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Fos-related antigen

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Below are the list of possible Fos-related antigen products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Fos-related antigen 1

 Fos-related antigen 1 ELISA Kit
 Fos-related antigen 1 Recombinant
 Fos-related antigen 1 Antibody
Also known as Fos-related antigen 1 (FRA-1).
FRA1: an oncogenic transcription factor of the bZIP family, Fos subfamily. The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator P
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rotein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent basic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity. Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate but short-lived, while FRA1 and FRA2 expression persists longer. FRA1 is involved in cell motility, invasiveness, and inhibits apoptosis. Elevated in many cancers and associated with tumorigenesis and cancer progression. Involved in Erk2-mediated Epithelial-to-Mesenchymal Transition (EMT) pathway. ERK2/FRA2 regulate ZEB1/2 expression, known to be associated with the EMT. Smad2/3-Fra1 complexes may reflect activation of the Smad/AP-1-dependent TGF¿-induced breast cancer invasion program. Activation of FRA1/C-JUN by ERK/AKT pathways can induce EZH2 overexpression, silencing integrin alpha-2 expression, and increasing the metastatic potential of colorectal cancer. Belongs to the bZIP family. Fos subfamily.

Protein type: DNA-binding; Transcription factor

Cellular Component: cytosol; intracellular membrane-bound organelle; neuron projection; nucleus; presynaptic membrane

Molecular Function: DNA binding

Biological Process: cellular response to extracellular stimulus; in utero embryonic development; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of cell cycle; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; vitellogenesis
 Fosl1 ELISA Kit
 Fosl1 Recombinant
 Fosl1 Antibody
 Fra1 ELISA Kit
 Fra1 Recombinant
 Fra1 Antibody
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Fos-related antigen 2

 Fos-related antigen 2 ELISA Kit
 Fos-related antigen 2 Recombinant
 Fos-related antigen 2 Antibody
Also known as Fos-related antigen 2 (FRA-2).
FRA2: an oncogenic transcription factor of the bZIP family, Fos subfamily. The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator Protein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent b
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asic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity. Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate but short-lived, while FRA1 and FRA2 expression persists longer. FRA2 and JUND up-regulate the expression of CCR4, MYB, MDM2, and BCL6, and are expressed at high levels in CCR4-expressing mature T-cell malignancies such as adult T-cell leukemia/lymphoma (ATLL) and cutaneous T-cell lymphomas (CTCLs). May play a role in regulating the transcription of ICOS downstream of TCR/CD28 and cytokine receptor signaling. Its transcription is significantly increased in metastatic clear cell renal cell carcinomas. Belongs to the bZIP family, Fos subfamily. Three isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Cellular Component: nucleoplasm; nucleus

Molecular Function: chromatin binding; DNA binding; double-stranded DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: aging; circadian rhythm; conditioned taste aversion; female pregnancy; photoperiodism; positive regulation of fibroblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to cAMP; response to cold; response to cytokine stimulus; response to estradiol stimulus; response to hypoxia; response to light stimulus; response to mechanical stimulus; response to organic cyclic substance; response to peptide hormone stimulus; response to progesterone stimulus; response to toxin; sleep; transcription from RNA polymerase II promoter
 Fosl2 ELISA Kit
 Fosl2 Recombinant
 Fosl2 Antibody
 Fra-2 ELISA Kit
 Fra-2 Recombinant
 Fra-2 Antibody
 Fra2 ELISA Kit
 Fra2 Recombinant
 Fra2 Antibody
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