix; focal adhesion; plasma membrane

Molecular Function: identical protein binding; protein binding

Biological Process: cytoskeletal anchoring; signal transduction

Disease: Atelosteogenesis, Type I; Atelosteogenesis, Type Iii; Boomerang Dysplasia; Larsen Syndrome; Spondylocarpotarsal Synostosis Syndrome
 FLNB ELISA Kit
 FLNB Recombinant
 FLNB Antibody
 FLN1L ELISA Kit
 FLN1L Recombinant
 FLN1L Antibody
 FLN3 ELISA Kit
 FLN3 Recombinant
 FLN3 Antibody
 TABP ELISA Kit
 TABP Recombinant
 TABP Antibody
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Filamin-C

 Filamin-C ELISA Kit
 Filamin-C Recombinant
 Filamin-C Antibody
Also known as Filamin-C (FLN-C) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin).
FLNC: Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. Defects in FLNC are the cause of myopathy myofibrillar type 5 (MFM5). A neur
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omuscular disorder, usually with an adult onset, characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations, and clinical features of a limb-girdle myopathy. Defects in FLNC are the cause of myopathy distal type 4 (MPD4). MPD4 is a slowly progressive muscular disorder characterized by distal muscle weakness and atrophy affecting the upper and lower limbs. Onset occurs around the third to fourth decades of life, and patients remain ambulatory even after long disease duration. Muscle biopsy shows non-specific changes with no evidence of rods, necrosis, or inflammation. Belongs to the filamin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: costamere; cytoplasm; focal adhesion; plasma membrane; sarcolemma; sarcoplasm

Molecular Function: ankyrin binding; cytoskeletal protein binding

Biological Process: muscle fiber development
 Flnc ELISA Kit
 Flnc Recombinant
 Flnc Antibody
 Abpl ELISA Kit
 Abpl Recombinant
 Abpl Antibody
 Fln2 ELISA Kit
 Fln2 Recombinant
 Fln2 Antibody
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