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Flap endonuclease

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Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Below are the list of possible Flap endonuclease products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Flap endonuclease 1

 Flap endonuclease 1 ELISA Kit
 Flap endonuclease 1 Recombinant
 Flap endonuclease 1 Antibody
Also known as Flap endonuclease 1 (FEN-1) (Cell death-related nuclease 1) (Flap structure-specific endonuclease 1).
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of
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a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
 crn-1 ELISA Kit
 crn-1 Recombinant
 crn-1 Antibody
 CBG14945 ELISA Kit
 CBG14945 Recombinant
 CBG14945 Antibody
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Flap endonuclease 1-1

 Flap endonuclease 1-1 ELISA Kit
 Flap endonuclease 1-1 Recombinant
 Flap endonuclease 1-1 Antibody
Also known as Flap endonuclease 1-1 (FEN-1-1) (Flap structure-specific endonuclease 1-1).
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki frag
>>>
ment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
 FEN1-1 ELISA Kit
 FEN1-1 Recombinant
 FEN1-1 Antibody
 GSPATT00011232001 ELISA Kit
 GSPATT00011232001 Recombinant
 GSPATT00011232001 Antibody
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Flap endonuclease 1-2

 Flap endonuclease 1-2 ELISA Kit
 Flap endonuclease 1-2 Recombinant
 Flap endonuclease 1-2 Antibody
Also known as Flap endonuclease 1-2 (FEN-1-2) (Flap structure-specific endonuclease 1-2).
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki frag
>>>
ment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
 FEN1-2 ELISA Kit
 FEN1-2 Recombinant
 FEN1-2 Antibody
 GSPATT00011429001 ELISA Kit
 GSPATT00011429001 Recombinant
 GSPATT00011429001 Antibody
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Flap endonuclease 1-A

 Flap endonuclease 1-A ELISA Kit
 Flap endonuclease 1-A Recombinant
 Flap endonuclease 1-A Antibody
Also known as Flap endonuclease 1-A (FEN-1-A) (Flap structure-specific endonuclease 1-A).
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki frag
>>>
ment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
 FEN1-A ELISA Kit
 FEN1-A Recombinant
 FEN1-A Antibody
 PHYPADRAFT_207454 ELISA Kit
 PHYPADRAFT_207454 Recombinant
 PHYPADRAFT_207454 Antibody
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Flap endonuclease 1-B

 Flap endonuclease 1-B ELISA Kit
 Flap endonuclease 1-B Recombinant
 Flap endonuclease 1-B Antibody
Also known as Flap endonuclease 1-B (FEN-1-B) (Flap structure-specific endonuclease 1-B).
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki frag
>>>
ment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
 FEN1b ELISA Kit
 FEN1b Recombinant
 FEN1b Antibody
 OsI_14202 ELISA Kit
 OsI_14202 Recombinant
 OsI_14202 Antibody
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Flap endonuclease GEN

 Flap endonuclease GEN ELISA Kit
 Flap endonuclease GEN Recombinant
 Flap endonuclease GEN Antibody
Also known as Flap endonuclease GEN (Flap structure-specific endonuclease GEN) (Xpg-like endonuclease).
Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at rep
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lication forks, in which the 5' single-strand overhang of the flap is double-stranded. Also possesses weak 5'- to 3'-exonuclease activity on nicked but not gapped double-stranded DNA. Does not cleave bubble-like or Holliday junction substrates ().
 Gen ELISA Kit
 Gen Recombinant
 Gen Antibody
 GA10481 ELISA Kit
 GA10481 Recombinant
 GA10481 Antibody
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Flap endonuclease GEN homolog 1

 Flap endonuclease GEN homolog 1 ELISA Kit
 Flap endonuclease GEN homolog 1 Recombinant
 Flap endonuclease GEN homolog 1 Antibody
GEN1: Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Bel
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ongs to the XPG/RAD2 endonuclease family. GEN subfamily.

Protein type: EC 3.1.-.-; Hydrolase

Cellular Component: centrosome

Molecular Function: crossover junction endodeoxyribonuclease activity

Biological Process: double-strand break repair via homologous recombination
 Gen1 ELISA Kit
 Gen1 Recombinant
 Gen1 Antibody
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Flap endonuclease GEN-like 1

 Flap endonuclease GEN-like 1 ELISA Kit
 Flap endonuclease GEN-like 1 Recombinant
 Flap endonuclease GEN-like 1 Antibody
Encodes one of two GEN1 homologs in Arabidopsis. It is a member of the class IV Rad2/XPG family of nucleases that processes Holliday junctions in a manner analogous to the HJ resolvases of phages, archaea, and bacteria.
 GEN1 ELISA Kit
 GEN1 Recombinant
 GEN1 Antibody
 At1g01880 ELISA Kit
 At1g01880 Recombinant
 At1g01880 Antibody
 F22M8.2 ELISA Kit
 F22M8.2 Recombinant
 F22M8.2 Antibody
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Flap endonuclease GEN-like 2

 Flap endonuclease GEN-like 2 ELISA Kit
 Flap endonuclease GEN-like 2 Recombinant
 Flap endonuclease GEN-like 2 Antibody
Encodes one of two GEN1 homologs in Arabidopsis. It is a member of the class IV Rad2/XPG family of nucleases that processes Holliday junctions in a manner analogous to the HJ resolvases of phages, archaea, and bacteria.
 GEN2 ELISA Kit
 GEN2 Recombinant
 GEN2 Antibody
 At3g48900/At3g48910 ELISA Kit
 At3g48900/At3g48910 Recombinant
 At3g48900/At3g48910 Antibody
 T21J18.170/T2J13.250 ELISA Kit
 T21J18.170/T2J13.250 Recombinant
 T21J18.170/T2J13.250 Antibody
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Flap endonuclease Xni

 Flap endonuclease Xni ELISA Kit
 Flap endonuclease Xni Recombinant
 Flap endonuclease Xni Antibody
Also known as Flap endonuclease Xni (FEN).
Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
 xni ELISA Kit
 xni Recombinant
 xni Antibody
 ygdG ELISA Kit
 ygdG Recombinant
 ygdG Antibody
 EcE24377A_3103 ELISA Kit
 EcE24377A_3103 Recombinant
 EcE24377A_3103 Antibody
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