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Folate receptor

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Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Below are the list of possible Folate receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Folate receptor alpha

 Folate receptor alpha ELISA Kit
 Folate receptor alpha Recombinant
 Folate receptor alpha Antibody
Also known as Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18).
FOLR1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate tr
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ansport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain- specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. Belongs to the folate receptor family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11q13.3-q14.1

Cellular Component: anchored to external side of plasma membrane; apical plasma membrane; basolateral plasma membrane; cell surface; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; Golgi membrane; integral to plasma membrane; membrane; nucleus

Molecular Function: drug binding; folic acid binding; folic acid transporter activity; methotrexate binding; receptor activity

Biological Process: axon regeneration; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; folic acid transport; heart looping; receptor-mediated endocytosis; regulation of transforming growth factor beta receptor signaling pathway

Disease: Neurodegeneration Due To Cerebral Folate Transport Deficiency
 FOLR1 ELISA Kit
 FOLR1 Recombinant
 FOLR1 Antibody
 FOLR ELISA Kit
 FOLR Recombinant
 FOLR Antibody
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Folate receptor beta

 Folate receptor beta ELISA Kit
 Folate receptor beta Recombinant
 Folate receptor beta Antibody
Also known as Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP).
FOLR2: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Belongs to the folate receptor family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of H
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uman Ortholog: 11q13.3-q13.5

Cellular Component: anchored to external side of plasma membrane; cell surface; membrane

Molecular Function: drug binding; folic acid binding; folic acid transporter activity; methotrexate binding

Biological Process: folic acid transport; monocyte chemotaxis; positive regulation of cell proliferation; receptor-mediated endocytosis; regulation of thymidylate synthase biosynthetic process
 FOLR2 ELISA Kit
 FOLR2 Recombinant
 FOLR2 Antibody
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Folate receptor gamma

 Folate receptor gamma ELISA Kit
 Folate receptor gamma Recombinant
 Folate receptor gamma Antibody
Also known as Folate receptor gamma (FR-gamma) (Folate receptor 3).
FOLR3: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate. Belongs to the folate receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal pe
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ptide

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extrinsic to membrane; membrane

Biological Process: folic acid transport
 FOLR3 ELISA Kit
 FOLR3 Recombinant
 FOLR3 Antibody
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